apollo
logo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
Select Delivery Location
compositionComposition:CARBOPLATIN-450MG
prescription
Prescription Medicine
info
image icons

Neocarb 450 Injection is used to treat ovarian cancer and small-cell lung cancer. It contains Carboplatin which works by stopping the cancer cells from naturally dividing and functioning. In some cases, this medicine may cause side effects such as nausea, diarrhoea, vomiting, and a low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Read more
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
OffersOffers & Discounts

Get Free delivery (₹99) with circle icon

Join Circle
Get 18% Off with Coupons
Extra 10% Off with Bank Offers
bank offer
bank offer
bank offer

More about the Product

Composition :

CARBOPLATIN-450MG

Manufacturer/Marketer :

Biological E Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Neocarb 450 Injection

Neocarb 450 Injection is a specialised injection used to treat certain types of cancer, most notably advanced cancer of the ovaries. It is also used to treat other cancers that have spread or have not responded to other therapies. This medication is a key component of chemotherapy regimens, aimed at stopping the multiplication of cancer cells.

This medicine is not a daily treatment; instead, it is given in cycles, usually once every few weeks. This structured schedule allows your body time to recover and rebuild healthy cells between treatments. While undergoing this treatment, maintaining a balanced diet, staying physically active within your limits, and resting adequately can help your body tolerate the therapy better.

Like most chemotherapy drugs, Neocarb 450 Injection can cause side effects. Common experiences include feeling very tired, nausea, and temporary hair thinning. However, you must contact your doctor immediately if you experience serious symptoms such as high fever, unusual bleeding, or sudden shortness of breath.

Do not use Neocarb 450 Injection if you have severe kidney problems, extremely low blood cell counts, or a history of serious allergic reactions to platinum-based chemotherapy medicines. Your doctor will review your complete medical history, kidney function, and blood counts before starting treatment to ensure this medicine is safe for you. Pregnant women should not use this medicine unless specifically advised by their doctor, as it may harm an unborn baby.

It is crucial to have a detailed discussion with your doctor about your complete medical history before starting this treatment. Women who are pregnant or breastfeeding, as well as elderly individuals, require special medical supervision while using this medicine.

Uses of Neocarb 450 Injection

Neocarb 450 Injection is prescribed as part of cancer treatment regimens to help control the growth and spread of cancer cells. It is mainly used for:

  • Ovarian Cancer: Neocarb 450 Injection is widely prescribed to treat advanced ovarian cancer, helping to shrink tumours and prevent the cancer from returning after surgery or other treatments.
  • Small Cell Lung Cancer: It is used in combination with other medications to control and slow down the spread of cancer cells in the lungs.
  • Other Advanced Cancers: Doctors may prescribe this medicine to treat cancers of the head, neck, cervix, or bladder when standard treatments need additional support.

Key Benefits

Neocarb 450 Injection helps manage advanced cancers by slowing cancer growth, reducing tumour size, and improving treatment outcomes when used as part of an appropriate chemotherapy plan. It actively works to control the disease and may help reduce cancer-related discomfort while supporting a better quality of life.

  • Tumour Reduction and Symptom Relief: By shrinking tumours, Neocarb 450 Injection can significantly reduce cancer-related pain, pressure, and physical discomfort, helping you move more comfortably and feel better in your daily life.
  • Slows Cancer Progression: Neocarb 450 Injection plays an important role in slowing down or halting the progression of cancer. This control may help extend survival time and improve overall quality of life, allowing you to spend more meaningful and active time with family and friends.
Side effects of Neocarb 450 Injection
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Avoid loud noises using ear protection aids like earplugs.
  • Take breaks from noisy environments.
  • Consult the doctor if you experience hearing problems; the doctor will monitor your condition and recommend suitable treatment measures.
  • Drink more fluids as dehydration can decrease blood flow to kidneys and increase BUN levels.
  • Eat less protein and stop protein supplements as high protein diet may increase BUN levels.
  • Severe cases may require kidney transplant or dialysis.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Neocarb 450 Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Neocarb 450 Injection Works

