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compositionComposition:PALBOCICLIB-125MG
prescription
Prescription Medicine
info
Brespal 125 Capsule 21's
Brespal 125 Capsule is an anti-cancer medicine used in the treatment of certain types of breast cancer. This medicine contains palbociclid which works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Common side effects include weakness, loss of appetite, infections and dry skin.
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PALBOCICLIB-125MG

Manufacturer/Marketer :

Aureate Healthcare

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Brespal 125 Capsule

Brespal 125 Capsule belongs to the group of anti-cancer drugs used to treat certain types of breast cancer. Cancer is the uninhibited and uncontrolled growth of cells in the body. Breast cancer is cancer that forms in the cells of the breast. It can form in the lobules, ducts or tubules of the breast or in the breast tissue itself.

Brespal 125 Capsule contains Palbociclib that works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Brespal 125 Capsule is effective in controlling cancer cells from multiplying and is used in the treatment of breast cancer. 

Take Brespal 125 Capsule as prescribed. In some cases, Brespal 125 Capsule may cause certain common side effects such as weakness, loss of appetite, infections and dry skin. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist or worsen. 

It is advisable to inform the doctor if you are allergic to any of its components. Do not take Brespal 125 Capsule if you are pregnant or breastfeeding. Brespal 125 Capsule may cause tiredness, so drive only if you are alert. Brespal 125 Capsule is not recommended for use in children below 18years. Keep your doctor informed about your health condition and medications to rule out any interactions.

Uses of Brespal 125 Capsule

Brespal 125 Capsule is used in the treatment of Breast Cancer. The detailed use of Brespal 125 Capsule is as follows:

  • Advanced or metastatic breast cancer: Brespal 125 Capsule is used in the treatment of Advanced or metastatic breast cancer that is hormone receptor (HR)-positive and HER2-negative.

    • Key Benefits

    Brespal 125 Capsule is an anti-cancer drug used in the treatment of a particular type of breast cancer that is hormone receptor-positive and human epidermal growth factor receptor-2-negative. Brespal 125 Capsule works by blocking the production of proteins called cyclin-dependent kinase 4 and 6 that are responsible for cell growth and division. By blocking them, Brespal 125 Capsule nips cell growth in the bud and prevents cancer cells from spreading further. Thus, Brespal 125 Capsule helps treat breast cancer.

    Side effects of Brespal 125 Capsule
    Here are the steps to manage the medication-triggered Upper respiratory tract infection:
    • Inform your doctor about the symptoms you're experiencing due to medication.
    • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
    • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
    • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
    • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
    • Rest well; get enough sleep.
    • Eat a balanced diet and drink enough water.
    • Manage stress with yoga and meditation.
    • Limit alcohol and caffeine.
    • Physical activities like walking or jogging might help boost energy and make you feel less tired.

    Directions for Use

    • Brespal 125 Capsule can be taken with or without food. However, avoid taking it with grapefruit or grapefruit juice.
    • It is recommended to take Brespal 125 Capsule once daily or as prescribed by your doctor.
    • Swallow Brespal 125 Capsule as a whole with a glass of water.
    • Do not break, chew, or crush it.

    How Brespal 125 Capsule Works

    Brespal 125 Capsule contains Palbociclib that works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Brespal 125 Capsule is effective in controlling cancer cells from multiplying and is used in the treatment of breast cancer.
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    Alcohol

    Caution

    It is not recommended to use alcohol with Brespal 125 Capsule . Please consult your doctor if you have any concerns.

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    Pregnancy

    Unsafe

    Brespal 125 Capsule is not recommended for use in pregnancy. Please consult your doctor if you have any concerns.

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    Breast Feeding

    Unsafe

    Brespal 125 Capsule is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

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    Driving

    Caution

    Brespal 125 Capsule may cause tiredness and lethargy, which may affect your ability to drive. Do not drive if you experience any side effects after using Brespal 125 Capsule .

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    Liver

    Caution

    Exercise caution before using Brespal 125 Capsule in case of established liver disease. Please consult your doctor to address any concerns.

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    Kidney

    Caution

    Exercise caution before using Brespal 125 Capsule in case of established kidney disease. Please consult your doctor to address any concerns.

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    Children

    Unsafe

    Brespal 125 Capsule is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

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    Heart

    Caution

    Brespal 125 Capsule should be taken with caution in patients with heart problems. Therefore, please talk to your doctor before using Brespal 125 Capsule .

