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compositionComposition:AXITINIB-1MG
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Prescription Medicine
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Bexinib 1 mg Tablet 14's is used to treat Renal Cell Carcinoma. It contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor. In this way, Bexinib 1 mg Tablet 14's stops the production, spread and growth of cancerous cells.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AXITINIB-1MG

Manufacturer/Marketer :

Adley Oncology

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Bexinib 1 mg Tablet 14's

Bexinib 1 mg Tablet 14's is a targeted anticancer medicine used to treat advanced kidney cancer (renal cell carcinoma). It works by blocking proteins involved in the formation of new blood vessels that supply tumours, helping to slow or stop cancer growth and spread. This medicine is commonly prescribed alone or in combination with other anticancer therapies to improve disease control in patients with advanced renal cell carcinoma.

You will typically take Bexinib 1 mg Tablet 14's twice daily, approximately 12 hours apart. You can take this medication with or without food, but it is important to take it consistently at the same times each day. To support your body during treatment, your doctor may suggest making simple lifestyle changes, such as eating a low-sodium diet and staying well-hydrated to help manage potential side effects.

While taking Bexinib 1 mg Tablet 14's, you may experience common side effects like diarrhoea, high blood pressure, and feeling unusually tired. If you experience severe side effects, such as sudden chest pain, unusual bleeding, or severe abdominal pain, you must contact your healthcare provider immediately.

Do not take this if you have uncontrolled high blood pressure or are allergic to any of its ingredients. Before starting this treatment, talk to your doctor if you have a history of blood clots, heart problems, liver damage, bleeding issues, or thyroid conditions.

Certain medications, as well as smoking and drinking alcohol, can change how Bexinib 1 mg Tablet 14's works in your body. It is vital to consult your doctor if you are pregnant, breastfeeding, or planning a family, as this medication can harm an unborn baby. Elderly individuals should also talk to their doctor to ensure this medication is safe for them.

Uses of Bexinib 1 mg Tablet 14's

Bexinib 1 mg Tablet 14's is used to treat advanced kidney cancer (renal cell carcinoma).. The detailed uses of Bexinib 1 mg Tablet 14's are as follows:

  • Advanced Kidney Cancer: Bexinib 1 mg Tablet 14's is used to treat advanced renal cell carcinoma (kidney cancer) that has spread to other parts of the body, particularly after other initial treatments have stopped working.

Key Benefits

Bexinib 1 mg Tablet 14's helps treat advanced kidney cancer by slowing the growth and spread of cancer cells. With regular use as prescribed, it helps control disease progression, reduce tumour-related symptoms, and support better long-term treatment outcomes.

  • Helps Slow Cancer Progression: By targeting pathways that promote cancer cell growth, this medicine helps delay the progression of advanced kidney cancer and supports effective disease control.
  • Reduces Tumour-Related Symptoms: By slowing the growth or shrinking tumours, this medicine may help relieve pain, pressure, and other symptoms caused by cancer, improving overall comfort.
  • Supports Quality of Life: Effective disease control helps maintain energy levels, improve daily functioning, and allows many patients to continue their regular activities with greater comfort during treatment.
Side effects of Bexinib 1 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Bexinib 1 mg Tablet 14's can be taken with or without food as prescribed by your doctor.
  • It is recommended to take twice daily; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the medicine as a whole with a glass of water.
  • Do not break, chew or crush Bexinib 1 mg Tablet 14's.

How Bexinib 1 mg Tablet 14's Works

Bexinib 1 mg Tablet 14's contains axitinib, which belongs to a group of medicines known as targeted therapies. It works by blocking specific proteins on the surface of cells that control the growth of blood vessels. Tumours need a constant blood supply to grow and spread throughout the body. By blocking these proteins, Bexinib 1 mg Tablet 14's helps cut off the blood supply to the kidney cancer cells, essentially starving them of the oxygen and nutrients they need to multiply.
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Alcohol

Caution

Limit alcohol consumption while taking Bexinib 1 mg Tablet 14's.

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Pregnancy

Unsafe

Bexinib 1 mg Tablet 14's is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Bexinib 1 mg Tablet 14's. You should not become pregnant while you are taking Bexinib 1 mg Tablet 14's. Using effective birth control methods while on treatment with Bexinib 1 mg Tablet 14's is suggested.

