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compositionComposition:BENDAMUSTINE-25MG
prescription
Prescription Medicine
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Bendastes 100 mg Injection 4 ml is used to treat Non-Hodgkin's disease and Chronic Lymphocytic Leukaemia. Bendastes 100 mg Injection 4 ml contains Bendamustine; it works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medication is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BENDAMUSTINE-25MG

Manufacturer/Marketer :

Halsted Pharma Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Bendastes 100 mg Injection 4 ml

Bendastes 100 mg Injection 4 ml is a prescription medication used to treat certain types of blood and lymph cancers, such as chronic lymphocytic leukaemia and indolent B-cell non-Hodgkin lymphoma. It works by targeting and slowing the growth of cancer cells in the body. This medicine is prescribed when other initial treatments may not have worked or when the disease has returned.

Since Bendastes 100 mg Injection 4 ml is given as an intravenous infusion in a clinic or hospital, it is scheduled in cycles by your healthcare team. It is crucial to attend all scheduled infusion appointments to maintain a consistent level of the medicine in your body. Because it is given directly into a vein, food intake does not affect how it is absorbed, but staying well-hydrated before and after your sessions is highly recommended to support your kidneys.

Some people may experience common side effects like nausea, extreme tiredness, low blood cell counts, or mild fever. It is very important to contact your doctor immediately if you experience serious symptoms such as signs of a severe infection (like high fever or chills), unusual bruising or bleeding, or breathing difficulties.

Do not take this if you have a known severe allergy to any of its ingredients, or if you have severe liver damage or severe kidney disease. Talk to your doctor before starting Bendastes 100 mg Injection 4 ml if you have a history of heart problems, active infections, or liver conditions.

Bendastes 100 mg Injection 4 ml can interact with other medications that affect your immune system or liver function, which may increase the risk of severe side effects. It is highly advised to avoid alcohol and smoking during treatment as they can strain your liver and worsen fatigue. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider immediately, as this medicine can harm an unborn baby.

Uses of Bendastes 100 mg Injection 4 ml

Bendastes 100 mg Injection 4 ml is used to treat certain types of blood and lymph cancers. The detailed uses of Bendastes 100 mg Injection 4 ml are as follows:

  • Chronic Lymphocytic Leukaemia: Bendastes 100 mg Injection 4 ml helps by destroying abnormal white blood cells that grow too quickly, allowing healthy blood cells to function better.
  • Indolent B-cell Non-Hodgkin Lymphoma: Bendastes 100 mg Injection 4 ml targets and slows down the growth of slow-growing cancer cells in the lymphatic system, especially when other treatments have stopped working.

Key Benefits

Bendastes 100 mg Injection 4 ml helps treat certain blood and lymph cancers by slowing the growth and spread of cancer cells. When used as prescribed, it helps control disease progression, relieve cancer-related symptoms, and support better long-term treatment outcomes.

  • Helps Control Blood and Lymph Cancers: By targeting rapidly dividing cancer cells, this medicine helps manage conditions such as leukaemia and lymphoma, supporting remission when achievable and slowing disease progression.
  • Relieves Cancer-Related Symptoms: As the number of cancer cells decreases, this medicine may help reduce symptoms such as swollen lymph nodes, night sweats, unexplained weight loss, and fatigue, improving daily comfort and quality of life.
  • Supports Recovery Between Treatment Cycles: Given in planned treatment cycles, this medicine allows healthy cells time to recover between doses, helping support your body's strength and tolerance throughout cancer therapy.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Bendastes 100 mg Injection 4 ml will be administered by a healthcare professional.
  • Do not self-administer.

How Bendastes 100 mg Injection 4 ml Works

Bendastes 100 mg Injection 4 ml contains bendamustine, which belongs to a group of medicines known as alkylating agents. It works by binding directly to the DNA inside rapidly multiplying cancer cells. Once attached, it creates cross-links that damage the DNA structure, preventing the cells from dividing and growing. Because cancer cells divide much faster than most normal cells, they are highly sensitive to this DNA damage. When the DNA is damaged beyond repair, the cancer cells receive a signal to self-destruct. This targeted destruction helps reduce the overall tumour burden in the body.
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Alcohol

Caution

Limit or avoid consumption of alcohol as it may worsen your condition.

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Pregnancy

Unsafe

Bendastes 100 mg Injection 4 ml is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Bendastes 100 mg Injection 4 ml. Use reliable methods of birth control while on treatment with Bendastes 100 mg Injection 4 ml.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Bendastes 100 mg Injection 4 ml. You should not breastfeed while on treatment with Bendastes 100 mg Injection 4 ml.

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Driving

Not applicable

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Bendastes 100 mg Injection 4 ml. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. Bendastes 100 mg Injection 4 ml is not recommended for use in patients with severe liver disease.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Bendastes 100 mg Injection 4 ml. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. This medicine should be avoided for patients with CrCl <40 ml/min.

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Children

Unsafe

Bendastes 100 mg Injection 4 ml is not recommended for use in children as the safety and efficacy is not established.

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Heart

Caution

Bendastes 100 mg Injection 4 ml should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Bendastes 100 mg Injection 4 ml.

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Geriatrics

Safe if prescribed

Bendastes 100 mg Injection 4 ml is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Bendastes 100 mg Injection 4 ml

Because this medication is prepared and given by trained medical professionals in a controlled clinical environment, an accidental overdose is highly unlikely. If an overdose is suspected, medical staff will monitor you closely and provide immediate supportive care. If you feel unwell or suspect an issue after leaving the clinic, seek immediate emergency medical attention.

