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compositionComposition:AMLODIPINE-5MG+METOPROLOL-50MG
prescription
Prescription Medicine
info
Ampine Mpl Tablet 10's
Ampine Mpl Tablet 10's

Ampine Mpl Tablet is used to treat hypertension (increased blood pressure). It contains Amlodipine and Metoprolol, which widen and relax the blood vessels, making the heart more efficient at pumping blood throughout the body. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke. It is generally safe to consume. Some people may experience side effects such as nausea, vomiting, diarrhoea, fatigue, headache, low heart rate, and breathlessness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

AMLODIPINE-5MG+METOPROLOL-50MG

Manufacturer/Marketer :

Sunij Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ampine Mpl Tablet

Ampine Mpl Tablet is a prescription medicine used to treat high blood pressure (hypertension) and chest pain (angina). It combines two medicines that work together to improve blood flow, reduce the workload on the heart, and lower the risk of heart attack and stroke.

Take Ampine Mpl Tablet exactly as prescribed by your doctor. It can be taken with or without food, but it is best to take it at the same time each day. Following a healthy lifestyle, including regular exercise, weight management, and a low-salt diet, can help improve treatment outcomes.

Some people may experience mild side effects such as headache, dizziness, tiredness, or ankle swelling. Contact your doctor immediately if you develop severe dizziness, fainting, an unusually slow heartbeat, breathing difficulties, or severe swelling.

Before taking Ampine Mpl Tablet , inform your doctor if you have asthma, liver disease, kidney disease, circulation problems, heart rhythm disorders, or heart failure. This medicine may not be suitable for certain heart conditions.

Alcohol and some medicines may interact with Ampine Mpl Tablet and increase the risk of low blood pressure or other side effects. If you are pregnant, planning a pregnancy, breastfeeding, or elderly, consult your doctor before starting treatment.

Uses of Ampine Mpl Tablet

Ampine Mpl Tablet is used to relieve hypertension and chest pain. The detailed uses of Ampine Mpl Tablet are as follows:

  • High Blood Pressure (Hypertension): Helps lower blood pressure by relaxing blood vessels and reducing the workload on the heart.
  • Chronic Stable Angina (Chest Pain): Improves blood flow to the heart and reduces its oxygen demand, helping prevent episodes of chest pain.
     

Key Benefits

Ampine Mpl Tablet provides comprehensive cardiovascular support by combining two blood pressure medicines to help control hypertension and improve heart function. By maintaining healthier blood pressure levels and supporting blood flow, this medicine offers several key health benefits:

  • Effective Blood Pressure Control: Ampine Mpl Tablet helps lower and maintain blood pressure, reducing the risk of serious complications such as heart attack, stroke, and damage to vital organs caused by uncontrolled hypertension.
  • Relief from Angina Symptoms: By improving blood flow to the heart, Ampine Mpl Tablet helps reduce episodes of chest pain and supports better tolerance of physical activities.
  • Simplified Heart Health Management: Combining two medicines in a single tablet makes treatment more convenient, helping improve adherence and making daily blood pressure management easier.
     
Side effects of Ampine Mpl Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Avoid triggers like alcohol, caffeine, and energy drinks.
  • Try relaxation techniques such as yoga, meditation, or deep breathing.
  • Exercise regularly as it helps maintain heart health.
  • Follow a nutritious and balanced diet.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.

Directions for Use

To get the full benefit of Ampine Mpl Tablet and minimise side effects, follow these simple guidelines:

  • Swallow the tablet whole with a glass of water.
  • Do not crush, chew, or break the tablet.
  • Take it at the same time every day.
  • It may be taken with or without food.
  • Continue taking the medicine even if you feel well.
  • Do not stop treatment suddenly without consulting your doctor.
     

How Ampine Mpl Tablet Works

Ampine Mpl Tablet contains two active ingredients that work together to control blood pressure and improve heart function. Metoprolol is a beta-blocker that slows the heart rate and reduces the force of heart contractions. This lowers the pressure inside the blood vessels and decreases the heart's workload. Amlodipine is a calcium channel blocker that relaxes and widens blood vessels. This improves blood flow and further reduces blood pressure. Together, these medicines help protect the heart and blood vessels from long-term damage.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Ampine Mpl Tablet to avoid unpleasant side-effects.

