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compositionComposition:CAPECITABINE-500MG
prescription
Prescription Medicine
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Capnat 500 mg Tablet is used to treat breast, colon and stomach cancer. It contains Capecitabine which works by interfering with the growth of cancer cells. In some cases, this medicine may cause side effects such as nausea, vomiting, weakness, loss of appetite, increased risk of infection, hair loss, diarrhoea, and mouth ulcers. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CAPECITABINE-500MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Capnat 500 mg Tablet

Capnat 500 mg Tablet is a prescription oral medication used to treat certain types of cancer, including colon, rectal, and breast cancer. It works by targeting rapidly dividing cancer cells to slow down or stop their growth. Your doctor will determine if Capnat 500 mg Tablet is suitable for your specific type of cancer.

You will typically take this medication twice a day, in the morning and evening, consistently at the same times. It is very important to take each dose within 30 minutes after finishing a meal to help your body absorb it properly. Staying well-hydrated and eating a balanced diet can help support your body during this treatment.

While taking Capnat 500 mg Tablet , you may experience some common side effects such as diarrhea, nausea, or redness and peeling on your hands and feet. If you experience severe diarrhea, vomiting, or a high fever, you must contact your doctor immediately, as these can become serious quickly.

Talk to your doctor if you have a history of kidney disease, liver damage, heart conditions, or a known enzyme deficiency called DPD deficiency. Do not take this if you have a complete lack of the DPD enzyme, as this can lead to severe, life-threatening reactions. Capnat 500 mg Tablet should not be taken by pregnant or breastfeeding individuals due to the risk of harm to the baby.

This medication can interact with other treatments, including blood thinners, certain antacids, and seizure medicines, which may increase your risk of severe bleeding or other side effects. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to discuss specific precautions and monitoring needed during your therapy.

Uses of Capnat 500 mg Tablet

Capnat 500 mg Tablet is used in the treatment of Breast cancer, rectal, and colon cancer. The detailed uses of Capnat 500 mg Tablet are as follows:

  • Breast Cancer: It is used to treat advanced or metastatic breast cancer, either alone or combined with other medications, when other standard treatments have stopped working.
  • Colorectal Cancer: Capnat 500 mg Tablet helps manage and treat advanced or metastatic colorectal cancer that has spread to other areas of the body.
  • Colon Cancer: Capnat 500 mg Tablet is used after surgery to help prevent the cancer from returning in patients who have had stage III colon cancer completely removed.

 

Key Benefits

Capnat 500 mg Tablet helps treat certain types of cancer by slowing or stopping the growth of cancer cells. As part of a comprehensive cancer treatment plan, it helps control disease progression and supports improved treatment outcomes.
Benefits may include:

  • Helps slow or stop the growth of certain cancer cells.
  • May help shrink tumours and delay the progression of cancer.
  • Supports treatment after surgery to help reduce the risk of cancer recurrence in appropriate patients.
  • Helps improve disease control as part of a comprehensive cancer treatment plan.
  • Provides the convenience of oral treatment, reducing the need for frequent intravenous chemotherapy visits.
  • Supports overall quality of life during cancer treatment by allowing greater flexibility in daily routines.
Side effects of Capnat 500 mg Tablet
  • Apply fragrance-free, thick moisturizing creams to your hands and feet, gently pat the skin and dry instead of rubbing.
  • Use ice packs wrapped in a towel to soothe irritated areas on your palms and soles.
  • Wash your hands and feet with mild, unperfumed soap and avoid using harsh cleaning products.
  • Wear loose-fitting, well-cushioned shoes that provide ample space for your feet.
  • Practice wearing cotton gloves when doing chores that may irritate your hands.
  • Avoid hot baths or showers, instead opt for lukewarm water.
  • Wear sunscreen with a high SPF on exposed skin and limit sun exposure.
  • Don't expose your hands and feet to direct heat like or fireplaces.
  • Reduce pressure by avoiding activities that put pressure on your hands and feet, like jogging or heavy lifting.
  • If required, go for low-impact exercises like walking or swimming.
  • To reduce swelling elevate your feet when resting.
  • Consult your doctor if redness or blistering on your palms or soles, severe pain or discomfort in your hands and feet, open sores or bleeding on your skin or if significant worsening of symptoms.
  • Consult your doctor or healthcare provider before making any changes to your treatment plan or lifestyle modifications related to hand-foot syndrome.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Know your allergens that cause dermatitis and avoid them.
  • Use fragrance-free detergents and soaps.
  • Apply moisturizer after taking bath to retain moisture in the skin.
  • Apply cool, moist compresses to the rash.
  • Talk to your doctor about creams and ointments to manage your dermatitis.

