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Bioplegia Injection is a cardioprotective medication used to induce cardioplegia (temporarily stop the heart) during heart surgeries such as heart valve replacement or a heart transplant. This medicine contains Magnesium chloride, Potassium chloride, and Procaine, which work by temporarily stopping the heart from beating and decreasing the sensation of pain by blocking nerve impulses. Let your doctor know if you are taking any medications or have any pre-existing medical conditions before receiving Bioplegia Injection.

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Written By ,
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Bioplegia Injection

Bioplegia Injection is a cardioprotective medication used to induce cardioplegia during heart surgeries that involve cardiopulmonary bypass. It is commonly used in procedures such as heart valve replacement and heart transplants to keep a donated heart safe. Cardioplegia is a treatment administered during heart surgeries to deliberately and temporarily stop the heart, helping to protect the heart muscle (myocardium).

Bioplegia Injection contains Magnesium chloride (an electrolyte), Potassium chloride (an electrolyte), and Procaine (a local anaesthetic). Magnesium Chloride and Potassium Chloride lower the heart's oxygen demand by calming its electrical activity, which prevents muscle damage during heart surgery. Procaine decreases the sensation of pain by blocking the transmission of nerve impulses.

A trained healthcare professional will administer Bioplegia Injection through an infusion during surgery; do not self-administer. Consult the doctor immediately if you experience unusual symptoms after surgery, such as nausea, muscle twitching, tremors, convulsions, or irregular/slow heartbeat.

Before receiving Bioplegia Injection, inform your doctor if you are allergic to any of its ingredients. Also, let your doctor know if you are taking any prescription or non-prescription medications, vitamins, and herbal supplements or have any pre-existing medical conditions to rule out any side effects or interactions. Please consult your doctor if you are pregnant or breastfeeding before receiving Bioplegia Injection.

Uses of Bioplegia Injection

Bioplegia Injection is used to induce cardioplegia during heart surgery. The detailed uses of Bioplegia Injection are as follows:

  • Induces Cardioplegia (Heart Arrest): Bioplegia Injection helps stop the heart from beating, allowing surgeons to perform delicate procedures and is used in open-heart surgeries to protect the heart muscle.
  • Acts as a Local Anesthetic: Bioplegia Injection is used to reduce discomfort during medical procedures.
  • Maintains Electrolyte Balance: Bioplegia Injection is essential for nerve function and muscle contraction and helps restore electrolyte levels in patients undergoing surgery.

Key Benefits

Bioplegia Injection is a cardioprotective medication used to induce cardioplegia (temporarily stop the heart) during heart surgeries that involve cardiopulmonary bypass. It is commonly used in procedures such as heart valve replacement and heart transplants to keep a donated heart safe. It contains Magnesium chloride, Potassium chloride, and Procaine. Potassium chloride works by increasing potassium levels, which causes the heart muscle to contract. This action triggers the release of calcium ions, temporarily pausing the activity of the heart. Magnesium chloride also works by reducing the heart’s contractions. Together, they lower the heart's oxygen demand by calming its electrical activity, which prevents muscle damage while the heart is temporarily stopped during surgery. Procaine works by blocking the transmission of nerve impulses, which helps decrease the sensation of pain.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Bioplegia Injection will be administered by a healthcare professional in a medical setting.
  • Do not self-administer.

How Bioplegia Injection Works

Bioplegia Injection contains a combination of three drugs: Magnesium chloride (an electrolyte), Potassium chloride (an electrolyte), and Procaine (a local anaesthetic). It works by stopping the heart from beating and minimising the energy requirements of the heart during surgery. It also helps prevent disturbances in heart rhythm straight after the surgery.
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Bioplegia Injection. Please consult your doctor before consuming alcohol.

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Pregnancy

Consult your doctor

There is no information available about the use of Bioplegia Injection during pregnancy. Please consult your doctor if you have any concerns regarding the use of Bioplegia Injection during pregnancy.

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Breast Feeding

Consult your doctor

It is not known if Bioplegia Injection passes into breastmilk. Please consult your doctor if you have any concerns regarding the use of Bioplegia Injection during breastfeeding.

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Driving

Caution

Avoid driving and operating machinery until your doctor confirms that it is safe to do so.

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Liver

Consult your doctor

Please consult your doctor before receiving Bioplegia Injection if you have liver problems.

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Kidney

Consult your doctor

Please consult your doctor before receiving Bioplegia Injection if you have kidney problems.

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Children

Consult your doctor

Limited information is available. Please consult your doctor if you have any concerns regarding the usage of Bioplegia Injection in children.

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Heart

Consult your doctor

Inform your doctor if you have heart problems before using Bioplegia Injection.

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Geriatrics

Consult your doctor

Bioplegia Injection can be given to geriatrics. If you have any concerns regarding the use of Bioplegia Injection, please consult a doctor.

What if I have taken an overdose of Bioplegia Injection

Bioplegia Injection is administered in a controlled medical setting by a healthcare professional, so an overdose is not likely to occur. If an overdose occurs, it will be treated quickly by your doctor. Signs of an overdose may include difficulty breathing (apnoea), reduced blood flow due to weakened heart function (circulatory depression), seizures (fits), and a reduced ability of the blood to carry oxygen (methaemoglobinaemia).

Have a query?

How Soon It Starts Working

The time required for Bioplegia Injection to start to work: The peak effect of Bioplegia Injection can be observed within a few minutes to hours of administration. The time for which the effects of Bioplegia Injection last: Bioplegia Injection effect usually lasts for approximately a few hours.

