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  3. Axpero 1 mg Tablet 14's

Axpero 1 mg Tablet 14's, Pack of 14 TabletS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Axpero 1 mg Tablet is used to treat Renal Cell Carcinoma. It contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor. In this way, Axpero 1 mg Tablet stops the production, spread and growth of cancerous cells.

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Composition :

AXITINIB-1MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Axpero 1 mg Tablet

Axpero 1 mg Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. Renal cell carcinoma, also known as kidney cancer, is a disease in which the cancer or malignant cells grow uncontrollably in the kidney and form a tumour.

Axpero 1 mg Tablet contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Axpero 1 mg Tablet may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you. Axpero 1 mg Tablet should be taken as advised by your doctor.

Avoid taking Axpero 1 mg Tablet if you are allergic to it or any other components of it. Before taking Axpero 1 mg Tablet , inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, thyroid disorders, or blood disorders. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Axpero 1 mg Tablet

Treatment of Renal Cell Carcinoma

Directions for Use

Take Axpero 1 mg Tablet as prescribed by the doctor. It can be taken with or without food in a 12-hour interval. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Medicinal Benefits

Axpero 1 mg Tablet contains Axitinib, which is used in treating advanced renal cell carcinoma after failure of prior systemic therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Axpero 1 mg Tablet stops the body's production, spread and growth of cancerous cells.

How Axpero 1 mg Tablet Works

Axpero 1 mg Tablet contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Axpero 1 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Axpero 1 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Axpero 1 mg Tablet may include dizziness, coughing up blood, and seizures. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

To treat your condition effectually, continue taking Axpero 1 mg Tablet for the period that your doctor has prescribed. Avoid taking Axpero 1 mg Tablet if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Axpero 1 mg Tablet may cause hypertension, arterial and venous thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes in some patients. Hence, inform your doctor about your complete medication and medical history before taking Axpero 1 mg Tablet .

Drug-Drug Interactions

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AxitinibDexamethasone
Severe
AxitinibIdelalisib
Severe

Drug-Drug Interactions

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AxitinibDexamethasone
Severe
How does the drug interact with Axpero 1 mg Tablet:
Taking Dexamethasone may reduce the blood levels of Axpero 1 mg Tablet, making the medication less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction, dexamethasone can be taken with Axpero 1 mg Tablet if prescribed by the doctor. Do not discontinue any medications without consulting a doctor.
AxitinibIdelalisib
Severe
How does the drug interact with Axpero 1 mg Tablet:
When Axpero 1 mg Tablet and Idelalisib are taken together, the breakdown of Axpero 1 mg Tablet in the body may be reduced.

How to manage the interaction:
Co-administration of Axpero 1 mg Tablet with Idelalisib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience: chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not discontinue any medications without consulting a doctor.
AxitinibAmprenavir
Severe
How does the drug interact with Axpero 1 mg Tablet:
Co-administration of Axpero 1 mg Tablet with Amprenavir may cause Axpero 1 mg Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Axpero 1 mg Tablet and Amprenavir, you can take these medicines together if prescribed by a doctor. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without consulting a doctor.
AxitinibKetoconazole
Severe
How does the drug interact with Axpero 1 mg Tablet:
Coadministration of ketoconazole with Axpero 1 mg Tablet can increase the levels of Axpero 1 mg Tablet in the body. This may increase the risk or severity of side effects.

How to manage the interaction:
Although taking Ketoconazole and Axpero 1 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
AxitinibLomitapide
Severe
How does the drug interact with Axpero 1 mg Tablet:
When Axpero 1 mg Tablet is taken with Lomitapide, increases the risk of liver damage.

How to manage the interaction:
Although there is a possible interaction between Axpero 1 mg Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact the doctor right away. Do not discontinue any medications without consulting a doctor.
AxitinibSaquinavir
Severe
How does the drug interact with Axpero 1 mg Tablet:
When Axpero 1 mg Tablet is taken with Saquinavir, the body's ability to break down Axpero 1 mg Tablet may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Axpero 1 mg Tablet and Saquinavir, but it can be taken if prescribed by a doctor. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
AxitinibDabrafenib
Severe
How does the drug interact with Axpero 1 mg Tablet:
When Axpero 1 mg Tablet is taken with Dabrafenib, the amount of Axpero 1 mg Tablet in the blood may decrease which may make Axpero 1 mg Tablet less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Dabrafenib and Axpero 1 mg Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
AxitinibRitonavir
Severe
How does the drug interact with Axpero 1 mg Tablet:
Taking Axpero 1 mg Tablet with ritonavir may significantly increase the blood levels of Axpero 1 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Axpero 1 mg Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor. Do not discontinue any medications without consulting a doctor.
AxitinibTroleandomycin
Severe
How does the drug interact with Axpero 1 mg Tablet:
Co-administration of Axpero 1 mg Tablet with troleandomycin may cause Axpero 1 mg Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Axpero 1 mg Tablet and Troleandomycin, you can take these medicines together if prescribed by a doctor. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor’s advice.
AxitinibTelithromycin
Severe
How does the drug interact with Axpero 1 mg Tablet:
Co-administration of Axpero 1 mg Tablet with telithromycin may cause Axpero 1 mg Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Taking Axpero 1 mg Tablet with Telithromycin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor’s advice.

