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compositionComposition:ATENOLOL-25MG+HYDROCHLOROTHIAZIDE-12.5MG
prescription
Prescription Medicine
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ATPURE D TABLET is used to treat high blood pressure. It contains Atenolol and Hydrochlorothiazide which slow down the heart rate and increase the amount of urine passed out from the kidneys. In some cases, this medicine may cause side effects such as headache, nausea, fatigue, dizziness, and slow heart rate. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ATENOLOL-25MG+HYDROCHLOROTHIAZIDE-12.5MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ATPURE D TABLET

ATPURE D TABLET is a prescription oral tablet used to treat high blood pressure (hypertension). By lowering high blood pressure, this medication helps prevent serious cardiovascular events like strokes, heart attacks, and kidney problems. It is designed to be taken long-term to keep your blood pressure under control.

For the best results, you must take ATPURE D TABLET consistently every single day, exactly as prescribed by your doctor. It can be taken with or without food, but it is best to take it at the same time each day, preferably in the morning to avoid waking up at night to urinate. Along with this medication, adopting a heart-healthy diet low in salt and engaging in regular moderate exercise can significantly improve your blood pressure readings.

While taking ATPURE D TABLET, some people may experience mild side effects like dizziness, fatigue, or cold hands and feet. However, you should consult your doctor immediately if you experience serious side effects, such as a very slow heart rate, severe dizziness, or signs of electrolyte imbalance like muscle cramps or extreme thirst.

Do not take this if you have certain health conditions like severe kidney or liver disease, a very slow heart rate, or a history of severe asthma. Talk to your doctor before starting ATPURE D TABLET if you have diabetes, gout, thyroid disorders, or blood circulation problems.

Let your doctor know about all other medicines you take, as ATPURE D TABLET can interact with other blood pressure drugs, lithium, and certain pain relievers like NSAIDs. Avoid drinking alcohol while taking this medicine, as it can excessively lower your blood pressure and cause dizziness. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, consult your doctor before using this medicine.

Uses of ATPURE D TABLET

Your doctor may prescribe this medicine to treat several conditions, including:

  • High Blood Pressure (Hypertension): ATPURE D TABLET helps lower elevated blood pressure when a single medicine is not enough, reducing the strain on your heart and blood vessels.
  • Reducing Cardiovascular Risks: By maintaining healthy blood pressure levels, this medication lowers your long-term risk of suffering a stroke or a heart attack.

Key Benefits

ATPURE D TABLET helps effectively lower and control high blood pressure through its dual-action formula. By combining two complementary blood pressure-lowering medicines in a single tablet, it provides consistent blood pressure control and helps protect your heart and blood vessels. Key benefits include:

  • Provides Effective Blood Pressure Control: This medication works through two different mechanisms to lower high blood pressure, helping maintain stable blood pressure levels throughout the day.
  • Helps Protect Vital Organs: By keeping blood pressure under control, this medication reduces the risk of long-term complications such as heart disease, stroke, and kidney damage.
  • Simplifies Daily Treatment: Combining two blood pressure medicines into one convenient tablet makes your treatment regimen easier to follow, supporting better medication adherence and providing consistent, 24-hour blood pressure control.
Side effects of Atpure D Tablet
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Reducing the amount of time you spend outside and indoors in the cold.
  • keeping your hands warm by donning mittens, gloves, or other protective clothing.
  • Observing a skincare regimen that safeguards your fingers and hands.
  • To improve circulation, give your hands and feet a little massage.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • ATPURE D TABLET can be taken with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow ATPURE D TABLET as a whole with a glass of water.
  • Do not crush, break, or chew it.

How ATPURE D TABLET Works

ATPURE D TABLET is a combination of two active components that work together in different ways to lower your blood pressure. The first active ingredient belongs to a group of medicines called beta-blockers. It works by blocking certain natural chemicals in your body, like adrenaline, which slows down your heart rate and allows your heart to beat with less force. This reduces the workload on your heart. The second active ingredient is a diuretic, often called a water pill. It helps your kidneys remove extra water and salt from your body through your urine. By reducing the total amount of fluid circulating in your blood vessels, it lowers the pressure against the walls of your arteries. Together, these two actions provide a highly effective way to manage hypertension.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with ATPURE D TABLET to avoid unpleasant side-effects.

