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  3. Bupicain-0.5% Injection 20 ml

Bupicain-0.5% Injection 20 ml, Pack of 1 INJECTION
Bupicain-0.5% Injection 20 ml, Pack of 1 INJECTION
Bupicain-0.5% Injection 20 ml, Pack of 1 INJECTION
Bupicain-0.5% Injection 20 ml, Pack of 1 INJECTION
Not for online sale
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Bupicain-0.5% Injection is used to reduce pain and discomfort during labour, surgery, dental treatment and other medical procedures. It contains Bupivacaine which works by blocking the transmission of pain signals and numbing the area. In some cases, this medicine may cause side effects such as weakness, numbness or tingling, restlessness, drowsiness, headache, nausea and vomiting. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Synonym :

BUPIVACAINE HYDROCHLORIDE

Composition :

BUPIVACAINE-5MG

Manufacturer/Marketer :

Themis Pharmaceutical Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Bupicain-0.5% Injection

Bupicain-0.5% Injection belongs to the class of 'local anaesthetics', primarily used to reduce pain and discomfort during labour, surgery, dental treatment and other medical procedures. It produces local numbness and relieves pain. Bupicain-0.5% Injection is given in the form of an epidural injection at the spinal cord to prevent pain during labour and Caesarean section. Pain is a symptom triggered by the nervous system, which causes uncomfortable sensations in the body. Pain may be dull or sharp, it might be constant or intermittent. The tolerance level of pain might vary from person to person.

Bupicain-0.5% Injection contains 'Bupivacaine' that belongs to the group of medicines called 'amide-type anaesthetics'. Bupivacaine is a numbing medication that blocks the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation and promotes temperature, touch, deep pressure and muscle control. Thus Bupicain-0.5% Injection helps in numbing the area and provides relief from pain.

Your doctor will decide the dose and duration based on the severity of your pain and response to treatment. Common side effects of Bupicain-0.5% Injection include weakness, numbness or tingling, restlessness, drowsiness, tremors or shakiness, headache, blurred vision, irregular heartbeat, chills or shivering, back pain, nausea and vomiting. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Inform your doctor if you have liver, kidney or heart diseases, high or low blood pressure, excess fat in the body and breathing problems before starting Bupicain-0.5% Injection. It is essential to let your doctor know if you are pregnant, planning to conceive or a breastfeeding mother before using Bupicain-0.5% Injection. Bupicain-0.5% Injection causes drowsiness, so do not drive until you are mentally alert. Avoid alcohol to further prevent the worsening of side effects like drowsiness. Bupicain-0.5% Injection is not recommended for children less than one year of age.

Uses of Bupicain-0.5% Injection

Treatment of Temporary pain relief.

Directions for Use

Bupicain-0.5% Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Bupicain-0.5% Injection contains 'Bupivacaine,' a local anaesthetic used to relieve pain and discomfort during labour, surgery, dental treatment and other medical procedures. It works by blocking the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation and promotes temperature, touch, deep pressure and muscle control. Thus Bupicain-0.5% Injection helps in numbing the localized area and provides relief from pain. Bupicain-0.5% Injection, when injected as an epidural injection at the spinal cord, it prevents pain during labour and Caesarean section.

How Bupicain-0.5% Injection Works

Bupicain-0.5% Injection contains 'Bupivacaine' that belongs to the group of medicines called 'amide-type anaesthetics'. Bupivacaine is a numbing medication that blocks the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation and promotes temperature, touch, deep pressure and muscle control. Thus Bupicain-0.5% Injection helps in numbing the area and provides relief from pain.

Storage

Store in a cool and dry place away from sunlight
Side effects of Bupicain-0.5% Injection 20 ml
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Bupicain-0.5% Injection

Since Bupicain-0.5% Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

Brief your medical history to the doctor if you have any liver, kidney or heart diseases, high or low blood pressure, excess fat in the body, breathing problems, excess fluid in womb during pregnancy (a condition called hydramnios), a tumour of the ovary, blood poisoning (septicaemia) and fluid around lungs before starting Bupicain-0.5% Injection. Let your doctor know if you use any prescription and non-prescription medications, including vitamins and herbal supplements, before starting Bupicain-0.5% Injection. Bupicain-0.5% Injection may affect the foetus when used by a pregnant mother. It is also released into breast milk during breastfeeding. Please consult your doctor know if you are pregnant, planning to conceive or a breastfeeding mother. Bupicain-0.5% Injection causes dizziness and drowsiness, so do not drive until you are mentally alert. Avoid alcohol to prevent the worsening of side effects further. Bupicain-0.5% Injection is not recommended in children younger than one year of age.