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Breast Feeding

Caution

It is not known whether Bexinib 1 mg Tablet 14's passes into breastmilk. Hence, if you are breastfeeding, inform your doctor before taking Bexinib 1 mg Tablet 14's. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Bexinib 1 mg Tablet 14's may cause dizziness and visual disturbances in some patients. Hence, do not drive, operate machinery, or engage in any activity that needs clear vision until you are confident that you can do so safely while you are on treatment with Bexinib 1 mg Tablet 14's.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Bexinib 1 mg Tablet 14's is known to cause elevated liver enzymes, which may be fatal. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Bexinib 1 mg Tablet 14's. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Bexinib 1 mg Tablet 14's is not recommended for use in children below 18 years of age as the safety and efficacy is not established.

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Heart

Consult your doctor

Please consult your doctor if you have any heart problems before taking Bexinib 1 mg Tablet 14's.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Bexinib 1 mg Tablet 14's to geriatric patients. Your doctor will prescribe Bexinib 1 mg Tablet 14's if the benefits outweigh the risks.

What if I have taken an overdose of Bexinib 1 mg Tablet 14's

If you take too much of this medicine, seek immediate medical attention or contact a nearby hospital. Do not wait for symptoms of an overdose to appear.

Diet & Lifestyle Advise

  • Monitor your blood pressure daily and keep a log to share with your healthcare provider, as this medication commonly raises blood pressure.
  • Protect your hands and feet by wearing comfortable, well-fitting shoes and applying thick moisturising creams to prevent peeling or soreness.
  • Stay well-hydrated throughout the day by drinking plenty of water, which helps manage and prevent dehydration from diarrhoea.
  • Avoid eating grapefruit or drinking grapefruit juice, as these can increase the level of the drug in your body to unsafe levels.
health query

Have a query?

How Soon It Starts Working

The time required for Bexinib 1 mg Tablet 14's to start to work: The time required for Bexinib 1 mg Tablet 14's to show its action is not clinically established. The time for which the effects of Bexinib 1 mg Tablet 14's last: The duration of action for Bexinib 1 mg Tablet 14's is not clinically established.

What if you forget to take Bexinib 1 mg Tablet 14's

If you miss a dose of Bexinib 1 mg Tablet 14's, skip the missed dose and take your next dose at your regularly scheduled time. Do not take two doses at the same time to make up for a missed one. If you vomit after taking a dose, do not take an extra tablet; simply wait and take your next scheduled dose at the normal time.

Storage

• Store Bexinib 1 mg Tablet 14's tablets at room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect your tablets before taking them; do not take any tablet that is broken, chipped, or damp.
  • Make sure your doctor knows you are taking Bexinib 1 mg Tablet 14's before scheduling any surgery or dental procedures, as you may need to temporarily stop taking this medicine to allow wounds to heal properly.
  • Get your thyroid function checked regularly with blood tests, as this medicine can affect your thyroid hormone levels.
  • Keep a written record of your daily blood pressure readings so your doctor can adjust your blood pressure medications if necessary.

Drug-Drug Interactions

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  • Strong CYP3A4/5 inhibitors: Taking these medications (such as certain antibiotics or antifungals) alongside Bexinib 1 mg Tablet 14's can raise the amount of the drug in your body, increasing the risk of serious side effects.
  • Strong CYP3A4/5 inducers: Taking these medications (such as certain seizure medicines or tuberculosis treatments) can decrease the amount of Bexinib 1 mg Tablet 14's in your blood, making the treatment less effective.
AxitinibPrimidone
Severe
AxitinibClarithromycin
Severe

Drug-Drug Interactions

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AxitinibPrimidone
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Coadministration of Bexinib 1 mg Tablet with primidone may decrease the blood levels of Bexinib 1 mg Tablet, which may make Bexinib 1 mg Tablet less effective in treating the condition.

How to manage the interaction:
Although there is an interaction between primidone and Bexinib 1 mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AxitinibClarithromycin
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Co-administration of Clarithromycin may increase the blood levels of Bexinib 1 mg Tablet may increase side effects.

How to manage the interaction:
Although there is a possible interaction Clarithromycin can be taken with Bexinib 1 mg Tablet if prescribed by the doctor. Seek immediate medical attention if you develop chest pain or pressure; coughing up or vomiting blood or blood clots; pain in the arms, back, neck, or jaw; swelling; shortness of breath; numbness or weakness on one side of the body; headache; vision changes; seizures, unusual bleeding or bruising; red or black stools; and severe stomach or abdominal pain. Do not discontinue the medication without consulting a doctor.
AxitinibMitotane
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Mitotane may decrease the blood levels of Bexinib 1 mg Tablet, which may make Bexinib 1 mg Tablet less effective in treating the condition.

