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Apritech 125/80 Capsule is used to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in adults and adolescents aged 12 years and above. It contains Aprepitant, which blocks a chemical that produces vomiting by acting on the neurological system. Thus, it helps prevent nausea and vomiting.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Uvtech Biosciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Apritech 125/80 Capsule

Apritech 125/80 Capsule is a prescription medicine used to prevent nausea and vomiting caused by cancer chemotherapy treatments. It is also used to prevent nausea and vomiting that can happen after surgical procedures. This medicine is specifically designed as a preventive measure and is not used to treat active nausea or vomiting that you already have.

You will typically take Apritech 125/80 Capsule as a multi-day regimen, starting on your first day of chemotherapy or just before surgery. It can be taken with or without food, but it is important to take it exactly at the scheduled times. Apritech 125/80 Capsule is commonly prescribed alongside other antiemetic medicines (such as a 5-HT3 antagonist like ondansetron and a corticosteroid like dexamethasone) as part of a multimodal combination regimen.

Some people taking this medicine may experience mild side effects, such as tiredness, hiccups, or a decreased appetite. While these are usually manageable, please contact your doctor right away if you experience serious symptoms like severe dizziness, yellowing of your skin or eyes, or signs of an allergic reaction.

Before starting Apritech 125/80 Capsule, tell your doctor if you have a history of liver damage, as this medicine is processed by the liver. Do not take this if you are allergic to any of its ingredients or if you are currently taking certain medicines that can cause serious drug interactions.

Apritech 125/80 Capsule can interact with several medicines, including hormonal birth control, making them less effective, so you should use an alternative contraceptive method during and for a month after treatment. Avoid drinking alcohol while taking this medicine as it can worsen drowsiness and stomach irritation. If you are pregnant, breastfeeding, or an elderly patient, discuss the potential risks and benefits with your doctor before starting this treatment.

Uses of Apritech 125/80 Capsule

Apritech 125/80 Capsule is used to prevent nausea and vomiting associated with chemotherapy and surgery. The detailed uses of Apritech 125/80 Capsule are as follows:

  • Chemotherapy-induced nausea and vomiting: Apritech 125/80 Capsule helps prevent both immediate and delayed nausea and vomiting associated with cancer chemotherapy drugs.
  • Post-operative nausea and vomiting: It is taken before surgery to help prevent nausea and vomiting that commonly occur during recovery from anaesthesia.

Key Benefits

Apritech 125/80 Capsule provides important benefits by helping prevent nausea and vomiting during cancer treatment and surgical recovery. The key benefits of Apritech 125/80 Capsule are as follows:

  • Comfort During Treatment: Using Apritech 125/80 Capsule helps you manage your cancer treatment or surgical recovery with greater comfort by blocking the signals in the brain that trigger the urge to vomit.
  • Better Nutrition and Hydration: By preventing severe nausea, this medicine allows you to maintain better nutrition and hydration, which are essential for your body's healing process.
  • Peace of Mind: It provides peace of mind, reducing the anxiety of chemotherapy sessions by offering consistent, multi-day protection against delayed vomiting.

Directions for Use

  • Apritech 125/80 Capsule can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Apritech 125/80 Capsule as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Apritech 125/80 Capsule Works

Apritech 125/80 Capsule contains an NK1 receptor antagonist that prevents nausea and vomiting by blocking specific signals in the central nervous system. Aprepitant works by targeting specific pathways in your central nervous system. During chemotherapy or surgery, your body releases a natural chemical called Substance P, which binds to neurokinin-1 (NK1) receptors in the brain to trigger the vomiting reflex. Aprepitant, as an NK1 receptor antagonist, selectively blocks these receptors. By preventing Substance P from binding to them, the medicine stops the brain from sending the signal that causes nausea and vomiting, helping you stay comfortable throughout your treatment cycle.
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Alcohol

Caution

The interaction of alcohol with Apritech 125/80 Capsule is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before taking Apritech 125/80 Capsule. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Aprepitant is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before taking Apritech 125/80 Capsule.

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Driving

Caution

Apritech 125/80 Capsule may cause dizziness or drowsiness in some people. Hence, do not drive or operate machinery if you feel dizzy or drowsy after taking Apritech 125/80 Capsule.

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Liver

Consult your doctor

If you have liver disease, inform your doctor before taking Apritech 125/80 Capsule. Your doctor may monitor your liver condition.

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Kidney

Consult your doctor

If you have kidney problems, inform your doctor before taking Apritech 125/80 Capsule.

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Children

Unsafe

Apritech 125/80 Capsule is not recommended for children below 12 years of age.

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Heart

Safe if prescribed

Apritech 125/80 Capsule is generally considered safe, but it’s still important to proceed with medical guidance.

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Geriatrics

Safe if prescribed

Apritech 125/80 Capsule is generally safe for geriatric individuals. Please consult your doctor if you have any concerns.

What if I have taken an overdose of Apritech 125/80 Capsule

If you take more than your prescribed dose, call emergency services (112) or go to the nearest hospital emergency room immediately. Watch for signs of extreme sleepiness or severe headache, and ensure you bring the original medicine packaging with you.

