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  3. ARIXTRA 7.5MG INJECTION

ARIXTRA 7.5MG INJECTION, Pack of 1 INJECTION
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Composition :

FONDAPARINUX SODIUM-7.5MG

Manufacturer/Marketer :

GlaxoSmithKline Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About ARIXTRA 7.5MG INJECTION

ARIXTRA 7.5MG INJECTION belongs to a class of drugs called anticoagulants (blood thinner) primarily used to prevent/treat deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), heart attack, and severe angina. It also reduces the risk of blood clots after orthopedic (such as hip or knee surgery), or abdominal surgery. ARIXTRA 7.5MG INJECTION prevents blood clot formation during and shortly after restricted movement because of an acute illness. Deep vein thrombosis is a medical condition in which blood clots form in deep veins, usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs.

ARIXTRA 7.5MG INJECTION contains ‘Fondaparinux sodium’ that works by inhibiting the action of clotting factors (a natural substance in the blood that causes clotting). Thereby preventing the conversion of fibrinogen to fibrin (a protein that binds platelets together and forms a clot) and helping prevent blood clot formation. It eases blood flow through the veins, making it less likely to develop a severe blood clot.

ARIXTRA 7.5MG INJECTION will be administered by a trained healthcare professional; hence do not self-administer. Some people may experience unusual bleeding, anemia (low number of red blood cells), bruising or swelling. Most of these side effects of ARIXTRA 7.5MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are pregnant or breastfeeding, it is advised to consult a doctor before using ARIXTRA 7.5MG INJECTION. ARIXTRA 7.5MG INJECTION is not recommended for children below 17 years of age. ARIXTRA 7.5MG INJECTION should be used with caution in the elderly above 60, as they may be at high risk of bleeding. If you have a stomach ulcer, kidney or liver problems, high blood pressure, or bleeding problems, inform your doctor before receiving ARIXTRA 7.5MG INJECTION. If you are about to undergo surgery, inform your doctor about the treatment with ARIXTRA 7.5MG INJECTION. Keep your doctor informed about your health condition and medications to rule out any interactions.

Uses of ARIXTRA 7.5MG INJECTION

Prevention of blood clot formation

Directions for Use

ARIXTRA 7.5MG INJECTION will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

ARIXTRA 7.5MG INJECTION belongs to a class of drugs known as anticoagulants or blood thinners. ARIXTRA 7.5MG INJECTION contains ‘Fondaparinux sodium’ used to prevent deep vein thrombosis (blood clot in the blood vessels of legs) and pulmonary embolism (blood clot in the blood vessels lungs). It also reduces the risk of blood clots during orthopedic (such as hip or knee surgery), abdominal surgery, or restricted movement because of an acute illness. ARIXTRA 7.5MG INJECTION works by stopping the action of clotting factor Xa (a natural substance in the blood that causes clotting). This inhibits fibrin production (a protein that binds platelets together and forms a clot), preventing blood clot formation. ARIXTRA 7.5MG INJECTION is also used to treat certain types of heart attack and chest pain called unstable angina.

How ARIXTRA 7.5MG INJECTION Works

ARIXTRA 7.5MG INJECTION contains ‘Fondaparinux sodium’ that works by inhibiting the action of clotting factors (a natural substance in the blood that causes clotting). Thereby preventing the conversion of fibrinogen to fibrin (a protein that binds platelets together and forms a clot) and helping prevent blood clot formation. It eases blood flow through the veins, making it less likely to develop a severe blood clot.

Storage

Store in a cool and dry place away from sunlight
Side effects of Arixtra 7.5mg Injection
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

What if I have taken an overdose of ARIXTRA 7.5MG INJECTION

A healthcare professional administers ARIXTRA 7.5MG INJECTION in a hospital. Hence, the chances of an overdose may be less. Overdose may cause abdominal or stomach pain or swelling, coughing up blood, decreased alertness, headache, joint pain or swelling, bruising or purple areas on the skin, and nosebleeds. Your doctor will initiate the necessary treatment if an overdose is suspected.

Drug Warnings

Do not receive ARIXTRA 7.5MG INJECTION if you are allergic to any of the contents; if you are bleeding excessively, have a bacterial heart infection, or have very severe kidney disease. If you are pregnant or breastfeeding, it is advised to consult a doctor before using ARIXTRA 7.5MG INJECTION. ARIXTRA 7.5MG INJECTION is not recommended for children as safety and effectiveness have not been established. ARIXTRA 7.5MG INJECTION should be used with caution in the elderly above 65, as they may be at high risk of bleeding. If you are about to undergo any surgery, inform your doctor that you are receiving ARIXTRA 7.5MG INJECTION. If you notice bleeding gums, blood in urine, coughing up blood or vomit that looks like coffee grounds, pain, swelling, dizziness, weakness, unusual bruising, nose bleeds, abnormal vaginal bleeding or heavy menstrual periods, bloody or tarry stools, please consult a doctor immediately. Avoid alcohol consumption during treatment with ARIXTRA 7.5MG INJECTION as it may increase the risk of stomach bleeding. Inform your doctor before receiving ARIXTRA 7.5MG INJECTION if you have a stomach ulcer, kidney or liver problems, high blood pressure, bleeding problems, are 75 years or older, or weigh less than 50kg. Do not discontinue using ARIXTRA 7.5MG INJECTION without consulting your doctor, as this may increase your chances of having another heart attack or stroke.

