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Bupain 400mg/325mg/250mg Tablet MR
Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CHLORZOXAZONE-250MG+IBUPROFEN-400MG+PARACETAMOL-325MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Bupain 400mg/325mg/250mg Tablet MR

Bupain 400mg/325mg/250mg Tablet MR is a prescription medicine used to relieve pain, inflammation, and muscle stiffness associated with painful muscle spasms. It combines a muscle relaxant with pain-relieving medicines to help reduce discomfort and improve mobility. This medicine is commonly prescribed for conditions such as back pain, neck pain, muscle strains, sprains, sports injuries, and other musculoskeletal disorders.

Take Bupain 400mg/325mg/250mg Tablet MR exactly as prescribed by your doctor. It is usually taken with food or milk to reduce the risk of stomach irritation. Depending on your condition, your doctor may recommend taking it several times a day for a short period. Gentle stretching exercises, adequate hydration, and appropriate rest may help support recovery while using this medicine.

Some people may experience mild side effects such as drowsiness, dizziness, nausea, or stomach discomfort. These effects are usually temporary and improve as the body adjusts to the medicine. Contact your doctor immediately if you develop severe stomach pain, black stools, yellowing of the skin or eyes, difficulty breathing, or signs of an allergic reaction. This medicine may not be suitable for people with severe liver disease, active gastrointestinal bleeding, severe heart failure, significant kidney impairment, known NSAID allergy, or previous NSAID-related asthma reactions. 

Because this medicine contains ibuprofen, an NSAID, it may increase the risk of serious cardiovascular events such as heart attack or stroke, particularly with higher doses or prolonged use. NSAIDs can also increase the risk of stomach ulcers and gastrointestinal bleeding. 

Before taking Bupain 400mg/325mg/250mg Tablet MR, inform your doctor if you have a history of stomach ulcers, gastrointestinal bleeding, liver disease, kidney disease, asthma, heart disease, or high blood pressure. This medicine may not be suitable for people with severe liver impairment, active stomach bleeding, severe heart failure, or known allergies to chlorzoxazone, ibuprofen, paracetamol, or other NSAIDs.

Avoid excessive alcohol consumption while taking this medicine, as alcohol may increase the risk of stomach bleeding, liver problems, and excessive drowsiness. Tell your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are older than 65 years, so they can determine whether this medicine is appropriate for you.

Uses of Bupain 400mg/325mg/250mg Tablet MR

Bupain 400mg/325mg/250mg Tablet MR is used to relieve pain, inflammation, and muscle spasms. The detailed uses of Bupain 400mg/325mg/250mg Tablet MR are as follows:

  • Painful Muscle Spasms: Helps relax tight muscles and reduce pain associated with muscle spasms.
  • Back and Neck Pain: Helps relieve pain, stiffness, and inflammation affecting the muscles and surrounding tissues.
  • Muscle Strains and Sprains: Helps reduce swelling, tenderness, and discomfort caused by muscle or ligament injuries.
  • Joint and Musculoskeletal Pain: Provides relief from pain associated with minor injuries and physical strain.
  • Sports Injuries: Helps improve comfort and mobility during recovery from acute musculoskeletal injuries.

Key Benefits

Bupain 400mg/325mg/250mg Tablet MR provides reliable, daily support to help you manage your health. This medicine brings several key health benefits:

  • Relieves Muscle Spasms: Helps relax tight and painful muscles, improving comfort and movement.
  • Reduces Pain and Inflammation: Helps decrease swelling and pain associated with musculoskeletal injuries and inflammation.
  • Improves Mobility: By reducing stiffness and discomfort, the medicine may help restore normal physical function.
  • Supports Recovery: Relief from pain and muscle spasms may help you participate more comfortably in rehabilitation exercises and daily activities.
     
Side effects of Bupain 400mg/325mg/250mg Tablet MR
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Eosinophil levels can be lowered by eating fruits and vegetables, avoiding smoking, and consuming alcohol in moderation.
  • Several foods, such as ginger, garlic, pepper, turmeric, and honey, might boost immunity.
  • Avoid dairy products, including cheese, yoghurt, and milk.
  • Drink water and keep yourself hydrated.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Low levels of protein in the blood could be due to underlying kidney or liver disease, malnutrition or any medication.
  • Intake of healthy and nutritious food that can enhance your blood protein level can be helpful.
  • Regularly practising yoga or meditation can improve your health and absorption of nutrients.
  • Avoid hair loss by taking protein that can improve hair growth.
  • Establish a consistent sleep schedule.
  • Limit or avoid alcohol and recreational substances.

