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compositionComposition:ACALABRUTINIB-100MG
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Prescription Medicine
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Calquence 100 mg Tablet 10's is used to treat Mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL). It contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that transmit signals to cells, telling them to grow and divide. Acalabrutinib inhibits these signals to cancer cells. Cells die when their signals are disrupted. This could help to slow the progression of the cancer.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ACALABRUTINIB-100MG

Manufacturer/Marketer :

AstraZeneca Pharma India Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Calquence 100 mg Tablet 10's

Calquence 100 mg Tablet 10's is a prescription medicine used to treat adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). It is also prescribed to treat adults with mantle cell lymphoma (MCL) who have already received at least one other treatment. This targeted medication is designed to help control the growth and spread of cancer cells in the blood and lymph nodes.

To get the best results, you must take Calquence 100 mg Tablet 10's consistently every day, exactly as your doctor prescribes. This medication is typically taken on a daily basis to maintain a steady level of the medicine in your body. You can take this oral capsule with or without food. Incorporating gentle, regular physical activity and eating a balanced, nutrient-dense diet can help support your body's energy levels and immune system during treatment.

While taking Calquence 100 mg Tablet 10's, you may experience common, mild side effects such as headaches, mild diarrhoea, or feeling very tired. However, you must contact your healthcare team immediately if you develop serious symptoms, such as unusual bleeding, severe bruising, high fever, or an irregular heartbeat.

Before starting this medication, talk to your doctor if you have a history of bleeding disorders, heart rhythm problems, or active infections, or if you plan to have any upcoming surgeries. Do not take this medicine if you have ever had a severe allergic reaction to any of its ingredients.

This medicine can interact with blood thinners, certain stomach acid reducers, and other medications, which can either reduce its effectiveness or increase your risk of severe bleeding. It is also important to avoid smoking and limit alcohol consumption, as these habits can put additional stress on your body and worsen side effects. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly patient, you must consult your doctor to discuss specific safety measures before starting treatment.

Uses of Calquence 100 mg Tablet 10's

Calquence 100 mg Tablet 10's is used to treat adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). The detailed uses of Calquence 100 mg Tablet 10's are as follows:

  • Chronic Lymphocytic Leukaemia (CLL) and Small Lymphocytic Lymphoma (SLL): Calquence 100 mg Tablet 10's helps by blocking signals that tell cancer cells to multiply, slowing down the progression of these blood and bone marrow cancers.
  • Mantle Cell Lymphoma (MCL): For patients who have already tried other therapies, Calquence 100 mg Tablet 10's targets specific proteins inside the abnormal B-cells, helping to shrink or control the tumour.
     

Key Benefits

Calquence 100 mg Tablet 10's offers significant clinical benefits by directly targeting cancer cells while sparing many healthy cells, which helps manage the disease with more manageable side effects than traditional chemotherapy. Some of the key benefits patients experience include:

  • Slowing Cancer Progression: By keeping the cancer from spreading, it helps patients maintain their daily activities and enjoy a better quality of life.
  • Convenient Oral Therapy: Because it is taken as an oral capsule, it reduces the need for frequent, lengthy hospital visits for intravenous infusions.
  • Symptom Control: Over time, successfully controlling the leukaemia or lymphoma can reduce symptoms like night sweats, extreme fatigue, and swollen lymph nodes.

Directions for Use

  • Calquence 100 mg Tablet 10's can be taken with or without food as advised by your doctor.
  • It is advised to take Calquence 100 mg Tablet 10's twice a day; however, follow your doctor’s advice regarding the dosage and duration.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Calquence 100 mg Tablet 10's Works

Calquence 100 mg Tablet 10's contains acalabrutinib, which works as a highly selective Bruton's tyrosine kinase (BTK) inhibitor. BTK is a specific protein inside B-cells (a type of white blood cell) that sends signals telling these cells to grow, survive, and multiply. In cancers like leukaemia and lymphoma, these signals become hyperactive, leading to the uncontrolled growth of abnormal B-cells. By binding directly to the BTK protein, Calquence 100 mg Tablet 10's blocks these growth signals. Without these signals, the cancerous B-cells cannot survive or replicate, which helps to shrink lymph nodes and lower the number of cancer cells in your blood and bone marrow. Because this therapy is targeted, it is designed to minimise damage to other healthy cells in your body.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Calquence 100 mg Tablet 10's.