Drug-Drug Interactions

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BupivacaineQuinine
Severe
BupivacaineTrimethoprim
Severe

Drug-Drug Interactions

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BupivacaineQuinine
Severe
How does the drug interact with Bupicain-0.5% Injection 20 ml:
Taking Bupicain-0.5% Injection 20 ml and Quinine may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Bupicain-0.5% Injection 20 ml and quinine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineTrimethoprim
Severe
How does the drug interact with Bupicain-0.5% Injection 20 ml:
Taking Bupicain-0.5% Injection 20 ml and Trimethoprim may cause methemoglobinemia, (blood disorder that affects how red blood cells deliver oxygen throughout the body).

How to manage the interaction:
Although there is an interaction between Bupicain-0.5% Injection 20 ml and trimethoprim, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, headache, dizziness, lightheadedness, fatigue, or shortness of breath. Do not discontinue any medications without consulting a doctor.
BupivacaineAmyl nitrite
Severe
How does the drug interact with Bupicain-0.5% Injection 20 ml:
Combining Bupicain-0.5% Injection 20 ml with Amyl nitrite can increase the risk of methemoglobinemia( a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood.)

How to manage the interaction:
Taking Bupicain-0.5% Injection 20 ml with Amyl nitrite together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, call a doctor right away. Do not stop using any medications without a doctor's advice.
BupivacaineNitrofurantoin
Severe
How does the drug interact with Bupicain-0.5% Injection 20 ml:
Taking Bupicain-0.5% Injection 20 ml and Nitrofurantoin may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Taking Bupicain-0.5% Injection 20 ml and nitrofurantoin together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineRasburicase
Severe
How does the drug interact with Bupicain-0.5% Injection 20 ml:
Taking Bupicain-0.5% Injection 20 ml with rasburicase can increase the risk of methemoglobinemia(blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Bupicain-0.5% Injection 20 ml with Rasburicase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineLevobupivacaine
Severe
How does the drug interact with Bupicain-0.5% Injection 20 ml:
C0administration of Bupicain-0.5% Injection 20 ml with levobupivacaine can have additive toxic effects, so using them together increases the risk of serious side effects like methemoglobinemia (a condition that can deprive tissues and organs of oxygen), reactions in the central nervous system (e.g-convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.g- low blood pressure, heart block, irregular heart rhythm).

How to manage the interaction:
There may be a possibility of interaction between Bupicain-0.5% Injection 20 ml and Levobupivacaine, but it can be taken if prescribed by a doctor. However, if you experience pale, grey, or blue-coloured skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue, consult a doctor. Do not stop using any medications without a doctor's advice.
BupivacaineNitric oxide
Severe
How does the drug interact with Bupicain-0.5% Injection 20 ml:
Taking Bupicain-0.5% Injection 20 ml and Nitric oxide may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Bupicain-0.5% Injection 20 ml and nitric oxide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineSulfasalazine
Severe
How does the drug interact with Bupicain-0.5% Injection 20 ml:
Coadministration of Bupicain-0.5% Injection 20 ml and sulfasalazine may result in methemoglobinemia, an uncommon disorder that lowers the blood's ability to carry oxygen, which can induce oxygen deprivation in tissues and essential organs.

How to manage the interaction:
Although taking Bupicain-0.5% Injection 20 ml and sulfasalazine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as grey discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacainePrimaquine
Severe
How does the drug interact with Bupicain-0.5% Injection 20 ml:
Coadministration of Primaquine and Bupicain-0.5% Injection 20 ml can induce methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Bupicain-0.5% Injection 20 ml and primaquine together may cause an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as gray discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, breathing difficulty, rapid or shallow breathing, a rapid heartbeat, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineGlyceryl trinitrate
Severe
How does the drug interact with Bupicain-0.5% Injection 20 ml:
Coadministration of Bupicain-0.5% Injection 20 ml and glyceryl trinitrate can increase the risk and severity of developing methemoglobinemia, (Red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Bupicain-0.5% Injection 20 ml and glyceryl trinitrate together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30 minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • Follow heat or cold therapy, apply a cold or hot compress on the painful areas for 15-20 minutes regularly.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

LOCAL ANESTHETICS

Bupicain-0.5% Injection Substitute

Substitutes safety advice

  • Bipivac Heavy Injection 4ml

    by AYUR

    ₹7.65per tablet

  • Bupitroy 0.5% Injection 20 ml

    by Others

    ₹4.46per tablet

  • Bupibloc Heavy 20 mg Injection 4 ml

    by Others

    ₹7.33per tablet

  • Bupibloc 0.5% Injection 20 ml

    by Others

    ₹4.38per tablet

  • Bupifix 0.5% Injection 20 ml

    by Others

    ₹4.37per tablet

Product Substitutes

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Alcohol

Caution

You are recommended to limit or avoid alcohol consumption while taking Bupicain-0.5% Injection. Alcohol intake, along with Bupicain-0.5% Injection, may cause increased drowsiness.