Diet & Lifestyle Advise

  • Eat Small, Frequent Meals: Eat small, frequent meals throughout the day instead of three large ones to keep your stomach settled.
  • Choose Bland Foods: Choose bland foods like toast, crackers, oatmeal, or plain rice, and avoid spicy, greasy, or highly sweet foods that can trigger nausea.
  • Sip Clear Liquids: Sip cool, clear liquids such as water, clear broths, or ginger tea slowly between meals rather than during meals.
  • Stay Upright After Eating: Sit upright for at least 30 to 60 minutes after eating to help digestion and prevent nausea.
  • Avoid Strong Odours: Avoid strong odours from cooking, perfumes, or smoke, as these can easily trigger a wave of nausea during your treatment period.
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How Soon It Starts Working

The time required for Apritech 125/80 Capsule to start to work: Apritech 125/80 Capsule shows its actions within 4 hours of administration. The time for which the effects of Apritech 125/80 Capsule last: The effect of Apritech 125/80 Capsule usually lasts approximately for 24 hours.

What if you forget to take Apritech 125/80 Capsule

If you miss a dose of Apritech 125/80 Capsule, contact your doctor or pharmacist immediately for instructions. Because this medicine is carefully timed with your chemotherapy or surgery, missing a dose can reduce its ability to prevent nausea. Do not take a double dose to make up for a missed one.

Storage

• Store Apritech 125/80 Capsule at room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the Packaging: Inspect the capsule packaging before use; do not take the medicine if the blister seal is broken or damaged.
  • Take the First Dose on Time: Always take the first dose of Apritech 125/80 Capsule at least 1 hour before your chemotherapy session begins to ensure maximum preventive effect.
  • Use Backup Contraception: If you use hormonal birth control (like pills, patches, or implants), use a backup, non-hormonal contraceptive method (like condoms) while taking this medicine and for 1 month after your last dose.
  • Avoid Driving and Operating Machinery: Avoid driving, operating machinery, or performing dangerous tasks until you know how this medicine affects you, as it can cause drowsiness or dizziness.
  • Keep a Dose Record: Keep a written record of when you take each dose to ensure you strictly adhere to the multi-day schedule prescribed by your doctor.

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  • Blood Thinners: May alter the effects of blood thinners (like warfarin) due to complex enzyme effects (initial inhibition followed by induction), requiring close INR monitoring by your doctor.
  • Hormonal Contraceptives: Decreases the effectiveness of hormonal contraceptives during treatment and for up to 28 days afterwards due to temporary liver enzyme induction (even though the medicine itself clears from the body in a few days).
  • Certain Medicines: Combining Apritech 125/80 Capsule with certain medicines (like ketoconazole, clarithromycin, or diltiazem) can increase the levels of Apritech 125/80 Capsule in your body, raising the risk of side effects.
  • Chemotherapeutic Agents and Corticosteroids: Can significantly increase the levels of certain chemotherapeutic agents or corticosteroids (like dexamethasone), which may require your doctor to adjust your steroid dose.

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  • Grapefruit: Avoid consuming grapefruit or grapefruit juice, as it can interfere with how your body breaks down this medicine, potentially leading to increased side effects.

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Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Apritech 125/80 Capsule is used to treat Chemotherapy-induced nausea and vomiting.
Apritech 125/80 Capsule contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it helps to prevent nausea and vomiting caused by anti-cancer medicines in adults and adolescents from the age of 12 years.
You are not recommended to take erythromycin with Apritech 125/80 Capsule as it may increase the blood levels and effects of Apritech 125/80 Capsule. Contact your doctor if your condition changes or you experience side effects such as diarrhoea, constipation, nausea, or loss of appetite. However, please consult your doctor before taking other medicines with Apritech 125/80 Capsule.
No, Apritech 125/80 Capsule is designed to prevent nausea and vomiting before it starts. It is not effective for treating active nausea or vomiting that has already begun. Talk to your doctor if you need medicine to treat active symptoms.
If you throw up shortly after swallowing your dose, do not take another capsule on your own. Contact your doctor or healthcare team immediately to ask for guidance on whether to take another dose.
Yes, feeling tired, weak, or sleepy is a common side effect of Apritech 125/80 Capsule. You should avoid driving, riding a bicycle, or operating machinery until you know how this medicine affects you. Talk to your doctor if the fatigue becomes severe.
Some pain medicines can interact with Apritech 125/80 Capsule. It is important to provide your doctor or pharmacist with a complete list of all prescription and over-the-counter medicines you are currently taking before starting your treatment.
Apritech 125/80 Capsule is cleared from your body within a few days after your last dose. However, because it temporarily affects how your liver processes certain medicines, interactions with drugs like birth control can continue for up to 28 days. Talk to your doctor for specific advice.
You should avoid drinking alcohol while taking this medicine. Alcohol can increase the risk of side effects like extreme drowsiness, dizziness, and stomach irritation. Talk to your doctor if you have concerns.
No, you should swallow the capsule whole with water. Do not crush, chew, or open the capsule, as this can change how the medicine is absorbed and make it less effective. Talk to your doctor or pharmacist if you have trouble swallowing capsules.
Yes. Apritech 125/80 Capsule can reduce the effectiveness of hormonal contraceptives, including birth control pills, patches, and implants. Use an effective non-hormonal back-up method, such as condoms, during treatment and for 28 days (1 month) after your last dose. Talk to your doctor about the most appropriate contraception for you.

Disclaimer

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Country of origin

India
Other Info - AP75305
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