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compositionComposition:TETRABENAZINE-25MG
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Prescription Medicine
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TETRABENAZINE-25MG

Manufacturer/Marketer :

Tripada Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Tetbenz 25 Tablet

Tetbenz 25 Tablet is a prescription medication used to manage involuntary, jerky, and uncontrollable movements (known as chorea) in patients with Huntington’s disease. It helps calm the excessive nerve activity in the brain that causes these sudden, disruptive movements. By regulating these signals, it makes physical actions more controlled and predictable.

For the best results, you must take Tetbenz 25 Tablet consistently every day, exactly as directed by your healthcare provider. This medication is usually taken multiple times a day and can be taken with or without food, though keeping a consistent routine helps maintain stable drug levels. Making simple changes, such as practicing stress-reduction techniques and pacing your physical activities, can further help manage movement symptoms.

Tetbenz 25 Tablet can cause side effects, with the most common being sleepiness, fatigue, and mild trouble sleeping. However, you must contact your doctor immediately if you experience serious side effects, such as signs of depression, thoughts of self-harm, severe muscle stiffness, or extreme restlessness.

Talk to your doctor before starting Tetbenz 25 Tablet if you have a history of depression, suicidal behaviour, or heart rhythm issues. Do not take this if you currently have active depression, untreated suicidal thoughts, or liver damage.

This medicine interacts with alcohol, which can cause dangerous drowsiness, and with certain antidepressants that can raise the drug levels in your body to unsafe limits. If you are pregnant, breastfeeding, an older adult, or considering this medicine for a child, you must consult your doctor to discuss whether it is appropriate. Tetbenz 25 Tablet is not approved for use in children, and safety and effectiveness in paediatric patients have not been established.

Uses of Tetbenz 25 Tablet

Tetbenz 25 Tablet is prescribed to help control involuntary movements caused by certain neurological disorders, including: 

  • Involuntary movements (chorea) associated with Huntington's disease: Tetbenz 25 Tablet helps reduce the frequency and severity of uncontrollable, jerky body movements, helping you gain better physical control.
  • Other movement disorders: In certain cases, some doctors may prescribe this medicine to help manage other severe, chronic movement conditions where muscles twitch, shake, or spasm uncontrollably.
     

Key Benefits

Tetbenz 25 Tablet offers the following benefits when used as prescribed:

  • Reduces involuntary movements: It helps decrease the severity and frequency of uncontrolled movements, improving overall motor control.
  • Makes daily activities easier: Better movement control can help with routine tasks such as eating, drinking, writing, dressing, and personal care.
  • Reduces physical fatigue: Controlling constant involuntary movements may lessen muscle strain, discomfort, and exhaustion throughout the day.
  • Improves balance and coordination: Reduced abnormal movements may contribute to safer walking, better stability, and a lower risk of falls or injuries.
  • Supports independence and quality of life: Improved movement control can enhance confidence, social participation, and the ability to perform everyday activities more comfortably.
  • Provides targeted symptom management: By acting on specific brain pathways involved in movement control, Tetbenz 25 Tablet helps reduce chorea and improve overall motor function. 
     
Side effects of Tetbenz 25 Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.

Directions for Use

To ensure you get the full benefit of this medicine and take it safely, please follow these instructions:

  • Swallow the tablet whole with a full glass of water. Do not chew, crush, or break the tablet.
  • You can take this medication with or without food, but try to be consistent with how you take it each day.
  • Your doctor will start you on a low dose and gradually increase the dose over several weeks to find what works best for you. Do not change your dose on your own.
  • Always follow your doctor's exact instructions regarding how and when to take this medicine.
     

How Tetbenz 25 Tablet Works

In the brain, chemical messengers called neurotransmitters—specifically dopamine—help control muscle movement. When dopamine levels are too high or overactive, it can trigger the rapid, involuntary body movements seen in chorea. Tetbenz 25 Tablet acts as a regulator to restore balance. This medication works by blocking a specific protein in the brain cells that stores dopamine. By blocking this protein, the medicine reduces the overall amount of dopamine released and active in the brain. With less dopamine overstimulating the movement pathways, muscle activity slows down, resulting in smoother, much more controlled physical actions.
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Alcohol

Unsafe

It causes excessive sleepiness if you consume alcohol while taking this Tetbenz 25 Tablet .