Neocarb 450 Injection works by targeting cells that grow and divide rapidly, which is a main characteristic of cancer cells. Once injected into the bloodstream, Carboplatin enters the cancer cells and binds directly to their DNA. By damaging the DNA structure, it prevents cancer cells from copying themselves and growing. As the cancer cells are unable to repair their DNA or multiply, they eventually die. However, because carboplatin also affects some normal rapidly dividing cells, such as hair roots and blood-producing bone marrow cells, it may cause side effects such as hair loss and changes in blood cell counts.
bannner image

Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Neocarb 450 Injection. It could lead to avoiding unpleasant side effects.

bannner image

Pregnancy

Unsafe

Neocarb 450 Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Neocarb 450 Injection and at least six months afterwards. Please consult your doctor about any concerns regarding this.

bannner image

Breast Feeding

Unsafe

Neocarb 450 Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers. Please consult your doctor about any concerns regarding this.

bannner image

Driving

Caution

Neocarb 450 Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Neocarb 450 Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

bannner image

Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Neocarb 450 Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

bannner image

Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Neocarb 450 Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

bannner image

Children

Unsafe

Efficacy and safety have not been established. Please consult your doctor. Your doctor will weigh the benefits and potential risks before prescribing them.

bannner image

Heart

Caution

Neocarb 450 Injection should be administered with caution, especially if you have a history of heart problems. Please inform your doctor about any existing heart problems before receiving Neocarb 450 Injection.

bannner image

Geriatrics

Caution

Neocarb 450 Injection should be administered with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Neocarb 450 Injection

Since this medicine is prepared and given by trained healthcare professionals, an accidental overdose is highly unlikely. However, if you suspect an error or experience severe side effects immediately after an infusion, inform your medical team or seek emergency medical attention right away.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of fluids, especially water, before and after your infusion to help support your kidneys and flush the medicine from your body.
  • Eat small frequent meals: Eat small, bland meals five to six times a day instead of three large meals to help manage nausea and maintain your strength.
  • Choose safe foods: Avoid raw or undercooked foods, and wash all fruits and vegetables thoroughly to protect yourself from infections when your immune system is weak.
  • Protect health: Use a soft-bristled toothbrush and avoid flossing vigorously to protect your gums from bleeding.
  • Prevent infections: Wash your hands frequently with soap and water, and avoid crowded areas or close contact with anyone who is sick.
health query

Have a query?

How Soon It Starts Working

The time required for Neocarb 450 Injection to start to work: Neocarb 450 Injection ideally shows its action within 15 minutes to an hour after administration. The time for which the effects of Neocarb 450 Injection last: The effect of Neocarb 450 Injection lasts for 24 to 36 hours.

What if you forget to take Neocarb 450 Injection

Because this medication is given on a strict clinical schedule, missing an appointment can affect your treatment progress. If you miss an appointment for your infusion, contact your clinic or doctor immediately to reschedule.

Storage

•The concentrated solution is stored by healthcare professionals at room temperature, ideally between 68°F to 77°F (20°C to 25°C). • It must be kept in its original packaging to protect it from light, and it should never be frozen.

Drug Warnings

  • Watch the injection site: If you feel any burning, coldness, pain, or notice swelling where the needle is placed during your infusion, tell your nurse immediately.
  • Get regular blood tests: You must complete all scheduled blood tests before each treatment cycle. Your doctor needs these results to verify that your kidneys and blood counts are healthy enough for the next dose.
  • Be careful during the infection-risk period: Neocarb 450 Injection can lower your white blood cell counts, usually reaching their lowest levels around 2 to 3 weeks after an infusion. During this period, your risk of infections may be higher. Follow your doctor's advice, avoid contact with people who are unwell, and report any fever or signs of infection immediately.
  • Avoid live vaccines: Do not receive any 'live' vaccines (such as the measles, mumps, rubella, or yellow fever vaccines) while using this medicine, as your weakened immune system may not be able to handle them.
  • Report hearing changes early: Neocarb 450 Injection may cause hearing problems that can worsen with repeated treatments. Tell your doctor if you notice ringing in your ears, difficulty hearing, or any changes in your hearing, even if they seem mild. Early reporting helps your doctor monitor and manage this side effect.
  • Use reliable birth control and discuss fertility: This medicine can cause severe harm to an unborn baby. Both men and women should use highly effective birth control during treatment and for several months afterwards. Neocarb 450 Injection may also affect fertility in some patients. If you wish to have children in the future, discuss fertility preservation options such as sperm banking or egg/embryo preservation with your doctor before starting treatment. 

