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compositionComposition:CYTARABINE-100MG/ML
prescription
Prescription Medicine
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Biobin 500 mg/5 ml Injection 5 ml is an anticancer medicine used to treat leukemia (blood cancer). It contains Cytarabine, which belongs to the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in cancer cells, which is essential for cell growth, repair, and multiplication. Thus, It stops the multiplication of abnormal cells, leads to the development of cells in an unbalanced way and causes the death of cells.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CYTARABINE-100MG/ML

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Biobin 500 mg/5 ml Injection 5 ml

Biobin 500 mg/5 ml Injection 5 ml is a prescription injection used to treat certain types of blood cancers, such as acute myeloid leukaemia and acute lymphocytic leukaemia. It is also used to treat or prevent cancer that has spread to the tissues covering the brain and spinal cord. This medicine works by targeting and stopping the growth of abnormal cancer cells in the body.

Because this medicine is given as an injection, a healthcare professional will give it to you in a hospital or clinic setting. The frequency of your treatment will depend on your specific condition and how well your body responds. Since it is given by injection, you do not need to worry about taking it with or without food, but staying well-hydrated before your appointments can help. Eating small, frequent, bland meals and avoiding raw foods can support your recovery during treatment.

Like all cancer treatments, Biobin 500 mg/5 ml Injection 5 ml can cause some unwanted effects, such as nausea, temporary hair loss, or mouth sores. These are common and usually manageable, but you must contact your doctor immediately if you experience signs of infection, like a fever or chills.

Do not take this if you have had a severe allergic reaction to it in the past. Before starting, talk to your doctor if you have a history of liver damage, kidney disease, or blood disorders, as these conditions may require special monitoring or adjustments to your treatment.

It is important to discuss all other medicines you are taking, as some can increase the risk of side effects when combined with Biobin 500 mg/5 ml Injection 5 ml. Avoid drinking alcohol and smoking, as they can worsen liver strain and general side effects. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare team immediately, as this medicine can harm an unborn baby.

Uses of Biobin 500 mg/5 ml Injection 5 ml

Your doctor may prescribe Biobin 500 mg/5 ml Injection 5 ml to treat the following conditions:

  • Acute Myeloid Leukaemia (AML): Biobin 500 mg/5 ml Injection 5 ml helps by slowing down or stopping the rapid production of abnormal white blood cells in the bone marrow.
  • Acute Lymphocytic Leukaemia (ALL): This medicine targets and destroys cancer cells that affect your lymphatic system and blood.
  • Meningeal Leukaemia: It is injected directly into the spinal fluid to treat or prevent the spread of leukaemia cells to the brain and spinal cord.

Key Benefits

Biobin 500 mg/5 ml Injection 5 ml helps control certain blood cancers by slowing the growth and multiplication of abnormal cancer cells. This supports disease control, promotes remission in suitable patients, and allows healthy blood cells to recover during treatment.

  • Helps control blood cancers: Slows the growth and spread of rapidly dividing cancer cells, helping manage conditions such as leukaemia and lymphoma.
  • Supports remission: By reducing the number of abnormal cancer cells, it may help achieve or maintain remission when used as part of an appropriate treatment plan.
  • Allows healthy blood cells to recover: As cancer cells are reduced, the bone marrow can gradually restore the production of normal red blood cells, white blood cells, and platelets.
  • Treats cancer involving the central nervous system: When administered into the spinal fluid (intrathecally), Biobin 500 mg/5 ml Injection 5 ml delivers treatment directly to the brain and spinal cord, helping control cancer cells in areas that intravenous chemotherapy may not adequately reach.
Side effects of Biobin 500 mg/5 ml Injection 5 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
  • To minimize pain and swelling, apply an ice pack or cold compress wrapped in a cloth as soon as there is bleeding or bruises.
  • Use a warm compress 48 hours later to promote blood flow and hasten the healing process.
  • Rest and limit activity to prevent further injury.
  • Elevate the affected area above the level of your heart to reduce blood flow.
  • To treat discomfort, your doctor may offer over-the-counter pain medicines.
  • Inform your doctor if you develop large bruises without injury or experience frequent bruising, as this may indicate an underlying condition.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Biobin 500 mg/5 ml Injection 5 ml will be administered in the hospital setting by a trained healthcare professional.
  • Do not self-administer.

How Biobin 500 mg/5 ml Injection 5 ml Works

Biobin 500 mg/5 ml Injection 5 ml contains cytarabine, which belongs to a group of medicines known as antimetabolites. It is designed to mimic the natural building blocks that your cells use to make DNA. When cancer cells rapidly divide, they absorb Biobin 500 mg/5 ml Injection 5 ml, thinking it is a normal nutrient they need to grow. Once inside the cancer cells, the medicine interferes with their DNA production and repair processes. Because the cells cannot successfully copy their DNA, they are unable to multiply and ultimately die off. This selective targeting helps reduce the overall number of cancer cells in your blood and bone marrow.
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Alcohol

Unsafe

Avoid consumption of alcohol with Biobin 500 mg/5 ml Injection 5 ml as it may increase the risk of liver damage.

