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compositionComposition:AZATHIOPRINE-50MG
prescription
Prescription Medicine
info
Azotas 50 mg Tablet 10's
Azotas 50 mg Tablet 10's
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

AZATHIOPRINE-50MG

Manufacturer/Marketer :

Tas Med India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Azotas 50 mg Tablet

Azotas 50 mg Tablet is a prescription medicine used to prevent the body from rejecting a newly transplanted kidney. It is also prescribed to treat severe rheumatoid arthritis when standard treatments have not worked. By calming an overactive immune system, this medicine helps reduce swelling, pain, and tissue damage.

For this medicine to work properly, you must take it consistently every day at the same time as directed by your doctor. It is usually taken once or twice daily, and taking it with or immediately after a meal can help prevent stomach upset. Eating a balanced diet and avoiding raw or undercooked foods can further support your immune health while on this treatment.

While taking Azotas 50 mg Tablet , you may experience some common side effects like mild nausea, decreased appetite, or temporary hair thinning. However, you must contact your doctor immediately if you develop serious symptoms such as a fever, sore throat, unusual bruising, or yellowing of your eyes or skin.

Before starting this medicine, talk to your doctor if you have liver disease, kidney disease, a history of cancer, or a genetic condition called TPMT deficiency. Do not take this if you have had a severe allergic reaction to it in the past, or if you are pregnant, as it can harm an unborn baby.

This medicine can interact with other drugs like gout medications, which can dangerously increase the levels of Azotas 50 mg Tablet in your body. It is also important to talk to your doctor or pharmacist if you are elderly, planning a pregnancy, breastfeeding, or if you consume alcohol regularly, as these factors require special precautions.

Uses of Azotas 50 mg Tablet

Azotas 50 mg Tablet is used to prevent kidney transplant rejection, to manage inflammatory bowel disease, and rheumatoid arthritis. The detailed uses of Azotas 50 mg Tablet are as follows:

  • Kidney transplant rejection: Azotas 50 mg Tablet helps prevent your body's immune system from attacking and rejecting a newly transplanted kidney.
  • Severe rheumatoid arthritis: This medicine helps control joint pain, stiffness, and swelling by reducing the autoimmune response that damages the joints.
  • Inflammatory bowel disease: It is sometimes prescribed to reduce long-term gut inflammation and help maintain remission in conditions like Crohn's disease or ulcerative colitis.

Key Benefits

Azotas 50 mg Tablet helps control an overactive immune system, reducing inflammation and preventing the body from attacking its own tissues or rejecting a transplanted organ. It supports long-term disease management and helps improve overall quality of life. Benefits may include:

  • Helps prevent rejection of transplanted organs, such as a kidney transplant.
  • Reduces joint pain, swelling, and stiffness in rheumatoid arthritis.
  • Improves mobility and ability to perform daily activities more comfortably.
  • Helps manage symptoms of inflammatory bowel disease, such as abdominal pain, diarrhoea, and intestinal inflammation.
  • Reduces the frequency and severity of disease flare-ups.
Side effects of Azotas 50 mg Tablet
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Directions for Use

To get the best results from your treatment, follow these guidelines:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as the active medicine can be harmful if it comes into direct contact with your skin or is accidentally inhaled.
  • Take this medicine with or immediately after a meal to help reduce stomach upset, nausea, or vomiting.
  • Try to take your dose at the same time every day to keep a steady amount of the medicine in your body.

Always follow your doctor's exact instructions regarding how and when to take your medicine. Do not change your dose or stop taking it without consulting your healthcare provider first.

How Azotas 50 mg Tablet Works

Azotas 50 mg Tablet belongs to a class of medicines called immunosuppressants. It works by interfering with the production of DNA and RNA, which are the building blocks cells need to grow and multiply. Because of this, it specifically targets cells that multiply rapidly in the body. In your body, the immune system produces white blood cells to fight off infections. However, in autoimmune diseases or after an organ transplant, these white blood cells mistakenly attack your own healthy tissues or the new organ. By blocking the multiplication of these rapidly dividing immune cells, Azotas 50 mg Tablet lowers the number of active white blood cells. This action calms your body's immune defence, stopping it from attacking your joints or your new kidney. Over time, this helps control chronic inflammation, prevents organ rejection, and allows your tissues to heal.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Azotas 50 mg Tablet . It could lead to increased dizziness and drowsiness.