Directions for Use

  • Capnat 500 mg Tablet should be taken within 30 minutes after a meal.
  • It is recommended to take Capnat 500 mg Tablet twice daily or as advised by your doctor.
  • Swallow Capnat 500 mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Capnat 500 mg Tablet Works

Capecitabine is an oral medicine that acts as a prodrug, meaning it is inactive when you swallow it. Once absorbed into your digestive system, it travels through your body and is converted into its active, cancer-fighting form primarily inside tumor cells. This conversion relies on specific enzymes that are highly active in cancer tissue. Once converted, the active medicine interferes with the production of DNA and RNA, which cancer cells need to grow, repair, and multiply. By disrupting this process, the medicine stops the cancer cells from dividing, leading to their destruction while causing less direct exposure to healthy body tissues compared to some other treatments.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Capnat 500 mg Tablet to avoid unpleasant side effects. Alcohol intake, along with Capnat 500 mg Tablet , may cause increased drowsiness.

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Pregnancy

Unsafe

Capnat 500 mg Tablet should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking fluorouracil and for at least six months afterwards. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Capnat 500 mg Tablet should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Unsafe

Capnat 500 mg Tablet may cause dizziness and drowsiness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Capnat 500 mg Tablet . Your doctor will weigh the benefits and potential risks before prescribing Capnat 500 mg Tablet .

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Capnat 500 mg Tablet . Your doctor will weigh the benefits and potential risks before prescribing Capnat 500 mg Tablet .

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Children

Unsafe

Capnat 500 mg Tablet should not be used by children, as efficacy and safety have not been established.

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Heart

Caution

Capnat 500 mg Tablet should be used with extreme caution due to the risk of cardiovascular problems. Please inform your physician if you have any concerns.

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Geriatrics

Safe if prescribed

Capnat 500 mg Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Capnat 500 mg Tablet

If you take more than your prescribed dose, seek emergency medical attention or contact a poison control center immediately. An overdose can cause severe nausea, diarrhea, bleeding, or infections.

Diet & Lifestyle Advise

  • Stay hydrated: Drink 8 to 10 glasses of water or clear fluids daily to prevent dehydration, especially if you experience mild diarrhea or nausea.
  • Protect your skin: Apply a thick, alcohol-free moisturizing cream to your hands and feet regularly. Avoid hot water, vigorous rubbing, and tight footwear to reduce the risk of hand-foot syndrome.
  • Eat smaller meals: Choose small, frequent, bland meals (such as bananas, rice, applesauce, and toast) to ease digestion and manage nausea. Avoid spicy, fatty, or highly acidic foods.
  • Practice gentle oral care: Use a soft-bristle toothbrush and rinse your mouth with water or a mild baking soda solution after meals to prevent mouth sores.
health query

Have a query?

How Soon It Starts Working

  • The time required for Capnat 500 mg Tablet to start to work: The time required for Capnat 500 mg Tablet to show its action is unknown.
  • The time for which the effects of Capnat 500 mg Tablet last: The duration of action for Capnat 500 mg Tablet is clinically unknown.

What if you forget to take Capnat 500 mg Tablet

If you miss a dose, skip the missed dose entirely. Take your next scheduled dose at your regular time. Do not take a double dose to make up for the missed one, and consult your doctor or pharmacist if you have concerns.

Storage

•Store Capnat 500 mg Tablet tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F) •Keep the medicine in its original container, tightly closed, to protect it from moisture and direct light.

Drug Warnings

  • Inspect the medicine before use: Do not take the tablets if they are cracked, chipped, broken, or otherwise damaged.
  • Separate antacids from your dose: Avoid taking antacids containing aluminum or magnesium hydroxide within 2 hours of Capnat 500 mg Tablet , as they may reduce its absorption and effectiveness.
  • Use effective contraception: Use reliable birth control during treatment and for the recommended period after your final dose, as Capnat 500 mg Tablet can harm an unborn baby. Follow your doctor's advice regarding the appropriate duration of contraception.
  • Protect your skin from sunlight: Capnat 500 mg Tablet may increase your sensitivity to sunlight. Limit direct sun exposure, wear protective clothing, and apply a broad-spectrum sunscreen when outdoors.
  • Reduce the risk of hand-foot skin reactions: Avoid long, hot baths or showers, as heat and friction can worsen hand-foot skin reactions. Keep your hands and feet cool, moisturized, and protected during treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (e.g., warfarin): Taking these medicines alongside Capnat 500 mg Tablet may significantly increase the risk of serious bleeding. Your doctor may monitor your blood clotting closely and adjust your treatment if needed.
  • Anti-seizure medicines (e.g., phenytoin): Capnat 500 mg Tablet may increase phenytoin levels in the body, raising the risk of side effects and toxicity.
  • Antacids: Certain antacids may increase the absorption of Capnat 500 mg Tablet , which could increase the risk of side effects. Consult your doctor or pharmacist before taking these medicines together.
CapecitabineCertolizumab
Severe
CapecitabineEtanercept
Severe