Drug-Food Interactions

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AXITINIB-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AXITINIB-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit or grapefruit juice might raise the medication's levels in the blood leading to side effects such as high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet. Avoid consuming grapefruit or grapefruit juice during treatment with Axpero 1 mg Tablet.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Axpero 1 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Limit alcohol consumption while taking Axpero 1 mg Tablet .

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Pregnancy

Unsafe

Axpero 1 mg Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Axpero 1 mg Tablet . You should not become pregnant while you are taking Axpero 1 mg Tablet . Using effective birth control methods while on treatment with Axpero 1 mg Tablet is suggested.

bannner image

Breast Feeding

Caution

It is not known whether Axpero 1 mg Tablet passes into breastmilk. Hence, if you are breastfeeding, inform your doctor before taking Axpero 1 mg Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

bannner image

Driving

Unsafe

Axpero 1 mg Tablet may cause dizziness and visual disturbances in some patients. Hence, do not drive, operate machinery, or engage in any activity that needs clear vision until you are confident that you can do so safely while you are on treatment with Axpero 1 mg Tablet .

bannner image

Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Axpero 1 mg Tablet is known to cause elevated liver enzymes, which may be fatal. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

bannner image

Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Axpero 1 mg Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Axpero 1 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy is not established.

Have a query?

FAQs

Axpero 1 mg Tablet is used to treat Renal Cell Carcinoma.

Axpero 1 mg Tablet contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

Axpero 1 mg Tablet is safe to be taken by a diabetic person. However, take Axpero 1 mg Tablet only after consulting with a doctor, as they may adjust the dosing according to your condition.

Axpero 1 mg Tablet may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.

The possible signs and symptoms of kidney cancer are haematuria (blood in urine), low back pain on one side, fever, fatigue, weight loss, loss of appetite, anaemia (low blood count), and a lump on the side or lower back.

Axpero 1 mg Tablet should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.

Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.

Your doctor may suggest blood tests, and liver & kidney function tests before starting Axpero 1 mg Tablet . If you are female, you will have to take a pregnancy test before starting treatment.

People who are allergic to any of the components in Axpero 1 mg Tablet should not take this medicine. It is also not recommended during pregnancy and breastfeeding.

Yes, Axpero 1 mg Tablet might decrease fertility in men and women. Talk to the doctor if you have any concerns regarding fertility during treatment with Axpero 1 mg Tablet .

Fatigue could be a side effect of Axpero 1 mg Tablet . To cope with fatigue rest properly, eat healthy food, limit alcohol/caffeine, and manage stress. However, consult the doctor if you have excessive tiredness as it could be a sign of heart failure.

Consult your doctor if you get tired more easily, generally feel colder than other people, or your voice deepens whilst taking this medicine as these could be signs of the thyroid problem. The doctor will recommend thyroid function tests before and during treatment with Axpero 1 mg Tablet .

Posterior Reversible Leukoencephalopathy Syndrome is a neurological condition characterised by headache, seizures (fits), confusion, and changes in vision with or without high blood pressure. Consult the doctor immediately if you notice these symptoms.

Swelling of the abdomen, legs or ankles, protruding neck veins, excessive tiredness, and shortness of breath could be an indication of heart failure. Consult the doctor if you experience these symptoms.

Store Axpero 1 mg Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Axpero 1 mg Tablet may cause side effects such as diarrhoea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - AXP0004

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 9:32 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202324lbl.pdf
  2. https://www.drugs.com/mtm/axitinib.html
  3. https://medlineplus.gov/druginfo/meds/a612017.html
  4. https://reference.medscape.com/drug/inlyta-axitinib-999715
  5. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/axitinib
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