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compositionComposition:AMPHOTERICIN B-50MG
prescription
Prescription Medicine
info
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Amphonat 50 mg Injection 1's is used to treat severe fungal infections. It contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. In some cases, this medicine may cause side effects such as fever, chills, nausea, vomiting, headache, muscle cramps or pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMPHOTERICIN B-50MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Amphonat 50 mg Injection 1's

Amphonat 50 mg Injection 1's is a prescription injection used to treat serious, potentially life-threatening fungal infections throughout the body. It is also prescribed to treat certain severe parasitic infections when other options are not suitable.

Because this medication is given as an injection or slow infusion into a vein, it is typically given by a healthcare professional in a hospital or specialised clinic. The frequency of your treatment depends on your specific medical condition and how well your body responds to the therapy. Staying well-hydrated and maintaining a balanced diet are important lifestyle habits that can support your body's recovery during this therapy.

Some people may experience side effects during treatment, such as fever, shaking, chills, nausea, or changes in kidney function. It is highly important to consult your doctor immediately if you experience severe symptoms like extreme weakness, an irregular heartbeat, or difficulty breathing.

Talk to your doctor before starting this medicine if you have a history of kidney disease, liver damage, heart conditions, or low levels of potassium or magnesium. Do not take this if you have had a severe, life-threatening allergic reaction to this medicine or any of its ingredients in the past.

This medicine can interact with other drugs, especially those that can cause kidney damage, as well as certain water pills or steroids. Always tell your healthcare provider if you are pregnant, breastfeeding, or if you are caring for an elderly patient, as these groups require careful medical supervision during treatment.

Uses of Amphonat 50 mg Injection 1's

Amphonat 50 mg Injection 1's is used in the treatment of severe fungal infections. The detailed uses of Amphonat 50 mg Injection 1's are as follows:

  • Severe fungal infections: This medicine is used to treat deep and potentially life-threatening fungal infections in organs like the lungs, blood, or brain. It works by stopping the growth and spread of the fungi causing the illness.
  • Visceral leishmaniasis: It is also used to treat a serious parasitic infection that affects internal organs, especially when other first-line treatments are not effective.

Key Benefits

Amphonat 50 mg Injection 1's helps treat severe fungal infections that can affect different parts of the body, supporting recovery and improving overall health.

The following are the benefits of this medication:

  • Highly effective at reaching and clearing severe infections that other antifungal medicines might not be strong enough to cure.
  • Rapidly targets the cell walls of fungi, helping prevent the infection from spreading to other vital organs in your body.
  • This medication is a trusted choice for doctors managing critical, systemic infections, helping patients recover and regain their health.
Side effects of Amphonat 50 mg Injection
  • Eat potassium-rich foods like avocados, bananas, spinach, and potatoes.
  • Stay hydrated by drinking plenty of water.
  • Exercise regularly and maintain healthy weight.
  • Manage stress.
  • Prioritize 7-9 hours of sleep each night to help your body and mind recharge.
  • Avoid smoking and limit intake of caffeine.
  • Practice stress-reducing activities like meditation, yoga, or deep breathing to help calm your mind and body.
  • Avoid stimulants and illegal drugs.
  • Call your doctor if it worsens.
  • Muscle cramps can be treated with regular exercise or yoga, which includes mild stretching, which helps strengthen the lower body.
  • Warm baths and gentle massage of the affected parts can help relieve cramps.
  • Avoid strenuous activity and take frequent breaks, as rest is critical.
  • Intake of nutritious food can help strengthen body and mind. A trained nutritionist can help design a balanced diet for strengthening muscles.
  • Speak to your doctor if the pain lasts an extended period. Medical help can be practical in finding a cure for cramps.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Directions for Use

  • Your doctor will determine the dosage and timing of Amphonat 50 mg Injection 1's based on the severity of your infection. Typically, it is administered once daily.
  • Amphonat 50 mg Injection 1's is administered by a healthcare professional in the hospital.
  • Do not self-administer it.

