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  1. Home
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  3. Atrest 25 Tablet 10's

Prescription drug
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Atrest 25 Tablet 10's, Pack of 10 TabletS
Atrest 25 Tablet 10's, Pack of 10 TabletS
Atrest 25 Tablet 10's, Pack of 10 TabletS
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Extra 15% Off with Bank Offers

Composition :

TETRABENAZINE-25MG

Manufacturer/Marketer :

Centaur Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Atrest 25 Tablet

Atrest 25 Tablet is used to treat Huntington's disease. Huntington's disease (HD) is a hereditary disorder where brain nerve cells gradually degrade. It usually begins in the late 30s or early 40s. Progressive motor, cognitive, and mental symptoms are typically the outcome of Huntington's disease.

Atrest 25 Tablet contains tetrabenazine, which works by depleting the stores of certain chemical messengers in the brain that help in controlling body movements.

The common side effects of Atrest 25 Tablet are nausea, insomnia (difficulty sleeping), anxiety, fatigue, sleepiness, akathisia (inability to stay still), and depression. Consult your doctor if you experience these side effects frequently.

Do not use Atrest 25 Tablet without a doctor's advice if you have a skin reaction or irritation to any medicine. Consult your doctor before using Atrest 25 Tablet if you are pregnant or breastfeeding. Do not use Atrest 25 Tablet in more than the prescribed doses or for a longer duration, as it may cause adverse effects. 

Uses of Atrest 25 Tablet

Atrest 25 Tablet is used in the treatment of Huntingtons disease. The detailed use of Atrest 25 Tablet is as follows:

  • Huntington’s Disease (Chorea): Atrest 25 Tablet treats involuntary, jerky movements caused by this genetic neurological disorder.

Have a query?

Directions for Use

  • Take Atrest 25 Tablet with or without food as advised by your doctor.
  • It is advised to take Atrest 25 Tablet once daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Atrest 25 Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Overactive secretion of chemicals like serotonin, norepinephrine, and dopamine in the brain causes degeneration of nerves, due to which you may lose the ability to control your thoughts, emotions, or movements.
  • Atrest 25 Tablet works by reducing the overactivity of these natural substances in the brain that transmit signals between nerves and, in turn, lower brain signals that trigger involuntary muscle movements.

How Atrest 25 Tablet Works

Atrest 25 Tablet contains tetrabenazine, which works by depleting the stores of certain chemical messengers in the brain that help in controlling body movements.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Atrest 25 Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.

What if I have taken an overdose of Atrest 25 Tablet

Do not take more than the prescribed dose of Atrest 25 Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, sweating, rapid eye movement, twisting or jerking movements, confusion, diarrhoea, extreme tiredness, redness of the skin, hallucinations, and uncontrollable shaking. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Inform your doctor if you are allergic to Atrest 25 Tablet .
  • You may have unusual changes in mood or behaviour, trouble sitting still, or feel nervous and irritable. Sit or stand slowly if you feel dizzy.
  • Check the progress of Atrest 25 Tablet at regular doctor visits and keep track of the symptoms and side effects if you notice any.
  • It may make some people severely depressed and increase the risks of suicidal thoughts and tendencies.
  • Do not take these medicines together with other medications such as risperidone and MAO inhibitors.
  • Do not use if you are severely depressed and are on current treatment with antidepressants.

Drug-Drug Interactions

verifiedApollotooltip
TetrabenazinePimozide
Critical
TetrabenazineFurazolidone
Critical

Drug-Drug Interactions

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TetrabenazinePimozide
Critical
How does the drug interact with Atrest 25 Tablet:
Coadministration of Pimozide and Atrest 25 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Pimozide and Atrest 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea, or vomiting. Do not discontinue any medications without consulting your doctor.
TetrabenazineFurazolidone
Critical
How does the drug interact with Atrest 25 Tablet:
Combining Furazolidone and Atrest 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Furazolidone and Atrest 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness, speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TetrabenazineTranylcypromine
Critical
How does the drug interact with Atrest 25 Tablet:
Coadministration of Tranylcypromine and Atrest 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Tranylcypromine and Atrest 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TetrabenazineProcarbazine
Critical
How does the drug interact with Atrest 25 Tablet:
Coadministration of Procarbazine and Atrest 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Procarbazine and Atrest 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness, speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TetrabenazineMetoclopramide
Critical
How does the drug interact with Atrest 25 Tablet:
Coadministration of Atrest 25 Tablet and Metoclopramide can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Atrest 25 Tablet and Metoclopramide together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, restlessness, and foot tapping, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TetrabenazineSelegiline
Critical
How does the drug interact with Atrest 25 Tablet:
Co-administration of Selegiline with Atrest 25 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Atrest 25 Tablet with Selegiline together can possibly result in an interaction, they can be taken together if advised by a doctor. However, contact a doctor if you experience severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, or lightheadedness. Do not stop taking any medications without consulting a doctor.
TetrabenazineDronedarone
Critical
How does the drug interact with Atrest 25 Tablet:
Combining Dronedarone and Atrest 25 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dronedarone and Atrest 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TetrabenazineIsocarboxazid
Critical
How does the drug interact with Atrest 25 Tablet:
Co-administration of Isocarboxazid and Atrest 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Isocarboxazid and Atrest 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness, speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TetrabenazineRasagiline
Critical
How does the drug interact with Atrest 25 Tablet:
Co-administration of Rasagiline and Atrest 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Rasagiline and Atrest 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TetrabenazineLinezolid
Critical
How does the drug interact with Atrest 25 Tablet:
Coadministration of Linezolid and Atrest 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Linezolid and Atrest 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy weight. Stay physically active.
  • Consume fresh fruits and vegetables. Avoid spicy, salty, and deep-fried foods. Eating healthy can help you recover faster.
  • Avoid tea, coffee, and cold drinks.
  • Drink plenty of fluids to stay hydrated. Fluids are necessary to maintain blood flow in your body.
  • Avoid the intake of alcoholic beverages as they can make you dehydrated and also affect your sleep.
  • Avoid physical and psychological stress.

