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compositionComposition:DULAGLUTIDE-0.75MG
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Prescription Medicine
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Aplevant 0.75 mg Injection is an anti-diabetic medicine used in the treatment of Type II diabetes. This medicine increases insulin release from the pancreas during high blood sugar levels (after meals) and decreases the amount of sugar the liver produces, thereby helping to control blood sugar levels. This medicine may cause common side effects like nausea, vomiting, diarrhoea, decreased appetite, stomach pain, constipation, and feeling tired.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

DULAGLUTIDE-0.75MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Aplevant 0.75 mg Injection

Aplevant 0.75 mg Injection belongs to the class of anti-diabetic drugs primarily used to treat type 2 diabetes mellitus. Diabetes mellitus is a metabolic disease that causes high blood sugar levels. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking down glucose to produce energy (insulin resistance) or the pancreas produces little or no insulin at all.

Aplevant 0.75 mg Injection contains Dulaglutide, which belongs to the class of ‘incretin mimetics’. Dulaglutide works by increasing insulin release from the pancreas during high blood sugar levels (after meals) and decreasing the amount of sugar the liver makes. Aplevant 0.75 mg Injection also prevents the risk of heart diseases in type 2 diabetes patients.

Your doctor will decide the dose and duration of Aplevant 0.75 mg Injection based on your medical condition. Some common side effects of Aplevant 0.75 mg Injection include nausea, vomiting, diarrhoea, decreased appetite, stomach pain, constipation, and feeling tired. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Before starting Aplevant 0.75 mg Injection, please inform your doctor if you have a history of heart, kidney, or liver disease. It is advised to limit your alcohol intake while using Aplevant 0.75 mg Injection to avoid low blood sugar levels. Pregnant and breastfeeding women should consult their doctor before starting Aplevant 0.75 mg Injection. Aplevant 0.75 mg Injection may make you feel tired, hence drive and operate machinery only when you are feeling better. Aplevant 0.75 mg Injection is not recommended for children and adolescents under 18 years of age.

Uses of Aplevant 0.75 mg Injection

Aplevant 0.75 mg Injection is used in the treatment of type 2 diabetes mellitus. The detailed uses of Aplevant 0.75 mg Injection are as follows:

  • Management of Type 2 Diabetes: Aplevant 0.75 mg Injection helps lower blood sugar levels in individuals diagnosed with type 2 diabetes.
  • Improvement of Insulin Sensitivity: Aplevant 0.75 mg Injection enhances the action of insulin, making the body’s tissues more responsive to it.
  • Reduction of Cardiovascular Risks: Regular use of Aplevant 0.75 mg Injection can help reduce the risk of cardiovascular diseases in diabetic patients.
  • Control of Blood Sugar Levels Post Meals: Aplevant 0.75 mg Injection assists in lowering postprandial blood sugar spikes, which is beneficial for overall diabetes management.

Key Benefits

Aplevant 0.75 mg Injection is used to treat type 2 diabetes mellitus. It is an incretin mimetic that mimics the action of a natural hormone called Incretin (a metabolic hormone that stimulates a decrease in blood glucose levels). It works by increasing insulin release from the pancreas during high blood sugar levels (after meals) and decreasing the amount of sugar the liver makes. Aplevant 0.75 mg Injection also reduces the risk of serious heart diseases, such as heart attack or stroke in patients with type 2 diabetes and heart disease. Aplevant 0.75 mg Injection may be advised with or without other medications along with diet and exercise to control blood sugar levels. 

Side effects of Aplevant 0.75 mg Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • To manage high lipase levels, take the prescribed medication as directed by your doctor.
  • Avoid alcohol to prevent irritation of the pancreas and liver and to prevent interactions with your medications.
  • Follow a low-fat, high-fibre, and low-red meat diet.
  • Stay well-hydrated by drinking 8-12 cups of fluids daily.
  • If you are diagnosed with pancreatitis, you may need to stay in the hospital for fluids, pain relief, and to manage nausea, with a gradual transition to an easy-to-digest diet.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

  • Follow your doctor's instructions regarding the dosage and duration of treatment.
  • Check the label for directions and use it as advised by the doctor. Aplevant 0.75 mg Injection should be injected subcutaneously (under the skin) on your stomach, thigh, or upper arm.
  • Rotate the injection site each time.
  • Never reuse or share dosing pens.

