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Reviewed By Santoshini Reddy G , M Pharmacy

Bioplegia Injection is a cardioprotective medication used to induce cardioplegia (temporarily stop the heart) during heart surgeries such as heart valve replacement or a heart transplant. This medicine contains Magnesium chloride, Potassium chloride, and Procaine, which work by temporarily stopping the heart from beating and decreasing the sensation of pain by blocking nerve impulses. Let your doctor know if you are taking any medications or have any pre-existing medical conditions before receiving Bioplegia Injection.

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Whats That

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Synonym :

POTASSIUM CHLORIDE HEXAHYDRATE+MAGNESIUM CHLORIDE+PROCAINE HYDROCHLORIDE

Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Bioplegia Injection

Bioplegia Injection is a cardioprotective medication used to induce cardioplegia during heart surgeries that involve cardiopulmonary bypass. It is commonly used in procedures such as heart valve replacement and heart transplants to keep a donated heart safe. Cardioplegia is a treatment administered during heart surgeries to deliberately and temporarily stop the heart, helping to protect the heart muscle (myocardium).

Bioplegia Injection contains Magnesium chloride (an electrolyte), Potassium chloride (an electrolyte), and Procaine (a local anaesthetic). Magnesium Chloride and Potassium Chloride lower the heart's oxygen demand by calming its electrical activity, which prevents muscle damage during heart surgery. Procaine decreases the sensation of pain by blocking the transmission of nerve impulses.

A trained healthcare professional will administer Bioplegia Injection through an infusion during surgery; do not self-administer. Consult the doctor immediately if you experience unusual symptoms after surgery, such as nausea, muscle twitching, tremors, convulsions, or irregular/slow heartbeat.

Before receiving Bioplegia Injection, inform your doctor if you are allergic to any of its ingredients. Also, let your doctor know if you are taking any prescription or non-prescription medications, vitamins, and herbal supplements or have any pre-existing medical conditions to rule out any side effects or interactions. Please consult your doctor if you are pregnant or breastfeeding before receiving Bioplegia Injection.

Uses of Bioplegia Injection

Bioplegia Injection is used to induce cardioplegia during heart surgery. The detailed uses of Bioplegia Injection are as follows:<br/>• Induces Cardioplegia (Heart Arrest): Bioplegia Injection helps stop the heart from beating, allowing surgeons to perform delicate procedures and used in open-heart surgeries to protect the heart muscle.<br/>• Acts as a Local Anesthetic: Bioplegia Injection is used to reduce discomfort during medical procedures.<br/>• Maintains Electrolyte Balance: Bioplegia Injection is essential for nerve function and muscle contraction and helps restore electrolyte levels in patients undergoing surgery.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Bioplegia Injection will be administered by a healthcare professional in a medical setting.• Do not self-administer.

Medicinal Benefits

Bioplegia Injection is a cardioprotective medication used to induce cardioplegia (temporarily stop the heart) during heart surgeries that involve cardiopulmonary bypass. It is commonly used in procedures such as heart valve replacement and heart transplants to keep a donated heart safe. It contains Magnesium chloride, Potassium chloride, and Procaine. Potassium chloride works by increasing potassium levels, which causes the heart muscle to contract. This action triggers the release of calcium ions, temporarily pausing the activity of the heart. Magnesium chloride also works by reducing the heart’s contractions. Together, they lower the heart's oxygen demand by calming its electrical activity, which prevents muscle damage while the heart is temporarily stopped during surgery. Procaine works by blocking the transmission of nerve impulses, which helps decrease the sensation of pain.

How Bioplegia Injection Works

Bioplegia Injection contains a combination of three drugs: Magnesium chloride (an electrolyte), Potassium chloride (an electrolyte), and Procaine (a local anaesthetic). It works by stopping the heart from beating and minimising the energy requirements of the heart during surgery. It also helps prevent disturbances in heart rhythm straight after the surgery.

Storage

• Store in a cool and dry place away from sunlight.
• Keep it out of sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Bioplegia Injection

Bioplegia Injection is administered in a controlled medical setting by a healthcare professional, so an overdose is not likely to occur. If an overdose occurs, it will be treated quickly by your doctor. Signs of an overdose may include difficulty breathing (apnoea), reduced blood flow due to weakened heart function (circulatory depression), seizures (fits), and a reduced ability of the blood to carry oxygen (methaemoglobinaemia).

Drug Warnings

Before receiving Bioplegia Injection, inform your doctor if you are allergic to any of its ingredients. Also, let your doctor know if you are taking any prescription or non-prescription medications, vitamins, and herbal supplements or have any pre-existing medical conditions to rule out any side effects or interactions. It is not known whether Bioplegia Injection can harm an unborn baby during pregnancy or pass into breast milk during breastfeeding. Therefore, please consult your doctor if you are pregnant or breastfeeding before receiving Bioplegia Injection.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Bioplegia Injection 20ml:
Taking Meclizine and Bioplegia Injection 20ml (oral form) together can increase the potassium levels in blood.