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Pregnancy

Unsafe

Calquence 100 mg Tablet 10's should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

Calquence 100 mg Tablet 10's should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

Calquence 100 mg Tablet 10's does not influence the ability to drive or use machines. However, go only if you are alert, as the Calquence 100 mg Tablet 10's may cause tiredness in some people.

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Liver

Caution

Avoid using Calquence 100 mg Tablet 10's in patients with severe hepatic impairment. The safety of Calquence 100 mg Tablet 10's has not been evaluated in patients with moderate or severe hepatic impairment. So, caution should be exercised while using Calquence 100 mg Tablet 10's in patients with liver impairment. If you have a pre-existing or a history of liver disease, inform your doctor before taking the Calquence 100 mg Tablet 10's. Your doctor will weigh the benefits and potential risks before prescribing Calquence 100 mg Tablet 10's.

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Kidney

Caution

Caution should be exercised while using Calquence 100 mg Tablet 10's in patients with kidney impairment. If you have a pre-existing or a history of kidney disease, inform your doctor before taking the Calquence 100 mg Tablet 10's. Your doctor will weigh the benefits and potential risks before prescribing Calquence 100 mg Tablet 10's.

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Children

Caution

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

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Heart

Caution

Calquence 100 mg Tablet 10's may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Calquence 100 mg Tablet 10's.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Calquence 100 mg Tablet 10's to geriatric patients. Your doctor will prescribe Calquence 100 mg Tablet 10's if the benefits outweigh the risks.

What if I have taken an overdose of Calquence 100 mg Tablet 10's

If you take too much of this medicine, seek immediate medical attention. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Avoid grapefruit and Seville oranges: These fruits can interact with how your body breaks down Calquence 100 mg Tablet 10's, potentially raising the levels of the medicine in your blood to unsafe levels.
  • Stay well-hydrated: Drink plenty of water throughout the day to support your kidney function and help manage mild side effects like headaches or diarrhoea.
  • Practice strict infection prevention: Because this medicine can lower your white blood cell count, wash your hands frequently, avoid close contact with people who are sick, and ensure all food is thoroughly washed and cooked.
  • Protect your skin from the sun: Some patients taking this class of medicine may have a slightly higher risk of developing skin cancers. Wear protective clothing and apply broad-spectrum sunscreen when outdoors.
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How Soon It Starts Working

The time required for Calquence 100 mg Tablet 10's to start to work: Calquence 100 mg Tablet 10's ideally shows its action within 1 hour after administration. The time for which the effects of Calquence 100 mg Tablet 10's last: The effect of Calquence 100 mg Tablet 10's lasts for 12 hours.

What if you forget to take Calquence 100 mg Tablet 10's

If you miss a dose of Calquence 100 mg Tablet 10's, take it as soon as you remember. However, if your next scheduled dose is less than 3 hours away, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

•Store Calquence 100 mg Tablet 10's capsules at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Check your capsules: Inspect your capsule before taking it. Do not use any capsule that is broken, cracked, or leaking.
  • Watch for bleeding: This medication can make you bleed or bruise more easily. Avoid activities that carry a high risk of physical injury or cuts.
  • Inform all healthcare providers: Tell any dentist, surgeon, or specialist that you are taking Calquence 100 mg Tablet 10's, as you may need to temporarily stop taking it before undergoing surgeries or dental procedures.
  • Monitor your heart rate: Keep track of your pulse. If you feel your heart racing, skipping a beat, or fluttering, report this to your doctor immediately.
  • Do not share your medicine: This is a highly specialised cancer medication. Never share it with anyone else, even if they have similar symptoms.

verifiedApollotooltip
  • Stomach acid reducers (Proton Pump Inhibitors): Taking drugs like omeprazole can significantly reduce how much Calquence 100 mg Tablet 10's your body absorbs. Avoid taking PPIs while on this medication.
  • Blood thinners (Anticoagulants/Antiplatelets): Medicines like warfarin, aspirin, or clopidogrel can increase your risk of severe bleeding when taken with Calquence 100 mg Tablet 10's.
  • Strong CYP3A inhibitors or inducers: Drugs like ketoconazole, clarithromycin, or rifampin can dramatically alter the levels of Calquence 100 mg Tablet 10's in your blood, increasing side effects or reducing efficacy.

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verifiedApollotooltip
  • Grapefruit and Seville oranges: These can interfere with the enzymes that break down Calquence 100 mg Tablet 10's, leading to dangerously high levels of the drug in your body.
     

