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compositionComposition:IRBESARTAN-300MG
prescription
Prescription Medicine
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Aprovel 300mg Tablet is used for the treatment of hypertension (high blood pressure) in adults. Additionally, it is used to reduce the risk of heart attack or stroke in adults. It contains Irbesartan, which widens and relaxes blood vessels. Thus, lowers high blood pressure. In some cases, you may experience nausea, vomiting, fatigue, and orthostatic hypotension. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IRBESARTAN-300MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Aprovel 300mg Tablet

Aprovel 300mg Tablet is an oral prescription medication used to treat high blood pressure (hypertension). It is also prescribed to protect kidney function in people with type 2 diabetes who suffer from high blood pressure. By managing these conditions, this medicine helps lower your risk of experiencing serious cardiovascular events.

For this medicine to work effectively, you must take it consistently every single day, even if you feel completely healthy. You can take your daily dose either with or without food, ideally at the same time each day to build a routine. Making positive changes, such as eating a low-salt diet and exercising regularly, will significantly support the work of this medication.

Many people use this medicine without experiencing major issues, though mild effects like dizziness or fatigue can occur. However, if you experience serious side effects such as difficulty breathing, swelling, or changes in how often you urinate, you should contact your doctor right away.

Before taking Aprovel 300mg Tablet, you should tell your doctor if you have liver damage, heart disease, or a history of dehydration. Do not take this medicine if you are pregnant, as it can cause severe injury or death to an unborn baby.

This medicine can interact with other treatments, such as water pills or pain relievers, and mixing it with alcohol may increase your risk of feeling dizzy. Pregnant, breastfeeding, or elderly individuals must consult their healthcare provider to ensure this medication is safe for their specific situation.

Uses of Aprovel 300mg Tablet

Aprovel 300mg Tablet is used in the treatment of high blood pressure. The detailed uses of this medicine are as follows:

  • High blood pressure (Hypertension): Aprovel 300mg Tablet relaxes the blood vessels in your body, allowing blood to flow more smoothly. This reduces the force against your artery walls, helping to lower blood pressure and protect against future strokes and heart attacks.
  • Diabetic kidney disease (Nephropathy): In patients with type 2 diabetes and high blood pressure, Aprovel 300mg Tablet helps preserve kidney function. It slows down the progression of kidney damage, protecting the delicate filters in the kidneys from failing over time.

Key Benefits

  • Aprovel 300mg Tablet helps keep your blood pressure under control, reducing the strain on your heart and blood vessels.
  • By maintaining healthy blood pressure over time, it lowers the risk of serious complications such as heart attack, stroke, and heart failure.
  • In people with type 2 diabetes and diabetic kidney disease, Aprovel 300mg Tablet helps slow kidney damage, reducing the risk of kidney failure and the need for dialysis or a kidney transplant.
  • Unlike some other blood pressure medicines, Aprovel 300mg Tablet is less likely to cause a persistent dry cough, making it easier for many people to continue treatment as prescribed.
  • Taking Aprovel 300mg Tablet regularly, along with a healthy diet, exercise, and other lifestyle changes, helps improve long-term heart and kidney health.
Side effects of Aprovel 300mg Tablet
  • Limit fruit intake to two servings a day, choose a low-potassium options like apples and strawberries.
  • Restrict starchy vegetables like potatoes and pumpkin to half a cup daily.
  • Avoid or limit foods like tomato products, high-bran cereals, and salty or sugary snacks.
  • Limit dairy products to 200g of yoghurt or 300ml of milk per day.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet unless your doctor specifically tells you to do so.
  • You can take this medication with or without food.
  • Try to take your dose at the same time every day to help you stay consistent and maintain steady levels of the medicine in your body.
  • Always follow your doctor's exact instructions regarding your treatment. Do not stop taking this medicine suddenly, even if you feel completely fine.