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Pregnancy

Caution

It is not known whether this ATPURE D TABLET will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

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Breast Feeding

Unsafe

ATPURE D TABLET may excrete into the breast milk. It is not recommended to use ATPURE D TABLET during breastfeeding. Please consult your doctor for more information before taking ATPURE D TABLET if you are a nursing mother.

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Driving

Unsafe

It is not recommended to drive after taking ATPURE D TABLET as it may cause drowsiness or fatigue.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking ATPURE D TABLET. The dosage will be initiated in lower doses and will be further increased in patients with liver diseases. However, ATPURE D TABLET is not recommended in patients with severe hepatic impairment.

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Kidney

Caution

ATPURE D TABLET may affect the kidney functioning. Hence it is advised to seek doctor advice before starting ATPURE D TABLET if you have kidney problems. However, it is not recommended in patients with severe renal impairment.

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Children

Unsafe

ATPURE D TABLET is not recommended for children. So, it is not safe for children.

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Heart

Safe if prescribed

ATPURE D TABLET is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

ATPURE D TABLET should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of ATPURE D TABLET

If you suspect an overdose, seek immediate emergency medical attention. Symptoms of an overdose may include extreme dizziness, a very slow heartbeat, severe weakness, or fainting.

Diet & Lifestyle Advise

  • Reduce Salt (Sodium) Intake: Limit your consumption of processed foods, canned soups, and table salt. A low-sodium diet directly supports the action of ATPURE D TABLET in lowering blood pressure.
  • Stay Adequately Hydrated: Since this medicine contains a diuretic, it is important to drink enough fluids throughout the day. However, consult your doctor about the right amount of fluid intake, especially if you have heart or kidney conditions.
  • Monitor Your Potassium Levels: Diuretics can sometimes alter your potassium levels. Talk to your doctor about whether you should include potassium-rich foods like bananas, spinach, and sweet potatoes in your diet, or if you need to limit them.
  • Limit Alcohol Consumption: Alcohol can interact with ATPURE D TABLET to cause a sudden drop in blood pressure, leading to dizziness, lightheadedness, and a higher risk of falls.
  • Exercise Regularly: Engage in moderate aerobic exercise, such as walking, cycling, or swimming, for at least 30 minutes most days of the week, with your doctor's approval.
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How Soon It Starts Working

The time required for ATPURE D TABLET to start to work: ATPURE D TABLET starts to show its action within 1 hour of administration. The time for which the effects of ATPURE D TABLET last: ATPURE D TABLET effect lasts for 24 hours.

What if you forget to take ATPURE D TABLET

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular routine. Do not take a double dose to make up for a missed one.

Storage

•Store ATPURE D TABLET tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the medication in its original packaging or container to protect it from moisture and direct light.

Drug Warnings

  • Check Your Pulse Regularly: This medicine can slow your heart rate. Ask your doctor how to check your pulse, and contact them immediately if your resting heart rate falls below 50 to 55 beats per minute.
  • Stand Up Slowly: To minimise dizziness or the risk of fainting when rising from a sitting or lying position, stand up slowly and steady yourself for a moment.
  • Monitor Your Blood Pressure at Home: Keep a daily log of your blood pressure readings to share with your doctor during checkups. This helps ensure the medicine is working effectively.
  • Inform Your Surgeon or Dentist: If you are planning to have any surgery or dental procedure, let the surgeon or dentist know you are taking ATPURE D TABLET, as it may affect how your body responds to anaesthesia.
  • Protect Your Skin from the Sun: The diuretic component in this medicine can make your skin more sensitive to sunlight. Wear sunscreen, protective clothing, and avoid tanning beds while taking this medication.
  • Check Blood Sugar Levels: If you have diabetes, monitor your blood glucose closely. This medicine can mask the warning signs of low blood sugar, such as a fast heart rate.

Drug-Drug Interactions

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Inform your doctor about all the medicines you are taking before taking this, as they may interact with ATPURE D TABLET and affect your treatment.