How Amphonat 50 mg Injection 1's Works

Amphonat 50 mg Injection 1's works by targeting the protective outer layer, or cell membrane, of the fungi causing your infection. It binds specifically to a component in this membrane called ergosterol. By doing this, the medicine creates physical holes or pores in the fungal cell wall. Once these holes are made, essential nutrients and minerals inside the fungal cell leak out. Without these vital components, the fungal cells cannot survive or multiply. This action effectively destroys the fungus, allowing your body's natural immune system to clear the rest of the infection.
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Alcohol

Caution

The interaction of Amphonat 50 mg Injection 1's with alcohol is unknown. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Consult your doctor

Amphonat 50 mg Injection 1's is a Category B pregnancy drug and is given to a pregnant woman if the doctor thinks the benefits outweigh the risks. Please consult your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Consult your doctor

It is unknown whether Amphonat 50 mg Injection 1's is excreted in human milk. If you are breastfeeding, inform your doctor before receiving this injection.

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Driving

Caution

Avoid driving after taking Amphonat 50 mg Injection 1's as it may affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Inform your doctor if you have a history of liver diseases/conditions before receiving Amphonat 50 mg Injection 1's.

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Kidney

Consult your doctor

Inform your doctor if you have a history of kidney diseases/conditions before receiving Amphonat 50 mg Injection 1's.

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Children

Caution

Amphonat 50 mg Injection 1's is not recommended for children below one month as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Amphonat 50 mg Injection 1's. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Amphonat 50 mg Injection 1's in elderly patients. Please consult your doctor.

What if I have taken an overdose of Amphonat 50 mg Injection 1's

An overdose is highly unlikely when the medicine is given by a professional in a hospital. If you suspect an overdose or experience severe symptoms during or after your infusion, tell your medical team immediately or seek emergency medical care.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water and clear fluids as advised by your doctor. Adequate hydration is crucial to help protect your kidneys while receiving this medicine.
  • Eat mineral-rich foods: Since this medicine can cause your body to lose potassium and magnesium, incorporate foods like bananas, leafy greens, avocados, and nuts into your diet if your doctor agrees.
  • Prioritise rest: Give your body ample time to heal by getting plenty of sleep and avoiding strenuous physical activities during your treatment course.
  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating smaller portions throughout the day can help you maintain your strength.
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How Soon It Starts Working

The time required for Amphonat 50 mg Injection 1's to start to work: Amphonat 50 mg Injection 1's ideally shows its action within 1 to 3 hours after administration The time for which the effects of Amphonat 50 mg Injection 1's last: The duration of action for Amphonat 50 mg Injection 1's is clinically unknown.

What if you forget to take Amphonat 50 mg Injection 1's

Since this medication is given by a healthcare professional in a clinical setting, it is unlikely that you will miss a dose. However, if you miss an appointment for your injection, contact your healthcare provider or clinic immediately to reschedule your treatment.

Storage

•Unopened vials of Amphonat 50 mg Injection 1's powder must be stored in a refrigerator at temperatures between 2°C to 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Inspect the solution: Your healthcare provider will inspect the vial before use; the liquid must be free of unusual particles or cloudiness unless using a specific lipid version, which is naturally milky.
  • Expect blood tests: Prepare for regular blood and urine tests during your treatment so your doctor can monitor your kidney health, liver function, and mineral levels.
  • Manage infusion reactions: Let your nurse know if y ouexperience fever or chills during the injection; your doctor can give you preventive medicines like acetaminophen or antihistamines beforehand.
  • Monitor the injection site: Tell your nurse immediately if you feel any burning, pain, redness, or swelling where the needle is inserted.
  • Complete the full course: Even if you start feeling much better, do not skip or stop treatments early, as the infection could return.