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    Geriatrics

    Consult your doctor

    Brespal 125 Capsule should be given to elderly patients only if prescribed by a doctor. Seek medical advice if you have any concerns.

    What if I have taken an overdose of Brespal 125 Capsule

    Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include nausea, vomiting, and neutropenia (low neutrophil levels). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

    Diet & Lifestyle Advise

    • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
    • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
    • Stay hydrated by drinking plenty of water as dehydration is often seen in cancers.
    • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
    • Avoid smoking and alcohol consumption.

    Health Queries

    Have a query?

    How Soon It Starts Working

    The time required for Brespal 125 Capsule to start to work: The time required for Brespal 125 Capsule to show its action is unknown. The time for which the effects of Brespal 125 Capsule last: The duration of action for Brespal 125 Capsule is clinically unknown.

    What if you forget to take Brespal 125 Capsule

    Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take a double dose to make up for your missed dose.

    Storage

    • Store in a cool and dry place away from sunlight. • Keep Brespal 125 Capsule out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

    Drug Warnings

    Do not take St. John's wort or grapefruit/grapefruit juice with Brespal 125 Capsule . It is advisable to inform the doctor if you are allergic to any of its components. Do not take Brespal 125 Capsule if you are pregnant or breastfeeding. Brespal 125 Capsule may cause tiredness, so drive only if you are alert. Brespal 125 Capsule is not recommended for use in children below 18years. If you experience any signs or symptoms of infections, inform your doctor. Keep your doctor informed about your health condition and medications to rule out any interactions. Consult your doctor immediately if you experience symptoms such as dry cough, chest pain, difficulty breathing or shortness of breath as it could be an indication of lung inflammation

    Drug-Drug Interactions

    verifiedApollotooltip

    Drug-DrugInteractions: Brespal 125 Capsule may interact antiviral/anti-HIV drug (lopinavir, ritonavir, nelfinavir, telaprevir, saquinavir), antidepressant (St John’s wort and nefazodone), antifungals (voriconazole, itraconazole, ketoconazole, posaconazole), antibiotics (clarithromycin, telithromycin) anti-rheumatoid drug (abatacept), heart medicine (quinidine), anti-gout medicine (colchicine), anaesthetics (alfentanyl and fentanyl), immunosuppressants (tacrolimus, cyclosporine), antipsychotics (pimozide) and anti-migraine drugs (dihydroergotamine, ergotamine).

    Drug-Food Interactions: Brespal 125 Capsule may interact with grapefruit and grapefruit juice.

    Drug-Disease Interactions: Brespal 125 Capsule should be used with caution in patients with a known hypersensitivity disorder, HIV, epilepsy, lactose intolerance, kidney disease, liver disease, lung or breathing disorders, hypertension, diabetes, heart disease, gout or a disease of the veins.

    PalbociclibKetoconazole
    Severe
    PalbociclibMorphine
    Severe

    Drug-Drug Interactions

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    PalbociclibKetoconazole
    Severe
    How does the drug interact with Brespal 125 Capsule:
    Coadministration of Ketoconazole and Brespal 125 Capsule may increase the blood level of Brespal 125 Capsule.

    How to manage the interaction:
    Although taking Ketoconazole and Brespal 125 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience nausea, vomiting, diarrhea, loss of appetite, mouth sores, hair loss, weakness, pain, numbness, or tingling in the hands and feet, more severely, consult a doctor. Without consulting a doctor, never stop taking any drugs.
    PalbociclibMorphine
    Severe
    How does the drug interact with Brespal 125 Capsule:
    Co-administration of Brespal 125 Capsule with Morphine may increase the blood levels and side effects of morphine.

    How to manage the interaction:
    Taking Morphine with Brespal 125 Capsule can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
    PalbociclibPosaconazole
    Severe
    How does the drug interact with Brespal 125 Capsule:
    When Brespal 125 Capsule is taken with Posaconazole can increase the blood levels of Brespal 125 Capsule.

    How to manage the interaction:
    Although there is an interaction between posaconazole and Brespal 125 Capsule, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, diarrhea, less desire to eat, mouth sores, hair loss, weakness, pain, numbness, or tingling in the hands and feet contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
    PalbociclibCladribine
    Severe
    How does the drug interact with Brespal 125 Capsule:
    Taking Cladribine with Brespal 125 Capsule can increase the risk of developing serious infections.

