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  3. Carbenz 450 Injection 45 ml

Carbenz 450 Injection 45 ml, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Carbenz 450 Injection is used to treat ovarian cancer and small-cell lung cancer. It contains Carboplatin which works by stopping the cancer cells from naturally dividing and functioning. In some cases, this medicine may cause side effects such as nausea, diarrhoea, vomiting, and a low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

CARBOPLATIN-450MG

Manufacturer/Marketer :

Admac Lifesciences(Oncology)

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Carbenz 450 Injection

Carbenz 450 Injection belongs to a group of anti-cancer medicines used for the treatment of ovarian cancer and small-cell lung cancer. It may sometimes be used to treat other cancers. Cancer forms in tissues of the ovary (one of a pair of female reproductive glands in which the ova, or eggs, are formed). Small-cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung.

Carbenz 450 Injection contains 'Carboplatin'. Carboplatin acts by penetrating the cell wall and binding to the cell's DNA, stopping the cell from naturally dividing and functioning, ultimately destroying the cell. These medicines target cancer cells because they often affect rapidly dividing cells.

Carbenz 450 Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection. You may experience nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy (nerves malfunction), nephrotoxicity at high doses and electrolyte disturbances. Most of these side effects of Carbenz 450 Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Carbenz 450 Injection for as long as your doctor has prescribed. Do not stop the Carbenz 450 Injection midway. Talk to your doctor before taking Carbenz 450 Injection if you have severe allergic reactions to Carbenz 450 Injection or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Carbenz 450 Injection should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Carbenz 450 Injection if you are pregnant or breastfeeding because this Carbenz 450 Injection can cause harmful effects on the unborn baby. Both women and men using this Carbenz 450 Injection should use birth control to avoid pregnancy.

Uses of Carbenz 450 Injection

Treatment of Ovarian cancer and Small cell lung cancer

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Carbenz 450 Injection will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Carbenz 450 Injection contains 'Carboplatin' which belongs to a group of anti-cancer medicines used to treat ovarian cancer and small cell lung cancer. It works by damaging the genetic material (DNA) of the cancer cells, which stops their growth and multiplication. It can be used alone or with other chemotherapy drugs depending on your cancer type.

How Carbenz 450 Injection Works

Carbenz 450 Injection contains 'Carboplatin'. Carboplatin acts by penetrating the cell wall and binding to the cell's DNA, stopping the cell from naturally dividing and functioning, ultimately destroying the cell. These medicines target cancer cells because they often affect rapidly dividing cells.

Storage

Keep Carbenz 450 Injection out of the sight and reach of children.
Side effects of Carbenz 450 Injection 45 ml
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Avoid loud noises using ear protection aids like earplugs.
  • Take breaks from noisy environments.
  • Consult the doctor if you experience hearing problems; the doctor will monitor your condition and recommend suitable treatment measures.
  • Drink more fluids as dehydration can decrease blood flow to kidneys and increase BUN levels.
  • Eat less protein and stop protein supplements as high protein diet may increase BUN levels.
  • Severe cases may require kidney transplant or dialysis.

What if I have taken an overdose of Carbenz 450 Injection

It is unlikely to overdose on parenteral medication as it is administered by a healthcare professional. However, seek medical attention if you experience symptoms of overdose such as black/tarry/bloody stools, bloody vomit or vomited material that looks like coffee grounds, unusual bruising or bleeding, decreased urination, pain, burning, or tingling in the hands or feet, ringing in ears and difficulty hearing.

Drug Warnings

Carbenz 450 Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Carbenz 450 Injection. To treat your condition effectually, continue taking Carbenz 450 Injection for as long as your doctor has prescribed. Do not stop the Carbenz 450 Injection midway. Talk to your doctor before taking Carbenz 450 Injection if you have severe allergic reactions to Carbenz 450 Injection or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Carbenz 450 Injection should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Carbenz 450 Injection if you are pregnant or breastfeeding because this Carbenz 450 Injection can cause harmful effects on the unborn baby. Both women and men using this Carbenz 450 Injection should use birth control to avoid pregnancy. Peripheral blood counts should be frequently monitored during Carbenz 450 Injection treatment and appropriate until recovery is achieved.

Drug-Drug Interactions

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CarboplatinSorafenib
Critical
CarboplatinTopotecan
Severe

Drug-Drug Interactions

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CarboplatinSorafenib
Critical
How does the drug interact with Carbenz 450 Injection 45 ml:
Co-administration of Sorafenib with Carbenz 450 Injection 45 ml can increase the risk or severity of serious side effects.

How to manage the interaction:
Taking Sorafenib with Carbenz 450 Injection 45 ml together is not recommended as it can cause an interaction, consult a doctor before taking it. However if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without consulting a doctor.
CarboplatinTopotecan
Severe
How does the drug interact with Carbenz 450 Injection 45 ml:
When Carbenz 450 Injection 45 ml is used with topotecan, it may increase the risk of side effects.

How to manage the interaction:
Co-administration of Carbenz 450 Injection 45 ml with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting your doctor.
CarboplatinAdalimumab
Severe
How does the drug interact with Carbenz 450 Injection 45 ml:
Using Adalimumab with Carbenz 450 Injection 45 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Carbenz 450 Injection 45 ml and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinCertolizumab
Severe
How does the drug interact with Carbenz 450 Injection 45 ml:
Using Carbenz 450 Injection 45 ml with Certolizumab can increase the risk of developing serious infections.

How to manage the interaction:
Taking Carbenz 450 Injection 45 ml with Certolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinCladribine
Severe
How does the drug interact with Carbenz 450 Injection 45 ml:
Using cladribine and Carbenz 450 Injection 45 ml together can increase the risk of serious infections.