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Pregnancy

Caution

Azotas 50 mg Tablet is a Category D pregnancy drug that is not recommended for pregnant women or given only under the strict guidance of the doctor, as there is no clinical data available on use in pregnant women.

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Breast Feeding

Caution

It is not recommended to take Azotas 50 mg Tablet while you are breastfeeding. Azotas 50 mg Tablet passes into breast milk.

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Driving

Caution

Azotas 50 mg Tablet may cause dizziness, drowsiness, and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Take Azotas 50 mg Tablet only as prescribed by your doctor, especially if you are dealing with Liver diseases/conditions, as your doctor may adjust the dose as required.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking Azotas 50 mg Tablet .

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Children

Unsafe

Azotas 50 mg Tablet should not be used by children below 18 years of age, as its efficacy and safety have not been established.

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Heart

Consult your doctor

Please consult your physician if you have any heart-related problems before taking Azotas 50 mg Tablet .

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Geriatrics

Caution

Exercise caution when administering Azotas 50 mg Tablet to geriatric patients; close monitoring is required.

What if I have taken an overdose of Azotas 50 mg Tablet

In case of an accidental overdose, seek immediate emergency medical attention or contact a poison control centre right away. An overdose can lead to severe bone marrow suppression, liver damage, and serious infections. Talk to your doctor if you experience any unusual symptoms after taking too much.

Diet & Lifestyle Advise

  • Practice strict food safety: Since this medicine lowers your immune system's ability to fight infections, avoid eating raw or undercooked meat, seafood, and eggs, and wash all raw fruits and vegetables thoroughly before eating.
  • Protect your skin from the sun: This medication can make your skin more sensitive to sunlight and increase your risk of skin cancer. Apply a broad-spectrum sunscreen with an SPF of 30 or higher daily, wear protective clothing, and avoid tanning beds.
  • Maintain strict hygiene: Wash your hands frequently with soap and water, especially before eating and after being in public spaces, to reduce your risk of catching common viruses or bacteria.
  • Avoid contagious illnesses: Stay away from anyone who has an active contagious illness, such as chickenpox, shingles, flu, or measles, as your body will find it harder to fight off these infections.

Have a query?

How Soon It Starts Working

  • The time required for Azotas 50 mg Tablet to start to work: The time required for Azotas 50 mg Tablet to show its action is unknown.
  • The time for which the effects of Azotas 50 mg Tablet last: The duration of action for Azotas 50 mg Tablet is unknown.

What if you forget to take Azotas 50 mg Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure, talk to your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Inspect your tablets: Always check them before taking; do not take them if they are discoloured, chipped, or broken.
  • Avoid handling broken tablets: Never handle broken or crushed tablets if you are pregnant or planning to become pregnant, as the active substance can be absorbed through the skin.
  • Keep up with regular lab tests: Ensure you complete all scheduled blood tests, as your doctor needs to monitor your white blood cell count and liver enzymes to keep you safe.
  • Alert other healthcare providers: Inform all healthcare professionals you visit, including dentists and surgeons, that you are taking an immunosuppressant before any procedure is scheduled.
  • Check your vaccine status: Avoid getting any live vaccines while taking this medicine, as they can cause severe infections. Always consult your doctor before receiving any immunisations.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Gout medications (e.g., Allopurinol and Febuxostat): These can dangerously increase the levels of Azotas 50 mg Tablet in your body, significantly raising the risk of severe blood disorders and infections.
  • Blood thinners (e.g., Warfarin): This medicine can reduce the effectiveness of blood thinners, meaning your doctor may need to adjust your dose and monitor your clotting times more frequently.
  • Other immunosuppressants or bone marrow-affecting drugs (e.g., Sulfasalazine or ACE inhibitors): Combining these can severely increase your risk of low blood counts and serious infections.