    How to manage the interaction:
    Taking Cladribine with Brespal 125 Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

    Drug-Food Interactions

    verifiedApollotooltip
    No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

    Drug-Food Interactions

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    All Substitutes & Brand Comparisons

    Habit Forming

    No

    Therapeutic Class

    [CHEMOTHERAPY]

    FAQs

    Brespal 125 Capsule belongs to the group of anti-cancer drugs used to treat certain types of breast cancer.
    Brespal 125 Capsule works blocking proteins responsible for cell growth and division, thereby arresting the progression of cancer cells.
    Do not stop taking Brespal 125 Capsule on your own. You are advised to take Brespal 125 Capsule for as long as your doctor has prescribed it for you depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Brespal 125 Capsule .
    A fibroadenoma is a benign state. Brespal 125 Capsule is indicated only in case of cancers. Please consult your doctor in case of any concerns.
    Brespal 125 Capsule can reduce fertility in men. Therefore, consider sperm preservation before starting Brespal 125 Capsule if you wish to father a child in the future. Effects on female fertility have not been established. Please consult your doctor before using Brespal 125 Capsule .
    Brespal 125 Capsule may reduce white blood cell count, thereby weakening the immune system. This might increase your risk of infections. If you notice any signs or symptoms of infections, consult your doctor.
    Brespal 125 Capsule is a type of targeted cancer drug. It is a treatment for breast cancer that is oestrogen receptor-positive (ER+) and human epidermal growth factor receptor-negative (HER2 -).
    The duration of taking Brespal 125 Capsule varies from person to person. You take it in cycles (21 days on, 7 days off.), and as long as it's working and manageable, you continue the treatment. Your healthcare team will monitor your progress and adjust the treatment plan as needed.
    Most side effects associated with Brespal 125 Capsule are temporary and can be effectively managed. However, certain side effects may persist or have a lasting impact in some cases. Common reversible side effects include fatigue, nausea, and hair loss, which typically resolve once treatment is stopped. In rare instances, more serious and potentially irreversible side effects may occur, such as permanent hair loss, increased infection risk, or heart problems. Regular monitoring and open communication with your healthcare team are essential to mitigate these risks and address any concerns that may arise during treatment.
    Yes, Brespal 125 Capsule treatment requires blood count monitoring. If neutropenia is mild in the first six cycles, monitor blood counts every 3 months afterwards. This monitoring schedule helps healthcare providers track potential changes in blood counts and adjust treatment accordingly.
    Take Brespal 125 Capsule exactly as your healthcare provider tells you. Swallow the capsule whole with water on an empty stomach at the same time each day. Follow the treatment schedule.
    While using Brespal 125 Capsule , birth control is necessary to prevent pregnancy. Female patients must take a pregnancy test before starting treatment and use birth control during treatment and for at least 3 weeks after the final dose. Male patients, along with their partners, should also use birth control during treatment and for 3 months after the final dose. It's crucial to inform your doctor if you're pregnant, plan to become pregnant, or plan to father a child so they can guide you on the appropriate measures to take.
    While women's fertility may not be affected, Brespal 125 Capsule can decrease fertility in men. Men taking palbociclib may want to talk to their treatment team about sperm preservation before starting treatment.
    In some cases, side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or seek emergency medical treatment: fever, chills, or signs of infection; difficulty breathing or shortness of breath; cough with or without mucus; chest pain; dizziness; fast, irregular, or pounding heartbeat; weakness; unusual bleeding or bruising; nosebleeds; or redness, pain, swelling, or blisters on the palms of your hands or soles of your feet, as well as skin blistering, peeling, or redness.

    Disclaimer

    While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

    Reference

    1. Electronic Medicines Compendium (EMC). Pil.4449 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
    2. National Center for Biotechnology Information (NCBI). Palbociclib Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026] Check here
    3. National Health Service (NHS). Fulvestrant Palbociclib - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
    4. National Health Service (NHS). Palbociclib Protocol Crp13 B033 V1.0 - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
    5. Palbociclib Palbociclib. 2015. [Accessed on 25 Jun. 2019] Check here
    6. Medicines and Healthcare products Regulatory Agency. (2023, July 26). IBRANCE 75 mg, 100 mg and 125 mg hard capsules - Summary of Product Characteristics (SmPC). Electronic Medicines Compendium Check here
    7. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 26 Mar. 2019]Check here

    Country of origin

    India

    Manufacturer/Marketer address

    S-40, 2Nd Floor, Janta Market, Rajouri Garden, New Delhi - 110 027. India
    Other Info - BRE0255

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