Directions for Use

To get the full benefit of Bupain 400mg/325mg/250mg Tablet MR and minimise side effects, follow these simple guidelines:

  • Take the tablet orally with a full glass of water.
  • Swallow the tablet whole. Do not crush, chew, or break the tablet unless advised by your doctor.
  • Take medicine with food or milk to reduce stomach irritation.
  • Avoid taking more than the prescribed dose.
  • Follow your doctor's instructions regarding how often and how long to take the medicine.

How Bupain 400mg/325mg/250mg Tablet MR Works

Bupain 400mg/325mg/250mg Tablet MR contains chlorzoxazone, ibuprofen, and paracetamol, which work together to relieve pain and muscle stiffness. Relaxes Muscles: Chlorzoxazone acts on the central nervous system to help reduce muscle spasms and muscle tightness. Reduces Inflammation: Ibuprofen blocks cyclooxygenase (COX) enzymes (chemicals in the body that trigger pain and swelling), reducing the production of prostaglandins that contribute to pain, swelling, and inflammation. Relieves Pain: Paracetamol is believed to act mainly through central pain pathways to reduce pain perception. Its exact mechanism is not fully understood and may involve effects on central COX pathways, endocannabinoid pathways, and other pain-modulating mechanisms. Together, these actions help relieve painful muscle conditions and improve mobility.
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Alcohol

Caution

Taking Bupain 400mg/325mg/250mg Tablet MR with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit intake of alcoholic beverages with Bupain 400mg/325mg/250mg Tablet MR.

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Pregnancy

Unsafe

Use of Bupain 400mg/325mg/250mg Tablet MR during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby.

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Breast Feeding

Caution

Take Bupain 400mg/325mg/250mg Tablet MR only if prescribed by your doctor.

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Driving

Unsafe

After taking Bupain 400mg/325mg/250mg Tablet MR you may notice dizziness, sleepiness, drowsiness or fatigue as it contain paracetamol which causes sedation. So, in this you should stop taking Bupain 400mg/325mg/250mg Tablet MR and contact your doctor.

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Liver

Caution

Bupain 400mg/325mg/250mg Tablet MR to be taken with caution, especially if you have a history of liver disease. Dose may have to be adjusted by your doctor.

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Kidney

Caution

Bupain 400mg/325mg/250mg Tablet MR to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

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Children

Caution

Bupain 400mg/325mg/250mg Tablet MR is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated. It should be use only when prescribed by a child specialist.

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Heart

Unsafe

Bupain 400mg/325mg/250mg Tablet MR should be avoided in cardiac patients as it can lead to serious cardiavascular risks

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Geriatrics

Caution

Bupain 400mg/325mg/250mg Tablet MR should be used under caution in geriatric patients as it can lead to serious side effects/

What if I have taken an overdose of Bupain 400mg/325mg/250mg Tablet MR

Do not take more than the prescribed dose of Bupain 400mg/325mg/250mg Tablet MR as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Stay Well Hydrated: Drinking adequate fluids may help support muscle function and overall recovery.
  • Practice Gentle Stretching: Light stretching exercises may help reduce muscle stiffness and improve flexibility once acute pain begins to improve.
  • Get Adequate Rest: Allowing your body time to recover can help reduce muscle strain and support healing.
  • Apply Heat or Cold Therapy: Warm compresses may help relax tight muscles, while cold packs may help reduce swelling after injuries.
  • Maintain Good Nutrition: A balanced diet rich in fruits, vegetables, and essential minerals supports muscle health and recovery.
    Avoid Excessive Physical Strain: Limit heavy lifting and strenuous activity until your symptoms improve.

Have a query?

How Soon It Starts Working

The time required for Bupain 400mg/325mg/250mg Tablet MR to start to work: Bupain 400mg/325mg/250mg Tablet MR ideally shows its action within few hours after administration. The time for which the effects of Bupain 400mg/325mg/250mg Tablet MR last: The duration of action for Bupain 400mg/325mg/250mg Tablet MR is unknown.

