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compositionComposition:ATRACURIUM-50MG
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Artacil 50 mg Injection 5 ml is used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care. It contains Atracurium, which stops sending pain signal to the brain, relieves muscle stiffness or muscle spasm. It is also used during general anaesthesia to ease tracheal intubation (a tube into the windpipe) and controlled ventilation.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ATRACURIUM-50MG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Artacil 50 mg Injection 5 ml

Artacil 50 mg Injection 5 ml is a prescription medicine used to relax muscles during surgical procedures and when a patient requires breathing support from a ventilator. It temporarily prevents muscle movement, allowing doctors to perform procedures safely and effectively. It is commonly used to make insertion of a breathing tube easier and to keep muscles relaxed during surgery.

Because Artacil 50 mg Injection 5 ml is given only in hospitals or specialised healthcare settings, it is administered as an injection or continuous infusion by trained medical professionals. Since it is given directly into a vein, food does not affect how it works. Following your healthcare team's recovery instructions can help support a smooth recovery after your procedure.

While receiving Artacil 50 mg Injection 5 ml, some people may experience temporary side effects such as skin flushing, mild skin rash, hives, or a temporary drop in blood pressure. You will be continuously monitored throughout your procedure, allowing your medical team to quickly identify and manage any unexpected reactions.

Before receiving Artacil 50 mg Injection 5 ml, tell your doctor if you have neuromuscular conditions such as myasthenia gravis, previous reactions to anesthesia, severe allergies, or any history of unusual responses to muscle-relaxing medicines. Do not receive Artacil 50 mg Injection 5 ml if you have had a severe allergic reaction to Artacil 50 mg Injection 5 ml or similar muscle-relaxing medicines from the same family.

Certain medicines, including some antibiotics, anesthetics, lithium, and magnesium-containing products, can affect how Artacil 50 mg Injection 5 ml works. If you are pregnant, breastfeeding, an older adult, or the parent of a child receiving Artacil 50 mg Injection 5 ml, discuss any concerns with your doctor before the procedure. Artacil 50 mg Injection 5 ml is often preferred in patients with kidney or liver impairment because its breakdown does not depend heavily on these organs. It is also commonly used in operating rooms and intensive care units where reliable muscle relaxation is needed.

Uses of Artacil 50 mg Injection 5 ml

Artacil 50 mg Injection 5 ml is used in the treatment of Muscle contraction during surgery. The detailed uses of Artacil 50 mg Injection 5 ml are as follows:

  • Muscle relaxation during surgery: It relaxes skeletal muscles, which helps surgeons perform operations safely and with fewer complications.
  • Support for mechanical ventilation: It relaxes the chest and airway muscles, allowing a breathing machine to work smoothly for patients in intensive care.
  • Tracheal intubation: It relaxes the throat muscles, making it easier and safer for a healthcare provider to insert a breathing tube.

Key Benefits

Artacil 50 mg Injection 5 ml helps provide controlled muscle relaxation during surgical procedures and intensive care treatment. By relaxing the muscles effectively, it supports safe medical procedures and helps healthcare professionals manage breathing support when needed. Benefits may include:

  • Provides reliable muscle relaxation during surgical procedures.
  • Helps prevent involuntary muscle movements, allowing greater surgical precision.
  • Facilitates endotracheal intubation and airway management during anesthesia.
  • Supports better synchronization with mechanical ventilation in critically ill patients.
  • Helps reduce the effort required for assisted breathing during intensive care treatment.
  • Can be used in patients with impaired kidney or liver function under appropriate medical supervision.
Side effects of Artacil 50 mg Injection 5 ml
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Injection site reaction can include numbness or redness.
  • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
  • Apply cold compress for pain relief.
  • Practice good hygiene and keep the injection site away from heat and pressure.
  • Avoid scratching the affected area.
  • Wear loose clothing to reduce irritation.
  • Keep the affected area moisturized with a gentle moisturiser.
  • To alleviate the reaction, remove the irritant by immediately stopping contact and washing the area with mild soap and cool water.
  • Apply a cool, wet compress to reduce inflammation and itching.
  • Consult a doctor if your skin reaction is severe, widespread, or accompanied by swelling, blistering, or breathing difficulties.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Directions for Use

  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Artacil 50 mg Injection 5 ml will be administered by a healthcare professional.
  • Do not self-administer.

How Artacil 50 mg Injection 5 ml Works

Artacil 50 mg Injection 5 ml contains Atracurium, which helps relax the muscles by temporarily blocking the signals between nerves and muscles. This makes it easier for healthcare professionals to perform procedures such as surgery or assist with breathing support when needed. It works for a short period and the muscle function gradually returns as the medicine is naturally broken down and cleared from the body.
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Alcohol

Unsafe

Avoid consumption of alcohol after taking Artacil 50 mg Injection 5 ml as it may increase the risk of side effects.

