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compositionComposition:AMIODARONE-100MG
prescription
Prescription Medicine
info
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Amipace 100 Tablet is used to treat an illness called Wolff-Parkinson-White Syndrome (heart beats unusually fast). It also treats other types of fast or uneven heartbeats known as atrial flutter or atrial fibrillation. It contains Amiodarone, that controls the heart's uneven beating (arrhythmia) or prevents irregular heartbeat. It reduces the impulses that cause abnormal heartbeat. It may cause common side effects such as blurred vision or visual halos around light. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

AMIODARONE-100MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Amipace 100 Tablet

Amipace 100 Tablet is a prescription medicine used to treat serious, life-threatening irregular heartbeats, also known as arrhythmias. It helps restore a normal, steady rhythm to your heart when other treatments have not worked or cannot be tolerated. This medication is essential for keeping your heart beating in a safe and stable pattern.

You must take Amipace 100 Tablet exactly as prescribed, consistently every single day to maintain a steady level of the medicine in your body. It is important to take it the same way each day, either always with food or always without food, to ensure your body absorbs it consistently. Making heart-healthy dietary changes, staying hydrated, and managing stress can also support your heart function while on this treatment.

While taking this medicine, some people may experience mild side effects like nausea, changes in taste, or increased sensitivity to sunlight. However, because this medicine stays in your body for a long time, you must consult your doctor immediately if you notice serious symptoms like shortness of breath, a persistent cough, vision changes, or yellowing of your skin or eyes.

Before starting Amipace 100 Tablet , tell your doctor if you have a history of lung, thyroid, or liver problems, as this medicine can affect these organs. Do not take this if you have certain serious heart conditions, such as a very slow heartbeat or a heart block, unless you have a working pacemaker.

This medication can interact with many other medicines, alcohol, and tobacco, which can change how it works or increase your risk of severe side effects. Pregnant women, breastfeeding mothers, and elderly individuals must consult their doctor before using Amipace 100 Tablet because of potential risks to the baby or increased sensitivity to the drug's effects.

Uses of Amipace 100 Tablet

Amipace 100 Tablet is used to treat arrhythmias. The detailed uses of Amipace 100 Tablet are as follows:

  • Severe irregular heartbeats (arrhythmias): Amipace 100 Tablet helps correct serious, life-threatening heart rhythm disturbances (such as recurrent ventricular fibrillation and unstable ventricular tachycardia) by stabilising the electrical signals in your heart.
  • Heart rhythm maintenance: It helps keep your heart beating at a normal, steady pace when other rhythm-controlling medicines have failed or are not suitable for you.

Key Benefits

Amipace 100 Tablet offers crucial benefits for individuals managing complex heart rhythm issues:

  • Restores steady heart rhythm: By stabilising electrical activity, it reduces sudden, frightening episodes of rapid or fluttering heartbeats, helping you feel more physically secure.
  • Reduces hospitalisations: Keeping your heart rate stable lowers the risk of severe cardiac events that could require emergency medical attention.
  • Improves daily physical stamina: When your heart pumps blood efficiently, your body gets the oxygen it needs, which can help reduce feelings of unusual fatigue or weakness during daily activities.
Side effects of Amipace 100 Tablet
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Your doctor may adjust the dose of your medication, discontinue, or switch to alternative medicines to manage your symptoms.
  • You may be treated with levothyroxine (a thyroid hormone replacement) to help with better absorption in those with digestive issues.
  • Your doctor will regularly monitor your progress with blood tests and adjust the dose as needed.
  • Get 8 hours of sleep each night, relax for 10 minutes a day, and do some light exercise for 10-20 minutes a few times a week.
  • Eat a healthy diet with veggies, fruits, whole grains, lean protein, and good fats.
  • Avoid excessive iodine from foods like seaweed or supplements, as it can worsen your symptoms.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Heart failure needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Take care of change in your weight as there can be sudden changes.
  • Rest and refrain from physical activity, and restart after a few days.
  • Reduce your salt intake and control your diet with the help of a dietician.
  • Track your symptoms and keep your follow-up appointments to manage severe side effects.
  • Cardiac arrest can be prevented by making lifestyle changes such as:
  • Eat a nutrient-rich balanced diet.
  • Limit foods high in fat, sugar, sodium, and processed meats.
  • Exercise for 30-60 minutes daily.
  • Maintain a healthy weight.
  • Manage stress with relaxation techniques.
  • Quit smoking and tobacco use.
  • Limit alcohol consumption.
  • Get regular heart health checkups and screenings.
  • Consider an implantable cardioverter-defibrillator (ICD) if recommended by your healthcare provider.