Drug-Drug Interactions

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FondaparinuxDefibrotide
Critical
FondaparinuxMifepristone
Critical

Drug-Drug Interactions

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FondaparinuxDefibrotide
Critical
How does the drug interact with Arixtra 7.5mg Injection:
Taking defibrotide with Arixtra 7.5mg Injection can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Arixtra 7.5mg Injection with Defibrotide is not recommended, but it can be taken if your doctor has advised it. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
FondaparinuxMifepristone
Critical
How does the drug interact with Arixtra 7.5mg Injection:
Using mifepristone together with Arixtra 7.5mg Injection may increase the risk and/or severity of vaginal bleeding in women

How to manage the interaction:
Taking Arixtra 7.5mg Injection with Mifepristone together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
FondaparinuxSulindac
Severe
How does the drug interact with Arixtra 7.5mg Injection:
Taking sulindac with Arixtra 7.5mg Injection can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
There may be a possibility of interaction between Arixtra 7.5mg Injection and Sulindac, but it can be taken if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
FondaparinuxRuxolitinib
Severe
How does the drug interact with Arixtra 7.5mg Injection:
Taking ruxolitinib and Arixtra 7.5mg Injection together may increase the risk of bleeding.

How to manage the interaction:
Taking Arixtra 7.5mg Injection with ruxolitinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
FondaparinuxIbuprofen
Severe
How does the drug interact with Arixtra 7.5mg Injection:
Coadministration of Arixtra 7.5mg Injection with ibuprofen can increase the risk of bleeding.

How to manage the interaction:
Taking Arixtra 7.5mg Injection and Ibuprofen together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
FondaparinuxTenecteplase
Severe
How does the drug interact with Arixtra 7.5mg Injection:
Taking tenecteplase with Arixtra 7.5mg Injection can increase the risk of bleeding.

How to manage the interaction:
Taking Tenecteplase with Arixtra 7.5mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
FondaparinuxRamucirumab
Severe
How does the drug interact with Arixtra 7.5mg Injection:
Using ramucirumab together with Arixtra 7.5mg Injection can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Arixtra 7.5mg Injection and Ramucirumab, but it can be taken if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
FondaparinuxTirofiban
Severe
How does the drug interact with Arixtra 7.5mg Injection:
Taking Tirofiban with Arixtra 7.5mg Injection can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Arixtra 7.5mg Injection and Tirofiban, it can be taken if your doctor has advised it. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FondaparinuxPiroxicam
Severe
How does the drug interact with Arixtra 7.5mg Injection:
Taking piroxicam with Arixtra 7.5mg Injection can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Arixtra 7.5mg Injection and Piroxicam, you can take these medicines together if prescribed by a doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact a doctor immediately. Do not stop using any medications without talking to a doctor.
FondaparinuxAntithrombin iii
Severe
How does the drug interact with Arixtra 7.5mg Injection:
Using Arixtra 7.5mg Injection together with antithrombin iii can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Arixtra 7.5mg Injection and Antithrombin iii, but it can be taken if your doctor has advised it. However, if you experience bleeding or bruising, feeling dizzy or lightheaded, dark or bloody stools, headache, weakness contact your doctor right away. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do not make any changes in your diet without first talking to your doctor.
  • Avoid vitamin K-rich foods such as coriander, cabbage, spinach, broccoli, collard greens, kale (leaf cabbage), black liquorice, turnip greens, avocados, and brussels sprouts as they may decrease the effectiveness of ARIXTRA 7.5MG INJECTION.
  • Avoid cranberry juice, grapefruit juice, noni juice, pomegranate juice and green tea as they may interact with ARIXTRA 7.5MG INJECTION and lead to unwanted side effects.
  • Do regular exercise as it helps to dissolve blood clots, especially in obese people.
  • Avoid consumption of alcohol as it may increase the risk of bleeding.

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

ARIXTRA 7.5MG INJECTION Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid consuming alcohol with ARIXTRA 7.5MG INJECTION as it may increase the risk of bleeding.

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Pregnancy

Caution

Please inform your doctor if you are pregnant or planning pregnancy. Your doctor will prescribe only if it is clearly necessary.