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Pregnancy

Consult your doctor

If you are pregnant, inform your doctor before receiving Artacil 50 mg Injection 5 ml; Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

If you are breastfeeding, inform your doctor before receiving Artacil 50 mg Injection 5 ml; Your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Unsafe

Artacil 50 mg Injection 5 ml causes sleepiness and drowsiness. So, avoid driving or operating heavy machinery after taking this medicine.

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Liver

Caution

Artacil 50 mg Injection 5 ml should be used with caution in patients with liver diseases. Your doctor may adjust the dose of Artacil 50 mg Injection 5 ml before prescribing.

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Kidney

Caution

Artacil 50 mg Injection 5 ml should be used with caution in patients with kidney diseases. Your doctor may adjust the dose of Artacil 50 mg Injection 5 ml before prescribing.

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Children

Consult your doctor

Artacil 50 mg Injection 5 ml use is not recommended in neonates (children under the age of one month). Your doctor will decide the dose of Artacil 50 mg Injection 5 ml based on age and condition of your child.

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Heart

Consult your doctor

Limited information is available; please consult your doctor.

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Geriatrics

Consult your doctor

Limited information available for use of Artacil 50 mg Injection 5 ml in elderly patients. Please consult your doctor.

What if I have taken an overdose of Artacil 50 mg Injection 5 ml

Since medical professionals inject this medication under strict monitoring, an overdose is highly unlikely. If an overdose occurs, your healthcare team is trained to immediately manage it by providing breathing support and using medicines to reverse the muscle relaxation.

Diet & Lifestyle Advise

  • Follow fasting instructions carefully: Do not eat or drink anything as directed by your surgical team before the procedure, as fasting helps reduce the risk of serious breathing complications during anesthesia.
  • Get adequate rest after the procedure: Rest quietly following your surgery to allow your muscles time to recover and regain their full strength.
  • Avoid walking without assistance: Do not get out of bed, stand, or walk on your own until your healthcare team confirms that the effects of the medicine have completely worn off.
  • Stay well hydrated when permitted: Once your doctor allows you to drink fluids, consume plenty of water to support recovery and help your body process fluids effectively.
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Have a query?

How Soon It Starts Working

The time required for Artacil 50 mg Injection 5 ml to start to work: The time required for Artacil 50 mg Injection 5 ml to start to work is 2 to 3 minutes after administration. 

The time for which the effects of Artacil 50 mg Injection 5 ml last: The effect of Artacil 50 mg Injection 5 ml lasts for 20 to 35 minutes.

What if you forget to take Artacil 50 mg Injection 5 ml

Because Artacil 50 mg Injection 5 ml is given only by healthcare professionals in a controlled medical setting, it is not possible for you to miss a dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Artacil 50 mg Injection 5 ml out of the sight and reach of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the solution before use: The solution should appear clear and colorless to pale yellow. Do not use it if it appears cloudy, discolored, or contains visible particles.
  • Inform your medical team about allergies: Tell your healthcare providers about any allergies, especially previous reactions to anesthesia, muscle relaxants, or other medicines.
  • Expect close monitoring during treatment: Your heart rate, blood pressure, oxygen levels, and breathing will be continuously monitored while Artacil 50 mg Injection 5 ml is being administered.
  • Discuss any muscle or nerve disorders: Inform your doctor if you have myasthenia gravis or any other condition affecting the muscles or nervous system, as these conditions may alter your response to the medicine.
  • Inform your doctor about electrolyte abnormalities: Tell your healthcare provider if you have abnormal blood levels of minerals such as potassium or calcium, as these may affect how the medicine works.
  • Avoid activities requiring coordination after anesthesia: Do not drive, operate machinery, or perform tasks requiring full alertness and coordination for at least 24 hours after anesthesia, or for as long as advised by your doctor.

Drug-Drug Interactions

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  • Inhalation anesthetics (e.g., isoflurane, halothane): Taking these medicines alongside Artacil 50 mg Injection 5 ml may increase and prolong its muscle-relaxing effects.
  • Certain antibiotics (e.g., aminoglycosides, polymyxins, tetracyclines): These medicines may enhance the effects of Artacil 50 mg Injection 5 ml and prolong muscle relaxation.
  • Lithium or magnesium-containing medicines: Combining these with Artacil 50 mg Injection 5 ml may increase its muscle-relaxing effects and raise the risk of excessive muscle weakness.
    Other muscle-relaxing medicines: Taking these alongside Artacil 50 mg Injection 5 ml may increase the risk of prolonged or excessive muscle weakness.

Drug-Drug Interactions

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How does the drug interact with Artacil 50 mg Injection 5 ml:
Co-administration of Artacil 50 mg Injection 5 ml with doxycycline may increase the risk of breathing problems.

How to manage the interaction:
Although there is an interaction between Artacil 50 mg Injection 5 ml and Doxycycline, bit it can be taken together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Artacil 50 mg Injection 5 ml:
Co-administration of Streptomycin with Artacil 50 mg Injection 5 ml may increase the risk or severity of side effects.