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Habit Forming

No

Therapeutic Class

[KINASE INHIBITORS]

FAQs

Calquence 100 mg Tablet 10's is used to treat Mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL).
Calquence 100 mg Tablet 10's contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that send signals to cells, directing them to grow and divide. Acalabrutinib blocks these signals to cancer cells. Cancer cells die when their signals are interrupted. This could help to delay the progression of the cancer.
You can take the missed dose if you forget to take your acalabrutinib, which is less than 3 hours after your usual time. Then, take the next dose at the regular time. Do not take your missed dose if more than 3 hours have passed. Wait and take the next dose at the regular time. Do not take a double dose to make up for a missing one.
Calquence 100 mg Tablet 10's may cause nausea as a side effect. If you experience nausea, you can manage it by drinking plenty of clear liquids like water, fruit juices, or flat soda to prevent dehydration. Eat smaller, more frequent meals of bland foods that are easy to digest, like crackers, toast, or bananas. Avoid greasy, fried, sweet, or spicy foods. However, consult your doctor if nausea persists or worsens.
To relieve diarrhoea caused by Calquence 100 mg Tablet 10's, stay hydrated by drinking plenty of water and clear fluids. Follow a bland diet of bananas, rice, applesauce, and toast. Avoid spicy, fatty, or high-fiber foods that can make diarrhoea worse. Talk to the doctor if you experience severe diarrhoea.
Avoid eating grapefruit and drinking grapefruit juice while taking Calquence 100 mg Tablet 10's, as it may interact with the medication. Limit intake of alcohol as it may increase the risk of bleeding.
Consult the doctor if you notice changes in your skin like rash, light bruising, and small red or purple spots on your skin after taking Calquence 100 mg Tablet 10's.
Calquence 100 mg Tablet 10's may cause bleeding gums due to reduced platelets. Try gentle brushing with a soft-bristled toothbrush. If the issue persists, consult your doctor for appropriate treatment.
After starting treatment with Calquence 100 mg Tablet 10's, you may feel tired or weak. To cope with this, prioritize rest and pace yourself. Take breaks, nap if needed, and engage in gentle exercises like yoga or short walks. Stay hydrated, eat small, frequent meals, and avoid heavy lifting or strenuous activities.
The doctor may advise regular blood tests before and during the treatment with Calquence 100 mg Tablet 10's to check blood count. Additionally, liver and kidney function tests may also be recommended by the doctor.
The common side effects of Calquence 100 mg Tablet 10's include anaemia (lack of blood), neutropenia (low count of neutrophils), upper respiratory tract infection, thrombocytopenia (Low platelet level), headache, diarrhoea, and musculoskeletal pain. You should talk to your doctor if you persistently experience these side effects.
Yes, you can take Calquence 100 mg Tablet 10's with or without food. However, try to take it at the same time each day to maintain consistent levels of the medicine in your body. Talk to your doctor or pharmacist if you experience stomach upset.
You must inform your surgeon or dentist that you are taking Calquence 100 mg Tablet 10's. Because this medicine can increase the risk of bleeding, you may need to stop taking it for a few days before and after your procedure. Always talk to your doctor before stopping your medication.
Some heartburn medicines, specifically proton pump inhibitors (PPIs), should be avoided because they lower stomach acid and reduce the absorption of Calquence 100 mg Tablet 10's. H2-blockers or antacids may be used if timed carefully. Talk to your doctor or pharmacist for a safe schedule.
Hair loss is not a commonly reported side effect of Calquence 100 mg Tablet 10's. Unlike traditional chemotherapy, this is a targeted therapy, meaning it is less likely to cause widespread hair loss. If you notice unusual hair thinning, talk to your doctor.
There is no direct, major interaction between Calquence 100 mg Tablet 10's and alcohol, but drinking alcohol can worsen side effects like headaches, dizziness, or dehydration. It is best to limit your alcohol intake and talk to your doctor about what is safe for you.
No, Calquence 100 mg Tablet 10's can cause harm to an unborn baby and should not be taken during pregnancy. You should also avoid breastfeeding while taking this medicine and for at least two weeks after your final dose. Talk to your doctor about highly effective birth control methods during your treatment.
In some patients, Calquence 100 mg Tablet 10's can cause or worsen high blood pressure. Your doctor will likely monitor your blood pressure regularly during your treatment. Talk to your doctor if you experience unusually high blood pressure readings.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

12Th Mile Bellary Road,Bangalore-560063
Other Info - CAL3960
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