Directions for Use

To get the best results from your treatment, follow these simple guidelines:

  • Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or break the tablet unless your doctor specifically tells you to do so.
  • Take this medicine consistently. Choose to take it either always with food or always on an empty stomach to keep the absorption level steady.
  • Avoid drinking grapefruit juice or eating grapefruit while using this medication, as it can dangerously increase the medicine's levels in your blood.
  • Always follow your doctor's exact instructions regarding your daily routine and never stop taking this medicine suddenly without consulting them.

How Amipace 100 Tablet Works

Amipace 100 Tablet contains amiodarone. To understand how Amipace 100 Tablet works, it helps to think of your heart as a pump controlled by an intricate electrical system. When you have an irregular heartbeat, the electrical signals in your heart are firing too quickly or out of order. This medication works by relaxing overactive heart muscle cells and slowing down these rapid electrical impulses. By blocking specific mineral pathways (like potassium, sodium, and calcium channels) and calming natural stress chemical receptors in the heart, Amipace 100 Tablet helps the heart's electrical system reset. This steadying effect allows your heart to pump blood more efficiently and return to a normal, regular rhythm.
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Alcohol

Unsafe

Amipace 100 Tablet may interact with alcohol and worsen the liver problems. So, it is recommended to avoid alcohol intake while using Amipace 100 Tablet .

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Pregnancy

Unsafe

Amipace 100 Tablet is a category D medicine. It shows harmful effects on the fetus when given during pregnancy.

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Breast Feeding

Unsafe

Amipace 100 Tablet may be excreted in breast milk in small amounts. So, it should be avoided in breastfeeding mothers.

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Driving

Unsafe

Amipace 100 Tablet may cause vision problems. So, avoid driving or operating heavy machinery after taking Amipace 100 Tablet .

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Liver

Caution

Amipace 100 Tablet may show an effect on the liver. So, it should be used with caution in patients with liver problems.

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Kidney

Caution

Amipace 100 Tablet should be used with caution in patients with kidney disease only when prescribed by a doctor.

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Children

Unsafe

Amipace 100 Tablet should not be used in children below 12 years of age unless prescribed by a doctor.

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Heart

Safe if prescribed

Amipace 100 Tablet is safe for use in heart patients if recommended by the physician.

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Geriatrics

Consult your doctor

Inform your doctor if you have any concerns regarding the use of Amipace 100 Tablet in geriatric patients.

What if I have taken an overdose of Amipace 100 Tablet

Do not take more than the prescribed dose of Amipace 100 Tablet as it may cause overdose. The symptoms of overdose include fainting, slow heartbeat, blurred vision, lightheadedness or nausea. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid grapefruit and grapefruit juice: Grapefruit interferes with how your body breaks down this medicine, which can raise the drug to unsafe levels in your bloodstream.
  • Protect your skin from the sun: This medicine makes your skin highly sensitive to ultraviolet light. Wear protective clothing, hats, and a high-SPF sunscreen (SPF 30 or higher) daily, and avoid tanning beds. Some areas of skin exposed to the sun may turn a blue-grey colour, which is often slow to fade.
  • Monitor your pulse: Learn how to check your pulse regularly. If your heart rate drops below your target range or feels unusually slow, contact your healthcare provider.
  • Keep all medical appointments: You will need regular blood tests to check your liver and thyroid function, as well as periodic chest X-rays, eye exams, and lung function tests to ensure the medicine is working safely.

Health Queries

I notice a fast, pulsing feeling in my stomach whenever I go for a walk. Is this something to worry about?

Vikas Singh

Vikas Singh

M Pharmacy

A fast pulsing feeling in the stomach during walking is usually the normal abdominal pulse becoming more noticeable when your heart rate increases with activity. Try slowing your pace and building up gradually so your body adjusts better, and avoid walking on a full stomach, as this can make the sensation more obvious. Stay well hydrated and keep your breathing steady while walking to reduce awareness of the pulse, and maintain regular exercise so your body gets used to activity over time. Pay attention if the pulsing feels very strong or painful, or if it happens even when you are resting. Consult a doctor to rule out any underlying issue if it concerns you.
health query

Have a query?

How Soon It Starts Working

  • The time required for Amipace 100 Tablet to start to work: Amipace 100 Tablet ideally shows its action within 2 to 3 days after administration.
  • The time for which the effects of Amipace 100 Tablet last: The effect of Amipace 100 Tablet lasts for 58 days.

What if you forget to take Amipace 100 Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

•Store Amipace 100 Tablet tablets at controlled room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original container to protect them from light and moisture.