How Aprovel 300mg Tablet Works

Aprovel 300mg Tablet belongs to a group of medications known as angiotensin receptor blockers (ARBs). Within your body, a natural substance called angiotensin II binds to specific receptors on your blood vessels, causing them to tighten, narrow, and raise your blood pressure. Aprovel 300mg Tablet works by blocking this substance from attaching to those receptors. When the action of angiotensin II is blocked, your blood vessels can relax and widen. This widening allows blood to circulate much more easily throughout your body, which immediately lowers your blood pressure. This process also decreases the physical workload on your heart and reduces the filtering pressure inside your kidneys, shielding them from progressive damage.
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Alcohol

Caution

Not recommended. Aprovel 300mg Tablet and alcohol together result in an abnormal decrease in blood pressure levels, thus strictly not to be taken together.

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Pregnancy

Unsafe

Not recommended in pregnant patients. Aprovel 300mg Tablet is harmful to an unborn baby, especially in the first 3 months of pregnancy. Aprovel 300mg Tablet is to be replaced with any other blood pressure-lowering drug on doctor consultation.

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Breast Feeding

Caution

Not recommended in breastfeeding patients. Enough data is not available on the usage of Aprovel 300mg Tablet in breastfeeding mothers; thus, it is replaced with any alternative blood pressure-lowering agents in doctors' consultations.

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Driving

Safe if prescribed

Aprovel 300mg Tablet is unlikely to affect your ability to drive or use heavy machines. However, occasionally, dizziness or slowness of movements may occur during the treatment of high blood pressure. If you experience these, talk to your doctor before attempting such activities.

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Liver

Caution

Aprovel 300mg Tablet has been found to affect liver function in certain cases; thus, patients with liver problems should discuss with their doctor for proper guidance regarding treatment with this medication.

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Kidney

Caution

Aprovel 300mg Tablet is not advised for patients with kidney disease as there have been cases of harmful interactions between kidney patients and Aprovel 300mg Tablet. Patients are strictly advised to consult and discuss this medication with their doctors before taking it.

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Children

Safe if prescribed

It is safe to give to children under 12 years of age. No harmful interaction has been reported in patients under 12 years of age, yet doctor's consultation is advised.

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Heart

Safe if prescribed

Aprovel 300mg Tablet is often prescribed to patients with heart problems to treat hypertension. However, it must be taken strictly under medical supervision, as it can affect liver and kidney function and may interact with other heart medications.

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Geriatrics

Caution

Aprovel 300mg Tablet should be taken with caution in geriatric patients. Please inform your doctor before using Aprovel 300mg Tablet.

What if I have taken an overdose of Aprovel 300mg Tablet

The symptoms of overdose include low blood pressure and a fast or slow heart rate. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Reduce your salt intake: Consuming high amounts of sodium can raise your blood pressure and make Aprovel 300mg Tablet less effective. Avoid adding extra salt to your meals and limit processed foods.
  • Avoid potassium-rich salt substitutes: Aprovel 300mg Tablet can naturally increase the amount of potassium in your blood. Avoid using salt substitutes that contain potassium, as this can lead to dangerously high potassium levels.
  • Monitor your blood pressure at home: Keep a regular log of your daily blood pressure readings to share with your doctor during your routine checkups.
  • Stay adequately hydrated: Dehydration can cause your blood pressure to drop too low when taking this medication. Drink plenty of water throughout the day, especially when exercising or in hot weather.
health query

Have a query?

How Soon It Starts Working

  • The time required for Aprovel 300mg Tablet to start to work: The time required for Aprovel 300mg Tablet to start to work is 2 hours after administration.
  • The time for which the effects of Aprovel 300mg Tablet last: The effect of Aprovel 300mg Tablet lasts for 24 hours.

