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  3. Carmendan Injection

Carmendan Injection, Pack of 1 INJECTION
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Carmendan Injection is used to treat acute heart failure in hospitalised patients. It contains levosimendan which works by relaxing and widening the smooth muscles of the heart, allowing blood and oxygen to flow easily throughout the body. In some cases, this medicine may cause side effects such as headache, low blood pressure, and nausea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

LEVOSIMENDAN-12.5MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Carmendan Injection

Carmendan Injection belongs to the group of medications called 'calcium sensitizer' primarily used to treat hospitalized patients with acute heart failure. Heart failure can occur when your heart cannot pump blood sufficiently required to the remainder of the body. A heart attack is the blockage of blood flow to the heart muscle. The blockage is most often a build-up of fat, cholesterol, and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).  Heart attack and brain stroke can occur simultaneously as the brain's stroke blood supply gets interrupted, causing a part of the brain to die.

Carmendan Injection contains 'levosimendan', which works by increasing the heart's sensitivity to calcium ion (Ca) without increasing the amount of calcium present in the heart's muscles cells. Carmendan Injection widens up the heart's blood vessels (coronary artery) and, in turn, relaxes the smooth muscles of the heart so that blood and oxygen can flow easily to the whole body. 

The most common side effects of Carmendan Injection are headache, low blood pressure, and nausea (stomach discomfort). Most of these side effects of Carmendan Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Carmendan Injection should not be given to the patients with low blood pressure (hypotension), dehydration, low blood count, chest pain (angina), or have abnormal heart rhythm. Pregnant or lactating women should consult a doctor before administration of Carmendan Injection. This medicine should not be given to children and adolescents under 18 years of age. 

Uses of Carmendan Injection

Treatment of Heart failure

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Carmendan Injection will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Carmendan Injection is a calcium sensitizer that enhances the heart's pumping forces and allows blood vessels to relax. Improvement of the cardiac function by Carmendan Injection helps reduce the congestion in your lungs and enhances blood and oxygen delivery to the organs. Thus, treatment with Carmendan Injection relieves the shortness of breath from severe heart failure.

How Carmendan Injection Works

Carmendan Injection contains 'levosimendan', which works by increasing the heart's sensitivity to calcium ion (Ca) without increasing the amount of calcium present in the heart's muscles cells. Carmendan Injection widens up the heart's blood vessels (coronary artery) and, in turn, relaxes the smooth muscles of the heart so that blood and oxygen can flow easily to the whole body.

Storage

Keep Carmendan Injection out of the sight and reach of children.

What if I have taken an overdose of Carmendan Injection

Take Carmendan Injection only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not use Carmendan Injection if you are allergic to any of its contents. Do not take Carmendan Injection if you are pregnant, think you may be pregnant, or trying for pregnancy. Consult your doctor before taking Carmendan Injection if you are breastfeeding. Try not to stop taking this medicine of your own as stopping Carmendan Injection abruptly may worsen your condition and increase your risk of a future heart attack. Carmendan Injection should not be given to the patients with low blood pressure (hypotension), dehydration, low blood count, chest pain (angina), or have abnormal heart rhythm. This medicine should not be given to children and adolescents under 18 years of age. Carmendan Injection should not be given into the same vein as other medicines except for heart-related medicines like frusemide, digoxin or glyceryl trinitrate. This is because if you have been given other heart-related medicines through your veins, your blood pressure might drop if you are given Carmendan Injection. 

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

  • Follow a cholesterol-lowering diet.
  • Consume a low-salt and a low-fat diet.
  • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
  • Limit salt and sugar intake.
  • Avoid smoking and alcohol consumption. 
  • Choose healthy fats and cut down on trans-fat.
  • Include omega-3 fatty acids, fibre-rich food, fruits, and vegetables.
  • Get active by doing any physical activity such as swimming, brisk walking, or jogging. Take the stairs instead of elevators/lifts.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

Carmendan Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Carmendan Injection as it may cause increased dizziness.

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Pregnancy

Unsafe

Do not take Carmendan Injection if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Consult a doctor immediately if you become pregnant while taking Carmendan Injection.

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Breast Feeding

Caution

It is not recommended to take Carmendan Injection if you are breastfeeding. Consult your doctor before taking Carmendan Injection; your doctor will decide whether Carmendan Injection can be taken by breastfeeding mothers or not.

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Driving

Caution

Carmendan Injection may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Carmendan Injection is not recommended for children as the safety and effectiveness have not been established.

Have a query?

FAQs

Carmendan Injection is used to treat heart failure.

Carmendan Injection is composed of levosimendan that belongs to the therapeutic class of drugs called calcium sensitizers used to increase the heart sensitivity to calcium without increasing the amount of calcium present in the heart cells. This medication widens up the blood vessels and relaxes the smooth muscles of the heart so that blood can flow easily to the whole body. Thus, treatment with Carmendan Injection relieves the shortness of breath from severe heart failure.

Do not discontinue Carmendan Injection without consulting your doctor as it could increase the risk of a heart attack. To treat your condition effectually continue taking Carmendan Injection for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Carmendan Injection.

Constipation could be a side-effect of Carmendan Injection. Drink plenty of fluids and eat fibre rich food if you experience constipation. Consult your doctor if you have severe constipation.

Orthostatic hypotension could be a side-effect of Carmendan Injection. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better. People taking Carmendan Injection are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.

Heart failure happen heart become unable to pump blood in the whole body as it should. Certain conditions like high blood pressure can put the heart at risk of heart failure.

Carmendan Injection may not be recommended for patients with severe liver disease. It should be used with caution in people with mild or moderate liver impairment. While no dose adjustment is typically needed, it's essential to monitor your liver function closely to ensure safe treatment. Inform the doctor if you have liver impairment or liver disease.

Carmendan Injection may cause a decrease in blood pressure. To ensure your safety, your blood pressure will be closely monitored after receiving the medicine. This will help the doctor detect any changes and take necessary actions.

Inform the doctor if you have kidney disease before receiving Carmendan Injection. Dose adjustment may be needed in people with mild to moderate kidney problems and it may not be recommended for patients with severe kidney problems.

Before and during treatment with Carmendan Injection, your doctor may advise monitoring of heart, kidneys, and liver function, ECG, blood pressure, and blood tests. The doctor may also check your urine output to ensure safety.

Carmendan Injection may increase heart rate. The doctor will take appropriate action if they notice a fast heart rate during treatment with Carmendan Injection.

Headaches are a common side effect of Carmendan Injection. To manage headaches, make sure to get plenty of rest, eat a balanced diet, and avoid alcohol. If your headache becomes severe, be sure to consult your doctor for further guidance and support.

The common side effects of Carmendan Injection include headache, low blood pressure, and nausea (stomach discomfort). Most of these side effects of Carmendan Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Country of origin

India

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - CAR1408

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:51 AM IST

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Reference

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868185/
  2. https://pubmed.ncbi.nlm.nih.gov/8907134/

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