Drug-Drug Interactions

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CapecitabineCertolizumab
Severe
How does the drug interact with Capnat 500 mg Tablet:
Co-administration of Capnat 500 mg Tablet is taken with Certolizumab, which may increase the risk or severity of infections.

How to manage the interaction:
Although taking Capnat 500 mg Tablet and Certolizumab together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
CapecitabineEtanercept
Severe
How does the drug interact with Capnat 500 mg Tablet:
Co-administration of Etanercept with Capnat 500 mg Tablet may increase the risk or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Capnat 500 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CapecitabineFingolimod
Severe
How does the drug interact with Capnat 500 mg Tablet:
Co-administration of Fingolimod with Capnat 500 mg Tablet may increase the risk of serious and potential infections.

How to manage the interaction:
Although there is an interaction, Capnat 500 mg Tablet can be taken with Fingolimod if prescribed by the doctor. Consult the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without consulting a doctor.
CapecitabineThalidomide
Severe
How does the drug interact with Capnat 500 mg Tablet:
Co-administration of Thalidomide with Capnat 500 mg Tablet may increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction, Capnat 500 mg Tablet can be taken with Thalidomide if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of blood clots such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue the medication without consulting a doctor.
CapecitabineFolic acid
Severe
How does the drug interact with Capnat 500 mg Tablet:
Co-administration of Folic acid with Capnat 500 mg Tablet may increase the risk of serious side effects such as bleeding problems, anemia, infections, and nerve damage.

How to manage the interaction:
Although there is a possible interaction between Folic acid and Capnat 500 mg Tablet, you can use these medicines together if prescribed by the doctor. However, if you experience paleness of skin, diarrhea, severe nausea and vomiting, over-tiredness, dizziness, fainting, blood in the stools, unusual bleeding or bruising, fever, chills, body aches, flu-like symptoms, skin reactions, mouth ulcers or sores, and/or numbness, burning or tingling sensation in the hands and feet, contact a doctor. Do not discontinue the medication without consulting a doctor. Do not discontinue the medication without consulting a doctor.
CapecitabineWarfarin
Severe
How does the drug interact with Capnat 500 mg Tablet:
Co-administration of Warfarin with Capnat 500 mg Tablet can increase the effect of Warfarin.

How to manage the interaction:
Although there is a possible interaction between Capnat 500 mg Tablet and Warfarin, you can take these medicines together if prescribed by a doctor. However, if you notice unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
CapecitabineBaricitinib
Severe
How does the drug interact with Capnat 500 mg Tablet:
Co-administration of Capnat 500 mg Tablet with Baricitinib may increase the risk of serious and potential infections.

How to manage the interaction:
Although there is an interaction, Capnat 500 mg Tablet can be taken with Baricitinib if prescribed by the doctor. Consult the doctor if you develop fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without consulting a doctor.
CapecitabineLeflunomide
Severe
How does the drug interact with Capnat 500 mg Tablet:
Co-administration of Leflunomide with Capnat 500 mg Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Capnat 500 mg Tablet can be taken with leflunomide if prescribed by the doctor. Consult the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without consulting a doctor.
CapecitabineTofacitinib
Severe
How does the drug interact with Capnat 500 mg Tablet:
Co-administration of Tofacitinib with Capnat 500 mg Tablet may increase the risk of serious and potential infections.

How to manage the interaction:
Although there is an interaction, Capnat 500 mg Tablet can be taken with Tofacitinib if prescribed by the doctor. Consult the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without consulting a doctor.
CapecitabineAdalimumab
Severe
How does the drug interact with Capnat 500 mg Tablet:
Co-administration of Capnat 500 mg Tablet is taken with Adalimumab, which may increase the risk or severity of infections.