How to manage the interaction:
Co-administration of Streptomycin with Artacil 50 mg Injection 5 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Artacil 50 mg Injection 5 ml:
Using Artacil 50 mg Injection 5 ml with Tobramycin can increase the risk of respiratory depression (breathing disorder).

How to manage the interaction:
Although there is a interaction between Tobramycin and Artacil 50 mg Injection 5 ml, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
How does the drug interact with Artacil 50 mg Injection 5 ml:
Co-administration of Polymyxin B with Artacil 50 mg Injection 5 ml may cause serious breathing problems

How to manage the interaction:
There may be a possibility of interaction between Polymyxin b and Artacil 50 mg Injection 5 ml, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Artacil 50 mg Injection 5 ml:
Coadministration of Botulinum toxin with Artacil 50 mg Injection 5 ml may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Botulinum toxin and Artacil 50 mg Injection 5 ml, it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience excessive muscle weakness or trouble breathing, swallowing, or speaking. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Artacil 50 mg Injection 5 ml:
Combining Artacil 50 mg Injection 5 ml with Fentanyl can increase the risk of irregular heart rhythm and low blood pressure.

How to manage the interaction:
There may be a possibility of interaction between Artacil 50 mg Injection 5 ml and Fentanyl, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Artacil 50 mg Injection 5 ml:
Co-administration of Amikacin with Artacil 50 mg Injection 5 ml can increase the risk of developing breathing difficulties.

How to manage the interaction:
Taking Artacil 50 mg Injection 5 ml with Amikacin together can result in an interaction, but it can be taken if your doctor has advised it. Consult your doctor if you experience shortness of breath, palpitations, chest discomfort, or dizziness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Artacil 50 mg Injection 5 ml:
Coadministration of Artacil 50 mg Injection 5 ml with Colistin can increase the risk of Artacil 50 mg Injection 5 ml side effects.

How to manage the interaction:
Although there is a possible interaction between Colistin and Artacil 50 mg Injection 5 ml, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, slurred speech, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Artacil 50 mg Injection 5 ml:
Co-administration of Clindamycin with Artacil 50 mg Injection 5 ml can increase the risk of muscle weakness.

How to manage the interaction:
Taking Clindamycin with Artacil 50 mg Injection 5 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. "Clindamycin can affect the muscles and nerves in your body. When used with other medications that also affect the muscles and nerves, it can cause a serious problem called neuromuscular blockade. If you have trouble breathing or can't breathe at all, please call your doctor right away." Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No interactions found

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MUSCLE RELAXANTS/SKELETAL MUSCLE RELAXANTS]

FAQs

Artacil 50 mg Injection 5 ml is used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care.
Artacil 50 mg Injection 5 ml contains 'Atracurium' that relaxes the muscles by blocking the impulses from the nerves. It is used for skeletal muscle relaxation during surgery.
Artacil 50 mg Injection 5 ml causes sleepiness and drowsiness. So, drive only if you are alert and omit driving or operating machinery if you feel sleepy or drowsy.
Artacil 50 mg Injection 5 ml is safe and effective when administered to patients with severe heart disease. However, rapid administration of large doses may occasionally produce transient hypotension in patients with heart problems. Please consult your doctor. Your doctor will prescribe only if the benefits outweigh the risks.
Do not use Artacil 50 mg Injection 5 ml have had myasthenia gravis or Eaton-Lambert syndrome, severe electrolyte disorder, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns, and lack of adequate circulatory filling (hypovolaemia), pregnant or breastfeeding mother. Avoid driving or performing hazardous tasks until you know how Artacil 50 mg Injection 5 ml will affect you, and your reactions could be impaired.
Artacil 50 mg Injection 5 ml is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer or the fridge.
Artacil 50 mg Injection 5 ml is given by IV injection administered by a healthcare professional under carefully controlled conditions. Do not self-administer Artacil 50 mg Injection 5 ml.
The common side effects of the Artacil 50 mg Injection 5 ml are tachycardia (rapid heartbeat), temporary hypotension (low blood pressure), wheezing, bronchospasm (asthma-like symptoms), skin flushing, and urticaria (nettle rash). However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
Artacil 50 mg Injection 5 ml usually begins working within 2 to 3 minutes after intravenous administration. Your anesthesiologist will monitor its effects throughout the procedure.
No. Artacil 50 mg Injection 5 ml only relaxes muscles and does not provide pain relief or cause sleep. It is used together with anesthetics and pain-relieving medicines during procedures.
Artacil 50 mg Injection 5 ml is often preferred for people with kidney or liver impairment because it is broken down mainly through Hofmann elimination and ester hydrolysis rather than relying heavily on these organs.
Artacil 50 mg Injection 5 ml may be used during pregnancy when medically necessary, such as during surgical procedures. Your doctor will carefully weigh the benefits and potential risks before use.
Doctors may allow the Artacil 50 mg Injection 5 ml to wear off naturally or use anticholinesterase medicines such as neostigmine to help restore normal muscle strength more quickly.

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Country of origin

INDIA

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - ART0080
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