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Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Biobin 500 mg/5 ml Injection 5 ml. You should not become pregnant while on treatment with Biobin 500 mg/5 ml Injection 5 ml.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving Biobin 500 mg/5 ml Injection 5 ml. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Unsafe

Biobin 500 mg/5 ml Injection 5 ml causes dizziness and may alter the ability to drive or operate machines. Hence, avoid driving or operating machines after receiving Biobin 500 mg/5 ml Injection 5 ml.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Biobin 500 mg/5 ml Injection 5 ml. It may lead to CNS toxicity in high doses.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Biobin 500 mg/5 ml Injection 5 ml as it may lead to kidney failure. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Biobin 500 mg/5 ml Injection 5 ml, combined with other approved anti-cancer medications, is suggested for inducing remission in adults and children with acute non-lymphocytic leukemia. Consult your doctor for more information.

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Heart

Caution

Biobin 500 mg/5 ml Injection 5 ml may be used in patients with heart problems, but only with close medical supervision. It can cause cardiac symptoms like fast or uneven heartbeat and chest pain, so monitoring is essential.

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Geriatrics

Caution

Geriatric patients can receive Biobin 500 mg/5 ml Injection 5 ml, but it may be more susceptible to side effects like low blood counts and neurotoxicity. Careful dosing and close medical monitoring are essential during treatment.

What if I have taken an overdose of Biobin 500 mg/5 ml Injection 5 ml

Since your treatment is managed and injected by trained medical staff, an accidental overdose is highly unlikely. If you suspect you have received too much of this medicine or notice sudden, severe side effects, tell your healthcare provider or seek emergency medical attention immediately.

Diet & Lifestyle Advise

  • Practice strict food safety: Because this medicine can lower your white blood cell count, avoid raw or undercooked foods, wash all fruits and vegetables thoroughly, and ensure all dairy products are pasteurized to prevent infections.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys flush out the waste products of destroyed cancer cells and to help manage nausea.
  • Eat soft, bland foods: To prevent mouth sores, opt for soft foods like yogurt, mashed potatoes, and well-cooked vegetables. Avoid spicy, salty, or highly acidic foods.
  • Use a soft toothbrush: Brush your teeth gently with a soft-bristled toothbrush to protect your gums from bleeding when your platelet counts are low.
  • Wash your hands frequently: Keep your hands clean and avoid crowded areas or contact with people who are sick to protect yourself from infections.
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How Soon It Starts Working

The time required for Biobin 500 mg/5 ml Injection 5 ml to start to work: Biobin 500 mg/5 ml Injection 5 ml ideally shows its action within 15 minutes of administration. The time for which the effects of Biobin 500 mg/5 ml Injection 5 ml last: Biobin 500 mg/5 ml Injection 5 ml effect lasts for 12-24 hours.

What if you forget to take Biobin 500 mg/5 ml Injection 5 ml

Because you will receive this medication under the direct supervision of a healthcare provider, it is unlikely that you will miss a dose. However, if you miss an appointment or need to reschedule, contact your doctor's office immediately to arrange a new time. Keeping your treatment on schedule is very important for the medicine to work effectively.

Storage

•Unopened vials should be stored at controlled room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the injection before use: Before each injection, ensure the solution is clear and free from visible particles. Do not use it if it appears cloudy, discoloured, or if the container is damaged.
  • Rotate injection sites: If you are self-administering subcutaneous injections, change the injection site with each dose to help reduce pain, bruising, and skin irritation.
  • Dispose of needles safely: Always discard used needles and syringes in a puncture-resistant sharps container. Never reuse needles or dispose of them in household waste.
  • Monitor for signs of infection: Check your temperature regularly and contact your doctor immediately if you develop a fever of 38°C (100.4°F) or higher, chills, sore throat, or any other signs of infection.
  • Avoid live vaccines: Do not receive live vaccines during treatment unless your doctor specifically advises you to, as your immune system may not respond normally.
  • Attend regular monitoring: Keep all scheduled appointments for blood tests so your doctor can monitor your blood cell counts, kidney function, liver function, and overall response to treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Live vaccines: Taking Biobin 500 mg/5 ml Injection 5 ml while receiving live vaccines may increase your risk of developing a severe infection from the vaccine.
  • Digoxin: Biobin 500 mg/5 ml Injection 5 ml may lower the absorption of digoxin tablets, making your heart medication less effective.
  • Other chemotherapy drugs: Combining this medicine with other cancer treatments can increase the risk of serious side effects, such as low blood counts and liver strain.
CytarabineKetoconazole
Severe
CytarabineBaricitinib
Severe

Drug-Drug Interactions

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CytarabineKetoconazole
Severe
How does the drug interact with Biobin 500 mg/5 ml Injection 5 ml:
Taking Biobin 500 mg/5 ml Injection 5 ml with Ketoconazole can increase the risk of liver damage.