What if you forget to take Bupain 400mg/325mg/250mg Tablet MR

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

•Store Bupain 400mg/325mg/250mg Tablet MR at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Avoid Driving Until You Know How It Affects You: This medicine may cause drowsiness or dizziness in some people.
  • Avoid Excessive Alcohol Consumption: Alcohol may increase the risk of liver problems, stomach bleeding, and excessive sedation.
  • Check Other Medicines Carefully: Many pain, cold, and flu medicines may contain paracetamol or NSAIDs. Avoid accidental duplication of ingredients.
  • Watch for Signs of Stomach Bleeding: Seek medical attention if you notice black stools, vomiting blood, or severe stomach pain.
  • Use Only as Prescribed: Long-term or excessive use may increase the risk of serious side effects.
    Chlorzoxazone has been associated with rare but serious liver injury. Contact your doctor immediately if you develop unusual tiredness, loss of appetite, yellowing of the skin or eyes, dark urine, or other signs of liver problems.
    Do not exceed the recommended daily limits of the individual ingredients. In adults, the maximum daily amount of paracetamol from all sources is generally 4,000 mg per day, while ibuprofen doses should not exceed the maximum recommended by your doctor. Avoid taking other medicines containing paracetamol or NSAIDs unless advised. 
     

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Bupain 400mg/325mg/250mg Tablet MR:

  • Blood Thinners: Medicines such as warfarin may increase the risk of bleeding.
  • Other NSAIDs: Medicines such as aspirin, naproxen, or diclofenac may increase the risk of stomach ulcers and bleeding.
  • Sedatives or Sleeping Tablets: These medicines may increase drowsiness and dizziness.
  • Certain Blood Pressure Medicines: Kidney function and blood pressure control may require monitoring.
  • Other Paracetamol-Containing Medicines: Concurrent use may increase the risk of overdose and liver toxicity.

SSRIs/SNRIs (Medicines used for depression, anxiety, or similar conditions for broader patient recognition): Medicines used for depression, such as SSRIs or SNRIs, may increase the risk of gastrointestinal bleeding when combined with ibuprofen.

  • Corticosteroids: Medicines such as prednisolone may increase the risk of stomach ulcers and bleeding when taken with ibuprofen.
  • Methotrexate: Ibuprofen may increase methotrexate levels and toxicity risk; medical supervision is required when used together.
  • Lithium: NSAIDs such as ibuprofen may increase lithium levels and require monitoring.


Drug-Food Interactions

  • Alcohol: Excessive alcohol consumption may increase the risk of liver damage, stomach bleeding, and excessive drowsiness.
     

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Bupain 400mg/325mg/250mg Tablet MR, as it may worsen your condition or require additional monitoring:

  • Liver Disease: May increase the risk of liver-related side effects.
  • Kidney Disease: May increase the risk of kidney complications.
  • Active Stomach Ulcers or Gastrointestinal Bleeding: Ibuprofen may worsen these conditions.
  • Heart Failure or Severe Cardiovascular Disease: NSAIDs may increase fluid retention in some individuals.
  • Asthma: Some people may experience worsening asthma symptoms after taking NSAIDs.
Ibuprofen + Paracetamol + ChlorzoxazoneKetorolac
Critical
Ibuprofen + Paracetamol + ChlorzoxazoneMeloxicam
Critical

Drug-Drug Interactions

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Ibuprofen + Paracetamol + ChlorzoxazoneKetorolac
Critical
How does the drug interact with Bupain 400mg/325mg/250mg Tablet MR:
Combining Bupain 400mg/325mg/250mg Tablet MR with ketorolac can increase the risk of such as inflammation(redness and swelling) bleeding and ulceration in the stomach.

How to manage the interaction:
Taking Bupain 400mg/325mg/250mg Tablet MR together with ketorolac is not recommended as it can lead to an interaction, it can be taken if advised by a doctor. However, if you experience dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Ibuprofen + Paracetamol + ChlorzoxazoneMeloxicam
Critical
How does the drug interact with Bupain 400mg/325mg/250mg Tablet MR:
Combining Bupain 400mg/325mg/250mg Tablet MR and Meloxicam can increase the risk of such as inflammation(redness and swelling) bleeding and ulceration in the stomach.

How to manage the interaction:
Taking Bupain 400mg/325mg/250mg Tablet MR together with Meloxicam is not recommended as it can lead to an interaction, it can be taken if advised by a doctor. However, if you experience dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANALGESICS]

FAQs

Bupain 400mg/325mg/250mg Tablet MR is used to relieve musculoskeletal pain and muscle spasms due to tissue injury. It may also be indicated in post-surgery inflammation and oedema (swollen tissue with fluid).

Bupain 400mg/325mg/250mg Tablet MR when taken by patients who are allergic to pain-killers or NSAIDs can be harmful. It should also be avoided in person with history of heart failure, kidney or liver disease, stomach ulcers and high blood pressure.

