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compositionComposition:PALBOCICLIB-125MG
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Prescription Medicine
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Palnat 125 mg Capsule is an anti-cancer medicine used in the treatment of certain types of breast cancer. This medicine contains palbociclid which works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Common side effects include weakness, loss of appetite, infections and dry skin.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PALBOCICLIB-125MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Palnat 125 mg Capsule

Palnat 125 mg Capsule is an oral prescription medicine used to treat hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer. It works by blocking specific proteins that help cancer cells grow and divide, thereby slowing the progression of the disease. Palnat 125 mg Capsule is commonly used in combination with hormone therapy to help improve treatment outcomes and prolong disease control.

For Palnat 125 mg Capsule to work effectively, it must be taken exactly as prescribed and at the same time each day. Palnat 125 mg Capsule capsules should be taken with food, while the tablet formulation may be taken with or without food. Maintaining a balanced diet, staying physically active as tolerated, getting adequate rest, and attending all scheduled medical appointments can help support your overall health during treatment.

Common side effects of Palnat 125 mg Capsule include fatigue, nausea, mouth sores, hair thinning, and a decrease in white blood cells, which can increase the risk of infections. Contact your healthcare provider immediately if you develop a fever, chills, difficulty breathing, chest pain, unusual bleeding, or any signs of a serious infection. Your doctor will perform regular blood tests to monitor your blood cell counts throughout treatment.

Before starting Palnat 125 mg Capsule , tell your doctor if you have liver disease, kidney disease, or any history of lung problems. Do not take Palnat 125 mg Capsule if you are pregnant or allergic to Palnat 125 mg Capsule or any of its ingredients. Because Palnat 125 mg Capsule can harm an unborn baby, effective contraception should be used during treatment and for the period recommended by your doctor after stopping Palnat 125 mg Capsule .

Palnat 125 mg Capsule may interact with several medicines, including certain antibiotics, antifungals, anticonvulsants, and herbal products such as St. John's wort, which can affect how Palnat 125 mg Capsule works. Grapefruit and grapefruit juice should also be avoided, as they may increase Palnat 125 mg Capsule levels in the body. If you are breastfeeding, planning to become pregnant, or are an older adult, discuss the potential risks and benefits with your healthcare provider before starting treatment.

Uses of Palnat 125 mg Capsule

Palnat 125 mg Capsule is used in the treatment of breast cancer. The detailed uses of Palnat 125 mg Capsule are as follows:

  • HR-Positive, HER2-Negative Advanced Breast Cancer: Palnat 125 mg Capsule helps slow the growth and spread of hormone receptor-positive, HER2-negative breast cancer that is advanced or has spread to other parts of the body. It is typically used in combination with hormone therapy to improve treatment outcomes.

Key Benefits

Palnat 125 mg Capsule helps treat certain types of advanced or metastatic breast cancer by slowing the growth and spread of cancer cells. When used in combination with hormone therapy, it helps control the disease and supports improved treatment outcomes.

Benefits may include:

  • Helps slow the growth and spread of certain hormone receptor-positive (HR-positive), HER2-negative breast cancers.
  • Supports long-term disease control and helps delay cancer progression.
  • May increase the length of time patients live without their cancer worsening when used with hormone therapy.
  • Helps maintain quality of life by supporting better management of cancer-related symptoms.
  • Allows many patients to continue their daily activities during treatment.
  • Supports overall treatment goals as part of a comprehensive cancer care plan under specialist supervision.
Side effects of Palnat 125 mg Capsule
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Palnat 125 mg Capsule can be taken with or without food. However, avoid taking it with grapefruit or grapefruit juice.
  • It is recommended to take Palnat 125 mg Capsule once daily or as prescribed by your doctor.
  • Swallow Palnat 125 mg Capsule as a whole with a glass of water.
  • Do not break, chew, or crush it.

How Palnat 125 mg Capsule Works

Palnat 125 mg Capsule helps slow down or stop the growth of certain breast cancer cells by blocking the signals that tell them to grow and divide. By preventing cancer cells from multiplying, it helps control the progression of hormone receptor-positive, HER2-negative breast cancer and may help shrink tumors or delay their growth. It is commonly used in combination with hormone therapy to improve treatment outcomes and help patients live longer without their cancer worsening.
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Alcohol

Caution

It is not recommended to use alcohol with Palnat 125 mg Capsule . Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Palnat 125 mg Capsule is not recommended for use in pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Unsafe

Palnat 125 mg Capsule is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

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Driving

Caution

Palnat 125 mg Capsule may cause tiredness and lethargy, which may affect your ability to drive. Do not drive if you experience any side effects after using Palnat 125 mg Capsule .

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Liver

Caution

Exercise caution before using Palnat 125 mg Capsule in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Palnat 125 mg Capsule in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Unsafe

Palnat 125 mg Capsule is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

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Heart

Caution

Palnat 125 mg Capsule should be taken with caution in patients with heart problems. Therefore, please talk to your doctor before using Palnat 125 mg Capsule .