How to manage the interaction:
Although there is a possible interaction between Biobin 500 mg/5 ml Injection 5 ml and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
CytarabineBaricitinib
Severe
How does the drug interact with Biobin 500 mg/5 ml Injection 5 ml:
Coadministration of Biobin 500 mg/5 ml Injection 5 ml with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Biobin 500 mg/5 ml Injection 5 ml and Baricitinib, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CytarabineCladribine
Severe
How does the drug interact with Biobin 500 mg/5 ml Injection 5 ml:
The combined use of cladribine with Biobin 500 mg/5 ml Injection 5 ml can increase the risk and severity of side effects.

How to manage the interaction:
Although taking Biobin 500 mg/5 ml Injection 5 ml and Cladribine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without a doctor's advice.
CytarabineTofacitinib
Severe
How does the drug interact with Biobin 500 mg/5 ml Injection 5 ml:
Taking Tofacitinib with Biobin 500 mg/5 ml Injection 5 ml may increase the risk of serious infection.

How to manage the interaction:
Taking Tofacitinib with Biobin 500 mg/5 ml Injection 5 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
CytarabineClozapine
Severe
How does the drug interact with Biobin 500 mg/5 ml Injection 5 ml:
Combining Biobin 500 mg/5 ml Injection 5 ml with Clozapine can increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Biobin 500 mg/5 ml Injection 5 ml and Clozapine, but it can be taken if prescribed by a doctor. If you notice any of these symptoms - such as fever, sore throat, or muscle aches - contact your doctor immediately. Do not stop using any medications without talking to a doctor.
CytarabineThalidomide
Severe
How does the drug interact with Biobin 500 mg/5 ml Injection 5 ml:
Taking thalidomide together with Biobin 500 mg/5 ml Injection 5 ml may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Biobin 500 mg/5 ml Injection 5 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
CytarabineEtanercept
Severe
How does the drug interact with Biobin 500 mg/5 ml Injection 5 ml:
When Etanercept is used with Biobin 500 mg/5 ml Injection 5 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Biobin 500 mg/5 ml Injection 5 ml with Etanercept together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CytarabineInfliximab
Severe
How does the drug interact with Biobin 500 mg/5 ml Injection 5 ml:
Combining Infliximab with Biobin 500 mg/5 ml Injection 5 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Biobin 500 mg/5 ml Injection 5 ml with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Biobin 500 mg/5 ml Injection 5 ml when used as directed
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Biobin 500 mg/5 ml Injection 5 ml is used to treat Chronic myeloid leukemia, Acute lymphocytic leukemia, Acute non-lymphocytic leukemia, and meningeal leukemia.
Biobin 500 mg/5 ml Injection 5 ml contains Cytarabine, which belongs to the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair.
If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella and polio vaccines, it is advised to inform your doctor that you are on treatment with Biobin 500 mg/5 ml Injection 5 ml as it may cause infections.
Biobin 500 mg/5 ml Injection 5 ml may cause embryo-fetal toxicity. Therefore, please consult a doctor before taking Biobin 500 mg/5 ml Injection 5 ml if you are planning to become pregnant.
Biobin 500 mg/5 ml Injection 5 ml contains cytarabine as its active component. It is an anticancer medicine which belongs to the class of anti-metabolites.
Biobin 500 mg/5 ml Injection 5 ml is not considered a vesicant (irritant), but it should be administered carefully to prevent any potential issues.
No, ototoxicity (hearing damage) has not been reported with Biobin 500 mg/5 ml Injection 5 ml use. However, if you experience any related symptoms, it is important to consult your doctor.
Yes, Biobin 500 mg/5 ml Injection 5 ml is a cytotoxic (cell-damaging).
Yes, Biobin 500 mg/5 ml Injection 5 ml may cause hair loss as this is one of its side effects. However, please, consult a doctor if this persists for longer durations.
Biobin 500 mg/5 ml Injection 5 ml causes side effects such as nausea, vomiting, mouth ulcers, loss of appetite, diarrhoea, dark-coloured urine, confusion, dizziness, stomach pain, weakness, and injection site reactions. These will gradually reduce over time. However, consult a doctor if any of these persists longer.
Biobin 500 mg/5 ml Injection 5 ml is injected by a healthcare provider into a vein, under the skin, or directly into the spinal fluid. Talk to your doctor to understand which method is right for your specific treatment plan.
Frequent blood tests are necessary to check your blood cell counts, kidney health, and liver function. This helps your medical team adjust your treatment schedule safely. Talk to your doctor for more details.
Some people may feel dizzy, weak, or tired after receiving Biobin 500 mg/5 ml Injection 5 ml. It is best to avoid driving or operating machinery until you know how this medicine affects you. Talk to your doctor if you experience these symptoms.
The length and frequency of your treatment cycles depend on your specific type of leukaemia and how your body responds to the medicine. Talk to your doctor to understand your personalised treatment schedule.
You must contact your doctor or seek emergency medical attention immediately if you develop a fever, as it can be a sign of a serious infection due to lowered white blood cells. Talk to your doctor about when to seek urgent care.

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Country of origin

India

Manufacturer/Marketer address

D' Block, 3rd Floor, Gillander House, Netaji Subhas Road, Kolkata - 700001 (Wb)
Other Info - BIO2208
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