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Pregnancy

Consult your doctor

If you are pregnant or trying to get pregnant, speak to your doctor before taking the Tetbenz 25 Tablet . It may harm the unborn baby.

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Breast Feeding

Consult your doctor

Do not take Tetbenz 25 Tablet or stop using it immediately if you are breastfeeding.

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Driving

Unsafe

It causes drowsiness and impairs your ability to drive carefully.

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Liver

Caution

If you have a history of liver disease/conditions, Tetbenz 25 Tablet should be taken with caution. However, dose adjustments will be made by the doctor accordingly.

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Kidney

Caution

If you have a history of kidney diseases, Tetbenz 25 Tablet should be taken with caution. However, dose adjustments will be made by the doctor accordingly.

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Children

Unsafe

It is not recommended for treatment in children.

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Heart

Consult your doctor

Please consult your doctor before using Tetbenz 25 Tablet if you have pre-existing heart problems. Your doctor will prescribe Tetbenz 25 Tablet if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before giivng Tetbenz 25 Tablet to geriatric patients. Your doctor will prescribe Tetbenz 25 Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Tetbenz 25 Tablet

Do not take more than the prescribed dose of Tetbenz 25 Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, sweating, rapid eye movement, twisting or jerking movements, confusion, diarrhoea, extreme tiredness, redness of the skin, hallucinations, and uncontrollable shaking. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Create a fall-proof home: Because uncontrolled movements and medication-induced drowsiness can affect your balance, secure loose rugs, install grab bars in the bathroom, and keep walking paths clear to prevent falls.
  • Strictly avoid alcohol: Drinking alcohol while on this medication can dangerously increase drowsiness, dizziness, and coordination problems, significantly raising your risk of accidents.
  • Prioritise regular sleep schedules: Fatigue can make movement symptoms worse and increase the risk of mood changes. Aim for a consistent sleep routine every night.
  • Keep a daily mood diary: Track your feelings and behaviours daily. Share this journal with close family members or caregivers so they can help spot early signs of depression, anxiety, or irritability.
  • Eat easy-to-manage foods: If involuntary movements make eating difficult or raise swallowing risks, opt for softer foods and use weighted utensils or cups with lids to prevent spills.
     

Have a query?

How Soon It Starts Working

The time required for Tetbenz 25 Tablet to start to work: The time required for Tetbenz 25 Tablet to show its action is not clinically established. 

The time for which the effects of Tetbenz 25 Tablet last: The effect of Tetbenz 25 Tablet lasts for 16 to 24 hours.

What if you forget to take Tetbenz 25 Tablet

If you miss a dose of Tetbenz 25 Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

•Store Tetbenz 25 Tablet tablets at room temperature, preferably between 20°C and 25°C, or as directed on the product packaging. •Keep the tablets in their original container with the lid tightly closed to protect them from light and moisture.

Drug Warnings

  • Avoid Driving Until You Know Its Effects: Do not drive, operate heavy machinery, or perform dangerous activities until you know how this medicine affects your alertness, as it frequently causes severe sleepiness.
  • Monitor for Mood and Behaviour Changes: Ask your family members or caregivers to watch you closely for any changes in your mood, behaviour, or signs of depression.
  • Do Not Stop Treatment Abruptly: Do not stop taking Tetbenz 25 Tablet suddenly; stopping abruptly can cause your involuntary movements to return quickly and worsen.
  • Report Swallowing Difficulties Immediately: If you experience difficulty swallowing or find yourself choking on food, contact your doctor immediately as this medicine can affect throat muscles.
  • Inform All Healthcare Providers: Alert all your healthcare providers that you are taking this medication, especially before starting any new prescription, over-the-counter medicine, or herbal supplement.
  • Take Extra Precautions Against Falls: Drowsiness, dizziness, balance problems, and falls may occur more frequently in older adults, so extra caution is advised when standing, walking, or performing daily activities. 
     