Drug-Drug Interactions

verifiedApollotooltip
  • Other medicines that can cause kidney damage (e.g., certain antibiotics, cancer medicines, or pain relievers): Combining Amphonat 50 mg Injection 1's with these medications can significantly increase the risk of kidney problems.
  • Water pills (diuretics) and steroids (e.g., furosemide, prednisone): Taking these alongside Amphonat 50 mg Injection 1's can cause your blood potassium levels to drop dangerously low.
  • Heart medications (e.g., digitalis): Low potassium levels caused by Amphonat 50 mg Injection 1's can increase the risk of toxic heart rhythms from digitalis.
Amphotericin bStreptozocin
Critical
Amphotericin bDroperidol
Severe

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
How does the drug interact with Amphonat 50 mg Injection:
Taking Amphonat 50 mg Injection and streptozocin together can enhance kidney injury and can cause damage to the ear.

How to manage the interaction:
Taking Streptozocin with Amphonat 50 mg Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it.
Amphotericin bDroperidol
Severe
How does the drug interact with Amphonat 50 mg Injection:
Using droperidol together with Amphonat 50 mg Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Amphonat 50 mg Injection and Droperidol together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms - an irregular heart rhythm, a heart condition, a condition called congenital long qt syndrome, problems with your heart's conduction, severe or long-lasting diarrhea, vomiting, complications, sudden dizziness, feeling lightheaded, fainting, difficulty breathing, heart palpitations, feeling weak, feeling sleepy, feeling confused, muscle pain, feeling nauseous or vomiting - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bIopamidol
Severe
How does the drug interact with Amphonat 50 mg Injection:
Coadministration of Amphonat 50 mg Injection and Iopamidol may increase the risk of kidney problem.

How to manage the interaction:
Taking Amphonat 50 mg Injection with Iopamidol together can result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on how much you pee. If you notice any changes like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bIotalamic acid
Severe
How does the drug interact with Amphonat 50 mg Injection:
Coadministration of Amphonat 50 mg Injection and Iotalamic acid may decrease the excretion rate of Iothalamic acid which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Amphonat 50 mg Injection and Iotalamic acid, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
Amphotericin bZiprasidone
Severe
How does the drug interact with Amphonat 50 mg Injection:
Co-administration of Ziprasidone with Amphonat 50 mg Injection may raise the chance of a significantly abnormal heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Amphonat 50 mg Injection and Ziprasidone, but it can be taken if prescribed by a doctor. However, if you experience abrupt dizziness, lightheadedness, fainting, or rapid or pounding heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting, contact a doctor immediately. You may need regular monitoring of your electrolyte (magnesium, potassium) levels. Do not stop using any medications without talking to a doctor.
Amphotericin bSirolimus
Severe
How does the drug interact with Amphonat 50 mg Injection:
Coadministration of Sirolimus with Amphonat 50 mg Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Amphonat 50 mg Injection and sirolimus together can result in an interaction, it can be taken if a doctor has prescribed it. Consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bAmiodarone
Severe
How does the drug interact with Amphonat 50 mg Injection:
Coadministration of amiodarone together with Amphonat 50 mg Injection may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Amphonat 50 mg Injection interact, they can be used if prescribed by a doctor. If you have heart issues or electrolyte imbalances, you may be at greater risk. If you experience unexpected dizziness, lightheadedness, fainting, shortness of breath, weakness, tiredness, drowsiness, confusion, muscle pain, dizziness, nausea, or vomiting, or heart palpitations, get medical attention. Do not discontinue any medications without consulting a doctor.
Amphotericin bAciclovir
Severe
How does the drug interact with Amphonat 50 mg Injection:
Coadministration of Aciclovir with Amphonat 50 mg Injection can increase the risk or severity of kidney disorder.

How to manage the interaction:
Taking Aciclovir with Amphonat 50 mg Injection together can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you experience irregular urination, muscle ache, shortness if breath, or palpitations. Do not discontinue any medications without consulting a doctor.
Amphotericin bDronedarone
Severe
How does the drug interact with Amphonat 50 mg Injection:
Dronedarone used with Amphonat 50 mg Injection may raise the chance of a significantly abnormal heart rhythm, although it is a rare side effect.