How Aplevant 0.75 mg Injection Works

Aplevant 0.75 mg Injection contains Dulaglutide that belongs to the class of ‘incretin mimetics’. Dulaglutide works by increasing insulin release from the pancreas during high blood sugar levels (after meals) and decreasing the amount of sugar the liver makes. Aplevant 0.75 mg Injection also prevents the risk of heart diseases in type 2 diabetes patients.
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Alcohol

Unsafe

It is advised to limit alcohol intake since it may worsen the side effects and increase the risk of developing low blood sugar levels.

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Pregnancy

Consult your doctor

Please consult your doctor before starting Aplevant 0.75 mg Injection if you are pregnant or planning to conceive. Your doctor will prescribe only if the benefit outweighs the risk.

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Breast Feeding

Consult your doctor

There is insufficient data on how Aplevant 0.75 mg Injection affects breastfeeding. It is safe to seek medical advice before starting Aplevant 0.75 mg Injection if you are lactating.

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Driving

Caution

Do not drive or operate machinery if you experience any signs of low blood sugar.

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Liver

Consult your doctor

Let your doctor know if you have any history of liver diseases or hepatic impairment when prescribed Aplevant 0.75 mg Injection.

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Kidney

Consult your doctor

Let your doctor know if you have any history of kidney disease when you are prescribed Aplevant 0.75 mg Injection.

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Children

Unsafe

Aplevant 0.75 mg Injection is not recommended for children and adolescents under 18 years of age.

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Heart

Caution

Aplevant 0.75 mg Injection should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before receiving Aplevant 0.75 mg Injection.

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Geriatrics

Caution

Aplevant 0.75 mg Injection should be administered with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Aplevant 0.75 mg Injection

Do not take more than the prescribed dose of Aplevant 0.75 mg Injection as it may cause an overdose. The symptoms of overdose include vomiting, nausea and symptoms of low blood sugar. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains to maintain your blood glucose levels.
  • Eat at regular intervals.
  • Monitor your weight and exercise regularly to maintain a healthy heart.
  • Follow your doctor's guide on noticing and managing the early symptoms of high/low blood sugar levels.
  • Gastrointestinal side effects can be managed with simple lifestyle modifications. These include cutting down on sugars and fatty foods, avoiding carbonated drinks and foods that cause gas. 
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Have a query?

How Soon It Starts Working

The time required for Aplevant 0.75 mg Injection to start to work: The exact onset time of Aplevant 0.75 mg Injection has not been clinically established. The time for which the effects of Aplevant 0.75 mg Injection last: The duration of Aplevant 0.75 mg Injection’s effect is clinically not established.

What if you forget to take Aplevant 0.75 mg Injection

If you miss a dose of Aplevant 0.75 mg Injection, administer it as soon as you remember, as long as there are at least 3 days (72 hours) before your next scheduled injection. Once you've taken the missed dose, return to your regular weekly injection routine. However, if fewer than 3 days remain until your next scheduled dose, skip the missed injection and continue with your usual dosing schedule. Do not give two injections within a short period, and never use a double dose to make up for the one you missed.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

Brief your medical history to the doctor if you have heart, kidney or liver diseases, pancreatitis (inflammation of the pancreas), stomach disorders like acid reflux, gastroparesis (delayed gastric emptying), hypoglycaemia (low blood sugar levels), diabetic retinopathy, and type 1 diabetes before starting Aplevant 0.75 mg Injection. Aplevant 0.75 mg Injection is contraindicated in patients with multiple endocrine neoplasia type 2, diabetic ketoacidosis (diabetes complication where the body produces excess blood acids (ketones)), and personal or family history of thyroid cancer. Do not share an injection pen, cartridge, or syringe with another person, even if the needle is changed. It is advised to limit your alcohol intake while using Aplevant 0.75 mg Injection to avoid low blood sugar levels. Pregnant and breastfeeding women should consult their doctor before starting this medication. Aplevant 0.75 mg Injection may cause you to feel tired; therefore, refrain from driving and operating machinery until you are feeling better. Aplevant 0.75 mg Injection is not recommended for children and adolescents under 18 years of age.