What if you forget to take Bioplegia Injection

Bioplegia Injection is administered by a health care professional in a hospital setting. Hence, the chances of missed doses are less.

Storage

• Store in a cool and dry place away from sunlight. • Keep it out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Before receiving Bioplegia Injection, inform your doctor if you are allergic to any of its ingredients. Also, let your doctor know if you are taking any prescription or non-prescription medications, vitamins, and herbal supplements or have any pre-existing medical conditions to rule out any side effects or interactions. It is not known whether Bioplegia Injection can harm an unborn baby during pregnancy or pass into breast milk during breastfeeding. Therefore, please consult your doctor if you are pregnant or breastfeeding before receiving Bioplegia Injection.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: No interactions found/established.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: No interactions found/established.

Magnesium chloride + Potassium chloride + ProcaineDifenoxin
Critical
Magnesium chloride + Potassium chloride + ProcaineSolifenacin
Critical

Drug-Drug Interactions

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Magnesium chloride + Potassium chloride + ProcaineDifenoxin
Critical
How does the drug interact with Bioplegia Injection 20ml:
Taking Difenoxin with Magnesium chloride and Potassium chloride and Procaine together can increase the risk of stomach ulcers, bleeding, and other gastrointestinal injury.

How to manage the interaction:
Taking Difenoxin with Magnesium chloride and Potassium chloride and Procaine is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately.
Magnesium chloride + Potassium chloride + ProcaineSolifenacin
Critical
How does the drug interact with Bioplegia Injection 20ml:
Taking Bioplegia Injection 20ml together with Solifenacin can increase the risk of stomach ulcers and bleeding.

How to manage the interaction:
Taking Bioplegia Injection 20ml with Solifenacin is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Magnesium chloride + Potassium chloride + ProcaineDicyclomine
Critical
How does the drug interact with Bioplegia Injection 20ml:
Co-administration of Bioplegia Injection 20ml with Dicyclomine can increase the risk of stomach ulcers and bleeding.

How to manage the interaction:
Taking Bioplegia Injection 20ml with Dicyclomine is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult a doctor immediately. Do not discontinue the medication without consulting a doctor.
Magnesium chloride + Potassium chloride + ProcaineEplerenone
Critical
How does the drug interact with Bioplegia Injection 20ml:
Using Bioplegia Injection 20ml together with Eplerenone may significantly increase potassium levels in the blood.

How to manage the interaction:
Taking Bioplegia Injection 20ml with eplerenone is not recommended as it can lead to an interaction, it can be take if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Magnesium chloride + Potassium chloride + ProcaineProcyclidine
Critical
How does the drug interact with Bioplegia Injection 20ml:
Taking Bioplegia Injection 20ml together with Procyclidine can increase the risk of stomach ulcers and bleeding.

How to manage the interaction:
Taking Bioplegia Injection 20ml with Procyclidine is not recommended, as it can lead to an interaction, but it can be taken together if advised by a doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Magnesium chloride + Potassium chloride + ProcainePhenindamine
Critical
How does the drug interact with Bioplegia Injection 20ml:
Taking Bioplegia Injection 20ml together with Phenindamine can increase the risk of stomach ulcers and bleeding.

How to manage the interaction:
Taking Bioplegia Injection 20ml with Phenindamine is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Magnesium chloride + Potassium chloride + ProcaineTolterodine
Critical
How does the drug interact with Bioplegia Injection 20ml:
Taking Bioplegia Injection 20ml together with Tolterodine can increase the risk of stomach ulcers and bleeding.

How to manage the interaction:
Taking Bioplegia Injection 20ml together with Tolterodine is not recommended, as it can lead to an interaction, they can be taken if prescribed by a doctor. However, contact a doctor immediately if you develop severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), or loss of appetite. Do not discontinue medications without consulting a doctor.
Magnesium chloride + Potassium chloride + ProcaineTrospium
Critical
How does the drug interact with Bioplegia Injection 20ml:
Taking Bioplegia Injection 20ml with Trospium can increase the risk of stomach ulcers an bleeding.

How to manage the interaction:
Taking Bioplegia Injection 20ml with Trospium is not recommended as it may lead to an interaction, it can be taken if prescribed by a doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Magnesium chloride + Potassium chloride + ProcaineFlavoxate
Critical
How does the drug interact with Bioplegia Injection 20ml:
Co-administration of Bioplegia Injection 20ml with Flavoxate can increase the risk of stomach ulcers and bleeding.

How to manage the interaction:
Taking Bioplegia Injection 20ml with Flavoxate is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult a doctor immediately. Do not discontinue the medication without consulting a doctor.
Magnesium chloride + Potassium chloride + ProcaineOrphenadrine (chloride)
Critical
How does the drug interact with Bioplegia Injection 20ml:
Taking Bioplegia Injection 20ml with Orphenadrine(chloride) can increase the risk of stomach ulcers and bleeding.

How to manage the interaction:
Taking Bioplegia Injection 20ml with Orphenadrine (chloride)is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Bioplegia Injection is a cardioprotective medication used to induce cardioplegia (temporarily stop the heart) during heart surgeries that involve cardiopulmonary bypass.

Bioplegia Injection works by stopping the heart from beating and minimizing the energy requirements of the heart during surgery. It also helps prevent disturbances in heart rhythm straight after the surgery.

Inform the doctor if you are taking any prescription or non-prescription medications, vitamins, and herbal supplements or have any pre-existing medical conditions before receiving Bioplegia Injection to rule out any side effects or interactions. Also, let your doctor know if you are pregnant or breastfeeding.

Bioplegia Injection should be stored below 25ºC, protected from light.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044
Other Info - BIO0122
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