Drug Warnings

  • Be patient during the start of treatment: This medicine builds up very slowly in your tissues, meaning it may take several weeks or even months before it reaches its full effect.
  • Report any dry cough or breathing changes immediately: Lung damage is a rare but serious risk with this medication; catching breathing changes early is vital.
  • Avoid driving if you experience vision changes: If you notice halos around lights or blurred vision, avoid driving or operating machinery and contact your eye doctor.
  • Never stop this medicine abruptly: Stopping Amipace 100 Tablet suddenly can cause your irregular heartbeats to return or worsen. Always consult your doctor before making any changes.
  • Inform all healthcare providers: Always tell any doctor, dentist, or surgeon you visit that you are taking Amipace 100 Tablet , as it can stay in your body for months after you stop taking it and may interact with anaesthetics or other treatments.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Blood thinners (like warfarin): Taking Amipace 100 Tablet can significantly increase the strength of your blood thinner, raising your risk of dangerous bleeding.
  • Heart medications (like digoxin or beta-blockers): Combining these can cause your heart rate to drop to dangerously slow levels.
  • Cholesterol-lowering medicines (statins): It can raise the levels of certain statins in your body, increasing your risk of muscle pain and damage.
  • Other heart rhythm drugs: Combining this with other medicines that control your heart rhythm can increase the risk of a different, serious type of irregular heartbeat.

Drug-Food Interactions

  • Grapefruit and grapefruit juice: This fruit blocks the enzymes that break down Amipace 100 Tablet , causing the drug's levels to rise dangerously high in your body.
  • Alcohol: Consuming alcohol while on this medication can increase your risk of liver damage and dizziness.
    Caffeine: High amounts of caffeine can stimulate your heart and interfere with the stabilising effects of this medicine.

Drug-Disease Interactions

  • Thyroid disease: Because this medicine contains high amounts of iodine, it can cause or worsen both underactive thyroid (hypothyroidism) and overactive thyroid (hyperthyroidism).
  • Lung disease: If you have pre-existing lung conditions, you are at a higher risk of developing severe lung inflammation or damage from this medicine.
  • Liver disease: It can cause liver irritation or liver damage, so your doctor will need to monitor your liver health closely.
  • Severe heart block or very slow heartbeat: Do not take this medicine if you have these conditions unless you have a functional artificial pacemaker.
AmiodaroneEliglustat
Critical
AmiodaroneSaquinavir
Critical

Drug-Drug Interactions

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AmiodaroneEliglustat
Critical
How does the drug interact with Amipace 100 Tablet:
The combination of Amipace 100 Tablet and Eliglustat may increase the risk of an irregular heartbeat considerably.

How to manage the interaction:
Even though Amipace 100 Tablet and Eliglustat interact, it can be taken if prescribed by a doctor. Consult a doctor if you have abrupt dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AmiodaroneSaquinavir
Critical
How does the drug interact with Amipace 100 Tablet:
The combination of Amipace 100 Tablet and Saquinavir may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Despite the fact that Amipace 100 Tablet and Saquinavir interact, it can be taken if prescribed by a doctor. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without visiting a doctor.
AmiodaroneIndinavir
Critical
How does the drug interact with Amipace 100 Tablet:
The combination of Amipace 100 Tablet and Indinavir may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Despite the fact that Amipace 100 Tablet and Indinavir interact, it can be taken if prescribed by a doctor. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without visiting a doctor.
AmiodaroneCiprofloxacin
Critical
How does the drug interact with Amipace 100 Tablet:
Taking Amipace 100 Tablet and Ciprofloxacin may significantly increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Amipace 100 Tablet with Ciprofloxacin is not recommended, it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
AmiodaronePimozide
Critical
How does the drug interact with Amipace 100 Tablet:
The combination of Amipace 100 Tablet and Pimozide may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Despite the fact that Amipace 100 Tablet and Pimozide interact, it can be taken if prescribed by a doctor. If you have other cardiac disorders, or imbalances in electrolytes, you may be at greater risk. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without visiting a doctor.
AmiodaroneDronedarone
Critical
How does the drug interact with Amipace 100 Tablet:
The combination of Amipace 100 Tablet and Dronedarone may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Despite the fact that Amipace 100 Tablet and Dronedarone interact, it can be taken if prescribed by a doctor.If you have other cardiac disorders, or imbalances in electrolytes, you may be at greater risk. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without visiting a doctor.
AmiodaroneGrepafloxacin
Critical
How does the drug interact with Amipace 100 Tablet:
The combination of Amipace 100 Tablet and Grepafloxacin may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Despite the fact that Amipace 100 Tablet and Grepafloxacin interact, it can be taken if prescribed by a doctor. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without visiting a doctor. Note: Grepafloxacin is no more available on the market. Grepafloxacin should not be combined with any other medications without doctor's advice.
AmiodaroneMoxifloxacin
Critical
How does the drug interact with Amipace 100 Tablet:
Taking Amipace 100 Tablet and Moxifloxacin may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Amipace 100 Tablet and Moxifloxacin is not recommended as it can lead to an interaction; it can be taken if advised by a doctor. If you get dizziness, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without visiting a doctor.
AmiodaroneCisapride
Critical
How does the drug interact with Amipace 100 Tablet:
The combination of Amipace 100 Tablet and Cisapride may significantly raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Despite the fact that Amipace 100 Tablet and Cisapride interact, it can be taken if prescribed by a doctor. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without visiting a doctor. Note: Cisapride is no longer available on the market. Cisapride should only be used under the supervision of a doctor.
AmiodaroneRitonavir
Critical
How does the drug interact with Amipace 100 Tablet:
The combination of Amipace 100 Tablet and Ritonavir may significantly increase the blood levels of Amipace 100 Tablet.