Drug-Drug Interactions

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Drug-Drug Interaction: Aplevant 0.75 mg Injection may interact with other anti-diabetic medicines (insulin glargine), hormones (levothyroxine), high blood pressure medicines (propranolol, metoprolol), and glaucoma eye drops (timolol). 

Drug-Food Interaction: Limit alcohol intake since it affects blood sugar levels. Avoid fatty foods and include healthy carbohydrates in your diet.

Drug-Disease Interaction: Tell your doctor before taking Aplevant 0.75 mg Injection if you have a medical history of allergic reactions to medicines, heart, kidney or liver diseases, pancreatitis, gastroparesis, reflux, and hypoglycaemia. Aplevant 0.75 mg Injection is contraindicated in patients with multiple endocrine neoplasia type 2, diabetic ketoacidosis, and personal or family history of thyroid cancer.

DulaglutideGatifloxacin
Severe
DulaglutideBexarotene
Severe

Drug-Drug Interactions

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DulaglutideGatifloxacin
Severe
How does the drug interact with Aplevant 0.75 mg Injection:
Co-administration of Aplevant 0.75 mg Injection with Gatifloxacin may increase the risk or severity of low blood sugar.

How to manage the interaction:
Although there is a possible interaction between Aplevant 0.75 mg Injection and Gatifloxacin, you can take these medicines together if prescribed by a doctor. However, if you experience sweating, headache, shortness of breath, or palpitations, contact a doctor immediately. Do not discontinue any medication without a doctor's advice.
DulaglutideBexarotene
Severe
How does the drug interact with Aplevant 0.75 mg Injection:
Co-administration of Aplevant 0.75 mg Injection with Bexarotene may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Aplevant 0.75 mg Injection and Bexarotene, you can take these medicines together if prescribed by a doctor. If you're having symptoms like vomiting, stomach pain, or vomiting, contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Aplevant 0.75 mg Injection belongs to the class of anti-diabetic drugs primarily used to treat type 2 diabetes mellitus.
Aplevant 0.75 mg Injection contains Dulaglutide, which increases the insulin release from the pancreas after meals when your body has high blood glucose levels. Thus, Aplevant 0.75 mg Injection helps lower the blood sugar levels in type 2 diabetes mellitus.
Aplevant 0.75 mg Injection may cause low blood sugar levels (hypoglycaemia) and can make you hungry, dizzy, irritable, confused, anxious, or shaky. Hence, it is advised to take Aplevant 0.75 mg Injection with a meal. To immediately treat hypoglycaemia, it is advised to eat or drink fast-acting sugar sources like fruit juices, hard candy, raisins, or non-diet soda.
Use injection solution only if it is clear, colourless, and contains no particles. Administer the injection subcutaneously (under the skin) in the abdomen, thigh or upper arm. Your doctor or nurse will guide you on how to use the injection. You can take Aplevant 0.75 mg Injection with or without a meal. However, it is advised to take the injection preferably with a meal since it lowers the blood sugar levels and may cause gastrointestinal side effects. Do not share an injection pen, cartridge, or syringe with another person, even if the needle is changed.
Your doctor may advise Aplevant 0.75 mg Injection with or without other medications to control your blood sugar levels. Take Aplevant 0.75 mg Injection with other anti-diabetic medicines only if prescribed by the doctor. If you are also prescribed insulin, take Aplevant 0.75 mg Injection and insulin injections separately. Please do not mix them. You can inject both injections in the same body region, but the injection sites should not be next to each other.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.
Store the unused Aplevant 0.75 mg Injection in a refrigerator at 2°C to 8°C protected from the light. You may also store Aplevant 0.75 mg Injection at a room temperature of 15°C to 30°C for up to 14 days before use. Do not freeze Aplevant 0.75 mg Injection. Do not use Aplevant 0.75 mg Injection if it is frozen.