How to manage the interaction:
Taking Meclizine with Bioplegia Injection 20ml is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Bioplegia Injection 20ml:
Taking Diphenhydramine with Bioplegia Injection 20ml can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Diphenhydramine with Bioplegia Injection 20ml is not recommended, as it can lead to an interaction, but it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, contact your doctor. Do not stop taking any medication without consulting your doctor.
How does the drug interact with Bioplegia Injection 20ml:
Taking Cyproheptadine with Bioplegia Injection 20ml can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Cyproheptadine with Bioplegia Injection 20ml is not recommended, as it can lead to an interaction, can be taken if your doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately. Do not stop any medication without talking to a doctor.
Potassium chloridePhenindamine
Critical
How does the drug interact with Bioplegia Injection 20ml:
Taking Phenindamine and Bioplegia Injection 20ml (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and other gastrointestinal injury.

How to manage the interaction:
Taking Phenindamine with Bioplegia Injection 20ml is not recommended, as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately.
How does the drug interact with Bioplegia Injection 20ml:
Taking Olanzapine with Bioplegia Injection 20ml can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Co-administration of Olanzapine and Bioplegia Injection 20ml is not recommended as it leads to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Bioplegia Injection 20ml:
Taking Dexchlorpheniramine and Bioplegia Injection 20ml can increase the risk of stomach inflammation.

How to manage the interaction:
Taking Dexchlorpheniramine with Bioplegia Injection 20ml (in tablet or capsule form) is avoided as it can lead to an interaction, it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, lightheadedness, vomiting, or dark stools, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Bioplegia Injection 20ml:
Co-administration of trihexyphenidyl with Bioplegia Injection 20ml can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking trihexyphenidyl with Bioplegia Injection 20ml is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, black stools contact a doctor immediately. Do not discontinue any medications without consulting to a doctor.
How does the drug interact with Bioplegia Injection 20ml:
The combination of Amitriptyline and Bioplegia Injection 20ml may cause stomach and upper intestinal discomfort. (Only applicable to an oral preparation)

How to manage the interaction:
Although co-administration of Amitriptyline and Bioplegia Injection 20ml is not recommended as it can possibly lead to an interaction, they can be taken if prescribed by a doctor. If you experience severe stomach pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (in particular with blood), decreased hunger, and black stools while taking these medications, consult a doctor immediately. Do not discontinue any medications without talking to a doctor.
Potassium chloridePropantheline
Critical
How does the drug interact with Bioplegia Injection 20ml:
Taking Propantheline with Bioplegia Injection 20ml can increase the chance of developing stomach ulcers.

How to manage the interaction:
Taking Propantheline with Bioplegia Injection 20ml is not recommended, as it can lead to an interaction, can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately.
How does the drug interact with Bioplegia Injection 20ml:
Taking Glycopyrrolate with Bioplegia Injection 20ml can increase the risk or severity of ulcers, bleeding, and other gastrointestinal injury.

How to manage the interaction:
Taking Glycopyrrolate with Bioplegia Injection 20ml together is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

MISCELLANEOUS
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Bioplegia Injection. Please consult your doctor before consuming alcohol.

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Pregnancy

Consult your doctor

There is no information available about the use of Bioplegia Injection during pregnancy. Please consult your doctor if you have any concerns regarding the use of Bioplegia Injection during pregnancy.

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Breast Feeding

Consult your doctor

It is not known if Bioplegia Injection passes into breastmilk. Please consult your doctor if you have any concerns regarding the use of Bioplegia Injection during breastfeeding.

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Driving

Caution

Avoid driving and operating machinery until your doctor confirms that it is safe to do so.

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Liver

Consult your doctor

Please consult your doctor before receiving Bioplegia Injection if you have liver problems.

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Kidney

Consult your doctor

Please consult your doctor before receiving Bioplegia Injection if you have kidney problems.

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Children

Consult your doctor

Limited information is available. Please consult your doctor if you have any concerns regarding the usage of Bioplegia Injection in children.

Have a query?

FAQs

Bioplegia Injection is a cardioprotective medication used to induce cardioplegia (temporarily stop the heart) during heart surgeries that involve cardiopulmonary bypass.

Bioplegia Injection works by stopping the heart from beating and minimizing the energy requirements of the heart during surgery. It also helps prevent disturbances in heart rhythm straight after the surgery.

Inform the doctor if you are taking any prescription or non-prescription medications, vitamins, and herbal supplements or have any pre-existing medical conditions before receiving Bioplegia Injection to rule out any side effects or interactions. Also, let your doctor know if you are pregnant or breastfeeding.

Bioplegia Injection should be stored below 25ºC, protected from light.

Country of origin

India

Manufacturer/Marketer address

FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044
Other Info - BIO0122

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