Diet & Lifestyle Advise

  • Stay Well-Hydrated: Drink plenty of fluids (such as water or clear broths) before, during, and after your treatment days. This helps your kidneys flush out the waste products of destroyed cancer cells and reduces the risk of kidney complications.
  • Eat Small, Frequent Meals: To help manage nausea, try eating smaller portions of bland foods throughout the day instead of three large meals. Avoid greasy, spicy, or extremely sweet foods.
  • Practice Strict Hygiene: Because Bendastes 100 mg Injection 4 ml can temporarily lower your white blood cell count (reducing your body's ability to fight infections), wash your hands frequently. Avoid crowded places and close contact with people who are sick.
  • Protect Your Skin from the Sun: Your skin may become more sensitive during treatment. Apply a broad-spectrum sunscreen, wear protective clothing, and limit your time in direct sunlight.
  • Prioritise Rest: Fatigue is a very common side effect. Listen to your body and schedule regular rest periods throughout the day, while maintaining light activity like walking if your doctor approves.
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Have a query?

How Soon It Starts Working

The time required for Bendastes 100 mg Injection 4 ml to start to work: The time required for Bendastes 100 mg Injection 4 ml to show its action is not clinically established. The time for which the effects of Bendastes 100 mg Injection 4 ml last: The duration of action for Bendastes 100 mg Injection 4 ml is not clinically established.

What if you forget to take Bendastes 100 mg Injection 4 ml

Since Bendastes 100 mg Injection 4 ml is given by healthcare professionals on a strict clinical schedule, it is unlikely that you will miss a dose. However, if you miss an appointment or need to reschedule, contact your doctor or clinic immediately to set up a new appointment. Keeping your treatment on schedule is vital for its success.

Storage

• Bendastes 100 mg Injection 4 ml is stored and handled exclusively by your clinic, hospital, or pharmacy.

Drug Warnings

  • Inspect the Infusion Site: Inform your nurse immediately if you feel any burning, pain, swelling, or redness near the injection site during or after the infusion.
  • Do Not Get Live Vaccines: Avoid getting live vaccines (such as the shingles, measles, or oral polio vaccines) during treatment, as your weakened immune system may not react safely.
  • Monitor Your Temperature Daily: Keep a reliable thermometer at home and check your temperature if you feel unwell. A fever during chemotherapy is a medical emergency.
  • Use Reliable Contraception: Both men and women should use highly effective birth control during treatment and for several months afterwards to prevent pregnancy, as Bendastes 100 mg Injection 4 ml can cause severe birth defects.
  • Prepare for Routine Blood Tests: Expect to have regular blood tests before each treatment cycle to monitor your liver function, kidney health, and blood cell counts.

verifiedApollotooltip
  • CYP1A2 Inhibitors/Inducers: Medicines that affect the liver enzyme CYP1A2 (such as fluvoxamine or ciprofloxacin) can change how your body breaks down Bendastes 100 mg Injection 4 ml, potentially increasing side effects or reducing effectiveness.
  • Immunosuppressants: Taking other drugs that weaken the immune system can dangerously increase your risk of severe infections.

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verifiedApollotooltip

No clinically significant food interactions are known with Bendastes 100 mg Injection 4 ml when used as directed.

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Hair thinning or mild hair loss can occur while receiving Bendastes 100 mg Injection 4 ml, although complete hair loss is less common than with some other chemotherapy medicines. Constipation may also occur in some people. These side effects are usually manageable. Tell your doctor if they become severe, persist, or interfere with your daily activities.
Bendastes 100 mg Injection 4 ml is given as an intravenous infusion into a vein by a trained healthcare professional in a clinic or hospital setting. Talk to your doctor if you have questions about the infusion process.
Some people feel very tired, dizzy, or weak after receiving an infusion of Bendastes 100 mg Injection 4 ml. It is best to have someone drive you to and from your appointments until you know how the medicine affects you. Talk to your doctor for personalised advice.
Treatment with Bendastes 100 mg Injection 4 ml is given in structured cycles determined by your doctor. A cycle typically lasts a few weeks, with the medicine given on specific days. Talk to your doctor to understand your specific treatment plan.
It is highly recommended to avoid alcohol while taking Bendastes 100 mg Injection 4 ml. Alcohol can increase the risk of liver strain and worsen side effects like nausea and fatigue. Talk to your doctor or pharmacist before drinking any alcohol.
Bendastes 100 mg Injection 4 ml can lower your white blood cells, red blood cells, and platelets. Regular blood tests are essential to ensure your blood counts recover safely before your next dose. Talk to your doctor about your blood test results.
A fever of 38°C (100.4°F) or higher is a medical emergency when you are receiving Bendastes 100 mg Injection 4 ml, as it can indicate a serious infection. Contact your doctor or seek emergency medical care immediately. Talk to your doctor about infection signs.
No, you should not plan to conceive during treatment. Bendastes 100 mg Injection 4 ml can cause severe harm to a developing baby. Use highly effective birth control during treatment and for the time period recommended by your healthcare team. Talk to your doctor about safe family planning options.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

SCF NO 265, SECOND FLOOR MOTOR MARKET MANIMAJRA Chandigarh, Chandigarh, 160101 India
Other Info - BEN0896
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