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compositionComposition:BARICITINIB-2MG
prescription
Prescription Medicine
info
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Barilup 2 Tablet belongs to the class of immunomodulators used in the treatment of rheumatoid arthritis, atopic dermatitis and coronavirus infection. This medicine works by stopping the viral entry into body cells, limits viral replication, and thereby controls the release of cytokines. Common side effects include throat infection, fatigue and high blood cholesterol.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BARICITINIB-2MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Barilup 2 Tablet

Barilup 2 Tablet is an oral prescription medication used to reduce pain, swelling, and joint damage in adults with moderate to severe rheumatoid arthritis. It is also prescribed to treat severe hair loss caused by alopecia areata and to manage moderate to severe eczema when other treatments have not worked. This medicine helps calm an overactive immune system to relieve these chronic inflammatory conditions.

You should take Barilup 2 Tablet once daily, and it is highly beneficial to take it at the same time every day to keep a consistent amount of medicine in your body. You can take this tablet with or without food. Along with taking this medicine, incorporating regular low-impact exercises, maintaining a balanced diet, and managing stress can significantly improve your treatment outcomes.

While taking Barilup 2 Tablet , some people may experience mild side effects like cold symptoms, nausea, or shingles. However, if you experience serious side effects such as signs of a severe infection, sudden shortness of breath, or chest pain, you must contact your doctor immediately.

Before starting Barilup 2 Tablet , tell your doctor if you have a history of tuberculosis, chronic infections, liver damage, kidney disease, or blood clots. Do not take this if you currently have an active, serious infection, as this medication can lower your body's ability to fight off germs.

This medicine can interact with certain vaccinations and medications that suppress the immune system, which may increase your risk of infections. It is also important to talk to your doctor or pharmacist if you are pregnant, planning to become pregnant, breastfeeding, or if you are an older adult, as special precautions may be needed.

Uses of Barilup 2 Tablet

Barilup 2 Tablet is used in the treatment of rheumatoid arthritis, alopecia areata, and atopic dermatitis. The detailed uses of Barilup 2 Tablet are as follows:

  • Rheumatoid arthritis: Barilup 2 Tablet helps by reducing the painful joint swelling, stiffness, and inflammation associated with this autoimmune condition, helping to prevent long-term joint damage.
  • Alopecia areata: Barilup 2 Tablet helps by targeting the immune response that attacks hair follicles, allowing hair to regrow in areas of severe hair loss.
  • Atopic dermatitis: Barilup 2 Tablet helps by lowering skin inflammation, which relieves the intense itching and redness associated with moderate to severe eczema.

Key Benefits

Barilup 2 Tablet helps reduce inflammation and improve symptoms in certain autoimmune and inflammatory conditions. The following are the benefits of this medication:

  • Helps relieve joint pain, swelling, and morning stiffness in people with rheumatoid arthritis, making everyday activities easier.
  • Improves joint movement and physical function, allowing greater comfort during daily tasks.
  • Helps clear skin plaques and reduces itching in people with severe inflammatory skin conditions.
  • Promotes hair regrowth in people with certain types of hair loss, helping improve appearance and confidence.
Side effects of Barilup 2 Tablet
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
  • If you experience symptoms like difficulty breathing, stridor (high-pitched whistling sound when breathing), high fever or chest pain, consult a doctor immediately.
  • Use a nebulizer or a cool-mist humidifier to help loosen mucus and soothe inflamed airway.
  • Drink lots of water to thin mucus and help with coughing.
  • Get enough sleep to allow the body to heal.
  • Suck on lozenges to soothe sore throat.
  • Quit smoking and alcohol consumption.

Directions for Use

  • Barilup 2 Tablet can be taken with or without food, or as a doctor advises.
  • Generally, it is recommended to be taken once daily. However, follow your doctor's instructions regarding dosage and timing for optimal results.
  • Swallow Barilup 2 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Barilup 2 Tablet Works

Barilup 2 Tablet belongs to a class of medications called Janus kinase (JAK) inhibitors. In patients with autoimmune conditions, the body's immune system mistakenly sends chemical signals that trigger continuous inflammation in the joints, skin, or hair follicles. This medicine works by blocking these specific chemical pathways inside your cells, effectively turning down the signals that cause the inflammation. By stopping these pathways, Barilup 2 Tablet helps calm your overactive immune response and protects your tissues from further damage.
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Alcohol

Caution

It is not recommended to use alcohol with Barilup 2 Tablet . Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Barilup 2 Tablet is absolutely contraindicated during pregnancy.

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Breast Feeding

Caution

Not enough studies exist to ascertain the effect of Barilup 2 Tablet on nursing. Barilup 2 Tablet is not recommended to use without contraception during and for at least 1 week after treatment. Please consult your doctor in case of any concerns.

