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  3. Azathioprine-50 Tablet 10's

Azathioprine-50 Tablet 10's, Pack of 10 TABLETS
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Composition :

AZATHIOPRINE-50MG

Manufacturer/Marketer :

Care Formulations Lab

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Azathioprine-50 Tablet

Azathioprine-50 Tablet is used to reduce the pain/inflammation in rheumatoid arthritis conditions and keep the immune system from attacking new transplant organs like kidneys. Besides this, it also treats pain and inflammation in gastrointestinal issues like Crohn's disease and ulcerative colitis for patients who have undergone a kidney transplant. 

Azathioprine-50 Tablet contains 'Azathioprine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Azathioprine-50 Tablet helps stop your body from rejecting a new organ by suppressing your immune system. 

Take Azathioprine-50 Tablet as prescribed. Your doctor will advise you on how often you take Azathioprine-50 Tablet based on your medical condition. In some cases, you may experience certain common side-effects such as nausea, headaches, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Azathioprine-50 Tablet for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Azathioprine-50 Tablet if you are pregnant or planning for pregnancy. Azathioprine-50 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Azathioprine-50 Tablet should not be given to children as safety and efficacy have not been established. Azathioprine-50 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using Azathioprine-50 Tablet . While taking Azathioprine-50 Tablet , do not contact anyone who has shingles, chickenpox, or measles. If you accidentally come in contact with any person who has them, please inform your doctor immediately, as special treatment is required if you have not had these illnesses. Your doctor may advise you to undergo regular blood tests and kidney and liver tests to monitor your condition. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Uses of Azathioprine-50 Tablet

Treatment of Rheumatoid arthritis, Immunosuppressant therapy after kidney transplant.

Directions for Use

Swallow Azathioprine-50 Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Azathioprine-50 Tablet contains 'Azathioprine', which is an immunosuppressant that works by reducing the function of the cells and causing inflammation in the joint tissues. It reduces pain and inflammation and slows joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Azathioprine-50 Tablet helps stop your body from rejecting a new organ by suppressing your immune system. Azathioprine-50 Tablet is also used to treat severe inflammatory diseases of the skin, Crohn's disease, ulcerative colitis, and some blood disorders.

How Azathioprine-50 Tablet Works

Azathioprine-50 Tablet contains 'Azathioprine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Azathioprine-50 Tablet helps stop your body from rejecting a new organ by suppressing your immune system.

Storage

Store in a cool and dry place away from sunlight
Side effects of Azathioprine-50 Tablet
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • If you suspect cervical cancer, get tested with: A pap smear or HPV test.
  • Get vaccinated against HPV to prevent cervical cancer.
  • Use condoms during sex to reduce the risk of HPV infection that can lead to cervical cancer.
  • To lower your risk of developing cervical cancer do not smoke.
  • Eat nutritious food and stay healthy to boost your immune system and fight against cancer.

What if I have taken an overdose of Azathioprine-50 Tablet

Do not take more than the prescribed dose of Azathioprine-50 Tablet as it may cause overdose. The symptoms of overdose include diarrhoea, nausea, vomiting, fever, sore throat, chills and other signs of infection. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Azathioprine-50 Tablet if you are allergic to any immunosuppressant medicines or Azathioprine. Let your doctor know before using Azathioprine-50 Tablet if you have liver or kidney problems, serious blood disorders, immune system problems, bone marrow problems, serious infections, immunodeficiency syndrome, or if you have a condition where your body produces too little of a natural chemical called thiopurine methyltransferase (TPMT), received any vaccinations. Do not take Azathioprine-50 Tablet if you are pregnant or planning for pregnancy as Azathioprine-50 Tablet is a Pregnancy category risk D medicines which can cause serious congenital disabilities to the unborn baby. Azathioprine-50 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. While taking Azathioprine-50 Tablet , do not contact anyone who has shingles, chickenpox, or measles. If you accidentally come in contact with any person having them, please inform your doctor immediately as it requires special treatment if you have not had these illnesses. Azathioprine-50 Tablet causes dizziness and drowsiness, so drive with caution. Azathioprine-50 Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol along with Azathioprine-50 Tablet as it could lead to increased dizziness. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Using Azathioprine-50 Tablet for a long time can increase your chance of getting certain types of cancer, such as lymphoma (cancer of the spleen, thymus gland, and bone marrow), leukemia (blood cancer), and skin cancer. Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using Azathioprine-50 Tablet .