What if you forget to take Aprovel 300mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose entirely and resume your normal routine. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Dizziness and Fall Prevention: Always stand up slowly from a sitting or lying position to minimise dizziness and prevent falls, especially when first starting this medication.
  • Pregnancy Risks: Do not take this medicine if you are pregnant or planning to become pregnant, as it can cause severe harm or death to an unborn baby.
  • Routine Monitoring: Attend all scheduled doctor appointments to have your kidney function and blood potassium levels monitored through routine blood tests.
  • Pain Relievers: Check with your pharmacist before taking over-the-counter pain relievers like ibuprofen or naproxen, as they can reduce the effectiveness of Aprovel 300mg Tablet and harm your kidneys.
  • Surgical and Dental Notification: Inform any doctor or dentist treating you that you are taking Aprovel 300mg Tablet, especially before undergoing surgery or receiving anaesthesia.
  • When Not to Use: Do not take Aprovel 300mg Tablet if you are pregnant, are allergic to Aprovel 300mg Tablet or any of the ingredients in this medicine, have bilateral renal artery stenosis (narrowing of the arteries supplying both kidneys), as this medicine may significantly reduce kidney function and is generally not recommended in this condition, or have diabetes or significant kidney impairment and are taking aliskiren, as this combination increases the risk of low blood pressure, high potassium levels, and worsening kidney function.
  • Paediatric use: Its safety and effectiveness in children and adolescents have not been established for most uses. It should only be used in people under 18 years of age if specifically prescribed and monitored by a specialist.

Drug-Drug Interactions

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Drug-Drug Interaction:

  • Potassium supplements or potassium-sparing diuretics (water pills): Taking these with Aprovel 300mg Tablet may cause high potassium levels (hyperkalemia), which can affect your heart rhythm.
  • Pain relievers (NSAIDs) such as ibuprofen or naproxen: Regular use may reduce the blood pressure-lowering effect of Aprovel 300mg Tablet and increase the risk of kidney damage, especially in older adults or people with kidney disease.
  • Lithium: Aprovel 300mg Tablet may increase lithium levels in the blood, raising the risk of lithium toxicity. Your doctor may monitor your lithium levels or recommend an alternative treatment.
  • Other blood pressure medicines (especially aliskiren): Taking these together may increase the risk of low blood pressure, high potassium levels, and reduced kidney function. This combination should generally be avoided in people with diabetes or kidney disease unless advised by a doctor.

Drug- Food Interaction:

  • Salt substitutes containing potassium: These products may increase potassium levels in your blood when taken with Aprovel 300mg Tablet. Speak to your doctor before using potassium-containing salt substitutes or supplements.

Drug-Disease Interaction:

  • Severe kidney disease or narrowing of the kidney arteries (renal artery stenosis): Aprovel 300mg Tablet may further reduce kidney function in some people. Your doctor may monitor your kidney function and potassium levels with regular blood tests.
  • Dehydration or severe heart failure: These conditions can increase the risk of a sudden drop in blood pressure or kidney problems, particularly when starting treatment. Your doctor may correct dehydration or adjust your dose before treatment.
Irbesartanpotassium phosphate
Severe
IrbesartanNaproxen
Severe

Drug-Drug Interactions

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Irbesartanpotassium phosphate
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Potassium phosphate may increase potassium levels in the blood. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis and heart problems.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with potassium phosphate together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, slow or irregular heartbeat. It is advised to reduce the intake of foods high in potassium, including tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and salt substitutes that include potassium during this treatment. Do not discontinue any medications without a doctor's advice.
IrbesartanNaproxen
Severe
How does the drug interact with Aprovel 300mg Tablet:
Co-administration of Aprovel 300mg Tablet along with naproxen may result in side effects including low blood pressure, impaired kidney function.

How to manage the interaction:
There may be a possible interaction between Naproxen and Aprovel 300mg Tablet, but they can be taken together if they are prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, decreased hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, breathing difficulty, muscle pains, dizziness, confusion, and irregular heart rhythm, consult the doctor. Do not discontinue any medication without a doctor's advice.
IrbesartanMoexipril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Moexipril may cause low blood pressure, kidney function impairment, and increased potassium levels in the blood.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Moexipril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanAmiloride
Severe
How does the drug interact with Aprovel 300mg Tablet:
When used with Aprovel 300mg Tablet, Amiloride may raise potassium levels in the blood. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythm, and heart problems in extreme cases.