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Pregnancy

Caution

Ampine Mpl Tablet is not recommended during pregnancy unless your doctor considers it essential. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Unsafe

Ampine Mpl Tablet is not recommended while breastfeeding. If you have any concerns regarding this, discuss them with your doctor.

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Driving

Unsafe

Ampine Mpl Tablet is unlikely to affect your ability to drive or to operate machinery. However, some people may occasionally feel dizzy or tired when taking Propranolol. If this happens to you, ask your doctor for advice.

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Liver

Caution

Ampine Mpl Tablet to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Ampine Mpl Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

The safety and efficacy of Ampine Mpl Tablet in children have not been established. Ampine Mpl Tablet is not recommended in children.

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Heart

Caution

Ampine Mpl Tablet is often prescribed to patients with heart problems to treat hypertension. However, it must be taken strictly under medical supervision, as it can affect liver and kidney function and may interact with other heart medications.

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Geriatrics

Caution

Ampine Mpl Tablet should be taken with caution in geriatric patients. Please inform your doctor before using Ampine Mpl Tablet .

What if I have taken an overdose of Ampine Mpl Tablet

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; rather, it may cause poisoning or serious side effects. If you suspect that you may have overdosed on Ampine Mpl Tablet or if you experience any adverse events, please go to the emergency department of the closest hospital.

Diet & Lifestyle Advise

  • Reduce salt intake: Limiting sodium helps improve blood pressure control.
  • Follow a heart-healthy diet: Eat fruits, vegetables, whole grains, lean proteins, and low-fat dairy products.
  • Avoid grapefruit: Grapefruit and grapefruit juice may increase medicine levels and raise the risk of side effects.
  • Stay physically active: Regular activities such as walking, swimming, or cycling can help improve cardiovascular health.
  • Manage stress: Practicing relaxation techniques such as meditation, yoga, or deep breathing may help control blood pressure.
     

Have a query?

How Soon It Starts Working

The time required for Ampine Mpl Tablet to start to work: Ampine Mpl Tablet ideally shows its action within 1 hour after administration. The time for which the effects of Ampine Mpl Tablet last: The effect of Ampine Mpl Tablet lasts for 24 hours.

What if you forget to take Ampine Mpl Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

•Store at room temperature between 20°C and 25°C. • Keep the tablets in their original packaging.

Drug Warnings

  • Do not stop suddenly: Stopping treatment abruptly may worsen chest pain or cause a sudden increase in blood pressure.
  • Rise slowly: This medicine may cause dizziness when standing up quickly.
  • Monitor blood pressure: Check your blood pressure and pulse regularly as advised by your doctor.
  • Limit alcohol: Alcohol can increase dizziness and lower blood pressure excessively.
  • Inform healthcare providers: Tell your doctor, surgeon, or dentist that you are taking Ampine Mpl Tablet before any procedure.
     

Drug-Drug Interactions

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Drug–Drug Interactions:

Inform your doctor if you are taking any of the following medicines, as they may interact with Ampine Mpl Tablet :

  • Other blood pressure medicines: May increase the risk of excessive blood pressure reduction.
  • Heart rhythm medicines: May slow the heart rate excessively when used together.
  • NSAIDs (such as ibuprofen): May reduce the blood-pressure-lowering effect of Ampine Mpl Tablet .
     

Drug–Food Interactions:

  • Grapefruit and grapefruit juice: May increase medicine levels and increase side effects.
  • Excessive caffeine: May reduce some of the beneficial heart-rate-lowering effects of the medicine.


Drug–Disease Interactions:

Inform your doctor if you have a history of the following conditions before taking Ampine Mpl Tablet , as it may worsen your condition or require additional monitoring:

  • Asthma or chronic lung disease: May worsen breathing difficulties in some patients.
  • Diabetes: May hide warning signs of low blood sugar, such as a fast heartbeat.
  • Liver disease: May slow the breakdown of the medicine, increasing the risk of side effects.
     