Habit Forming

No

Therapeutic Class

CENTRAL NERVOUS SYSTEM AGENTS

Atrest 25 Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

It causes excessive sleepiness if you consume alcohol while taking this Atrest 25 Tablet .

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Pregnancy

Consult your doctor

If you are pregnant or trying to get pregnant, speak to your doctor before taking the Atrest 25 Tablet . It may harm the unborn baby.

bannner image

Breast Feeding

Consult your doctor

Do not take Atrest 25 Tablet or stop using it immediately if you are breastfeeding.

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Driving

Unsafe

It causes drowsiness and impairs your ability to drive carefully.

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Liver

Caution

If you have a history of liver disease/conditions, Atrest 25 Tablet should be taken with caution. However, dose adjustments will be made by the doctor accordingly.

bannner image

Kidney

Caution

If you have a history of kidney diseases, Atrest 25 Tablet should be taken with caution. However, dose adjustments will be made by the doctor accordingly.

bannner image

Children

Unsafe

It is not recommended for treatment in children.

FAQs

Atrest 25 Tablet is used to treat Huntington's disease. Huntington's disease (HD) is an inherited disease that causes certain nerve cells in the brain to waste away. People are born with defective genes.

Atrest 25 Tablet contains tetrabenazine, which works by depleting the stores of certain chemical messengers in the brain that help in controlling body movements.

No, if you forget to take one dose, never make up for the missing dose by doubling it at the next time. Instead, please continue with the next dose when it is due.

No, if taken more than the recommended dose, you may develop drowsiness, sweating, low blood pressure, and extremely low body temperature. Contact your doctor right away in this case.

No, do not take Atrest 25 Tablet ; instead, reach out to your doctor if you are intolerant to sugars because these tablets contain lactose.

No, do not stop taking Atrest 25 Tablet on your own unless instructed by your doctor. Abruptly stopping may lead to the recurrence of disease conditions.

If necessary, Atrest 25 Tablet may be broken in half, but they should not be crushed or chewed.

Atrest 25 Tablet contains Tetrabenazine is formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders.

Atrest 25 Tablet is a medication used to manage chorea, a movement disorder often associated with Huntington's disease. It works by reducing the levels of certain neurotransmitters in the brain. While it can be effective in controlling involuntary movements, it's important to be aware of potential side effects like depression, sleepiness, and dizziness. If you're considering tetrabenazine or have questions about its use, consult with a healthcare professional for personalized advice.

To avoid side effects while taking Atrest 25 Tablet , try to limit your alcohol intake, and be cautious about combining it with other medications. Be mindful of activities that require alertness, as tetrabenazine can cause drowsiness. If you’re pregnant or breastfeeding, talk to your doctor before taking it.

If you're considering stopping or adjusting your tetrabenazine dosage, it's essential to discuss it with your doctor. They can help you determine if it's safe to make changes and provide personalized recommendations. Remember, abruptly stopping tetrabenazine can lead to a worsening of your chorea symptoms.

It's generally not recommended to consume alcohol while taking tetrabenazine. Alcohol can interact with tetrabenazine and increase the risk of side effects.

Atrest 25 Tablet can influence blood pressure. Some individuals may experience low blood pressure (hypotension) as a side effect of taking this medication. This is more likely to occur if you have a history of low blood pressure or if you're taking other medications that can lower your blood pressure. If you notice symptoms of low blood pressure, such as dizziness, lightheadedness, or fainting, it's crucial to inform your doctor. They may adjust your dosage or recommend additional monitoring to manage this side effect effectively.

The common side-effects of Atrest 25 Tablet are nausea, insomnia (difficulty sleeping), anxiety, fatigue, sleepiness, akathisia (inability to stay still), and depression. Most of these side effects fade away gradually over time without the need for medical intervention. However, consult your doctor if you experience these side effects frequently.

Country of origin

INDIA

Manufacturer/Marketer address

CENTAUR HOUSE, Near Grand Hyatt, Vakola ,Santacruz – East, Mumbai – 400 055, India.
Other Info - ATR0117

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Oct 1, 2025 | 11:08 AM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a618009.html
  2. https://go.drugbank.com/drugs/DB04844#pharmacology-header
  3. https://www.medicines.org.uk/emc/product/2668/pil
  4. https://www.mayoclinic.org/drugs-supplements/tetrabenazine-oral-route/precautions/drg-20072216
  5. https://www.singlecare.com/prescription/tetrabenazine/what-is#overview
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