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Driving

Safe if prescribed

Barilup 2 Tablet does not affect your ability to drive.

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Liver

Caution

Exercise caution before using Barilup 2 Tablet in case of established liver disease as it may cause a derangement of liver enzymes. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Barilup 2 Tablet in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Caution

Not enough studies exist to ascertain the effect of Barilup 2 Tablet in children. Please consult your doctor in case of any concerns.

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Heart

Caution

Barilup 2 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Barilup 2 Tablet .

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Geriatrics

Caution

Barilup 2 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Barilup 2 Tablet .

What if I have taken an overdose of Barilup 2 Tablet

If you suspect an overdose or have taken more than your prescribed dose, seek emergency medical care or contact a poison control centre immediately.

Diet & Lifestyle Advise

  • Protect against infections: Since this medicine can lower your immune system's strength, wash your hands frequently, avoid close contact with people who are sick, and practice safe food hygiene.
  • Support your joints: If taking this for arthritis, engage in regular, low-impact exercises such as swimming or cycling to keep your joints flexible without putting excess stress on them.
  • Hydrate your skin: If treating eczema, apply a gentle, fragrance-free moisturiser immediately after bathing to lock in moisture and protect your skin barrier.
  • Monitor your diet: Eat a heart-healthy diet low in saturated fats to help manage your cholesterol levels, which can sometimes rise while taking this medicine.
health query

Have a query?

How Soon It Starts Working

The time required for Barilup 2 Tablet to start to work: Barilup 2 Tablet ideally shows its action within 1 hour after administration. The time for which the effects of Barilup 2 Tablet last: The effect of Barilup 2 Tablet lasts for 72 hours.

What if you forget to take Barilup 2 Tablet

If you miss a dose of Barilup 2 Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Barilup 2 Tablet at room temperature, between 20°C to 25°C (68°F to 77°F).• Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Get tested for TB: Your doctor must test you for tuberculosis (TB) before you start taking Barilup 2 Tablet , as this medicine can reactivate inactive TB infections.
  • Avoid live vaccines: Do not receive any live vaccines while taking this medicine, as your weakened immune system may not react safely to them.
  • Watch for infection signs: Stop taking the medicine and contact your doctor immediately if you develop a fever, chills, or any other signs of an active infection.
  • Monitor laboratory tests: Keep all appointments for scheduled blood tests so your doctor can monitor your liver enzymes, cholesterol, and blood cell counts.
  • Report unusual pain: Alert your healthcare provider immediately if you experience sudden leg swelling, chest pain, or shortness of breath.

Drug-Drug Interactions

verifiedApollotooltip
  • Other immunosuppressants (e.g., adalimumab, abatacept, tofacitinib): Taking Barilup 2 Tablet with biological medicines or other JAK inhibitors is not recommended, as it can severely weaken your immune system and increase the risk of infections.
  • Medicines used to treat gout (e.g., probenecid): Combining Barilup 2 Tablet with probenecid can increase the levels of Barilup 2 Tablet in your blood, raising the risk of side effects. Your doctor may need to adjust your dose.
     
BaricitinibCiclosporin
Critical
BaricitinibBexarotene
Severe

Drug-Drug Interactions

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BaricitinibCiclosporin
Critical
How does the drug interact with Barilup 2 Tablet:
Co-administration of Barilup 2 Tablet with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Ciclosporin with Barilup 2 Tablet is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BaricitinibBexarotene
Severe
How does the drug interact with Barilup 2 Tablet:
Coadministration of Barilup 2 Tablet and bexarotene can raise the risk of developing harmful infections.

How to manage the interaction:
Although there is an interaction, Barilup 2 Tablet can be taken with bexarotene if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BaricitinibRituximab
Severe
How does the drug interact with Barilup 2 Tablet:
Taking Rituximab with Barilup 2 Tablet may significantly increases the risk of infections.

How to manage the interaction:
Although taking Rituximab and Barilup 2 Tablet together can cause an interaction, it can be taken if A doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, breathing difficulty, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
BaricitinibMycophenolic acid
Severe
How does the drug interact with Barilup 2 Tablet:
Coadministration of Barilup 2 Tablet and Abatacept can increase the risk of developing serious infections.

