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  1. Home
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  3. AMITRYN C PLUS TABLET

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AMITRYN C PLUS TABLET, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

AMITRYN C PLUS TABLET is used to treat moderate to severe depression associated with moderate to severe anxiety. It contains Amitriptyline and Chlordiazepoxide, which works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Also, it helps suppress the excessive and abnormal activity of the nerve cells in the brain. In some cases, you may experience common side effects such as dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

AMITRIPTYLINE-25MG + CHLORDIAZEPOXIDE-10MG

Manufacturer/Marketer :

Gracewell Co

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About AMITRYN C PLUS TABLET

AMITRYN C PLUS TABLET is used to treat moderate to severe depression associated with moderate to severe anxiety. Depression is a mood disorder characterised by sadness, unhappiness, anger, hopelessness or loss. Anxiety is a mental health disorder characterised by feelings of anxiety, worry or fear that are strong enough to interfere with one’s daily activities. Anxiety and depression can occur at the same time.

AMITRYN C PLUS TABLET is a combination of two drugs: Amitriptyline (tricyclic anti-depressant) and Chlordiazepoxide (benzodiazepine anxiolytic). Amitriptyline works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain. 

You are advised to take AMITRYN C PLUS TABLET only for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Do not take AMITRYN C PLUS TABLET if you are pregnant, as it may cause birth defects. Consult your doctor before taking AMITRYN C PLUS TABLET if you are breastfeeding. Avoid driving or operating machinery as AMITRYN C PLUS TABLET causes sleepiness and dizziness and might impair thinking and motor skills. Avoid consuming alcohol along with AMITRYN C PLUS TABLET as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of AMITRYN C PLUS TABLET

AMITRYN C PLUS TABLET is used in the treatment of depression associated with anxiety. The detailed uses of AMITRYN C PLUS TABLET are as follows:

  • Managing Anxiety Disorders: AMITRYN C PLUS TABLET is often prescribed to alleviate symptoms of anxiety, offering relief from excessive worry and nervousness.
  • Treating Depression: AMITRYN C PLUS TABLET plays a role in treatment plans for depression, helping to improve mood and emotional well-being.
  • Sleep Aid: With its sedative properties, AMITRYN C PLUS TABLET may assist in managing insomnia and other sleep-related concerns.
  • Neuropathic Pain Relief: AMITRYN C PLUS TABLET is effective in alleviating chronic pain caused by nerve damage, improving the quality of life for affected individuals.
  • ADHD Management: As part of a comprehensive treatment approach, AMITRYN C PLUS TABLET can help enhance focus and concentration in patients with attention deficit hyperactivity disorder.

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Directions for Use

  • Take AMITRYN C PLUS TABLET with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

AMITRYN C PLUS TABLET is a combination of two drugs: Amitriptyline and Chlordiazepoxide. AMITRYN C PLUS TABLET is used to treat moderate to severe depression and anxiety. Amitriptyline is a tricyclic anti-depressant that affects certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide is a benzodiazepine anxiolytic that works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain. AMITRYN C PLUS TABLET has a calming effect on various functions of the brain. Thereby, AMITRYN C PLUS TABLET helps in treating anxiety and depression.

How AMITRYN C PLUS TABLET Works

AMITRYN C PLUS TABLET is a combination of two drugs: Amitriptyline (tricyclic anti-depressant) and Chlordiazepoxide (benzodiazepine anxiolytic). Amitriptyline works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Amitryn C Plus Tablet
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of AMITRYN C PLUS TABLET

Do not take more than the prescribed dose of AMITRYN C PLUS TABLET as it may cause overdose. The symptoms of overdose include difficulty sleeping, disorientation, dizziness, blurred vision, confusion, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, headache, loss of consciousness, fast/slow/irregular heartbeat, hallucinations, mood or other mental changes, seeing/hearing/feeling things that are not there, nightmares, seizures (fits), sweating, trouble breathing, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, or unusual excitement, nervousness, restlessness, or irritability. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take AMITRYN C PLUS TABLET if you are allergic to any of its contents, if you recently had a heart attack or heart problems, are taking monoamine oxidase inhibitors (MAOI). Do not take opioids with AMITRYN C PLUS TABLET as it may result in increased sedation, depression, coma and death. AMITRYN C PLUS TABLET should not be taken for longer durations as it may cause physical dependence. Inform your doctor before taking AMITRYN C PLUS TABLET if you have bipolar disorder, eye problems, urination problems, seizures, thyroid problems, kidney or liver problems or if you are due to have any surgery. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Talk to your doctor before taking AMITRYN C PLUS TABLET if you have a history of drug abuse, addiction or alcohol abuse as AMITRYN C PLUS TABLET may cause dependence. Do not take AMITRYN C PLUS TABLET if you are pregnant, as it may cause birth defects. Consult your doctor before taking AMITRYN C PLUS TABLET if you are breastfeeding. Avoid driving or operating machinery as AMITRYN C PLUS TABLET causes sleepiness, dizziness and might impair thinking and motor skills. Avoid consuming alcohol along with AMITRYN C PLUS TABLET as it could lead to increased drowsiness and dizziness. AMITRYN C PLUS TABLET should not be given to children as safety and effectiveness have not been established.