How to manage the interaction:
Co-administration of Carbenz 450 Injection 45 ml and cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, red or inflamed skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinCidofovir
Severe
How does the drug interact with Carbenz 450 Injection 45 ml:
Taking cidofovir with Carbenz 450 Injection 45 ml can increase the risk of kidney problems.

How to manage the interaction:
Although taking Carbenz 450 Injection 45 ml and cidofovir together can possibly cause an interaction, it can be taken if your doctor has suggested it. However, if you experience loss of hunger, increased or decreased urination, swelling, shortness of breath, bone pain, muscle cramps, irregular heart rhythm, consult a doctor immediately. It is advised to wait at least for 7 days after stopping Carbenz 450 Injection 45 ml, before taking Cidofovir. Do not stop using any medications without talking to a doctor.
CarboplatinBaricitinib
Severe
How does the drug interact with Carbenz 450 Injection 45 ml:
Coadministration of baricitinib and Carbenz 450 Injection 45 ml can raise your risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Carbenz 450 Injection 45 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
CarboplatinLeflunomide
Severe
How does the drug interact with Carbenz 450 Injection 45 ml:
Co-administration of leflunomide with Carbenz 450 Injection 45 ml can increase the risk of infections.

How to manage the interaction:
Co-administration of Carbenz 450 Injection 45 ml with leflunomide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
CarboplatinClozapine
Severe
How does the drug interact with Carbenz 450 Injection 45 ml:
Taking Carbenz 450 Injection 45 ml with Clozapine may enhance the risk of serious infection.

How to manage the interaction:
Co-administration of Carbenz 450 Injection 45 ml with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinFingolimod
Severe
How does the drug interact with Carbenz 450 Injection 45 ml:
Using Carbenz 450 Injection 45 ml with Fingolimod can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Carbenz 450 Injection 45 ml and Fingolimod, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep; rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Carbenz 450 Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Carbenz 450 Injection. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Carbenz 450 Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Carbenz 450 Injection and at least six months afterwards. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Carbenz 450 Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers. Please consult your doctor about any concerns regarding this.

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Driving

Caution

Carbenz 450 Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Carbenz 450 Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Carbenz 450 Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Carbenz 450 Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

bannner image

Children

Unsafe

Efficacy and safety have not been established. Please consult your doctor. Your doctor will weigh the benefits and potential risks before prescribing them.

Have a query?

FAQs

Carbenz 450 Injection is used to treat ovarian cancer and small-cell lung cancer.

Carbenz 450 Injection contains 'Carboplatin'. Carboplatin works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.

Yes, Carbenz 450 Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.

Carbenz 450 Injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.

Before you receive treatment with Carbenz 450 Injection, tell your doctor about all of your medical conditions. You should not receive Carbenz 450 Injection if you are allergic to carboplatin or any contents in Carbenz 450 Injection. It should not be employed in patients with severe bone marrow depression or significant bleeding.

If not given an inappropriate dose, Carbenz 450 Injection can cause toxic effects, although not everyone gets it. So, Carbenz 450 Injection is prescribed by a doctor experienced in the use of medications to treat cancer only.

Avoid taking Carbenz 450 Injection if you are pregnant because Carbenz 450 Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Carbenz 450 Injection.

Carbenz 450 Injection is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a medical facility.

Carbenz 450 Injection is not cell cycle specific. It works by forming DNA adducts, which leads to cell death. This mechanism of action is not specific to any particular phase of the cell cycle, meaning it can affect cells at various stages of their life cycle.

Yes, Carbenz 450 Injection is FDA approved. It was approved on 3 March 1989.

Yes, Carbenz 450 Injection is a platinum-containing compound medication that works by stopping or slowing the growth of cancer cells.

Carbenz 450 Injection may cause side effects, including neuropathy (tingling and numbness) in the hands and feet, hearing loss, temporary hair loss, and constipation. Weight gain is rare but possible. While leukemia is not typically associated with Carbenz 450 Injection, the long-term use of any chemotherapy drug can increase the risk of secondary cancers. It's important to discuss any side effects with your doctor to manage them effectively.

Carbenz 450 Injection is not a vesicant, and it does not cause blistering or tissue damage if it leaks out of the vein. It is also not cardio-toxic, so it does not specifically target the heart. Additionally, Carboplatin is not an anthracycline, as it does not belong to that class of platinum-containing compounds.

Yes, sometimes the doctor may suggest Carbenz 450 Injection to treat breast cancer based on your health situation. It is often given in combination with other chemotherapy drugs for optimal results.

Carbenz 450 Injection is not available in pill form; It is available in two primary dosage forms: injection and powder for injection.

The common side effects of the Carbenz 450 Injection are nausea, vomiting, diarrhoea, constipation, sores in the mouth and throat, pain, burning, or tingling in the hands or feet, pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected, hair loss, pain, weakness, loss in ability to taste food. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

The efficacy and safety of Carbenz 450 Injection have yet to be established for using children. Please consult your doctor. The doctor will help determine whether the potential benefits outweigh the possible risks and make the appropriate recommendation.

Country of origin

India

Manufacturer/Marketer address

SCO 84, Sector 5, Panchkula (Haryana) 134112 INDIA.
Other Info - CAR0888

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:50 AM IST

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Reference

  1. https://www.uhs.nhs.uk/Media/SUHTExtranet/Services/Chemotherapy-SOPs/Ovarian-cancer/Carboplatin(AUC5).pdf
  2. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/carboplatin
  3. https://medlineplus.gov/druginfo/meds/a695017.html
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020452s005lbl.pdf
  5. https://www.drugs.com/mtm/carboplatin.html
  6. https://www.asbestos.com/treatment/chemotherapy/carboplatin/
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