How to manage the interaction:
There may be a possibility of interaction between Capnat 500 mg Tablet and Adalimumab, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include an enlarged spleen or liver, stomach pain, ongoing fever, excessive sweating at night, unexplained weight loss, complications, infection, fever, chills, diarrhea, a sore throat, muscle aches, difficulty breathing, or pain or discomfort while urinating. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Food: Always take Capnat 500 mg Tablet within 30 minutes after finishing a meal. Taking it on an empty stomach may affect how the medicine is absorbed and increase the risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Capnat 500 mg Tablet belongs to a group of medicines known as anti-cancer‚ used to treat breast, colon and stomach cancer.
Capnat 500 mg Tablet interferes with the growth of the cancer cells genetic material (DNA). This slows the growth of cancer cells and eventually kills them.
Capnat 500 mg Tablet can make your skin more sensitive to the harmful effects of sunlight. Hence it is advised to wear protective clothing while using Capnat 500 mg Tablet . It is recommended to avoid tanning booths and sunlamps.
Yes, Capnat 500 mg Tablet may change the results of blood tests and other laboratory tests. Inform the person doing the tests that you are taking Capnat 500 mg Tablet as regular monitoring of liver and kidney functions tests, electrolyte levels and blood cells is required.
Yes, Capnat 500 mg Tablet commonly affects the hair by making it thin, which further causes hair loss. However, it is not very common. Hair reduction possibly happens due to the estrogen-lowering effect of Capnat 500 mg Tablet . These effects are not long-lasting and may return after some time. If it matters to you, then consult your doctor for further advice.
Capnat 500 mg Tablet may cause osteoporosis (bone thinning) due to the reduction of estrogen in the body. Regular bone density tests may help you monitor osteoporosis. Contact your doctor if you observe any sign of tendon pain or swelling while taking Capnat 500 mg Tablet .
Your doctor will decide the number of treatment cycles and the frequency of Capnat 500 mg Tablet to be taken, depending on the type and stage of the cancer being treated.
No, it is advised not to use these two medicines at the same time as they may cause severe drug reactions. Maintain a gap of at least four weeks between the last dose of brivudine and the first dose of Capnat 500 mg Tablet .
Capnat 500 mg Tablet contains Capecitabine, an anti-cancer medication used to treat breast cancer, stomach, rectal and colon cancer.
Capnat 500 mg Tablet may cause side-effects such as nausea, vomiting, weakness, loss of appetite, increased risk of infection, hair loss, diarrhoea, decreased blood cells (red cells, white cells, and platelets), mouth ulcers, blisters on fingers/feet in some cases. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
No, you should not crush, chew, or split Capnat 500 mg Tablet tablets. They must be swallowed whole with water to ensure you receive the correct dose and to prevent exposure to the active medicine. If you have difficulty swallowing, talk to your doctor or pharmacist for alternative options.
Do not take an extra dose to replace the one you vomited. Simply wait and take your next scheduled dose at the normal time. Inform your doctor as soon as possible if you frequently vomit after taking your medication. Talk to your doctor for guidance on managing nausea.
Taking Capnat 500 mg Tablet shortly after a meal helps your body absorb the medication properly and safely. It also helps reduce the likelihood of experiencing stomach irritation and nausea. Talk to your doctor or pharmacist if you struggle to eat before your doses.
Hand-foot syndrome is a skin reaction that causes redness, swelling, tingling, numbness, or peeling on the palms of your hands and soles of your feet. If you notice these symptoms becoming painful or interfering with your daily activities, talk to your doctor immediately.
It is best to avoid or strictly limit alcohol while taking Capnat 500 mg Tablet . Alcohol can worsen stomach irritation, dehydration, and liver strain, which are already potential side effects of your treatment. Talk to your doctor or pharmacist before drinking alcohol.
You should avoid getting live vaccines during your treatment, as Capnat 500 mg Tablet can weaken your immune system and increase the risk of infection from the vaccine. Always talk to your doctor before receiving any vaccine or booster shot.
Capnat 500 mg Tablet can cause harm to an unborn baby and may affect fertility in both men and women. Reliable birth control must be used by both male and female patients during treatment and for a period after stopping. Talk to your doctor if you have concerns about family planning.
Your healthcare team will monitor your progress through regular checkups, blood tests, and imaging scans (like CT or MRI scans) to see how your body is responding. Do not stop taking the medicine unless directed, and talk to your doctor about your treatment progress.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - CAP0066
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