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Geriatrics

Consult your doctor

Palnat 125 mg Capsule should be given to elderly patients only if prescribed by a doctor. Seek medical advice if you have any concerns.

What if I have taken an overdose of Palnat 125 mg Capsule

If you accidentally take more than your prescribed dose, seek immediate emergency medical attention or contact a poison control center right away. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Avoid Grapefruit Products: Do not eat grapefruit or drink grapefruit juice while taking Palnat 125 mg Capsule , as it can significantly increase the levels of Palnat 125 mg Capsule in your blood, raising your risk of severe side effects.
  • Prioritize Infection Prevention: Because Palnat 125 mg Capsule can lower your white blood cell count, wash your hands frequently, avoid close contact with people who are sick, and ensure all food is thoroughly washed and cooked.
  • Stay Well-Hydrated: Drink plenty of fluids, especially water, throughout the day to help manage mild diarrhea and support kidney function.
  • Eat Small, Frequent Meals: If you experience nausea or a loss of appetite, eating smaller portions of bland foods throughout the day can help you maintain your strength.
  • Engage in Gentle Exercise: Light physical activity, such as a daily short walk, can help combatcancer-related fatigue without overexerting your body.
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Have a query?

How Soon It Starts Working

The time required for Palnat 125 mg Capsule to start to work: The time required for Palnat 125 mg Capsule to show its action is unknown. The time for which the effects of Palnat 125 mg Capsule last: The duration of action for Palnat 125 mg Capsule is clinically unknown.

What if you forget to take Palnat 125 mg Capsule

If you miss a dose or vomit after taking your dose, do not take an extra dose to make up for it. Skip the missed dose entirely and take your next scheduled dose at your regular time. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

• Store Palnat 125 mg Capsule at room temperature, safely between 68°F to 77°F (20°C to 25°C).

Drug Warnings

  • Check Your Medication: Before taking your dose, inspect each capsule or tablet. If they are broken, leaking, or look damaged, do not take them and contact your pharmacy.
  • Monitor Your Temperature: Always keep a working digital thermometer at home. Since your body's ability to fight infections is reduced, checking your temperature immediately when you feel unwell is a critical safety step.
  • Get Regular Blood Tests: You will need frequent blood tests before starting and during your treatment cycles to check your blood cell counts. Always keep these scheduled appointments.
  • Inform All Healthcare Providers: Let every doctor, dentist, or specialist you visit know that you are taking Palnat 125 mg Capsule , especially before any planned surgeries or dental procedures.
  • Use Effective Birth Control: Both men and women taking this medication must use highly effective birth control during treatment and for several months after the final dose to prevent pregnancy.

Drug-Drug Interactions

verifiedApollotooltip
  • Antifungal Medicines (e.g., ketoconazole): These medicines are strong CYP3A inhibitors and may increase the amount of Palnat 125 mg Capsule in the body, raising the risk of side effects.
  • Macrolide Antibiotics (e.g., clarithromycin): These medicines are strong CYP3A inhibitors and may increase the amount of Palnat 125 mg Capsule in the body, raising the risk of side effects.
  • Antibiotic Medicines (e.g., rifampin): These medicines are strong CYP3A inducers and may reduce the effectiveness of Palnat 125 mg Capsule by increasing its breakdown in the body.
  • Antiepileptic Medicines (e.g., phenytoin): These medicines are strong CYP3A inducers and may reduce the effectiveness of Palnat 125 mg Capsule by increasing its breakdown in the body.
PalbociclibCladribine
Severe
PalbociclibKetoconazole
Severe

Drug-Drug Interactions

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PalbociclibCladribine
Severe
How does the drug interact with Palnat 125 mg Capsule:
Taking Cladribine with Palnat 125 mg Capsule can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Palnat 125 mg Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
PalbociclibKetoconazole
Severe
How does the drug interact with Palnat 125 mg Capsule:
Coadministration of Ketoconazole and Palnat 125 mg Capsule may increase the blood level of Palnat 125 mg Capsule.

How to manage the interaction:
Although taking Ketoconazole and Palnat 125 mg Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience nausea, vomiting, diarrhea, loss of appetite, mouth sores, hair loss, weakness, pain, numbness, or tingling in the hands and feet, more severely, consult a doctor. Without consulting a doctor, never stop taking any drugs.
PalbociclibPosaconazole
Severe
How does the drug interact with Palnat 125 mg Capsule:
When Palnat 125 mg Capsule is taken with Posaconazole can increase the blood levels of Palnat 125 mg Capsule.