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Pregnancy

Caution

Bupicain-0.5% Injection is a pregnancy category C drug. It may be unsafe to use during pregnancy since animal studies of Bupicain-0.5% Injection showed harmful effects on the foetus. Please consult your doctor before taking Bupicain-0.5% Injection if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Bupicain-0.5% Injection is excreted into the breast milk. Please consult your doctor before taking Bupicain-0.5% Injection if you are a nursing mother.

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Driving

Unsafe

Bupicain-0.5% Injection may make you feel dizzy and drowsy that can affect your ability to drive. Do not drive or operate machinery if you experience these side effects.

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Liver

Caution

Please consult your doctor since Bupicain-0.5% Injection should be used with caution in patients with liver impairment/liver disease.

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Kidney

Caution

Please consult your doctor since Bupicain-0.5% Injection should be used with caution in patients with kidney impairment/kidney disease.

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Children

Caution

Bupicain-0.5% Injection is not recommended in children, unless prescribed by a doctor.

Have a query?

FAQs

Bupicain-0.5% Injection is used to induce anaesthesia to reduce pain and discomfort during labour, surgery, dental treatment and other medical procedures.

Bupicain-0.5% Injection temporarily blocks the pain signals from the nerves of the painful area to the brain, thereby causing numbness at the affected site and provides relief from pain.

Bupicain-0.5% Injection may affect your blood pressure. It is advised to inform your doctor before using Bupicain-0.5% Injection if you have high blood pressure during pregnancy or low blood pressure.

You are recommended to consult your doctor to know the after-effects of Bupicain-0.5% Injection if you are using an epidural injection of Bupicain-0.5% Injection. Some epidural numbing medications may have long-lasting or permanent effects on body functions like bowel movement or bladder control, sexual function and movement in your legs. Please discuss the risks and benefits thoroughly with your doctor.

After using Bupicain-0.5% Injection, you may not be able to move your body or the localized part for certain time. You may feel numbness in the injected area. When you are injected with an epidural, you may not be able to move your lower part of the body for a certain period. It is advised to stay careful during such times to avoid any injuries. After a dental procedure with the usage of Bupicain-0.5% Injection, please don't eat, chew gum or drink hot beverages until your mouth is completely free of numbness.

Bupicain-0.5% Injection should be used with caution and only under doctor's supervision if you have any liver, kidney or heart diseases, high or low blood pressure, excess fat in the body, breathing problems, excess fluid in womb during pregnancy (a condition called hydramnios), a tumour of the ovary, blood poisoning (septicaemia) and fluid around lungs. Please let your doctor know if you suffer from any medical issues before using Bupicain-0.5% Injection.

The common side effects of the Bupicain-0.5% Injection may include weakness, numbness or tingling, restlessness, drowsiness, tremors or shakiness, headache, blurred vision, chills or shivering, back pain, nausea, and vomiting. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

Bupicain-0.5% Injection contains Bupivacaine, which belongs to the group of medicines called amide-type anesthetics.

Pregnancy Category C means that animal studies have shown potential risks, but there are no good studies in pregnant women. As a result, the medication should only be used during pregnancy if the potential benefits justify the possible risks. Always consult your healthcare provider for personalized guidance.

Bupicain-0.5% Injection is not an opioid or narcotic. It belongs to the class of local anesthetics. It primarily reduces pain and discomfort during surgery, dental treatments, and other medical procedures.

Bupicain-0.5% Injection is a local anesthetic for numbing a specific area during surgeries or medical procedures. Depending on your condition, pain extent, and overall health, your doctor may combine it with other medications for optimal pain relief. Following your doctor's advice is best to avoid any potential interactions.

Both Ropivacaine and Bupicain-0.5% Injection are safe and effective local anesthetics. Your doctor will prescribe the one most suitable for you based on your health status and the severity of your condition.

Early signs of local anesthesia toxicity can include symptoms like perioral numbness (numbness around the mouth), tinnitus (ringing in the ears), agitation, difficulty speaking (dysarthria), and confusion. These may be followed by more severe central nervous system (CNS) derangements such as seizures and coma.

Country of origin

India

Manufacturer/Marketer address

11/12, Udyog Nagar, S. V. Road, Goregaon (W), Mumbai- 400104.
Other Info - BUP0046

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/mtm/bupivacaine.html
  2. https://www.medicines.org.uk/emc/files/pil.5763.pdf
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