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any medicines, as some treatments may increase the risk of side effects. 

  • Strong antibiotics (such as aminoglycosides): May increase the risk of kidney damage or hearing loss when used alongside Neocarb 450 Injection.
  • Water pills (loop diuretics): May increase the risk of hearing problems and dehydration.
  • Other chemotherapy medicines: May further lower your blood cell counts, increasing the risk of infection or bleeding.
CarboplatinSorafenib
Critical
CarboplatinCidofovir
Severe

Drug-Drug Interactions

Login/Sign Up

CarboplatinSorafenib
Critical
How does the drug interact with Neocarb 450 Injection:
Co-administration of Sorafenib with Neocarb 450 Injection can increase the risk or severity of serious side effects.

How to manage the interaction:
Taking Sorafenib with Neocarb 450 Injection together is not recommended as it can cause an interaction, consult a doctor before taking it. However if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without consulting a doctor.
CarboplatinCidofovir
Severe
How does the drug interact with Neocarb 450 Injection:
Taking cidofovir with Neocarb 450 Injection can increase the risk of kidney problems.

How to manage the interaction:
Although taking Neocarb 450 Injection and cidofovir together can possibly cause an interaction, it can be taken if your doctor has suggested it. However, if you experience loss of hunger, increased or decreased urination, swelling, shortness of breath, bone pain, muscle cramps, irregular heart rhythm, consult a doctor immediately. It is advised to wait at least for 7 days after stopping Neocarb 450 Injection, before taking Cidofovir. Do not stop using any medications without talking to a doctor.
CarboplatinCertolizumab
Severe
How does the drug interact with Neocarb 450 Injection:
Using Neocarb 450 Injection with Certolizumab can increase the risk of developing serious infections.

How to manage the interaction:
Taking Neocarb 450 Injection with Certolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinFingolimod
Severe
How does the drug interact with Neocarb 450 Injection:
Using Neocarb 450 Injection with Fingolimod can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Neocarb 450 Injection and Fingolimod, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinTopotecan
Severe
How does the drug interact with Neocarb 450 Injection:
When Neocarb 450 Injection is used with topotecan, it may increase the risk of side effects.

How to manage the interaction:
Co-administration of Neocarb 450 Injection with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting your doctor.
CarboplatinThalidomide
Severe
How does the drug interact with Neocarb 450 Injection:
Taking Neocarb 450 Injection with thalidomide can increase the risk of blood clots.

How to manage the interaction:
Co-administration of Neocarb 450 Injection with thalidomide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience chest pain, breathing difficulty, coughing up blood, and pain, redness, or swelling in an arm or leg, sudden loss of vision, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CarboplatinInfliximab
Severe
How does the drug interact with Neocarb 450 Injection:
Taking Infliximab with Neocarb 450 Injection can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Infliximab with Neocarb 450 Injection can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhoea, sore throat, muscle pain, difficulty breathing, pain or burning when you pee, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CarboplatinGolimumab
Severe
How does the drug interact with Neocarb 450 Injection:
Using Neocarb 450 Injection with Golimumab can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Neocarb 450 Injection and Golimumab, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinDeferiprone
Severe
How does the drug interact with Neocarb 450 Injection:
Using Neocarb 450 Injection with Deferiprone, can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Neocarb 450 Injection and Deferiprone, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinBacitracin
Severe
How does the drug interact with Neocarb 450 Injection:
Taking Neocarb 450 Injection and bacitracin can increase the risk of nephrotoxicity(kidney damage).