Amlodipine + MetoprololDantrolene
Critical
Amlodipine + MetoprololSaquinavir
Severe

Drug-Drug Interactions

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Amlodipine + MetoprololDantrolene
Critical
How does the drug interact with Ampine Mpl Tablet:
Co-administration of Amlodipine and Metoprolol together with Dantrolene may increase the risk of side effects.

How to manage the interaction:
Taking Amlodipine with Dantrolene can cause an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Amlodipine + MetoprololSaquinavir
Severe
How does the drug interact with Ampine Mpl Tablet:
Co-administration of Amlodipine and Metoprolol with Saquinavir can increase the risk of an irregular heart rhythm.

How to manage the interaction:
There may be a possible interaction between Amlodipine and Metoprolol with Saquinavir, but they can be taken together if a doctor has prescribed them. However, consult a doctor immediately if you experience dizziness, slow pulse, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
Amlodipine + MetoprololClonidine
Severe
How does the drug interact with Ampine Mpl Tablet:
Co-administration of Clonidine and Metoprolol may lower blood pressure and slow the heart rate.

How to manage the interaction:
Although there is a possible interaction between Clonidine and Metoprolol, you can take these medicines together if prescribed by a doctor. However, if you experience slow heartbeat, headaches contact a doctor. Do not stop using any medications without talking to a doctor.
Amlodipine + MetoprololSirolimus
Severe
How does the drug interact with Ampine Mpl Tablet:
Co-administration of Amlodipine and Metoprolol with Sirolimus may increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Amlodipine and Metoprolol with Sirolimus, but it can be taken if prescribed by a doctor. However, consult the doctor if you notice any mouth sores and inflammation, abdominal pain, breathing problems. Do not stop using any medications without a doctor's advice.
Amlodipine + MetoprololArtemether
Severe
How does the drug interact with Ampine Mpl Tablet:
Co-administration of Amlodipine and Metoprolol with Artemether may increase the blood levels and effects of Metoprolol activity.

How to manage the interaction:
Taking Amlodipine and Metoprolol with Artemether together can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Amlodipine + MetoprololAcebutolol
Severe
How does the drug interact with Ampine Mpl Tablet:
Taking Amlodipine and Metoprolol with Acebutolol can increase the risk of low blood pressure.

How to manage the interaction:
Although taking Amlodipine and Metoprolol with acebutolol can result in an interaction, they can be taken if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
Amlodipine + MetoprololItraconazole
Severe
How does the drug interact with Ampine Mpl Tablet:
Co-administration of Amlodipine and Metoprolol with Itraconazole may significantly raise the blood levels and effects of Amlodipine.

How to manage the interaction:
Although Amlodipine and Metoprolol with Itraconazole may interact, they can be used together if prescribed by a doctor. Consult a doctor if you develop irregular heart rhythm, low blood pressure, dizziness, chest pain; or difficulty breathing. Do not discontinue the medication without consulting a doctor.
Amlodipine + MetoprololCeritinib
Severe
How does the drug interact with Ampine Mpl Tablet:
Taking Ceritinib with Amlodipine and Metoprolol can slow the heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Amlodipine and Metoprolol with Ceritinib, but they can be taken together if a doctor has prescribed them. However, consult a doctor immediately if you experience any dizziness, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
Amlodipine + MetoprololDolasetron
Severe
How does the drug interact with Ampine Mpl Tablet:
Using Dolasetron together with Amlodipine can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Amlodipine and Dolasetron, but it can be taken if prescribed by a doctor. If you experience dizziness, heart beating irregularly, it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
Amlodipine + MetoprololAminophylline
Severe
How does the drug interact with Ampine Mpl Tablet:
Co-administration of Aminophylline with Amlodipine and Metoprolol together can make Metoprolol less effective and increase the effects of Aminophylline.

