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compositionComposition:CARMUSTINE-100MG
prescription
Prescription Medicine
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Bicnu 100 mg Injection is used in the treatment of brain tumors. Bicnu 100 mg Injection is also used in the treatment of multiple myeloma in combination with prednisone, Hodgkin’s Disease, and non-Hodgkin’s Disease in combination with other approved drugs. It contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CARMUSTINE-100MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Bicnu 100 mg Injection

Bicnu 100 mg Injection injection is a specialised prescription medicine used to treat certain types of brain tumours, multiple myeloma, and cancers of the lymphatic system. It is designed to target and slow down the growth of cancer cells in the body, providing a critical treatment option for advanced conditions. Your healthcare provider will determine the exact schedule for this therapy based on your specific medical needs.

Because this medicine is given as a slow injection into a vein, it is typically scheduled at specific intervals, such as once every few weeks, to allow your body time to recover. Maintaining all your scheduled appointments is essential to ensure the treatment works consistently. To support your body during therapy, eating a balanced diet, staying well-hydrated, and getting plenty of rest are highly recommended lifestyle steps.

While receiving this treatment, you may experience some common side effects like nausea, vomiting, or temporary hair loss. However, you must contact your doctor immediately if you experience serious side effects, such as shortness of breath, a persistent dry cough, or signs of an infection like a fever.

Before starting your treatment, tell your doctor if you have a history of lung disease, kidney issues, or liver problems. Do not take this medicine if you have severely low blood cell counts or are allergic to any of its ingredients. It is also not suitable for individuals who are pregnant or planning to become pregnant due to risks to the unborn baby.

This medicine can interact with other treatments, including certain seizure medicines and other chemotherapy drugs, which may increase the risk of severe side effects. It is also important to avoid alcohol and smoking during treatment, as they can put extra stress on your liver and lungs. If you are breastfeeding or are an older adult, discuss the risks and benefits thoroughly with your doctor before starting therapy.

Uses of Bicnu 100 mg Injection

Bicnu 100 mg Injection is used to treat certain types of cancers. The detailed uses of Bicnu 100 mg Injection are as follows:

  • Brain tumours: Help slow the growth and spread of cancer cells in the brain, including glioblastoma and astrocytoma.
  • Multiple myeloma: Works in combination with other therapies to target and manage cancer cells in the bone marrow.
  • Hodgkin's disease: Helps treat this specific cancer of the lymphatic system when other treatments have not been successful.
  • Non-Hodgkin's lymphoma: Assists in controlling the spread of abnormal lymphatic cells to help manage the disease.

Key Benefits

Bicnu 100 mg Injection provides important support in managing certain cancers by slowing the growth of cancer cells. The key benefits of Bicnu 100 mg Injection are as follows:

  • Tumour Growth Control: Helps slow the growth and spread of cancer cells, reducing tumour size and relieving pressure or pain in affected areas, including the brain.
  • Effective Brain Penetration: Crosses the blood–brain barrier, allowing it to reach brain tumours that many other medicines cannot access, helping improve disease control and support quality of life.
Side effects of Bicnu 100 mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Drink adequate water to stay hydrated and support kidney function.
  • Limit sodium intake and avoid processed foods to reduce blood pressure.
  • Consume moderate amounts of high-quality protein from sources like lean meats, fish, and plant-based options.
  • Restrict potassium-rich foods and control phosphorus intake to minimize kidney strain.
  • Include antioxidant-rich foods like fruits, vegetables, and omega-3 fatty acids in your diet.
  • Avoid consuming processed and high-sugar foods that can worsen kidney damage.
  • Limit alcohol consumption and caffeine intake to reduce kidney stress.
  • Quit smoking to significantly lower the risk of kidney damage.
  • Engage in regular exercise to control weight, improve circulation, and lower blood pressure.
  • Consider taking nutritional supplements like omega-3 fatty acids, vitamin D, and antioxidants under medical guidance.
  • Regularly schedule medical checkups to monitor kidney function and adjust your plan as needed.
  • Collaborate with a healthcare provider to develop a personalized diet and lifestyle plan tailored to your needs.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Bicnu 100 mg Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Bicnu 100 mg Injection Works

Bicnu 100 mg Injection contains carmustine, an alkylating agent that works by targeting the genetic material inside cancer cells. It attaches to the DNA and RNA of rapidly dividing cells, damaging their structure and preventing them from copying their genetic code and multiplying. As a result, the cancer cells eventually die, helping to shrink tumours and slow disease progression. Bicnu 100 mg Injection can also cross the blood–brain barrier, allowing it to reach brain tumours that many other medicines cannot access and deliver its anti-cancer effects directly within the central nervous system.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Bicnu 100 mg Injection to prevent serious adverse effects.