Drug-Drug Interactions

verifiedApollotooltip
AmitriptylineLinezolid
Critical
AmitriptylineSparfloxacin
Critical

Drug-Drug Interactions

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AmitriptylineLinezolid
Critical
How does the drug interact with Amitryn C Plus Tablet:
Taking Linezolid with Amitryn C Plus Tablet can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Linezolid and Amitryn C Plus Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amitryn C Plus Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineSparfloxacin
Critical
How does the drug interact with Amitryn C Plus Tablet:
Combining Amitryn C Plus Tablet and Sparfloxacin may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitryn C Plus Tablet with Sparfloxacin may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor. Note: Sparfloxacin is no longer available in the market. Grepafloxacin should not be combined with any other medications.
AmitriptylineDronedarone
Critical
How does the drug interact with Amitryn C Plus Tablet:
Combining Amitryn C Plus Tablet and Dronedarone may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitryn C Plus Tablet with Dronedarone may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineSaquinavir
Critical
How does the drug interact with Amitryn C Plus Tablet:
Combining Amitryn C Plus Tablet and Saquinavir may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitryn C Plus Tablet with Saquinavir may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineMethylene blue
Critical
How does the drug interact with Amitryn C Plus Tablet:
Combining Methylene blue with Amitryn C Plus Tablet can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Methylene blue and Amitryn C Plus Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amitryn C Plus Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineGrepafloxacin
Critical
How does the drug interact with Amitryn C Plus Tablet:
Combining Amitryn C Plus Tablet and Grepafloxacin may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitryn C Plus Tablet with Grepafloxacin may result in an interaction, it can be used if a doctor recommends it. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor. Note: Grepafloxacin is no longer available in the market. Grepafloxacin should not be combined with any other medications.
AmitriptylineBepridil
Critical
How does the drug interact with Amitryn C Plus Tablet:
Combining Amitryn C Plus Tablet and Bepridil may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitryn C Plus Tablet with Bepridil may result in an interaction, it can be used if a doctor recommends it. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineMesoridazine
Critical
How does the drug interact with Amitryn C Plus Tablet:
Coadministration of Amitryn C Plus Tablet and Mesoridazine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitryn C Plus Tablet with Mesoridazine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineZiprasidone
Critical
How does the drug interact with Amitryn C Plus Tablet:
Taking Amitryn C Plus Tablet and Ziprasidone may increase the risk of irregular heartbeat.

How to manage the interaction:
Although there is a interaction between Amitryn C Plus Tablet with Ziprasidone, but it can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats . Do not discontinue any medication without consulting a doctor.
AmitriptylineCisapride
Critical
How does the drug interact with Amitryn C Plus Tablet:
Coadministration of Amitryn C Plus Tablet and Cisapride may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitryn C Plus Tablet with Cisapride may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.

  • Regularly attend therapy sessions.

  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.

  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.

  • Include foods rich in omega-fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.

  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products and certain fruits and vegetables help in the proper maintenance of neurotransmitters.

  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.

  • Exercising helps in the production of the body’s natural anti-depressants. It also helps in relieving stress, improving mood, boosting self-esteem and providing restful sleep.

  • Avoid smoking and alcohol consumption.

  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

Yes

Therapeutic Class

PSYCHOTHERAPEUTICS

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Alcohol

Unsafe

Avoid consumption of alcohol while taking AMITRYN C PLUS TABLET as it may cause increased sleepiness and dizziness.

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Pregnancy

Unsafe

Avoid taking AMITRYN C PLUS TABLET if you are pregnant unless prescribed by a doctor as it may cause birth defects.

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Breast Feeding

Caution

Consult your doctor before taking AMITRYN C PLUS TABLET; your doctor will decide whether AMITRYN C PLUS TABLET can be taken by breastfeeding mothers or not.

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Driving

Unsafe

AMITRYN C PLUS TABLET may cause sleepiness, dizziness and might impair thinking and motor skills. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

AMITRYN C PLUS TABLET should not be given to children as safety and effectiveness have not been established.

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Heart

Unsafe

This medicine is contraindicated in cardiac patients due to its adverse effects.

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Geriatrics

Caution

AMITRYN C PLUS TABLET should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using AMITRYN C PLUS TABLET.

FAQs

AMITRYN C PLUS TABLET is used to treat moderate to severe depression associated with moderate to severe anxiety.

AMITRYN C PLUS TABLET contains Amitriptyline and Chlordiazepoxide. Amitriptyline works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain.

AMITRYN C PLUS TABLET may cause weight gain due to increased appetite. Eat a healthy diet and exercise regularly to maintain a healthy weight.

Do not discontinue AMITRYN C PLUS TABLET without consulting your doctor, as it could cause withdrawal symptoms. To treat your condition effectually, continue taking AMITRYN C PLUS TABLET for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking AMITRYN C PLUS TABLET.

Dry mouth could be a side-effect of AMITRYN C PLUS TABLET. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Country of origin

INDIA

Manufacturer/Marketer address

G-785,Ghandhi Nagar,Kurukshetra,Thanesar, Haryana 136119
Other Info - AMI0120

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Dec 3, 2025 | 7:32 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/016949s040lbl.pdf
  2. https://www.drugs.com/mtm/amitriptyline-and-chlordiazepoxide.html
  3. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=66a756f2-ac77-451c-a19a-08896d73b15c

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