  • Other Blood Pressure Medicines: Taking these medicines with ATPURE D TABLET may cause your blood pressure to drop too low, increasing the risk of dizziness or fainting.
  • Lithium: ATPURE D TABLET may increase lithium levels in the body, raising the risk of lithium toxicity. Your doctor may monitor your lithium levels or adjust your dose.
  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs) (such as ibuprofen): These medicines may reduce the blood pressure-lowering effect of ATPURE D TABLET and increase the risk of kidney problems.
  • Diabetes Medicines: ATPURE D TABLET may affect blood sugar levels and alter the response to diabetes medicines, so your doctor may need to adjust your treatment.
Atenolol + HydrochlorothiazideRitodrine
Severe
Atenolol + HydrochlorothiazideSaquinavir
Severe

Drug-Drug Interactions

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Atenolol + HydrochlorothiazideRitodrine
Severe
How does the drug interact with Atpure D Tablet:
Coadministration of atenolol and ritodrine may cause either medication to be less effective.

How to manage the interaction:
Although taking atenolol with ritodrine can result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
Atenolol + HydrochlorothiazideSaquinavir
Severe
How does the drug interact with Atpure D Tablet:
Coadministration of atenolol with saquinavir increase the risk of a serious abnormal heart rhythm.

How to manage the interaction:
Taking atenolol and saquinavir together can result in an interaction, it can be taken if a doctor has advised it. However, if you happen to experience sudden dizziness, lightheadedness, fainting, slow pulse, or irregular heartbeat, you should seek immediate medical attention. Do not discontinue the use of any medication without a doctor's advice.
Atenolol + HydrochlorothiazideDroperidol
Severe
How does the drug interact with Atpure D Tablet:
Co-administration of Droperidol and Hydrochlorothiazide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Droperidol and Hydrochlorothiazide together can possibly result in an interaction, but they can be taken if advised by your doctor. However, consult the doctor immediately if you experience any symptoms like dizziness, lightheadedness, fainting, fast heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting. Do not stop using any medications without a doctor's advice.
Atenolol + HydrochlorothiazideDolasetron
Severe
How does the drug interact with Atpure D Tablet:
Using dolasetron together with atenolol can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Atenolol and Dolasetron, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms, like feeling dizzy, lightheaded, or your heart beating irregularly, it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
Atenolol + HydrochlorothiazideZiprasidone
Severe
How does the drug interact with Atpure D Tablet:
Taking Ziprasidone and Hydrochlorothiazide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone and Hydrochlorothiazide together can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
Atenolol + HydrochlorothiazideAmiodarone
Severe
How does the drug interact with Atpure D Tablet:
Coadministration of Amiodarone together with Hydrochlorothiazide may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Hydrochlorothiazide interact, they can be used if prescribed by a doctor. If you have cardiac problems or electrolyte imbalances, you may be at greater risk. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, Weakness, tiredness, drowsiness, confusion, painful muscle cramping, dizziness, nausea, or vomiting, get medical attention. Do not discontinue any medications without consulting a doctor.
Atenolol + HydrochlorothiazideAcebutolol
Severe
How does the drug interact with Atpure D Tablet:
Coadministration of Atenolol and Acebutolol they both may enhance blood pressure-lowering effect.

How to manage the interaction:
Taking atenolol and acebutolol together can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Atenolol + HydrochlorothiazideDronedarone
Severe
How does the drug interact with Atpure D Tablet:
Co-administration of Dronedarone and Hydrochlorothiazide can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Taking Dronedarone and Hydrochlorothiazide together can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, fast heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Atenolol + HydrochlorothiazideCeritinib
Severe
How does the drug interact with Atpure D Tablet:
Coadministration of atenolol with ceritinib can slow heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking atenolol and ceritinib together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, or an irregular heartbeat while taking these medications, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
Atenolol + HydrochlorothiazideLithium
Severe
How does the drug interact with Atpure D Tablet:
Coadministration of Lithium and Hydrochlorothiazide can increase the effects of lithium.