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Pregnancy

Unsafe

Bicnu 100 mg Injection is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Bicnu 100 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data is available on the effect of Bicnu 100 mg Injection on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Bicnu 100 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Bicnu 100 mg Injection will be administered in the hospital setting. Hence, avoid driving.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Bicnu 100 mg Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Bicnu 100 mg Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Children

Consult your doctor

Limited information is available for the use of Bicnu 100 mg Injection in children. Hence, it will be given to the children only if needed. If administered, careful monitoring of the child is needed.

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Heart

Caution

Take Bicnu 100 mg Injection with caution, especially if you have a history of heart diseases/conditions. The dose may be adjusted by your doctor as required.

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Geriatrics

Caution

Bicnu 100 mg Injection should be used in the elderly only if advised by a doctor, as dose adjustment may be required.

What if I have taken an overdose of Bicnu 100 mg Injection

Since your medical team prepares and gives this injection, an overdose is highly unlikely. If you suspect an issue or experience severe symptoms after your treatment, seek immediate medical attention or inform your clinic's emergency staff right away.

Diet & Lifestyle Advise

  • Avoid Infections: Keep away from people who are sick, especially those with colds, flu, or other contagious infections, as your body's ability to fight off germs may be temporarily lowered.
  • Stay Well-Hydrated: Drink plenty of water and clear fluids throughout the day to help your kidneys process and eliminate the medicine.
  • Reduce Bleeding Risk: Use a very soft toothbrush and an electric shaver to help reduce the risk of bleeding gums or cuts, as your blood's ability to clot may be reduced during treatment.
  • Protect Your Lungs: Avoid smoking and exposure to second-hand smoke, as Bicnu 100 mg Injection can affect your lungs and smoking may increase the risk of serious lung damage.
  • Manage Nausea: Eat small, frequent meals of bland, simple foods to help reduce nausea and maintain your energy levels.
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Have a query?

How Soon It Starts Working

The time required for Bicnu 100 mg Injection to start to work: The onset of time for Bicnu 100 mg Injection is unknown. The time for which the effects of Bicnu 100 mg Injection last: The duration of Bicnu 100 mg Injection effect is unknown.

What if you forget to take Bicnu 100 mg Injection

Because this medicine is given by healthcare professionals in a clinic, missing a dose is uncommon. However, if you miss a scheduled appointment for your injection, contact your healthcare team immediately to reschedule your treatment.

Storage

• Unopened vials of Bicnu 100 mg Injection must be stored in a refrigerator at a controlled temperature between 2°C to 8°C (36°F to 46°F). • They should be kept in their original packaging to protect the medicine from light.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the Vial: Before your injection begins, ensure the medical staff inspects the vial to confirm the powder has not melted or turned into an oily liquid, as this may indicate product damage.
  • Report Injection Site Problems: Tell your nurse immediately if you feel any burning, stinging, pain, or coldness around your vein during the injection, as this may indicate the medicine is leaking into the surrounding tissues.
  • Use Effective Contraception: Use two reliable forms of birth control during treatment and for several months after your final dose to prevent pregnancy, as Bicnu 100 mg Injection can cause severe harm to an unborn baby.
  • Attend Regular Monitoring: Keep all scheduled baseline and ongoing lung function tests and blood tests. Lung toxicity risk increases with higher total (cumulative) doses, and bone marrow suppression typically peaks 4 to 6 weeks after a dose—much later than standard chemotherapy. 

