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compositionComposition:BUPIVACAINE-5MG
prescription
Prescription Medicine
info
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Bupifix 0.5% Injection 20 ml is used to reduce pain and discomfort during labour, surgery, dental treatment and other medical procedures. It contains Bupivacaine, which works by blocking the transmission of pain signals and numbing the area. In some cases, this medicine may cause side effects such as weakness, numbness or tingling, restlessness, drowsiness, headache, nausea and vomiting. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUPIVACAINE-5MG

Manufacturer/Marketer :

VARENYAM HEALTHCARE PVT LTD

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Bupifix 0.5% Injection 20 ml

Bupifix 0.5% Injection 20 ml is a prescription local anesthetic used to numb a specific area of the body during surgery, medical procedures, labor, or pain management treatments. It works by temporarily blocking pain signals from the nerves, allowing procedures to be performed without causing pain while you remain comfortable. Bupifix 0.5% Injection 20 ml is administered only by a trained healthcare professional in a hospital or clinical setting.

Since Bupifix 0.5% Injection 20 ml is given as an injection by a healthcare professional, you should receive it exactly as directed by your doctor. It is not intended for self-administration or routine home use. Depending on the type of procedure, your doctor may advise you not to eat or drink for several hours beforehand. Following all pre-procedure instructions can help ensure Bupifix 0.5% Injection 20 ml works safely and effectively.

Common side effects of Bupifix 0.5% Injection 20 ml include nausea, dizziness, low blood pressure, slow heart rate, or temporary numbness and weakness in the treated area. These effects are usually short-lived, but seek immediate medical attention if you experience difficulty breathing, chest pain, severe dizziness, seizures, blurred vision, ringing in the ears, or numbness around the mouth.

Before receiving Bupifix 0.5% Injection 20 ml, tell your doctor if you have heart disease, liver disease, kidney disease, bleeding disorders, low blood pressure, or a history of seizures. Do not receive Bupifix 0.5% Injection 20 ml if you are allergic to Bupifix 0.5% Injection 20 ml or other similar local anesthetics. Your healthcare provider will carefully assess your medical history to determine whether Bupifix 0.5% Injection 20 ml is appropriate for you.

Bupifix 0.5% Injection 20 ml may interact with certain heart medicines, other local anesthetics, and medicines that affect heart rhythm or blood pressure, so inform your doctor about all Bupifix 0.5% Injection 20 mls and supplements you are taking. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, discuss the potential benefits and risks with your healthcare provider before receiving Bupifix 0.5% Injection 20 ml.

Uses of Bupifix 0.5% Injection 20 ml

Bupifix 0.5% Injection 20 ml is used to relieve pain. The detailed uses of Bupifix 0.5% Injection 20 ml are as follows:

  • Surgical Pain Prevention: Bupifix 0.5% Injection 20 ml helps by completely numbing a specific part of the body, allowing surgeons to perform operations without you feeling pain.
  • Labor and Childbirth Pain Relief: It is used in epidurals to ease pain during labor and delivery while keeping you awake and alert.
  • Post-Operative Pain Relief: It helps manage pain after surgery by continuing to block pain signals from the surgical site to the brain.
  • Diagnostic and Therapeutic Nerve Blocks: It helps temporarily block nerve pathways to relieve chronic pain or help doctors find the source of your pain.
     

Key Benefits

Bupifix 0.5% Injection 20 ml provides effective local or regional pain relief during surgical procedures, childbirth, and after surgery. Blocking pain signals at their source, it improves comfort while supporting a smoother recovery.

Benefits may include:

  • Provides targeted pain relief by numbing the specific area being treated.
  • Helps control pain during surgery, medical procedures, and childbirth.
  • Reduces the need for strong opioid pain medicines after surgery.
  • Supports earlier movement and participation in rehabilitation after procedures.
  • Helps improve comfort during recovery from surgery or injury.
  • Provides long-lasting pain relief under medical supervision.
     

Directions for Use

  • Bupifix 0.5% Injection 20 ml will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer it.