How to manage the interaction:
Although there is an interaction between posaconazole and Palnat 125 mg Capsule, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, diarrhea, less desire to eat, mouth sores, hair loss, weakness, pain, numbness, or tingling in the hands and feet contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PalbociclibMorphine
Severe
How does the drug interact with Palnat 125 mg Capsule:
Co-administration of Palnat 125 mg Capsule with Morphine may increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking Morphine with Palnat 125 mg Capsule can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit, grapefruit juice, and Seville oranges: Avoid consuming these while taking Palnat 125 mg Capsule , as they may increase the amount of Palnat 125 mg Capsule in your bloodstream and raise the risk of side effects. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Palnat 125 mg Capsule belongs to the group of anti-cancer drugs used to treat certain types of breast cancer.
Palnat 125 mg Capsule works blocking proteins responsible for cell growth and division, thereby arresting the progression of cancer cells.
Do not stop taking Palnat 125 mg Capsule on your own. You are advised to take Palnat 125 mg Capsule for as long as your doctor has prescribed it for you depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Palnat 125 mg Capsule .
A fibroadenoma is a benign state. Palnat 125 mg Capsule is indicated only in case of cancers. Please consult your doctor in case of any concerns.
Palnat 125 mg Capsule may reduce fertility in men. Men who wish to father children in the future should discuss sperm preservation before starting treatment. The effects on female fertility are not fully established. Talk to your doctor if fertility preservation is important to you before beginning treatment.
Palnat 125 mg Capsule may reduce white blood cell count, thereby weakening the immune system. This might increase your risk of infections. If you notice any signs or symptoms of infections, consult your doctor.
Palnat 125 mg Capsule is a type of targeted cancer drug. It is a treatment for breast cancer that is oestrogen receptor-positive (ER+) and human epidermal growth factor receptor-negative (HER2 -).
Most side effects associated with Palnat 125 mg Capsule are temporary and can be effectively managed. However, certain side effects may persist or have a lasting impact in some cases. Common reversible side effects include fatigue, nausea, and hair loss, which typically resolve once treatment is stopped. In rare instances, more serious and potentially irreversible side effects may occur, such as permanent hair loss, increased infection risk, or heart problems. Regular monitoring and open communication with your healthcare team are essential to mitigate these risks and address any concerns that may arise during treatment.
Whether you should take Palnat 125 mg Capsule with food depends on the formulation you have been prescribed. Follow your doctor's instructions and the directions on your prescription label. If you are unsure, ask your pharmacist or healthcare provider before taking your dose.
In some cases, side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or seek emergency medical treatment: fever, chills, or signs of infection; difficulty breathing or shortness of breath; cough with or without mucus; chest pain; dizziness; fast, irregular, or pounding heartbeat; weakness; unusual bleeding or bruising; nosebleeds; or redness, pain, swelling, or blisters on the palms of your hands or soles of your feet, as well as skin blistering, peeling, or redness.
No. Do not take Palnat 125 mg Capsule if you are pregnant or breastfeeding because it can seriously harm an unborn baby. Women of childbearing potential should have a pregnancy test before starting treatment and use effective birth control during treatment and for at least 3 weeks after the last dose. Men with female partners should use effective birth control during treatment and for at least 3 months after the last dose. Tell your doctor if you are pregnant, planning a pregnancy, or planning to father a child.
Yes. Regular blood tests are required because Palnat 125 mg Capsule can lower your white blood cell count, increasing your risk of infection. Your healthcare provider will monitor your blood counts closely, especially during the first six treatment cycles, and then at regular intervals (often every 3 months if counts remain stable) to determine whether your treatment needs to be adjusted or temporarily stopped.
It is highly recommended to avoid or severely limit alcohol while taking Palnat 125 mg Capsule . Alcohol can worsen common side effects like fatigue, dizziness, and nausea, and it can also place extra strain on your liver. Talk to your doctor or pharmacist about what is safe for you.
If you develop a fever of 100.4°F (38°C) or higher, call your doctor or seek emergency medical care immediately. A fever can be a sign of a low white blood cell count and a serious, potentially life-threatening infection. Do not take fever-reducing medications without contacting your healthcare provider first.
Yes, hair thinning or mild hair loss is a recognized side effect of Palnat 125 mg Capsule , although it does not typically cause complete baldness. This is usually temporary, and hair often grows back after the treatment is completed. Talk to your doctor if this is causing you distress.
You should consult your doctor before taking any over-the-counter pain relievers or anti-inflammatory drugs. Some pain relievers can interact with your treatment or mask symptoms of an infection, such as a fever. Talk to your doctor or pharmacist for a safe recommendation.
You will usually take Palnat 125 mg Capsule in repeated treatment cycles (typically 21 days on treatment followed by 7 days off) for as long as it continues to control your cancer and the side effects remain manageable. Your doctor will monitor your response with regular blood tests and scans and adjust treatment as needed.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.4449 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Center for Biotechnology Information (NCBI). Palbociclib Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Fulvestrant Palbociclib - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Palbociclib Protocol Crp13 B033 V1.0 - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Palbociclib Palbociclib. 2015. [Accessed on 25 Jun. 2019]Check here
  6. Medicines and Healthcare products Regulatory Agency. (2023, July 26). IBRANCE 75 mg, 100 mg and 125 mg hard capsules - Summary of Product Characteristics (SmPC). Electronic Medicines CompendiumCheck here
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 26 Mar. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - PAL0234
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