How to manage the interaction:
Although taking Bexinib 1 mg Tablet and Mitotane together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
AxitinibErythromycin
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Coadministration of Bexinib 1 mg Tablet and erythromycin increases the blood levels of Bexinib 1 mg Tablet.

How to manage the interaction:
Although taking Erythromycin and Bexinib 1 mg Tablet together may result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience pain in the arms, back, neck, or jaw, swelling, shortness of breath, weakness on one side of the body, headache, red or black stools, coughing up or vomiting blood or blood clots, and severe abdominal pain. Do not discontinue any medications without consulting a doctor,
AxitinibItraconazole
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Coadministration of Itraconazole and Bexinib 1 mg Tablet may significantly increase the blood levels of Bexinib 1 mg Tablet.

How to manage the interaction:
Bexinib 1 mg Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Any of the following symptoms should be reported: high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling skin on the hands and feet, chest pain, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, fits, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood. Do not stop any medications without consulting a doctor.
AxitinibRitonavir
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Taking Bexinib 1 mg Tablet with ritonavir may significantly increase the blood levels of Bexinib 1 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Bexinib 1 mg Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor. Do not discontinue any medications without consulting a doctor.
AxitinibCarbamazepine
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Taking carbamazepine and Bexinib 1 mg Tablet together can reduce the effects of Bexinib 1 mg Tablet, which may make medication less effective in treating your condition.

How to manage the interaction:
Taking carbamazepine and Bexinib 1 mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AxitinibFosphenytoin
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Fosphenytoin may decrease the blood levels of Bexinib 1 mg Tablet, which may make Bexinib 1 mg Tablet less effective in treating your condition

How to manage the interaction:
Co-administration of Bexinib 1 mg Tablet with Fosphenytoin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
AxitinibPhenobarbital
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Phenobarbital can considerably lower Bexinib 1 mg Tablet levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Bexinib 1 mg Tablet can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
AxitinibEfavirenz
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Efavirenz may decrease the blood levels of Bexinib 1 mg Tablet, which may make Bexinib 1 mg Tablet less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Bexinib 1 mg Tablet and Efavirenz, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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  • Grapefruit and grapefruit juice: May increase the risk of severe side effects by slowing down how your body breaks down the medication.
  • Smoking tobacco: Can decrease the amount of the medication in your body, which may reduce how well the drug works.
AXITINIB-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AXITINIB-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit or grapefruit juice might raise the medication's levels in the blood leading to side effects such as high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet. Avoid consuming grapefruit or grapefruit juice during treatment with Bexinib 1 mg Tablet.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

No. Bexinib 1 mg Tablet 14's should not be used during pregnancy because it can seriously harm an unborn baby. It is also not recommended while breastfeeding. Do not take Bexinib 1 mg Tablet 14's if you are allergic to axitinib or any of its ingredients. Use effective contraception during treatment and for the period recommended by your doctor. If you are pregnant, planning a pregnancy, or think you may be pregnant, contact your doctor immediately.
Yes, you can take Bexinib 1 mg Tablet 14's with or without food. Try to be consistent with how you take it each day. Talk to your doctor or pharmacist if you need help planning your schedule.
If you throw up after taking your dose, do not take an extra dose. Simply wait and take your next dose at your regular scheduled time. Talk to your doctor or pharmacist if vomiting continues.
Some people may experience hair thinning or hair loss while taking Bexinib 1 mg Tablet 14's, though this is usually temporary. Talk to your doctor if you are concerned about hair changes.
While there is no direct interaction, alcohol can worsen side effects like dehydration, dizziness, and liver strain. Talk to your doctor or pharmacist before drinking alcohol during your treatment.
You should check your blood pressure regularly, often daily, especially during the first few weeks of starting Bexinib 1 mg Tablet 14's. Talk to your doctor if your blood pressure begins to rise.
Bexinib 1 mg Tablet 14's can interfere with how your body heals wounds. You may need to stop taking it before and after a planned surgery or dental work. Talk to your doctor for specific instructions.
No, Bexinib 1 mg Tablet 14's is a targeted therapy rather than traditional chemotherapy. It specifically blocks the signals and blood supply that cancer cells need to grow, rather than killing all fast-growing cells. Talk to your doctor for more details.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

42, Sector 12 Rd, Railla, Sector 12, Panchkula, Haryana 134113
Other Info - BEX0038
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