Drug-Drug Interactions

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  • Other chemotherapy drugs: Taking Bicnu 100 mg Injection alongside other medicines that suppress the immune system can increase the risk of severe infections and dangerously low blood cell counts.
  • Seizure medicines (such as phenytoin): Combining these can lower the effectiveness of your seizure medicine, increasing the risk of seizures.
  • Cimetidine: This stomach acid medicine may increase the side effects and toxicity of Bicnu 100 mg Injection.
CarmustineInfliximab
Severe
CarmustineEtanercept
Severe

Drug-Drug Interactions

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CarmustineInfliximab
Severe
How does the drug interact with Bicnu 100 mg Injection:
When Bicnu 100 mg Injection is taken with Infliximab it can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Infliximab and Bicnu 100 mg Injection, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, losing weight, or experiencing pain or burning while urinating, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
CarmustineEtanercept
Severe
How does the drug interact with Bicnu 100 mg Injection:
When Etanercept is used with Bicnu 100 mg Injection, the severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Bicnu 100 mg Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CarmustineClozapine
Severe
How does the drug interact with Bicnu 100 mg Injection:
Combining Bicnu 100 mg Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Taking Clozapine with Bicnu 100 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any of these symptoms - severe infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain during urination, contact your doctor immediately. Do not stop using any medications without talking to a doctor.
CarmustineBaricitinib
Severe
How does the drug interact with Bicnu 100 mg Injection:
Coadministration of baricitinib and Bicnu 100 mg Injection can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Bicnu 100 mg Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
CarmustineCladribine
Severe
How does the drug interact with Bicnu 100 mg Injection:
Taking Cladribine with Bicnu 100 mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Bicnu 100 mg Injection, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarmustineLeflunomide
Severe
How does the drug interact with Bicnu 100 mg Injection:
Combining Bicnu 100 mg Injection with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Co-administration of Bicnu 100 mg Injection with Leflunomide can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - liver problems, complications, infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, dark urine or bleeding - contact your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Bicnu 100 mg Injection is used to treat Brain Tumors, Multiple Myeloma, Hodgkin’s Disease and Non-Hodgkin’s Disease.
Bicnu 100 mg Injection contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.
Bicnu 100 mg Injection may cause pulmonary toxicity, bone marrow suppression, gastrointestinal toxicity, nephrotoxicity and hepatotoxicity in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.
Bicnu 100 mg Injection is safe if taken at the prescribed dose and duration as advised by your doctor. It is effectively used in the treatment of brain tumours, multiple myeloma, Hodgkin's disease, and non-Hodgkin's disease. However, it may cause some side effects like nausea, vomiting, headache, pale skin, dizziness, stomach upset, tiredness, loss of balance, and pain at the site of injection while taking it.
Bicnu 100 mg Injection is typically classified as an irritant among chemotherapy drugs. However, when given in high doses, it can have stronger effects and be considered a vesicant.
The common side effects of Bicnu 100 mg Injection may include nausea, vomiting, headache, pale skin, dizziness, stomach upset, tiredness, loss of balance, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Bicnu 100 mg Injection is given as a slow injection into a vein (intravenously) by trained healthcare professionals in a hospital or clinical setting. Talk to your doctor if you have questions about your specific treatment schedule.
Yes, Bicnu 100 mg Injection can sometimes cause lung damage, such as scarring or breathing difficulties, which may develop weeks or months after treatment. Your doctor will monitor your lung function closely. Talk to your doctor immediately if you develop a dry cough or shortness of breath.
This medicine causes delayed bone marrow suppression, meaning your white blood cells, red blood cells, and platelets usually reach their lowest levels (nadir) 4 to 6 weeks after your infusion—later than most other chemotherapy drugs. Regular blood tests help your doctor track these counts over time and ensure it is safe to give your next cycle. Talk to your doctor about your test results.
You should avoid getting live vaccines while using this medicine, as your weakened immune system may not react safely to them. Always check with your healthcare team before getting any vaccine. Talk to your doctor for a safe vaccination plan.
Yes, temporary hair loss is a common side effect of Bicnu 100 mg Injection. Hair typically grows back after the treatment is completed. Talk to your doctor or nurse for tips on managing hair loss.
While the medicine itself is processed relatively quickly, its effects on your blood cells and lungs can last or appear several weeks after your last dose. Talk to your doctor to understand what to expect during and after your treatment cycle.
It is highly recommended to avoid alcohol during treatment, as both alcohol and Bicnu 100 mg Injection can place extra stress on your liver, increasing the risk of liver damage. Talk to your doctor about lifestyle choices during your therapy.
If you feel pain, burning, or swelling near your vein during or after the injection, tell your healthcare provider immediately, as the medicine may have leaked outside the vein. Talk to your doctor or nurse if you notice any changes around the injection site.

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Country of origin

India

Manufacturer/Marketer address

A €“ 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - BIC0045
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