How to manage the interaction:
Despite the fact that Amipace 100 Tablet and Ritonavir interact, it can be taken if prescribed by a doctor. If you get dizziness, shortness of breath, weakness, or chest tightness, consult a doctor. Do not stop taking any medications without visiting a doctor.

Drug-Food Interactions

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AMIODARONE-100MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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AMIODARONE-100MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit juice with Amipace 100 Tablet can cause an increase in Amipace 100 Tablet levels in your body, which might lead to side effects. Avoid grapefruit juice while being treated with Amipace 100 Tablet. If you suffer symptoms such as an abnormal heartbeat, chest tightness, blurred vision, or nausea, consult a doctor.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIARRHYTHMICS]

FAQs

Amipace 100 Tablet is used to treat an illness called Wolff-Parkinson-White Syndrome (heart beats unusually fast). It also treats other types of fast or uneven heartbeats known as atrial flutter or atrial fibrillation.
Amipace 100 Tablet is an antiarrhythmic drug used to treat arrhythmias (irregular heartbeat). It acts by blocking the potassium channels in the heart and slows down heart activity. It blocks the abnormal electrical activity in the heart and normalizes the heartbeat.
Do not take grapefruit or grapefruit juice, coffee, and alcohol while taking Amipace 100 Tablet as it increases the risk of side-effects. Do not take other medicines unless prescribed by your doctor.
Amipace 100 Tablet has a toxic effect on the thyroid and may cause thyroid dysfunction. So, people with hypothyroidism should not take Amipace 100 Tablet .
Do not take Amipace 100 Tablet if you are pregnant as it may cause toxic effects to the fetus.
Prolonged use of Amipace 100 Tablet may cause toxic effects. However, your doctor may prescribe for the long-term if the benefits outweigh the risks. It may also cause proarrhythmic effects when used long-term. Proarrhythmic effects are the medication-induced occurrence of pre-existing arrhythmias.
Wolf-Parkinson-White (WPW) syndrome is a condition in which the upper and lower chambers (ventricles) of the heart cause rapid heartbeat because of an extra electrical pathway present between them.
Amipace 100 Tablet may cause low blood pressure. Let the doctor know if you have high/low blood pressure before starting Amipace 100 Tablet . Regularly monitor blood pressure while treatment with Amipace 100 Tablet .
Amipace 100 Tablet blocks the abnormal electrical activity in the heart and normalizes the heartbeat.
The warning signs of liver toxicity caused by Amipace 100 Tablet are nausea, vomiting, fatigue, jaundice (yellowing of skin and eyes), weight loss, and abdominal pain. Consult the doctor if you notice these symptoms.
Yes, Amipace 100 Tablet is safe if taken in the dose and duration prescribed by the doctor.
Amipace 100 Tablet may cause vision problems like blurred vision or visual halos around light. Consult the doctor if you experience any vision problems.
Common side-effects of Amipace 100 Tablet are blurred vision or visual halos around light. Amipace 100 Tablet may affect thyroid gland function. It may also cause skin photosensitivity (redness or rashes on the sun-exposed skin, especially the face) and tremors when you move your arms or legs. Consult your doctor if any of these effects persist or worsen over time.
This medicine can affect several parts of your body over time, including your liver, thyroid gland, lungs, and eyes. Regular tests allow your doctor to monitor these organs closely and detect any early signs of side effects before they become severe. Talk to your doctor to learn more.
This medicine breaks down very slowly and can stay in your body for several weeks or even months after your last dose. Because of this, potential side effects and drug interactions can still occur long after you have stopped taking it. Talk to your doctor if you have concerns.
Yes, a rare side effect of long-term use is a blue-grey colouring of the skin, especially on areas exposed to sunlight, like your face and hands. Protecting your skin with sunscreen and clothing can help prevent this. The colour usually fades slowly after stopping the medicine, but you should talk to your doctor if you notice skin colour changes.
If you feel your irregular heartbeat returning, or if you experience severe dizziness, fainting, or chest pain, seek medical attention immediately. These can be signs that your condition is changing or that you are experiencing a serious side effect. Talk to your doctor right away.

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Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - AMI0138
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