Drug-Drug Interactions

verifiedApollotooltip
AzathioprineFebuxostat
Critical
AzathioprineCertolizumab
Severe

Drug-Drug Interactions

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AzathioprineFebuxostat
Critical
How does the drug interact with Azathioprine-50 Tablet-50 Tablet:
Taking Azathioprine-50 Tablet and Febuxostat together can increase the blood levels of Azathioprine-50 Tablet

How to manage the interaction:
Taking Azathioprine-50 Tablet with Febuxostat is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AzathioprineCertolizumab
Severe
How does the drug interact with Azathioprine-50 Tablet-50 Tablet:
When Azathioprine-50 Tablet and Certolizumab are taken together, they may raise the risk of severe infections

How to manage the interaction:
Although there is a possible interaction between Azathioprine-50 Tablet and certolizumab, you can take these medicines together if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm (a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineNatalizumab
Severe
How does the drug interact with Azathioprine-50 Tablet-50 Tablet:
Taking Azathioprine-50 Tablet with Natalizumab can raise the risk of severe infections.

How to manage the interaction:
Although taking Azathioprine-50 Tablet and Natalizumab together can cause an interaction, it can be taken if a doctor has suggested it. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm(a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory and personality, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineAllopurinol
Severe
How does the drug interact with Azathioprine-50 Tablet-50 Tablet:
Co-administration of Allopurinol with Azathioprine-50 Tablet may increase the effects of Azathioprine-50 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Azathioprine-50 Tablet and allopurinol, but it can be taken if prescribed by a doctor. However, if you experience chills, fever, body pains, sore throat, weakness, muscle pain, mouth sores, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhoea, consult a doctor. Do not stop using any medications without a doctor's advice.
AzathioprineBCG vaccine
Severe
How does the drug interact with Azathioprine-50 Tablet-50 Tablet:
Taking the BCG vaccine with Azathioprine-50 Tablet can increase the risk of infection.

How to manage the interaction:
Co-administration of Azathioprine-50 Tablet with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
AzathioprineEtanercept
Severe
How does the drug interact with Azathioprine-50 Tablet-50 Tablet:
When Etanercept is used with Azathioprine-50 Tablet, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Azathioprine-50 Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AzathioprineRibavirin
Severe
How does the drug interact with Azathioprine-50 Tablet-50 Tablet:
Coadministration of Azathioprine-50 Tablet and ribavirin used together can increase the risk of side effects. This can increase your chances of developing anemia(lack of blood), bleeding issues, or infections.

How to manage the interaction:
Although using Ribavirin and Azathioprine-50 Tablet together may cause an interaction, they can be taken together if advised by a doctor. However, consult a doctor if you have pale skin, tiredness, disorientation, fainting, unusual bleeding or bruises, fever, chills, sore throat, body aches, or other flu-like symptoms. Do not stop taking any medications without consulting a doctor.
AzathioprineCladribine
Severe
How does the drug interact with Azathioprine-50 Tablet-50 Tablet:
The use of cladribine with Azathioprine-50 Tablet can increase the risk of serious infections.

How to manage the interaction:
Although taking Azathioprine-50 Tablet and Cladribine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience symptoms fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain during urination, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
AzathioprineOlaratumab
Severe
How does the drug interact with Azathioprine-50 Tablet-50 Tablet:
Using Azathioprine-50 Tablet together with olaratumab may increase the risk of serious infections.

