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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Amivate-M Tablet is used to treat neuropathic pain (nerve pain). It works by lowering the pain signals to the brain and promoting the synthesis of myelin, a substance that protects nerve fibres and rejuvenates injured nerve cells. In some cases, this medicine may cause side effects such as constipation, dizziness, dry mouth, feeling sleepy, and headache.
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Manufacturer/Marketer :

Trumac Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Amivate-M Tablet

Amivate-M Tablet is used to manage neuropathic pain due to damaged nerves. Neuropathic pain is pain caused by a lesion or disease of the somatosensory nervous system. The pain could be intermittent or continuous, like a prickling, stabbing, tingling, or burning sensation.

Amivate-M Tablet is a combination of two drugs: Amitriptyline and Methylcobalamin. Amitriptyline belongs to a class of medications known as tricyclic antidepressants, and it works by boosting serotonin levels in the brain. This can make you feel better. This can also alter how your nerves receive pain signals, causing pain to subside. Methylcobalamin is a vitamin B derivative that promotes the synthesis of myelin, which protects nerve fibres and rejuvenates injured nerve cells. They work together to alleviate neuropathic pain (pain from damaged nerves).

Take Amivate-M Tablet as prescribed by your doctor. Depending on your medical condition, you are advised to take Amivate-M Tablet for as long as your doctor has prescribed it for you. In some cases, you may experience certain common side effects such as constipation, dizziness, dry mouth, feeling sleepy, difficulty peeing, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not take Amivate-M Tablet if you have had an allergic reaction to Amivate-M Tablet or any ingredients in it. Tell your doctor if you're pregnant, trying to get pregnant, or breastfeeding. Amivate-M Tablet is generally not recommended in pregnancy and breastfeeding. Your doctor will only prescribe Amivate-M Tablet for your pain while you're pregnant or breastfeeding if the benefits of taking medicine outweigh the risks. Amivate-M Tablet may cause side effects like Light-headedness or dizziness, which may affect your concentration ability. Hence, it is recommended not to drive or operate machinery until you are mentally alert. Seek medical attention if the symptoms persist longer. Avoid consuming alcohol along with Amivate-M Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Amivate-M Tablet

Treatment of Neuropathic pain

Directions for Use

Swallow Amivate-M Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Amivate-M Tablet is a combination of two drugs: Amitriptyline and Methylcobalamin. Amitriptyline belongs to a class of medications known as tricyclic antidepressants. Antidepressants are considered to function by boosting serotonin levels in the brain, making you feel better. And also, these can alter how your nerves receive pain signals, causing pain to subside. Methylcobalamin is a vitamin B derivative that promotes the synthesis of myelin, which protects nerve fibres and rejuvenates injured nerve cells. They work together to alleviate neuropathic pain (pain from damaged nerves).

How Amivate-M Tablet Works

Amivate-M Tablet is a combination of two drugs: Amitriptyline and Methylcobalamin. Amitriptyline belongs to a class of medications known as tricyclic antidepressants, and it works by boosting serotonin levels in the brain. This can make you feel better. This can also alter how your nerves receive pain signals, causing pain to subside. Methylcobalamin is a vitamin B derivative that promotes the synthesis of myelin, which protects nerve fibres and rejuvenates injured nerve cells. They work together to alleviate neuropathic pain (pain from damaged nerves).

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Amivate-M Tablet

Take Amivate-M Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Amivate-M Tablet if you have allergic reactions to Amivate-M Tablet or any ingredients. Tell your doctor if you're pregnant, trying to get pregnant, or breastfeeding. Amivate-M Tablet is generally not recommended in pregnancy and breastfeeding. Your doctor will only prescribe Amivate-M Tablet for your pain while pregnant or breastfeeding if the benefits of taking medicine outweigh the risks. Amivate-M Tablet may cause side effects like Light-headedness or dizziness, affecting your concentration. Hence, it is recommended not to drive or operate machinery until you are mentally alert. Seek medical attention if the symptoms persist longer. Avoid consuming alcohol with Amivate-M Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects. Let your doctor know if you have a history of heart disease, severe kidney disease, a blood disorder called porphyria, epilepsy, glaucoma, or suicidal tendency.

Drug-Drug Interactions

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AmitriptylineIsocarboxazid
Critical

Drug-Drug Interactions

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How does the drug interact with Amivate-M Tablet:
Coadministration of Amivate-M Tablet and Cisapride may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amivate-M Tablet with Cisapride may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineIsocarboxazid
Critical
How does the drug interact with Amivate-M Tablet:
Combining Isocarboxazid with Amivate-M Tablet can increase the risk of serotonin syndrome (increase serotonin hormone).