How to manage the interaction:
Taking Barilup 2 Tablet and Abatacept together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BaricitinibIfosfamide
Severe
How does the drug interact with Barilup 2 Tablet:
Coadministration of Barilup 2 Tablet and ifosfamide can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barilup 2 Tablet can be taken with ifosfamide if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BaricitinibUstekinumab
Severe
How does the drug interact with Barilup 2 Tablet:
Taking Barilup 2 Tablet with Ustekinumab can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Barilup 2 Tablet and Ustekinumab, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
BaricitinibDaratumumab
Severe
How does the drug interact with Barilup 2 Tablet:
Coadministration of Barilup 2 Tablet and daratumumab can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barilup 2 Tablet can be taken with daratumumab if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BaricitinibAdalimumab
Severe
How does the drug interact with Barilup 2 Tablet:
Coadministration of Barilup 2 Tablet and adalimumab can raise your risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barilup 2 Tablet can be taken with adalimumab if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
BaricitinibCorticotropin
Severe
How does the drug interact with Barilup 2 Tablet:
Coadministration of Corticotropin with Baricitinibcan increases the risk of developing serious infections.

How to manage the interaction:
Co-administration of Barilup 2 Tablet with Corticotropin can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BaricitinibFingolimod
Severe
How does the drug interact with Barilup 2 Tablet:
Coadministration of Barilup 2 Tablet and fingolimod can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Barilup 2 Tablet can be taken with fingolimod if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Barilup 2 Tablet .
 

BARICITINIB-2MGHigh fat foods
Mild

Drug-Food Interactions

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BARICITINIB-2MGHigh fat foods
Mild
Common Foods to Avoid:
Frozen Meals, Cheese, Red Meat, Potato Chips, Hamburgers, Hot Dogs, Ice Cream

How to manage the interaction:
Coadministration of Barilup 2 Tablet and high-fat meals can decrease the absorption of Barilup 2 Tablet. Avoid fatty food and oily food while being treated with Barilup 2 Tablet.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[IMMUNOMODULATORS]

FAQs

Barilup 2 Tablet belongs to the group of immunomodulators. It is used in the treatment of hospitalised cases of coronavirus disease, an infection caused by COVID-19 and is also used to treat Rheumatoid Arthritis.
Barilup 2 Tablet works by preventing the virus from attaching to the body’s cell receptors and thereby blocking its entry and spread.
Advanced age, obesity, chronic kidney disease, lung disease, sickle cell disease, neurodevelopmental disorders (for example cerebral palsy) and diseases of metabolism are some risk factors for disease progression.
If you have liver problems, you should consult a healthcare practitioner before using Baricitinib. Baricitinib may impair liver function, so your doctor will need to analyze your specific circumstances to determine whether the benefits exceed risk.
While Barilup 2 Tablet has not been directly related to cancer, you should discuss any potential concerns with your doctor. They can give you with information based on the most recent research and your individual health needs.
Before starting Barilup 2 Tablet , your doctor may recommend certain investigations to assess your overall health and to monitor for any potential side effects. These may include blood tests, liver function tests, and other assessments as needed.
No, Barilup 2 Tablet is generally not recommended during pregnancy as it may cause harm to an unborn baby. If you are planning a pregnancy or discover you are pregnant while taking this medicine, talk to your doctor immediately.
Yes, your doctor will order routine blood tests to check your liver enzymes, cholesterol levels, and blood cell counts to ensure the medicine is safe for you to continue. Talk to your doctor about how often you need these tests.
While there is no direct food or alcohol interaction with Barilup 2 Tablet , both alcohol and this medication can affect your liver. To protect your liver, it is best to limit alcohol consumption. Talk to your doctor.
Yes, because Barilup 2 Tablet lowers your body's ability to fight off infections, you may need to temporarily pause taking it if you develop a fever or a serious infection. Talk to your doctor before stopping or restarting your medication.
You can receive non-live vaccines (like the seasonal flu shot), but you must avoid live vaccines (such as the shingles or yellow fever vaccines) while using Barilup 2 Tablet , as they could cause a serious infection. Talk to your doctor before scheduling any vaccines.
No, Barilup 2 Tablet is actually prescribed to treat severe hair loss caused by alopecia areata. It does not cause hair loss. Talk to your doctor if you notice any unusual changes in your hair.
No, you should swallow the tablets whole with water. Crushing, chewing, or splitting the tablet can alter how the medicine is absorbed into your bloodstream. Talk to your doctor if you have difficulty swallowing tablets.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). Coronavirus Covid 19 Update Fda Authorizes Drug Combination Treatment Covid 19 [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Baricitinib [Prescribing Information]. 2018. [Accessed on 16 Oct. 2024]Check here
  4. Lilly S.A., Avda. de la Industria. Electronic Medicines Compendium (EMC). [Revised on January 2021] [Accessed on 27th April 2022]Check here
  5. Eli Lilly and Company. Baricitinib. [Revised on December 2021] [Accessed on 27th April 2022]Check here
  6. . [Accessed on 02 Jun. 2026]Check here
  7. Medscape Clinical Reference. Olumiant Baricitinib 1000107 Dosage & Guidelines. New York, NY: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Lupin Ltd, 3Rd Floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country Of Origin: India
Other Info - BAR0198
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