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  3. Cabotib 20 mg Tablet 30's

Cabotib 20 mg Tablet 30's, Pack of 1 TABLET
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Composition :

CABOZANTINIB-20MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Cabotib 20 mg Tablet

Cabotib 20 mg Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. It is a disease in which cancer cells grow uncontrollably in the kidney and form a tumor. Cabotib 20 mg Tablet is used in treating advanced renal cell carcinoma as first-line therapy for advanced renal cell carcinoma in combination with nivolumab and hepatocellular carcinoma in patients who have previously been treated with sorafenib.

Cabotib 20 mg Tablet contains Cabozantinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Cabotib 20 mg Tablet may cause certain side effects such as diarrhea, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, decreased weight, dizziness, and constipation. Inform your doctor if any of these side effects bother you. Cabotib 20 mg Tablet should be taken as advised by your doctor.

Avoid taking Cabotib 20 mg Tablet if you are allergic to it or any other components of it. Before taking Cabotib 20 mg Tablet , inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, blood or bleeding disorders, open or healing wounds, and a history of recent surgery. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Cabotib 20 mg Tablet

Treatment of Renal Cell Carcinoma and Hepatocellular carcinoma

Directions for Use

Take Cabotib 20 mg Tablet as prescribed by the doctor. It should be taken at least one hour before food or 2 hours after food. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Medicinal Benefits

Cabotib 20 mg Tablet contains Cabozantinib, which is used in treating advanced renal cell carcinoma and liver cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Cabotib 20 mg Tablet stops the body's production, spread and growth of cancerous cells.

How Cabotib 20 mg Tablet Works

Cabotib 20 mg Tablet contains Cabozantinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Cabotib 20 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Maintain your magnesium levels and general health by drinking lots of water.
  • Maintain a diet high in magnesium-rich foods such as spinach, almonds, chickpeas and brown rice.
  • Limit your alcohol intake because too much of it lowers your magnesium levels.
  • Plan blood testing on a regular basis to monitor magnesium levels.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Cabotib 20 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Cabotib 20 mg Tablet may include memory loss, confusion, and weight loss. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort.

Drug Warnings

To treat your condition effectually, continue taking Cabotib 20 mg Tablet for the period that your doctor has prescribed. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, blood or bleeding disorders, open/healing of wound, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Cabotib 20 mg Tablet may cause hypertension, thrombotic events, hemorrhagic events, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), hepatotoxicity, severe diarrhoea, Osteonecrosis of the jaw (ONJ), Palmar-Plantar Erythrodysesthesia (PPE), adrenal insufficiency, impaired wound healing, and proteinuria in some patients. Hence, inform your doctor about your complete medication and medical history before taking Cabotib 20 mg Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause dizziness. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Drug-Drug Interactions

verifiedApollotooltip
CabozantinibBuprenorphine
Severe
CabozantinibGoserelin
Severe

Drug-Drug Interactions

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CabozantinibBuprenorphine
Severe
How does the drug interact with Cabotib 20 mg Tablet:
Taking buprenorphine with carbozantinib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Concomitant administration of buprenorphine alongside carbozantinib can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
CabozantinibGoserelin
Severe
How does the drug interact with Cabotib 20 mg Tablet:
Taking Goserelin and Cabotib 20 mg Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Goserelin and Cabotib 20 mg Tablet together can possibly result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CabozantinibPazopanib
Severe
How does the drug interact with Cabotib 20 mg Tablet:
Taking pazopanib with Cabotib 20 mg Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Pazopanib and Cabotib 20 mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
CabozantinibHydroxyzine
Severe
How does the drug interact with Cabotib 20 mg Tablet:
Taking Hydroxyzine with Cabotib 20 mg Tablet increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Hydroxyzine with Cabotib 20 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately Do not stop using any medications without a doctor's advice.
CabozantinibDalteparin
Severe
How does the drug interact with Cabotib 20 mg Tablet:
Using Cabotib 20 mg Tablet together with dalteparin may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Dalteparin and Cabotib 20 mg Tablet, you can take these medicines together if prescribed by your doctor. If you notice any of these signs, it's important to contact your doctor right away: bleeding, severe bleeding, problems, bruising, feeling dizzy or lightheaded, stools that are red or black and sticky, intense headache, weakness, bleeding, or vomiting. Do not stop using any medications without first talking to your doctor.
CabozantinibPrasugrel
Severe
How does the drug interact with Cabotib 20 mg Tablet:
When Cabotib 20 mg Tablet is taken with Prasugrel, it can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Prasugrel with Cabotib 20 mg Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
CabozantinibMefenamic acid
Severe
How does the drug interact with Cabotib 20 mg Tablet:
Using Cabotib 20 mg Tablet together with mefenamic acid may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Mefenamic acid and Cabotib 20 mg Tablet, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms like blood clotting problems, excessive bleeding, or severe headaches, it's best to contact a doctor right away. They can help address any complications and provide the necessary support. Do not stop using any medications without talking to a doctor.
CabozantinibOxytocin
Severe
How does the drug interact with Cabotib 20 mg Tablet:
Using Cabotib 20 mg Tablet together with oxytocin can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Oxytocin and Cabotib 20 mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
CabozantinibVenlafaxine
Severe
How does the drug interact with Cabotib 20 mg Tablet:
Taking Venlafaxine with Cabotib 20 mg Tablet increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Venlafaxine and Cabotib 20 mg Tablet, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
CabozantinibIbrutinib
Severe
How does the drug interact with Cabotib 20 mg Tablet:
Co-administration of Ibrutinib with Cabotib 20 mg Tablet can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Taking Ibrutinib with Cabotib 20 mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Cabotib 20 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

bannner image

Alcohol

Caution

Avoid consumption of alcohol while on treatment with Cabotib 20 mg Tablet as it may cause serious side effects.

bannner image

Pregnancy

Unsafe

Cabotib 20 mg Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Cabotib 20 mg Tablet . You should not become pregnant while you are taking Cabotib 20 mg Tablet for at least four months from the last dose of Cabotib 20 mg Tablet . Using effective birth control methods while on treatment is suggested.

bannner image

Breast Feeding

Unsafe

Cabotib 20 mg Tablet should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least four months from the last dose of medicine.

bannner image

Driving

Unsafe

In some cases, Cabotib 20 mg Tablet may cause dizziness and visual problems. As a result, do not drive, operate machinery, or engage in any activity that requires clear vision until you are satisfied you can drive while on Cabotib 20 mg Tablet therapy.

bannner image

Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Cabotib 20 mg Tablet is known to cause hepatotoxicity when taken in combination with nivolumab. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

bannner image

Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Cabotib 20 mg Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Cabotib 20 mg Tablet is not recommended for use in children as the safety and efficacy are not established.

Have a query?

FAQs

Cabotib 20 mg Tablet is used to treat Renal Cell Carcinoma and Hepatocellular carcinoma.

Cabotib 20 mg Tablet contains Cabozantinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

Cabotib 20 mg Tablet may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - CAB0098

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 9:32 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/208692s010lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a616037.html
  3. https://reference.medscape.com/drug/cometriq-cabometyx-cabozantinib-999791
  4. https://www.cabometyx.com/
  5. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/cabozantinib

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