Drug-Drug Interactions

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Drug-Drug Interactions

The following medications may affect how Tetbenz 25 Tablet works or increase the risk of side effects:

  • Monoamine Oxidase Inhibitors (MAOIs): Do not take this medicine with MAOIs, or within 14 days of stopping them, as combining them can cause a dangerous, life-threatening rise in blood pressure.
  • Antidepressants (such as fluoxetine or paroxetine): These medications can significantly increase the levels of Tetbenz 25 Tablet in your body, increasing the risk of severe side effects. Your doctor may need to lower your dose.
  • Central Nervous System Depressants: Taking this medicine with sleep aids, muscle relaxants, or strong prescription pain relievers can cause extreme drowsiness and slowed breathing.
  • Antipsychotic medications: Combining these can increase the risk of severe muscle stiffness, tremors, and a life-threatening reaction that affects body temperature and muscles.
  • Reserpine: Do not take Tetbenz 25 Tablet together with reserpine. Both medicines reduce dopamine activity, and using them together can significantly increase the risk of severe side effects. Tetbenz 25 Tablet should not be started until at least 20 days after stopping reserpine. 

Drug-Food Interactions

Certain foods and beverages may affect the safety or effectiveness of Tetbenz 25 Tablet , including:
Alcohol: Avoid consuming alcohol while taking this medicine. Alcohol significantly worsens sleepiness, dizziness, and coordination issues.

Drug-Disease Interactions

Some medical conditions may affect the safety or effectiveness of Tetbenz 25 Tablet , including:

  • Depression or Suicidal Thoughts: This medicine can worsen or trigger severe depression and suicidal behavior. It must not be used if you have active or untreated depression.
  • Liver Damage: Your body processes this medicine through the liver. If you have liver damage, the medicine can build up to toxic levels in your system.
  • Parkinson's Disease: This medicine can make stiffness, tremors, and slow movements worse if you already have Parkinson's disease.
     

Drug-Drug Interactions

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How does the drug interact with Tetbenz 25 Tablet:
Co-administration of Rasagiline and Tetbenz 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Rasagiline and Tetbenz 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tetbenz 25 Tablet:
Coadministration of Tranylcypromine and Tetbenz 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Tranylcypromine and Tetbenz 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tetbenz 25 Tablet:
Coadministration of Thioridazine and Tetbenz 25 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Thioridazine and Tetbenz 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea, or vomiting. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tetbenz 25 Tablet:
Taking Tetbenz 25 Tablet and Sparfloxacin can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Tetbenz 25 Tablet with Sparfloxacin together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tetbenz 25 Tablet:
Combining Furazolidone and Tetbenz 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Furazolidone and Tetbenz 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness, speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tetbenz 25 Tablet:
Coadministration of Tetbenz 25 Tablet and Metoclopramide can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Tetbenz 25 Tablet and Metoclopramide together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, restlessness, and foot tapping, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tetbenz 25 Tablet:
Co-administration of Tetbenz 25 Tablet with Ziprasidone together can raise the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Tetbenz 25 Tablet with Ziprasidone together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Tetbenz 25 Tablet:
Coadministration of Linezolid and Tetbenz 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Linezolid and Tetbenz 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tetbenz 25 Tablet:
Coadministration of Pimozide and Tetbenz 25 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Pimozide and Tetbenz 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea, or vomiting. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Tetbenz 25 Tablet:
Coadministration of Procarbazine and Tetbenz 25 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Procarbazine and Tetbenz 25 Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness, speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CENTRAL NERVOUS SYSTEM AGENTS]

FAQs

Tetbenz 25 Tablet is used to treat Huntington's disease. Huntington's disease (HD) is an inherited disease that causes certain nerve cells in the brain to waste away. People are born with defective genes.

Tetbenz 25 Tablet contains tetrabenazine, which works by depleting the stores of certain chemical messengers in the brain that help in controlling body movements.

No, if you forget to take one dose, never make up for the missing dose by doubling it at the next time. Instead, please continue with the next dose when it is due.

No, if taken more than the recommended dose, you may develop drowsiness, sweating, low blood pressure, and extremely low body temperature. Contact your doctor right away in this case.

No, do not take Tetbenz 25 Tablet ; instead, reach out to your doctor if you are intolerant to sugars because these tablets contain lactose.