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Breast Feeding

Caution

Breastfeeding is not recommended during treatment with ARIXTRA 7.5MG INJECTION. If you are a nursing mother, inform your doctor before receiving this injection.

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Driving

Caution

It is unknown if ARIXTRA 7.5MG INJECTION affects your ability to drive or operate machinery. Therefore, drive or operate machinery only if you are alert.

bannner image

Liver

Caution

ARIXTRA 7.5MG INJECTION should be used with caution, especially if you have a history of liver diseases. Your doctor may adjust the dose if required based on your condition.

bannner image

Kidney

Caution

ARIXTRA 7.5MG INJECTION should be administered with caution if you have a history of kidney diseases. Your doctor may adjust the dose if required based on your condition. This medicine is not recommended for patients with severe kidney disease.

bannner image

Children

Caution

ARIXTRA 7.5MG INJECTION is not recommended for children below 17 years of age as safety and effectiveness have not been established.

Have a query?

FAQs

ARIXTRA 7.5MG INJECTION belongs to a class of drugs called anticoagulants (blood thinner) primarily used to prevent/treat deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), heart attack, and severe angina. It also reduces the risk of blood clots after orthopedic (such as hip or knee surgery), or abdominal surgery. ARIXTRA 7.5MG INJECTION prevents blood clot formation during and shortly after restricted movement because of an acute illness.

ARIXTRA 7.5MG INJECTION stops the action of clotting factors. This prevents the formation of unwanted blood clots (thrombosis) in the blood vessels.

If you have diabetes, inform your doctor before receiving ARIXTRA 7.5MG INJECTION. ARIXTRA 7.5MG INJECTION should be used with caution in diabetic patients as they may be at increased risk of bleeding. Regular blood tests are advised to monitor blood clotting time while receiving ARIXTRA 7.5MG INJECTION.

You are not recommended to take aspirin with ARIXTRA 7.5MG INJECTION as co-administration of these two medicines may increase the risk of haemorrhage. However, please consult a doctor immediately if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, vomiting, weakness or headache. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately.

Yes, ARIXTRA 7.5MG INJECTION may increase the risk of bleeding, and the effects of ARIXTRA 7.5MG INJECTION may last for four days even after discontinuation. Always be careful while doing activities that may cause injury or bleeding. Please inform your doctor immediately if you notice purple spots on the skin, unusual bruising, blood in urine, black tarry stools, or unusual bleeding from the gums or nose.

Tests such as platelet count, factor V assay, fibrinogen level test, prothrombin time test (PT or PT-INR), and the INR (international normalized ratio) are used to determine blood clotting time.

You are usually not advised to have a tattoo or body piercing while receiving ARIXTRA 7.5MG INJECTION as it may increase the risk of bleeding and infection. If you still wish to proceed further, contact your doctor to adjust the dose, or any antibiotics may be prescribed. Let the piercer or tattooist know in advance that you are on treatment with a blood thinner.

Please consult your doctor if you are due to undergo any surgery. The doctor might stop the administration of ARIXTRA 7.5MG INJECTION a few days before surgery as it can cause an increased risk of bleeding during surgery.

No, you should not take ARIXTRA 7.5MG INJECTION with OTC painkillers as it may cause interactions. Consult the doctor if you have any odd pain.

No, you should not self-administer ARIXTRA 7.5MG INJECTION because some people may experience anemia (low number of red blood cells), unusual bleeding, bruising or swelling. It should be administered by the doctor or nurse to prevent adverse effects.

Excessive menstrual bleeding while taking ARIXTRA 7.5MG INJECTION may be concerning, as this medication increases the risk of bleeding due to its anticoagulant effect. It’s important to consult the doctor if you have excessive bleeding, as they may need to evaluate your condition and adjust your treatment to ensure your safety.

The long-term use of ARIXTRA 7.5MG INJECTION will be based on your specific clotting disorder and risk factors. The doctor will assess the risks and benefits and determine how long the treatment should be continued. Consult the doctor if you have any concerns.

Yes, ARIXTRA 7.5MG INJECTION may increase the risk of bleeding, with its effects lasting up to four days after discontinuing the medication. Take extra caution during activities that might cause injury or bleeding.

The side effects of ARIXTRA 7.5MG INJECTION include anaemia (low number of red blood cells), unusual bleeding, bruising or swelling. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Stiefel India Ltd., 401& 402, A Wing, IV Floor, Floral Deck Plaza, Opp. Rolta Bhavan, Central MIDC Road, Andheri (East), Mumbai – 400093
Other Info - ARI0094

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jan 1, 2025 | 2:46 PM IST

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Reference

  1. https://www.drugs.com/mtm/fondaparinux.html
  2. https://www.medicines.org.uk/emc/files/pil.3340.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021345s019lbl.pdf

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