How Bupifix 0.5% Injection 20 ml Works

Bupifix 0.5% Injection 20 ml works by temporarily blocking the pathway of pain signals along your nerves. Inside your body, nerves send messages to your brain using tiny electrical currents that rely on sodium. Bupifix 0.5% Injection 20 ml works by stopping sodium from entering the nerve endings in the area where it is injected. When these sodium channels are blocked, the nerve cannot generate or transmit the electrical signal. As a result, the pain messages never reach your brain, and you feel temporary numbness in the targeted part of your body. Once Bupifix 0.5% Injection 20 ml naturally wears off, the sodium channels open back up, and normal sensation slowly returns.
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Alcohol

Caution

You are recommended to limit or avoid alcohol consumption while taking Bupifix 0.5% Injection 20 ml. Alcohol intake, along with Bupifix 0.5% Injection 20 ml, may cause increased drowsiness.

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Pregnancy

Caution

Bupifix 0.5% Injection 20 ml is a pregnancy category C drug. Please consult your doctor before taking Bupifix 0.5% Injection 20 ml if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Bupifix 0.5% Injection 20 ml is excreted into the breast milk. Please consult your doctor before taking Bupifix 0.5% Injection 20 ml if you are a nursing mother.

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Driving

Unsafe

Bupifix 0.5% Injection 20 ml may make you feel dizzy and drowsy that can affect your ability to drive. Do not drive or operate machinery if you experience these side effects.

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Liver

Caution

Please consult your doctor since Bupifix 0.5% Injection 20 ml should be used with caution in patients with liver impairment/liver disease.

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Kidney

Caution

Please consult your doctor since Bupifix 0.5% Injection 20 ml should be used with caution in patients with kidney impairment/kidney disease.

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Children

Caution

Bupifix 0.5% Injection 20 ml is not recommended in children, unless prescribed by a doctor.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Bupifix 0.5% Injection 20 ml. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Bupifix 0.5% Injection 20 ml in elderly patients. Please consult your doctor.

What if I have taken an overdose of Bupifix 0.5% Injection 20 ml

An overdose is rare because a trained medical professional carefully calculates and injects the dose. However, if you experience symptoms like dizziness, ringing in the ears, numbness around the mouth, or trouble breathing during or shortly after your injection, tell your healthcare provider immediately. Medical staff are equipped to manage any adverse reactions on-site.

Diet & Lifestyle Advise

  • Follow fasting guidelines: If you are scheduled to receive this injection for a surgery, strictly follow your doctor’s instructions regarding when to stop eating and drinking beforehand.
  • Rest and avoid sudden movements: Because Bupifix 0.5% Injection 20 ml numbs your body, you may have temporary weakness or lack of feeling in your legs or other areas. Avoid standing up or walking without assistance until the sensation completely returns to prevent falls.
  • Protect the numbed area: Since you cannot feel pain while Bupifix 0.5% Injection 20 ml is active, be careful not to bump, scrape, or burn the numbed part of your body.
  • Stay hydrated: Drink plenty of fluids after your procedure, as advised by your healthcare team, to help your body process the medication and support recovery.
     
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How Soon It Starts Working

The time required for Bupifix 0.5% Injection 20 ml to start to work: Bupifix 0.5% Injection 20 ml ideally shows its action within 10 to 15 minutes after administration. The time for which the effects of Bupifix 0.5% Injection 20 ml last: The effect of Bupifix 0.5% Injection 20 ml lasts for 2 to 9 hours.

What if you forget to take Bupifix 0.5% Injection 20 ml

Since Bupifix 0.5% Injection 20 ml is administered by a healthcare professional for specific medical procedures, missing a dose is highly unlikely. It is given only when needed for pain control during or after a medical procedure.

Storage

•Bupifix 0.5% Injection 20 ml must be kept at controlled room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Verify the solution: If you are involved in preparing the medication, always inspect the vial before use; the solution should be clear and colorless, without any visible particles.
  • Monitor your heart: Ensure that medical staff are monitoring your blood pressure and heart rate during and after the injection.
  • Speak up immediately: Tell your doctor right away if you feel anxious, dizzy, or experience a strange metallic taste during the injection.
  • Avoid driving post-procedure: Do not drive or operate heavy machinery until your doctor confirms that Bupifix 0.5% Injection 20 ml has fully worn off and your reflexes have returned to normal.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Other local anesthetics: Taking these medicines alongside Bupifix 0.5% Injection 20 ml may increase the risk of side effects and local anesthetic toxicity.
  • Heart medicines (e.g., beta-blockers, blood pressure medicines): Combining these with Bupifix 0.5% Injection 20 ml may cause your heart rate or blood pressure to drop too low.
  • Medicines for irregular heartbeats (antiarrhythmic medicines): Taking these alongside Bupifix 0.5% Injection 20 ml may increase the risk of serious heart-related side effects.
     