Drug-Food Interactions

  • Alcohol: Drinking alcohol while taking this medicine can increase the risk of liver damage and should be avoided.

Drug-Disease Interactions

  • Liver or kidney disease: These conditions make it harder for your body to clear the medicine, which can cause it to build up and increase the risk of severe side effects.
  • TPMT deficiency: A genetic lack of the thiopurine methyltransferase (TPMT) enzyme stops your body from safely breaking down this drug, leading to potentially life-threatening bone marrow suppression.
  • Active infections: Taking this medicine while you have an active infection (such as tuberculosis) can make it much harder for your body to fight the infection.
AzathioprineFebuxostat
Critical
AzathioprineDeferiprone
Severe

Drug-Drug Interactions

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AzathioprineFebuxostat
Critical
How does the drug interact with Azotas 50 mg Tablet:
Taking Azotas 50 mg Tablet and Febuxostat together can increase the blood levels of Azotas 50 mg Tablet

How to manage the interaction:
Taking Azotas 50 mg Tablet with Febuxostat is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AzathioprineDeferiprone
Severe
How does the drug interact with Azotas 50 mg Tablet:
Taking Azotas 50 mg Tablet with Deferiprone can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Azotas 50 mg Tablet and Deferiprone, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
AzathioprineGolimumab
Severe
How does the drug interact with Azotas 50 mg Tablet:
When Azotas 50 mg Tablet and Golimumab are taken together, they may raise the risk of severe infections

How to manage the interaction:
There may be a possibility of interaction between Azotas 50 mg Tablet and Golimumab, but it can be taken if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm (a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineAllopurinol
Severe
How does the drug interact with Azotas 50 mg Tablet:
Co-administration of Allopurinol with Azotas 50 mg Tablet may increase the effects of Azotas 50 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Azotas 50 mg Tablet and allopurinol, but it can be taken if prescribed by a doctor. However, if you experience chills, fever, body pains, sore throat, weakness, muscle pain, mouth sores, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhoea, consult a doctor. Do not stop using any medications without a doctor's advice.
AzathioprineBCG vaccine
Severe
How does the drug interact with Azotas 50 mg Tablet:
Taking the BCG vaccine with Azotas 50 mg Tablet can increase the risk of infection.

How to manage the interaction:
Co-administration of Azotas 50 mg Tablet with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
AzathioprineTeriflunomide
Severe
How does the drug interact with Azotas 50 mg Tablet:
When Azotas 50 mg Tablet is taken with Teriflunomide, may raise the risk of side effects affecting bone marrow function, resulting in low levels of different types of blood cells. This can increase your chances of developing anemia, bleeding issues, or infections.

How to manage the interaction:
Taking Azotas 50 mg Tablet with Teriflunomide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience paleness, exhaustion, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, or pain or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineRibavirin
Severe
How does the drug interact with Azotas 50 mg Tablet:
Coadministration of Azotas 50 mg Tablet and ribavirin used together can increase the risk of side effects. This can increase your chances of developing anemia(lack of blood), bleeding issues, or infections.

How to manage the interaction:
Although using Ribavirin and Azotas 50 mg Tablet together may cause an interaction, they can be taken together if advised by a doctor. However, consult a doctor if you have pale skin, tiredness, disorientation, fainting, unusual bleeding or bruises, fever, chills, sore throat, body aches, or other flu-like symptoms. Do not stop taking any medications without consulting a doctor.
AzathioprineCladribine
Severe
How does the drug interact with Azotas 50 mg Tablet:
The use of cladribine with Azotas 50 mg Tablet can increase the risk of serious infections.

How to manage the interaction:
Although taking Azotas 50 mg Tablet and Cladribine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience symptoms fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain during urination, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
AzathioprineEtanercept
Severe
How does the drug interact with Azotas 50 mg Tablet:
When Etanercept is used with Azotas 50 mg Tablet, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Azotas 50 mg Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AzathioprineBaricitinib
Severe
How does the drug interact with Azotas 50 mg Tablet:
Coadministration of baricitinib and Azotas 50 mg Tablet can raise the risk of developing harmful infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Azotas 50 mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Azotas 50 mg Tablet is used to prevent kidney transplant rejection. It is also used to treat symptoms of active rheumatoid arthritis (a condition in which the immune system attacks the joints, causing pain and inflammation).