No, do not stop taking Tetbenz 25 Tablet on your own unless instructed by your doctor. Abruptly stopping may lead to the recurrence of disease conditions.

If necessary, Tetbenz 25 Tablet may be broken in half, but they should not be crushed or chewed.

Tetbenz 25 Tablet contains Tetrabenazine is formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders.

Tetbenz 25 Tablet is a medication used to manage chorea, a movement disorder often associated with Huntington's disease. It works by reducing the levels of certain neurotransmitters in the brain. While it can be effective in controlling involuntary movements, it's important to be aware of potential side effects like depression, sleepiness, and dizziness. If you're considering tetrabenazine or have questions about its use, consult with a healthcare professional for personalized advice.

Avoid alcohol and use caution when driving, operating machinery, or performing activities requiring alertness, as Tetbenz 25 Tablet may cause drowsiness or dizziness. Consult your doctor before taking other medicines, and inform them if you are pregnant or breastfeeding.

No. Do not stop taking Tetbenz 25 Tablet without consulting your doctor, even if your symptoms improve. Stopping the medicine suddenly may cause your involuntary movements (chorea) to return or worsen. If treatment needs to be discontinued, your doctor will advise you on the safest way to do so.

No. You should avoid alcohol while taking Tetbenz 25 Tablet . Alcohol can increase side effects such as drowsiness, dizziness, impaired coordination, and loss of balance, increasing the risk of falls and accidents.

Tetbenz 25 Tablet can influence blood pressure. Some individuals may experience low blood pressure (hypotension) as a side effect of taking this medication. This is more likely to occur if you have a history of low blood pressure or if you're taking other medications that can lower your blood pressure. If you notice symptoms of low blood pressure, such as dizziness, lightheadedness, or fainting, it's crucial to inform your doctor. They may adjust your dosage or recommend additional monitoring to manage this side effect effectively.

The common side-effects of Tetbenz 25 Tablet are nausea, insomnia (difficulty sleeping), anxiety, fatigue, sleepiness, akathisia (inability to stay still), and depression. Most of these side effects fade away gradually over time without the need for medical intervention. However, consult your doctor if you experience these side effects frequently.

No, Tetbenz 25 Tablet does not cure Huntington's disease, nor does it slow down the progression of the disease. It is prescribed solely to help manage and reduce the involuntary, jerky movements (chorea) caused by the condition. Talk to your doctor if you have questions about managing other symptoms of Huntington's disease.

If you, your family, or your caregiver notice any signs of depression, severe sadness, anxiety, or thoughts of hurting yourself, contact your doctor immediately or seek emergency medical help. This is a serious side effect that requires immediate medical evaluation. Talk to your doctor about alternative treatment options if needed.

You may begin to notice some reduction in your involuntary movements within the first few weeks of starting the treatment. Because your doctor will start you on a low dose and gradually increase the dose, it may take several weeks to find the dose that provides the best control for your symptoms. Talk to your doctor about your progress.

Yes, daytime sleepiness and fatigue are very common side effects of this medicine. Because of this, you should avoid driving, riding a bicycle, or operating tools or machinery until you know exactly how the medicine affects you. Talk to your doctor if the sleepiness interferes with your daily activities.

You should not take this medication if you have liver damage, as your liver is responsible for breaking down the medicine. If your liver is not working properly, the drug can build up to unsafe levels in your body. Talk to your doctor about alternative options that are safer for your liver.

If you miss taking your medication for more than a few days, do not simply restart taking your regular dose. You must contact your doctor or pharmacist first, as you may need to restart the medicine at a lower dose and gradually increase it again to avoid severe side effects. Talk to your doctor or pharmacist for specific guidance.

Tetbenz 25 Tablet is not approved for use in children, and there is limited information regarding its safety and effectiveness in paediatric patients. It should only be used if specifically recommended and closely supervised by a specialist. Talk to your doctor for guidance on appropriate treatment options.

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Country of origin

India

Manufacturer/Marketer address

3 Yogi Complex, Nr Doordarshan, Kendra, Thaltej, Ahmedabad, India 380054.
Other Info - TET0107
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