How to manage the interaction:
Although there is a possible interaction between Amphonat 50 mg Injection and Dronedarone, you can take these medicines together if prescribed by a doctor. You should also notify a doctor if you suffer any of the following symptoms: weakness, weariness, sleepiness, disorientation, muscular pain, cramps, dizziness, nausea, or vomiting. Do not stop using any medications without talking to a doctor.
Amphotericin bIopromide
Severe
How does the drug interact with Amphonat 50 mg Injection:
Coadministration of Amphonat 50 mg Injection and Iopromide may increase the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Amphonat 50 mg Injection and Iopromide, but it can be taken if prescribed by a doctor. If you notice any changes, like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food or drink interactions have been found with Amphonat 50 mg Injection 1's.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

Amphonat 50 mg Injection 1's is used to treat severe fungal infections like leishmaniasis.
Amphonat 50 mg Injection 1's contains Amphotericin B, an antifungal that works by damaging fungal cell membranes, thereby killing fungi.
You are not recommended to take Amphonat 50 mg Injection 1's with furosemide as co-administration of these medicines may increase the risk of hypokalaemia (low potassium levels in the blood), and in severe cases, it may lead to paralysis, muscle weakness, irregular heart rhythm, difficulty in breathing or swallowing. However, please consult your doctor before taking Amphonat 50 mg Injection 1's with other medicines.
Amphonat 50 mg Injection 1's may cause blue lips and skin, probably during infusion or in the initial 2 days of treatment. However, your doctor or nurse may arrange certain simple treatments to control such adverse effects.
Yes, a test dose of Amphonat 50 mg Injection 1's may be given in smaller amounts before starting the treatment to check if you are sensitive to any of the ingredients.
No. Amphonat 50 mg Injection 1's is not effective against viral infections. It is an antifungal medicine that works by damaging fungal cell membranes and is used only for the treatment of severe fungal infections and certain parasitic infections such as leishmaniasis.
Amphonat 50 mg Injection 1's is administered as an intravenous (IV) infusion by a healthcare professional. It should not be self-administered and is not available as a tablet or pill for treating severe systemic fungal infections because it is poorly absorbed from the stomach.
Amphonat 50 mg Injection 1's is fungicidal in nature, it works by killing the infection-causing fungus.
Inform the doctor if you are allergic to any of the components in Amphonat 50 mg Injection 1's or if you experience allergic reactions during treatment with Amphonat 50 mg Injection 1's. Let the doctor know if you have kidney problems, diabetes, or if you are taking any other medicines.
Amphonat 50 mg Injection 1's is an antifungal medication used to treat severe fungal infections like leishmaniasis
Common side effects include fever, chills, nausea, vomiting, headache, and muscle cramps or pain. Fever and chills commonly occur during the infusion and can often be managed by slowing the infusion or giving additional medicines. Inform your doctor or nurse if these symptoms are severe or persistent.
This medicine can affect your kidneys and lower your body's levels of essential minerals like potassium. Regular blood tests allow your healthcare team to monitor your organ function and keep you safe. Talk to your doctor about how often you will need these tests.
This medicine is generally used during pregnancy only if the potential benefits outweigh the risks to the unborn baby. Your doctor will make this decision based on your specific medical situation. Talk to your doctor if you are pregnant or breastfeeding.
While kidney function often decreases during treatment, it usually returns to normal or improves after the medicine is stopped. Your healthcare team will monitor you closely to prevent severe damage. Talk to your doctor if you have concerns about your kidney health.
Some patients may feel dizzy, weak, or tired after receiving this medicine. It is highly recommended to have someone else drive you home, especially after your first few treatment sessions. Talk to your doctor or pharmacist about whether it is safe for you to drive.
Because of the risk of infusion reactions and the need for careful preparation, this medicine is almost always given in a hospital or specialised infusion clinic. In rare cases, home-care nurses may give it if appropriate monitoring is set up. Talk to your doctor to see what options are available for you.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - AMP0248
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