Yes. But ensure pain killers or any other drugs you are taking does not contain paracetamol, aceclofenac or chlorzoxazone. As, it may lead to overdosage leading to unpleasant side effects.

It depends on whether your cough and cold pills contain ibuprofen, chlorzoxazone and paracetamol or not. If it contains these two medicines, do not take it. It may lead to overdosage, thereby producing unpleasant side effects. Consult your doctor before taking it in such cases.

Bupain 400mg/325mg/250mg Tablet MR is known to be contra-indicated in patients allergic to painkillers (NSAIDs) or any of the components or excipients of this medicine. Its use should also be avoided in patients with history of heart failure, high blood pressure, stomach ulcer and kidney/liver disease.

Bupain 400mg/325mg/250mg Tablet MR is generally used for short term and can be stopped when the pain reduces. However, Bupain 400mg/325mg/250mg Tablet MR should be continued if the doctor has advised to do so.

Yes, the use of Bupain 400mg/325mg/250mg Tablet MR can cause nausea and vomiting as a side effect. Taking it with milk, food or with antacids can prevent nausea. In case of vomiting, drink plenty of water or other fluids by taking small, frequent sips and avoid taking fatty or fried foods along with Bupain 400mg/325mg/250mg Tablet MR. Consult your doctor if vomiting persists.

After taking Bupain 400mg/325mg/250mg Tablet MR, you may notice dizziness as a side effect. If you feel dizzy or lightheaded, it is better to rest for some time and resume once you feel better.

Yes, Bupain 400mg/325mg/250mg Tablet MR can be taken with Vitamin B-complex supplement. However, consult your doctor before taking Bupain 400mg/325mg/250mg Tablet MR with other supplements or medicines to avoid potential interactions.

No, use of Bupain 400mg/325mg/250mg Tablet MR doesn’t causes addiction. However, follow the dose and duration as prescribed by your doctor to avoid any potential misuse or overuse.

Yes, the long-term use of Bupain 400mg/325mg/250mg Tablet MR can cause damage to the kidneys. Use of Bupain 400mg/325mg/250mg Tablet MR lowers the levels of prostaglandins in the body leading to kidney damage on long-term use. It is not advised to take painkillers for patients with underlying renal (kidney) illness. Therefore consult your doctor, before taking Bupain 400mg/325mg/250mg Tablet MR.

No, taking Bupain 400mg/325mg/250mg Tablet MR in higher doses than prescribed is not more effective and can be dangerous which can lead to increased side effects. Therefore, use Bupain 400mg/325mg/250mg Tablet MR as prescribed by your doctor.

Store Bupain 400mg/325mg/250mg Tablet MR in a cool and dry place at room temperature. Keep Bupain 400mg/325mg/250mg Tablet MR out of the reach of children and pets.

The common side effects of Bupain 400mg/325mg/250mg Tablet MR are nausea, indigestion, diarrhoea, drowsiness, dizziness, heartburn, stomach pain and restlessness. If these side effects persist or worsen, please consult your doctor.

It is best to avoid or limit alcohol consumption while taking this medicine. Alcohol may increase the risk of stomach bleeding, liver problems, and excessive drowsiness. Talk to your doctor or pharmacist if you have concerns.

Many people may begin to notice pain relief within 30 to 60 minutes after taking this medicine; however, the onset can vary depending on individual response, severity of symptoms, and whether it is taken with food.

Taking this medicine with food or milk may help reduce the risk of stomach irritation and indigestion. Talk to your doctor or pharmacist if stomach discomfort persists.

Drowsiness can occur because the medicine contains a muscle relaxant. Avoid driving or operating machinery if you feel sleepy, dizzy, or less alert than usual.

Some pain medicines may contain similar ingredients or interact with this medicine. Always consult your doctor or pharmacist before combining medications.

This medicine should not be used during the third trimester of pregnancy because ibuprofen may increase the risk of premature closure of the fetal ductus arteriosus (a blood vessel in the unborn baby's heart that needs to stay open during pregnancy) and other pregnancy complications. If you are pregnant or planning a pregnancy, consult your doctor before using this medicine, especially during the first and second trimesters.

This medicine is generally intended for short-term treatment of painful muscle conditions. Prolonged or unnecessary use may increase the risk of stomach bleeding, kidney problems, cardiovascular complications related to NSAIDs, and liver injury.

If you miss a dose, take it when you remember unless it is almost time for your next scheduled dose. Do not take two doses together to make up for a missed dose. Talk to your doctor or pharmacist if you are unsure.

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Country of origin

India
Other Info - BU73086
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