Cut back on foods high in sodium, alcohol, fried foods, and high-carb food and drinks like sugary drinks, drinks with added sugar, white rice and starchy vegetables.
Aplevant 0.75 mg Injection should not be discontinued without a doctor's consultation. Consult the doctor if you feel uncomfortable after taking Aplevant 0.75 mg Injection.
The injection site should be changed to prevent skin changes, such as lumps under the skin. Aplevant 0.75 mg Injection may not work well if injected into the lumpy area.
Maintain a healthy diet and exercise regularly. Limit sugar intake and avoid smoking & alcohol consumption. Manage stress by doing meditation or yoga.
Hypoglycaemia (low blood sugar) may occur because you inject too much insulin, miss or delay meals, do not eat enough, eat food containing less carbohydrate than usual, drink alcohol, lose carbohydrates due to vomiting or diarrhoea, do more exercise than usual or a different type of physical activity, are recovering from an injury, illness, operation or stress, or are taking/have stopped taking other medicines.
A haemoglobin A1C (HbA1C) test is used to diagnose type 2 diabetes and prediabetes. It helps measure the amount of blood glucose attached to haemoglobin. It is used to monitor your condition and check how well you've been able to control your blood sugar levels.
Aplevant 0.75 mg Injection can be taken at any time of the day, with or without meals.
Aplevant 0.75 mg Injection slows down digestion, causing the person to eat less and leading to weight loss. However, Aplevant 0.75 mg Injection is not indicated for weight loss.
No, Aplevant 0.75 mg Injection is not an insulin. It contains Dulaglutide, an anti-diabetic drug.
Aplevant 0.75 mg Injection can be taken with insulin if prescribed by the doctor. Please do not mix them, take Aplevant 0.75 mg Injection and insulin separately. You may administer an injection of Aplevant 0.75 mg Injection and insulin in the same body area (such as the stomach area), but not directly adjacent to each other.
No, Aplevant 0.75 mg Injection is not used to treat type 1 diabetes. It is used to treat type 2 diabetes mellitus.
Aplevant 0.75 mg Injection may cause pancreatitis (inflammation of the pancreas). Stop using Aplevant 0.75 mg Injection and consult the doctor if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting.
Regular self-monitoring of blood sugar may not be required while taking Aplevant 0.75 mg Injection. However, regular self-monitoring of blood sugar may be required while taking Aplevant 0.75 mg Injection with other anti-diabetic medicines.
Avoid foods high in sugar and fried or fatty foods. Also, avoid eating saturated, trans fats, and greasy foods.
Aplevant 0.75 mg Injection may cause serious side effects, such as possible thyroid tumours, including cancer. Inform your doctor if you notice symptoms of thyroid cancer, such as a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath.
Yes, Aplevant 0.75 mg Injection can be used in combination with other diabetes medications if prescribed by a doctor.
Yes, you can take a protein-rich diet along with Aplevant 0.75 mg Injection. Proteins which are building blocks of the body are one of the major energy providers. They break down into glucose to release energy.
Though artificial sweeteners may not affect blood sugar levels, it is advised to consult a doctor before using artificial sweeteners while taking Aplevant 0.75 mg Injection.
Uncontrolled diabetes may cause kidney problems leading to diabetic nephropathy. To prevent this, keep your blood sugar levels under control and regularly monitor your kidney function.
No, there is no cure for diabetes. However, using diabetic medicines and following diet and exercise may help manage diabetes.

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Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - APL0045
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