How to manage the interaction:
Taking Lithium and Hydrochlorothiazide together can possibly result in an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like loose stools, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol while taking this medicine, as it may enhance the blood pressure-lowering effect and increase the risk of dizziness, lightheadedness, or fainting.
  • Liquorice: Natural liquorice may raise blood pressure and reduce the effectiveness of this medicine.
ATENOLOL-25MG+HYDROCHLOROTHIAZIDE-12.5MGFruit juices
Moderate

Drug-Food Interactions

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ATENOLOL-25MG+HYDROCHLOROTHIAZIDE-12.5MGFruit juices
Moderate
Common Foods to Avoid:
Grapefruit Juice, Pineapple Juice, Pomegranate Juice, Noni Juice, Orange Juice, Cranberry Juice

How to manage the interaction:
Orange juice could decrease the effectiveness of atenolol. Avoid consumption of large amounts of orange juice to prevent any changes in your atenolol levels.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

ATPURE D TABLET is used to treat high blood pressure.
ATPURE D TABLET consists of anti-hypertensive/ blood pressure-lowering drugs: Atenolol, and Hydrochlorothiazide. These medicines collectively lower the blood pressure by preventing the fluid build-up, improving the excretion of electrolytes and water from the body, and widening the blood vessels. Thus together, it helps lower increased blood pressure, prevent heart attack, angina, and prevents edema (swelling due to fluid overload).
Yes, ATPURE D TABLET can make you feel dizzy. Dizziness usually occurs when you suddenly stand up from a lying or sitting position. Try rising slowly when you change your posture to relieve dizziness. If the side effect persists longer, please seek medical help.
ATPURE D TABLET may cause frequent urination since it is composed of a diuretic (water pill), Hydrochlorothiazide that increases the urination. It is advised to take ATPURE D TABLET at least 4 hours before bedtime to avoid waking up in the night to urinate. Also, take enough fluids to cope up with the dehydration caused by frequent urination.
An unhealthy diet is a risk factor for increasing blood pressure. A high-fat diet, high-calorie, and a diet that is excessively high in salt raises your risk of increasing blood pressure.
Yes, ATPURE D TABLET can affect your blood sugar levels and may also mask the physical warning signs of low blood sugar, such as a rapid heart rate. If you have diabetes, monitor your blood sugar closely and talk to your doctor.
Cold extremities are a common, usually mild side effect of beta-blockers because they reduce blood flow to your hands and feet. Dressing warmly can help, but if the coldness becomes painful or your skin changes colour, talk to your doctor.
You should avoid taking certain pain relievers like ibuprofen or naproxen regularly without consulting a professional, as they can reduce the effectiveness of ATPURE D TABLET and strain your kidneys. Talk to your doctor or pharmacist for safe alternatives.
ATPURE D TABLET is generally not recommended during pregnancy as it may cause harm to the developing baby. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor immediately to discuss alternative options.
No, you should not stop taking ATPURE D TABLET suddenly. High blood pressure often has no symptoms, and stopping the medication can cause your blood pressure to spike dangerously. Talk to your doctor if you have concerns about your treatment.
It is generally recommended to take ATPURE D TABLET in the morning. Because it contains a diuretic (water pill) that increases urination, taking it early in the day helps prevent sleep disruptions at night. Talk to your doctor to find the best routine for you.
Some people may notice mild weight changes or fluid retention when taking beta-blockers. If you notice rapid, unexplained weight gain or swelling in your ankles or feet, talk to your doctor immediately.
It is highly advised to avoid or strictly limit alcohol while taking ATPURE D TABLET. Alcohol can amplify the blood pressure-lowering effect, causing severe dizziness, lightheadedness, or fainting. Talk to your doctor or pharmacist about safe limits.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.6015 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Hctz Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Atenolol Atenolol. 2015. [Accessed on 04 Feb. 2019]Check here
  4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 30th December 2022]Check here
  5. Mylan Pharmaceuticals Inc. U.S. Food and Drug Administration. [Revised in May 2011] [Accessed on 30th December 2022] docs/label/2011/040735s004,040770s003lbl.pdfCheck here
  6. Central Drugs Standard Control Organization. Atenolol (25mg, 50mg) + HCTZ (12.5mg, 12.5 mg) Tablet. January 2005. [Accessed on 30th December 2022]Check here

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - ATP0007
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