How to manage the interaction:
Co-administration of Neocarb 450 Injection and bacitracin can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult the doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Neocarb 450 Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Neocarb 450 Injection is used to treat ovarian cancer and small-cell lung cancer.
Neocarb 450 Injection contains 'Carboplatin'. Carboplatin works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.
Yes, Neocarb 450 Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.
Neocarb 450 Injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
Before you receive treatment with Neocarb 450 Injection, tell your doctor about all of your medical conditions. You should not receive Neocarb 450 Injection if you are allergic to carboplatin or any contents in Neocarb 450 Injection. It should not be employed in patients with severe bone marrow depression or significant bleeding.
If not given an inappropriate dose, Neocarb 450 Injection can cause toxic effects, although not everyone gets it. So, Neocarb 450 Injection is prescribed by a doctor experienced in the use of medications to treat cancer only.
Avoid taking Neocarb 450 Injection if you are pregnant because Neocarb 450 Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Neocarb 450 Injection.
Neocarb 450 Injection is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a medical facility.
Neocarb 450 Injection is not cell cycle specific. It works by forming DNA adducts, which leads to cell death. This mechanism of action is not specific to any particular phase of the cell cycle, meaning it can affect cells at various stages of their life cycle.
Yes, Neocarb 450 Injection is FDA approved. It was approved on 3 March 1989.
Yes, Neocarb 450 Injection is a platinum-containing compound medication that works by stopping or slowing the growth of cancer cells.
Neocarb 450 Injection may cause side effects, including neuropathy (tingling and numbness) in the hands and feet, hearing loss, temporary hair loss, and constipation. Weight gain is rare but possible. While leukemia is not typically associated with Neocarb 450 Injection, the long-term use of any chemotherapy drug can increase the risk of secondary cancers. It's important to discuss any side effects with your doctor to manage them effectively.
Neocarb 450 Injection is not a vesicant, and it does not cause blistering or tissue damage if it leaks out of the vein. It is also not cardio-toxic, so it does not specifically target the heart. Additionally, Carboplatin is not an anthracycline, as it does not belong to that class of platinum-containing compounds.
Yes, sometimes the doctor may suggest Neocarb 450 Injection to treat breast cancer based on your health situation. It is often given in combination with other chemotherapy drugs for optimal results.
Neocarb 450 Injection is not available in pill form; It is available in two primary dosage forms: injection and powder for injection.
The common side effects of the Neocarb 450 Injection are nausea, vomiting, diarrhoea, constipation, sores in the mouth and throat, pain, burning, or tingling in the hands or feet, pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected, hair loss, pain, weakness, loss in ability to taste food. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
The efficacy and safety of Neocarb 450 Injection have yet to be established for using children. Please consult your doctor. The doctor will help determine whether the potential benefits outweigh the possible risks and make the appropriate recommendation.
Hair thinning or temporary hair loss is a common side effect of this medicine. In most cases, your hair will begin to grow back gradually after you complete your entire treatment plan. Talk to your doctor for advice on managing hair loss.
This medicine can make you feel extremely tired, dizzy, or weak. It is highly recommended to arrange for a family member or friend to drive you home after your appointment. Talk to your doctor about when it is safe for you to drive.
Yes, this medication can put stress on your kidneys. Your healthcare team will run blood tests before every treatment cycle to monitor how well your kidneys are working. Drinking plenty of water helps protect your kidneys during treatment. Talk to your doctor if you experience decreased urination.
No, this medicine can cause severe birth defects. Both male and female patients must use reliable, highly effective birth control methods during treatment and for a specified time after the final dose. Talk to your doctor immediately if a pregnancy occurs.
Focus on small, frequent meals consisting of bland, easy-to-digest foods like crackers, toast, or rice to help prevent nausea. Staying hydrated with water and clear broths is also highly important. Talk to your doctor or a clinical dietitian for personalised nutrition advice.
Yes, repeated treatment with Neocarb 450 Injection may sometimes cause hearing changes, including ringing in the ears or reduced hearing ability. Inform your doctor about any new hearing symptoms during treatment so they can monitor your condition and provide appropriate advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Biological E. Limited, Road No. 35,Jubilee Hills, Hyderabad, Telangana -500033
Other Info - NEO0450
whatsapp Floating Button
Buy Now
Add to Cart