How to manage the interaction:
Although taking Amiloride and Aprovel 300mg Tablet together may lead to an interaction it can be taken if prescribed by the doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanLisinopril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Lisinopril may increase potassium levels in the blood.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Lisinopril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanPerindopril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Perindopril may cause low blood pressure and kidney problems.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Perindopril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in the legs, or a slow or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
IrbesartanRamipril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Ramipril together with Aprovel 300mg Tablet may increase the risk of side effects such as low blood pressure, kidney function impairment, and a condition called hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Ramipril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanTrimethoprim
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Trimethoprim may increase potassium levels in the blood and kidney problems.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Trimethoprim together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult your doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanPotassium chloride
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Potassium chloride may increase potassium levels in the blood.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Potassium chloride together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanTriamterene
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Triamterene may increase potassium levels in the blood. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis and heart problems.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Triamterene together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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IRBESARTAN-300MGPotassium rich foods
Moderate

Drug-Food Interactions

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IRBESARTAN-300MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Consuming potassium-containing substances during treatment with Aprovel 300mg Tablet can lead to high potassium levels which may result in side effects like weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs. Avoid potassium-containing salt substitutes and over-the-counter potassium supplements during Aprovel 300mg Tablet therapy.

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Aprovel 300mg Tablet is indicated for the treatment of hypertension (high blood pressure) in adults. Additionally, it is used to reduce the risk of heart attack or stroke in adults.
Aprovel 300mg Tablet may increase potassium levels in the blood (hyperkalemia). Therefore, it is recommended to avoid intake of potassium supplements and foods that are rich in potassium, like coconut water, bananas and broccoli.
Only on a doctor's consultation, a patient can take Aprovel 300mg Tablet with metformin, which has been found to have a beneficial effect on the kidneys in a diabetic patient with hypertension.
Not recommended in overweight patients as per studies conducted by researchers, Aprovel 300mg Tablet causes weight gain in normal individuals and thus is contraindicated in overweight patients.
No, Aprovel 300mg Tablet is an angiotensin receptor blocker (ARB) and is highly unlikely to cause the persistent, dry cough commonly associated with ACE inhibitors. If you do develop a dry cough, talk to your doctor to find the exact cause.
Absolutely safe to be used in patients with stomach ulcers, as there has been no harmful interaction between Aprovel 300mg Tablet and peptic ulcers except occasional nausea. Recently, it has been found to have a protective role against stomach ulcers, but it is not yet approved for stomach diseases.
No. Aprovel 300mg Tablet should not be used during pregnancy, as it can cause serious harm or even death to an unborn baby, especially during the second and third trimesters. If you are pregnant, think you may be pregnant, or are planning to become pregnant, contact your doctor immediately. Your doctor will advise you on safely stopping Aprovel 300mg Tablet and switching to a more suitable treatment for pregnancy. Do not stop or change your medicine without medical advice.
It is highly recommended to limit or avoid alcohol while taking this medicine. Alcohol can increase the blood-pressure-lowering effect of Aprovel 300mg Tablet, making you feel severely dizzy, lightheaded, or prone to fainting when you stand up. Talk to your doctor about your alcohol intake.
Yes, your healthcare provider will likely order routine blood tests to check your kidney function and measure the level of potassium in your blood. This monitoring ensures the medication remains safe for you to use. Talk to your doctor to set up a testing schedule.
Dizziness is common, especially when starting Aprovel 300mg Tablet or gradually increasing your dose. If you feel dizzy, sit or lie down immediately until the feeling passes, and ensure you rise very slowly next time. If dizziness persists or causes fainting, talk to your doctor right away.
Many over-the-counter cold and flu products contain decongestants (such as pseudoephedrine) that constrict blood vessels and raise blood pressure, directly working against Aprovel 300mg Tablet. Talk to your doctor or pharmacist before purchasing any cold remedies.
No, Aprovel 300mg Tablet is not a water pill; it is a blood vessel relaxant. However, doctors sometimes prescribe Aprovel 300mg Tablet alongside a diuretic if your blood pressure requires multiple medications to stay under control. Talk to your doctor to understand your specific prescription regimen.

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Country of origin

India
Other Info - AP76648
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