How to manage the interaction:
Taking Olaratumab with Azathioprine-50 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. If you need to take both medications together, it's important to closely monitor your health and get regular blood tests to check for any problems with your blood cells. If you notice any of these symptoms - like feeling weak, getting sick easily, having a fever or sore throat, or having trouble breathing - it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
AzathioprineBaricitinib
Severe
How does the drug interact with Azathioprine-50 Tablet-50 Tablet:
Coadministration of baricitinib and Azathioprine-50 Tablet can raise the risk of developing harmful infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Azathioprine-50 Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.

  • Acupuncture, massage, and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.

  • Avoid smoking and alcohol consumption.

 

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Azathioprine-50 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Azathioprine-50 Tablet . It could lead to increased dizziness and drowsiness.

bannner image

Pregnancy

Caution

Azathioprine-50 Tablet is a Category D pregnancy drug that is not recommended for pregnant women or given only when strictly guidance of the doctor as there is no clinical data available on use in pregnant women.

bannner image

Breast Feeding

Caution

It is not recommended to take Azathioprine-50 Tablet while you are breastfeeding. Azathioprine-50 Tablet passes into breast milk.

bannner image

Driving

Caution

Azathioprine-50 Tablet may cause dizziness, drowsiness, and tiredness; do not drive or operate heavy machinery if you feel dizzy.

bannner image

Liver

Caution

Take Azathioprine-50 Tablet only after the doctor's prescription, especially if you are dealing with Liver diseases/conditions as your doctor may adjust the dose as required.

bannner image

Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Azathioprine-50 Tablet .

bannner image

Children

Unsafe

Azathioprine-50 Tablet should not be used by children below 18 years of age, as the efficacy and safety have not been established.

Have a query?

FAQs

Azathioprine-50 Tablet is used in treating Rheumatoid arthritis and immunosuppressant therapy after kidney transplant.

Azathioprine-50 Tablet causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.

Azathioprine-50 Tablet acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby provides relief from rheumatoid arthritis.

If you miss a dose of Azathioprine-50 Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

Diarrhoea might be a side-effect of Azathioprine-50 Tablet . Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience excess diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

Azathioprine-50 Tablet is a Category D pregnancy drug that is not recommended for pregnant women or given only when strictly guidance of the doctor as there is no clinical data available on use in pregnant women.

Azathioprine-50 Tablet starts to work gradually. it can take up to 12 weeks of taking the right adjusted dose before you notice any benefits.

If you miss a prescription dose, take it as soon as you recall and resume your regular routine. If you are near the next dose, skip the missing dose and resume your regular schedule. Do not take a double dose to make up for a forgotten dose.

It depends on your individual medical condition and response to the medication. Your doctor will determine the appropriate duration of treatment based on your specific needs.

Taking Azathioprine-50 Tablet for a long time can increase your risk of developing some types of cancer, including skin cancer. As a result, avoid direct sunlight, apply sunscreen (SPF 30 or higher), and wear in clothes that shield your arms and legs.

You'll have regular blood tests while taking azathioprine. These tests will ensure that any concerns or problems are found quickly.

Azathioprine-50 Tablet may have an effect on your liver, kidneys, or bone marrow. Before you begin taking this medication, you will undergo blood tests to assess your liver function, renal function, and blood count. From week one to week eight of your treatment, you will undergo at least one blood test every week.

Yes, taking Azathioprine-50 Tablet for a long time can increase your risk of developing some types of cancer, including skin cancer. Seek medical attention if you experience any changes in your body.

Using Cyclosporine together with Azathioprine-50 Tablet may decrease the effects of cyclosporine. Caution is advised if Cyclosporine must be taken with Azathioprine-50 Tablet . You may need a dose adjustment or special test if you use both medications.

Alcohol does not affect the way azathioprine works. However, both azathioprine and alcohol can affect your liver. For this reason, limit or avoid the consumption of alcohol is recommended.

Common side effects of Azathioprine-50 Tablet may include nausea, headaches, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, increase in liver enzymes, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

886 South Civil Line, Jat Colony, Muzaffarnagar. Up
Other Info - AZA0106

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:49 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.3301.pdf
  2. https://www.nhs.uk/medicines/azathioprine/
  3. https://www.drugs.com/mtm/azathioprine.html

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