BupivacaineFlutamide
Severe
BupivacaineTrimethoprim
Severe

Drug-Drug Interactions

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BupivacaineFlutamide
Severe
How does the drug interact with Bupifix 0.5% Injection 20 ml:
Taking Bupifix 0.5% Injection 20 ml and Flutamide may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Bupifix 0.5% Injection 20 ml and Flutamide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineTrimethoprim
Severe
How does the drug interact with Bupifix 0.5% Injection 20 ml:
Taking Bupifix 0.5% Injection 20 ml and Trimethoprim may cause methemoglobinemia, (blood disorder that affects how red blood cells deliver oxygen throughout the body).

How to manage the interaction:
Although there is an interaction between Bupifix 0.5% Injection 20 ml and trimethoprim, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, headache, dizziness, lightheadedness, fatigue, or shortness of breath. Do not discontinue any medications without consulting a doctor.
BupivacaineRasburicase
Severe
How does the drug interact with Bupifix 0.5% Injection 20 ml:
Taking Bupifix 0.5% Injection 20 ml with rasburicase can increase the risk of methemoglobinemia(blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Bupifix 0.5% Injection 20 ml with Rasburicase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineQuinine
Severe
How does the drug interact with Bupifix 0.5% Injection 20 ml:
Taking Bupifix 0.5% Injection 20 ml and Quinine may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Bupifix 0.5% Injection 20 ml and quinine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacainePrimaquine
Severe
How does the drug interact with Bupifix 0.5% Injection 20 ml:
Coadministration of Primaquine and Bupifix 0.5% Injection 20 ml can induce methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Bupifix 0.5% Injection 20 ml and primaquine together may cause an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as gray discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, breathing difficulty, rapid or shallow breathing, a rapid heartbeat, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineRopivacaine
Severe
How does the drug interact with Bupifix 0.5% Injection 20 ml:
Combining Ropivacaine with Bupifix 0.5% Injection 20 ml can have additive toxic effects, so using them together increases the risk of serious side effects like methemoglobinemia (a condition that can deprive tissues and organs of oxygen), reactions in the central nervous system (e.g-convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.g- low blood pressure, heart block, irregular heart rhythm).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Bupifix 0.5% Injection 20 ml, you can take these medicines together if prescribed by a doctor. However, if you experience pale, grey, or blue-coloured skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue, consult a doctor. Do not stop using any medications without consulting a doctor.
BupivacainePhenazopyridine
Severe
How does the drug interact with Bupifix 0.5% Injection 20 ml:
Taking phenazopyridine with Bupifix 0.5% Injection 20 ml can increase the risk of methemoglobinemia,(a blood disorder that affects how red blood cells deliver oxygen throughout your body).

How to manage the interaction:
Although taking Bupifix 0.5% Injection 20 ml and phenazopyridine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineLevobupivacaine
Severe
How does the drug interact with Bupifix 0.5% Injection 20 ml:
C0administration of Bupifix 0.5% Injection 20 ml with levobupivacaine can have additive toxic effects, so using them together increases the risk of serious side effects like methemoglobinemia (a condition that can deprive tissues and organs of oxygen), reactions in the central nervous system (e.g-convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.g- low blood pressure, heart block, irregular heart rhythm).

How to manage the interaction:
There may be a possibility of interaction between Bupifix 0.5% Injection 20 ml and Levobupivacaine, but it can be taken if prescribed by a doctor. However, if you experience pale, grey, or blue-coloured skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue, consult a doctor. Do not stop using any medications without a doctor's advice.
BupivacaineGlyceryl trinitrate
Severe
How does the drug interact with Bupifix 0.5% Injection 20 ml:
Coadministration of Bupifix 0.5% Injection 20 ml and glyceryl trinitrate can increase the risk and severity of developing methemoglobinemia, (Red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Bupifix 0.5% Injection 20 ml and glyceryl trinitrate together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineChloroquine
Severe
How does the drug interact with Bupifix 0.5% Injection 20 ml:
Taking Bupifix 0.5% Injection 20 ml with chloroquine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Bupifix 0.5% Injection 20 ml and chloroquine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Bupifix 0.5% Injection 20 ml when used as directed.     
 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[LOCAL ANESTHETICS]