How to manage the interaction:
Although using Isocarboxazid and Amivate-M Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amivate-M Tablet. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amivate-M Tablet:
Combining Amivate-M Tablet and Pimozide may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amivate-M Tablet with Pimozide may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Amivate-M Tablet:
The combination of Amivate-M Tablet and Potassium chloride may cause stomach and upper intestinal discomfort. (Only applicable to an oral preparation)

How to manage the interaction:
Although co-administration of Amivate-M Tablet and Potassium chloride is not recommended as it can possibly lead to an interaction, they can be taken if prescribed by a doctor. If you experience severe stomach pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (in particular with blood), decreased hunger, and black stools while taking these medications, consult a doctor immediately. Do not discontinue any medications without talking to a doctor.
How does the drug interact with Amivate-M Tablet:
Taking Linezolid with Amivate-M Tablet can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Linezolid and Amivate-M Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amivate-M Tablet. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amivate-M Tablet:
Amivate-M Tablet and Thioridazine can enhance each other's effects when used together.

How to manage the interaction:
Although using Amivate-M Tablet and Thioridazine together can cause an interaction, they can be used if prescribed by a doctor. If you have extreme sleepiness, confusion, anxiety, vomiting, vision problems, feeling hot or cold, sweating, muscle stiffness, fainting, fits, or coma, seek medical help. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amivate-M Tablet:
Combining Methylene blue with Amivate-M Tablet can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Methylene blue and Amivate-M Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amivate-M Tablet. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amivate-M Tablet:
Taking Tranylcypromine with Amivate-M Tablet can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although using Tranylcypromine and Amivate-M Tablet together is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, consult a doctor if you have symptoms such as confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
AmitriptylineHalofantrine
Critical
How does the drug interact with Amivate-M Tablet:
Combining Amivate-M Tablet and Halofantrine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amivate-M Tablet with Halofantrine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Amivate-M Tablet:
Combining Furazolidone with Amivate-M Tablet can increase the risk of serotonin syndrome(increased serotonin hormone).

How to manage the interaction:
Although using Furazolidone and Amivate-M Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Amivate-M Tablet. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Nutritional deficits can cause neuropathy symptoms. Choose foods high in nutrients, such as fruits, vegetables, and whole grains.

  • Replace fatty protein sources with lean alternatives and consume modest quantities of healthy fat sources for improved well-being. Saturated fat in fatty meats and dairy products has been linked to inflammation and an increased risk of type 2 diabetes.

  • Elevated blood sugar levels are linked to various chronic health problems, including diabetic peripheral neuropathy. Increase Omega–3 fatty acids, Fiber, and Antioxidants such as flaxseeds, fruits, vegetables, nuts, and beans to help you maintain a healthy blood sugar level and control your diabetes.

  • Create a diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.

  • Instead of saturated and trans fats, choose monounsaturated and polyunsaturated fats (fish, nuts, and vegetable oils).

  • Select/prepare foods and beverages with fewer added sugars/caloric sweeteners.

  • Be mindful of salt; consume no more than 2,300 mg each day.

  • Limit or avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

CENTRAL NERVOUS SYSTEM AGENTS
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Alcohol

Caution

It is unclear whether alcohol can be taken while using this medication. However, as a precautionary measure, it is best to avoid alcohol while taking medication.

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Pregnancy

Caution

Amivate-M Tablet is generally not recommended in pregnancy. Your doctor will only prescribe Amivate-M Tablet for your pain while you're pregnant if the benefits of taking medicine outweigh the risks.

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Breast Feeding

Caution

Amivate-M Tablet is generally not recommended in breastfeeding. Your doctor will only prescribe Amivate-M Tablet for your pain while you're breastfeeding if the benefits of taking medicine outweigh the risks.

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Driving

Caution

Amivate-M Tablet may cause side effects like Light-headedness or dizziness, affecting your ability to concentrate and drive. Hence, it is recommended not to drive or operate machinery until you are mentally alert. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Limited information was available for the use of Amivate-M Tablet in patients with liver impairment. Please consult the doctor. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Limited information was available for the use of Amivate-M Tablet in patients with Kidney impairment. Please consult the doctor. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Limited information was available for the use of Amivate-M Tablet in paediatric patients. Please consult the doctor. Your doctor will prescribe only if the benefits outweigh the risks.

Have a query?

FAQs

Amivate-M Tablet is used to manage neuropathic pain due to damaged nerves.

Amivate-M Tablet is a combination of two drugs: Amitriptyline and Methylcobalamin. Amitriptyline belongs to a class of medications known as tricyclic antidepressants. Antidepressants are considered to function by boosting serotonin levels in the brain, making you feel better. And also, these can alter how your nerves receive pain signals, causing pain to subside. Methylcobalamin is a vitamin B derivative that promotes myelin synthesis, a material that protects nerve fibres and rejuvenates injured nerve cells. They work together to alleviate neuropathic pain (pain from damaged nerves).

No, it is a prescribed drug given by a physician to prevent specific medical conditions. Taking it on your own can cause unwanted side effects.

Do not discontinue Amivate-M Tablet without consulting your doctor, as it could lead to withdrawal symptoms. To treat your condition effectually, continue taking Amivate-M Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Amivate-M Tablet ; your doctor will reduce the dose gradually.

Amivate-M Tablet is safe if used in the dose and duration recommended by your doctor. Take it precisely as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.

Country of origin

India

Manufacturer/Marketer address

Plot 231, Phase-1, Industrial Area, Panchkula, Haryana (134113)
Other Info - AMI0585

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