Azotas 50 mg Tablet causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.

Azotas 50 mg Tablet acts as an immunosuppressant, which helps in reducing inflammation and preventing joint stiffness, thereby providing relief from rheumatoid arthritis.

If you miss a dose of Azotas 50 mg Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

Diarrhoea might be a side effect of Azotas 50 mg Tablet . Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

If you miss a prescription dose, take it as soon as you recall and resume your regular routine. If you are near the next dose, skip the missing dose and resume your regular schedule. Do not take a double dose to make up for a forgotten dose.

It depends on your individual medical condition and response to the medication. Your doctor will determine the appropriate duration of treatment based on your specific needs.

Taking Azotas 50 mg Tablet for a long time can increase your risk of developing some types of cancer, including skin cancer. As a result, avoid direct sunlight, apply sunscreen (SPF 30 or higher), and wear clothes that shield your arms and legs.

You'll have regular blood tests while taking azathioprine. These tests will ensure that any concerns or problems are found quickly.

Yes, taking Azotas 50 mg Tablet for a long time can increase your risk of developing some types of cancer, including skin cancer. Seek medical attention if you experience any changes in your body.

Using Cyclosporine together with Azotas 50 mg Tablet may decrease the effects of cyclosporine. Caution is advised if Cyclosporine must be taken with Azotas 50 mg Tablet . You may need a dose adjustment or a special test if you use both medications.

It is best to avoid or limit alcohol while taking this medicine. Both alcohol and Azotas 50 mg Tablet can strain your liver, and combining them increases your risk of liver damage. Talk to your doctor or pharmacist.

Common side effects of Azotas 50 mg Tablet may include nausea, headache, vomiting, diarrhoea, unusual fatigue, dizziness, loss of appetite, increased liver enzymes, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Azotas 50 mg Tablet does not work immediately. For autoimmune conditions like rheumatoid arthritis or inflammatory bowel disease, it can take anywhere from a few weeks to several months before you notice a full improvement in your symptoms. Talk to your doctor.

You can receive inactive (killed) vaccines, such as the yearly flu shot, though they may be less effective. However, you must avoid live vaccines, such as those for shingles, yellow fever, or measles, because your weakened immune system may not be able to handle the vaccine virus safely. Talk to your doctor.

Azotas 50 mg Tablet can lower the number of blood cells your bone marrow makes, which increases your risk of infections, anaemia, and bleeding. Regular blood tests allow your doctor to monitor your white and red blood cell counts, platelets, and liver health, ensuring your dose remains safe. Talk to your doctor.

Azotas 50 mg Tablet can cause harm to an unborn baby and is generally not recommended during pregnancy. Both men and women taking this medication should use reliable birth control during treatment and for a period after stopping. Talk to your doctor.

Small amounts of Azotas 50 mg Tablet can pass into breast milk and could potentially harm a nursing infant. It is generally advised to discuss alternative options with your healthcare provider. Talk to your doctor or pharmacist.

Mild hair thinning is a known, usually temporary, side effect of this medicine. It often improves over time or after the treatment is stopped. If your hair loss is severe or bothersome, do not stop taking your medicine without medical advice. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.3301 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. U.S. Food and Drug Administration (FDA). 016324S039Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  3. National Health Service (NHS). Azathioprine - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Drugs.com Clinical Review Team. Azathioprine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  5. Azathioprine [Prescribing Information]. 2014. [Accessed on 06 Apr. 2019] Check here
  6. Azathioprine [Product Information]. 2021. [Accessed on 09 Jun, 2023] Check here
  7. Mohammadi O, Kassim TA Azathioprine. [Updated 2023 May 1]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023Check here

Country of origin

India

Manufacturer/Marketer address

Plot No. 45, N.T.M., Sector -26, Chandigarh
Other Info - AZO0146

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