FAQs

Bupifix 0.5% Injection 20 ml is used to induce anaesthesia to reduce pain and discomfort during labour, surgery, dental treatment and other medical procedures.
Bupifix 0.5% Injection 20 ml temporarily blocks the pain signals from the nerves of the painful area to the brain, thereby causing numbness at the affected site and providing relief from pain.
Bupifix 0.5% Injection 20 ml may affect your blood pressure. It is advised to inform your doctor before using Bupifix 0.5% Injection 20 ml if you have high blood pressure during pregnancy or low blood pressure.
You are recommended to consult your doctor to know the after-effects of Bupifix 0.5% Injection 20 ml if you are using an epidural injection of Bupifix 0.5% Injection 20 ml. Some epidural numbing medications may have long-lasting or permanent effects on body functions like bowel movement or bladder control, sexual function and movement in your legs. Please discuss the risks and benefits thoroughly with your doctor.
After using Bupifix 0.5% Injection 20 ml, you may not be able to move your body or the localised part for a certain time. You may feel numbness in the injected area. When you are injected with an epidural, you may not be able to move the lower part of your body for a certain period. It is advised to stay careful during such times to avoid any injuries. After a dental procedure with the usage of Bupifix 0.5% Injection 20 ml, please don't eat, chew gum or drink hot beverages until your mouth is completely free of numbness.
Bupifix 0.5% Injection 20 ml should be used with caution and only under doctor's supervision if you have any liver, kidney or heart diseases, high or low blood pressure, excess fat in the body, breathing problems, excess fluid in womb during pregnancy (a condition called hydramnios), a tumour of the ovary, blood poisoning (septicaemia) and fluid around lungs. Please let your doctor know if you suffer from any medical issues before using Bupifix 0.5% Injection 20 ml.
The common side effects of the Bupifix 0.5% Injection 20 ml may include weakness, numbness or tingling, restlessness, drowsiness, tremors or shakiness, headache, blurred vision, chills or shivering, back pain, nausea, and vomiting. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
Bupifix 0.5% Injection 20 ml contains Bupivacaine, which belongs to the group of medicines called amide-type anesthetics.
Bupifix 0.5% Injection 20 ml is not an opioid or narcotic. It belongs to the class of local anesthetics. It primarily reduces pain and discomfort during surgery, dental treatments, and other medical procedures.
Bupifix 0.5% Injection 20 ml is a local anesthetic for numbing a specific area during surgeries or medical procedures. Depending on your condition, pain extent, and overall health, your doctor may combine it with other medications for optimal pain relief. Following your doctor's advice is best to avoid any potential interactions.
Both Ropivacaine and Bupifix 0.5% Injection 20 ml are safe and effective local anesthetics. Your doctor will prescribe the one most suitable for you based on your health status and the severity of your condition.
Early signs of local anesthesia toxicity can include symptoms like perioral numbness (numbness around the mouth), tinnitus (ringing in the ears), agitation, difficulty speaking (dysarthria), and confusion. These may be followed by more severe central nervous system (CNS) derangements such as seizures and coma.
The effect typically lasts between 2 to 9 hours, but it can vary based on the injection site and the specific dose used. Talk to your doctor or pharmacist if you have concerns.
Serious or permanent nerve damage is extremely rare when Bupifix 0.5% Injection 20 ml is administered by a qualified professional. Talk to your doctor if you experience persistent numbness after your recovery period.
It is commonly used for pain relief during labor and delivery (such as epidurals). However, you should talk to your doctor about the risks and benefits if you require this injection during other stages of pregnancy.
Yes, you are typically awake during the injection, though you may receive a mild sedative to help you relax. Talk to your doctor about what to expect.
Fasting guidelines depend entirely on the medical procedure you are undergoing. Always follow the specific fasting instructions provided by your healthcare team.
General anesthesia puts your entire body to sleep, while Bupifix 0.5% Injection 20 ml only numbs a specific part of your body, keeping you awake and pain-free. Talk to your doctor for more information.
If you still feel numb or weak several hours after your doctor said Bupifix 0.5% Injection 20 ml should wear off, contact your healthcare provider immediately. Talk to your doctor or pharmacist for guidance.

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Country of origin

India

Manufacturer/Marketer address

2, Vitrag Appartment, Karelibaug, Vadodara-390018, Gujarat, India
Other Info - BUP0054
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