How to manage the interaction:
Taking Aminophylline with Amlodipine and Metoprolol may lead to an interaction, it can be taken only if a doctor has advised it. If you experience vomiting, sleeplessness, irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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AMLODIPINE-5MG+METOPROLOL-50MGFruit juices, Fruits
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+METOPROLOL-50MGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Amlodipine and Metoprolol with grapefruit and grapefruit juice significantly increases the metabolism of Amlodipine. Avoid taking Amlodipine and Metoprolol with grapefruit and grapefruit juice.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Ampine Mpl Tablet is used to treat high blood pressure (hypertension) and heart-related chest pain (angina pectoris). It widens and relaxes the blood vessels, making the heart more efficient at pumping blood throughout the body.
In case you have missed a dose of Ampine Mpl Tablet , you are advised to take it as soon as you remember. However, try not to miss a dose in the first place. If it's time for you to take your next dose, then do not take both doses together. Take only one dose; taking a double dose of Ampine Mpl Tablet will lead to low blood pressure.
Follow your doctor's dietary recommendations while taking Ampine Mpl Tablet . Depending on your medical condition and other medicines you take, your doctor may advise limiting certain foods. Consult your healthcare provider before making significant dietary changes.
You should continue taking Ampine Mpl Tablet for as long as your doctor prescribes it. High blood pressure is often a long-term condition requiring ongoing treatment. Do not stop taking Ampine Mpl Tablet on your own, even if your blood pressure is under control. If treatment changes are needed, your doctor may adjust the dose or gradually discontinue the medicine based on your condition and blood pressure readings.
Yes, Ampine Mpl Tablet is contraindicated in people with known allergy to any of the components of this medicine. It should be avoided in people with severe kidney or liver impairment and people with anuria (reduction or absence of urine). It should also be avoided in women who are in the second and third trimesters of their pregnancy.
Common side effects of Ampine Mpl Tablet may include nausea, vomiting, diarrhoea, fatigue, headache, low heart rate, and breathlessness. Most of the side effects of Ampine Mpl Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
Eating well, exercising regularly, maintaining a healthy weight, quitting smoking, getting enough sleep, and managing stress are all lifestyle changes that can help lower blood pressure.
Store in a cool and dry place away from sunlight. Keep out of the sight and reach of children. To help protect the environment, avoid throwing away medicines in wastewater or household waste. Ask your doctor or pharmacist about the disposal of medicines.
Ampine Mpl Tablet does not generally affect hormonal contraception. However, some contraceptive methods may not be suitable for people with high blood pressure. If you are pregnant, planning a pregnancy, or using contraception, consult your doctor for advice specific to your condition and treatment.
Drinking alcohol can increase the risk of side effects with Ampine Mpl Tablet . It can make you feel dizzy or lightheaded. It's best to stop drinking alcohol until you see how the medicine affects you.
You can take it at any time of day, but it should be taken at the same time every day. Follow your doctor's recommendation.
Mild ankle swelling can occur with this medicine. Elevating your legs may help. Contact your doctor if the swelling becomes severe, worsens, or is accompanied by breathing problems.
The metoprolol component can mask some symptoms of low blood sugar, such as a rapid heartbeat. If you have diabetes, monitor your blood sugar regularly and follow your doctor's advice.
It is unlikely that Ampine Mpl Tablet affects fertility in men or women, although available evidence is limited. Some people have reported decreased sexual desire or difficulty achieving an erection while taking this medicine, but these effects are uncommon and may not be directly caused by the medication. Consult your doctor if you experience concerns about fertility or sexual function during treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.5200 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Amlodipine With Metoprolol Succinate Er 172 0 1615 14142 Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. Electronic Medicines Compendium (EMC). Pil.5701 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  4. CiplaMed Clinical Compendium. Metolar Ams Product Specification Guide. Mumbai, India: Cipla; 2024. [Accessed on 02 Jun. 2026] Check here
  5. Torrent pharmaceuticals Ltd. Tolol AM 50 (Metoprolol Succinate Prolonged release and Amlodipine Tablets). [Revised in May 2020] [Accessed on 20th October 2022]Check here

Country of origin

INDIA

Manufacturer/Marketer address

T-1/B National Park, Gulbai Tekra, Ahmedabad ? 380 015, (India)
Other Info - AMP0180

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