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compositionComposition:CEFTRIAXONE-250MG
prescription
Prescription Medicine
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Cesafe 250mg Injection is used to treat bacterial infections of the brain, lungs, middle ear, abdomen, urinary tract, kidneys, bones, joints, skin, soft tissues, blood, heart, chest, Lyme disease (caused by tick bites), and gonorrhoea (sexually transmitted disease). It contains Ceftriaxone, which kills the bacteria and helps in treating bacterial infection. In some cases, it may cause side effects such as diarrhoea, rashes, changes in results of blood and liver tests, and abnormalities (increase/decrease) in the number of white blood cells and platelets. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CEFTRIAXONE-250MG

Manufacturer/Marketer :

Gujarat Terce Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Cesafe 250mg Injection

Cesafe 250mg Injection is a prescription injection antibiotic used to treat a wide variety of severe bacterial infections. It is commonly prescribed for serious conditions such as lung infections, meningitis, and infections of the skin, bones, or blood. This medication works by targeting and destroying the bacteria responsible for your illness, helping your body recover.

For this medication to work effectively, it must be injected consistently at the exact times prescribed by your healthcare provider. Because it is given as an injection, food intake does not affect how well it works, meaning it can be injected on an empty or full stomach. Incorporating plenty of rest and staying well-hydrated during your treatment course will significantly support your recovery.

While using Cesafe 250mg Injection, you may experience mild side effects such as temporary pain at the injection site, mild nausea, or loose stools. However, you should contact your doctor immediately if you develop severe watery diarrhoea, a widespread skin rash, or yellowing of your skin and eyes.

Before starting treatment, it is vital to discuss your medical history with your doctor, especially if you have liver disease, kidney problems, or gallbladder issues. This medication must not be used in premature infants, newborns who require calcium-containing fluids through an intravenous line, or anyone with a known severe allergy to cephalosporin antibiotics.

Inform your healthcare provider about all medications you take, as this injection can interact with blood thinners and certain intravenous fluids. It is also wise to avoid alcohol during treatment, and special care should be taken if you are pregnant, breastfeeding, or an elderly patient. Talk to your doctor or pharmacist for personalised advice.

Uses of Cesafe 250mg Injection

Cesafe 250mg Injection is a broad-spectrum antibiotic used to treat a variety of serious bacterial infections and to prevent infections in certain surgical procedures.

  • Severe bacterial infections: Cesafe 250mg Injection is used to treat serious infections affecting the bloodstream, bones, joints, abdomen, and other parts of the body by eliminating susceptible bacteria.
  • Bacterial meningitis: It helps treat infections of the membranes surrounding the brain and spinal cord by reaching effective concentrations within the central nervous system.
  • Community-acquired pneumonia: Cesafe 250mg Injection is used to treat bacterial lung infections, helping clear the infection and improve breathing.
  • Urinary tract infections (UTIs): It is effective against many bacteria responsible for complicated infections of the bladder, urinary tract, and kidneys.
  • Surgical infection prevention: The medication may be given before certain surgical procedures to reduce the risk of postoperative bacterial infections.
  • Gonorrhoea: Cesafe 250mg Injection is commonly used as an effective treatment for uncomplicated gonorrhoea caused by susceptible strains of bacteria.

Key Benefits

Cesafe 250mg Injection provides effective treatment for serious bacterial infections and helps promote faster recovery when used as prescribed.

  • Provides rapid antibacterial action: Because it is administered by injection, Cesafe 250mg Injection enters the bloodstream directly and begins fighting susceptible bacteria quickly.
  • Helps treat severe infections effectively: It is often used when infections are serious, widespread, or unlikely to respond adequately to oral antibiotics.
  • Offers convenient once-daily dosing for many infections: Its long duration of action often allows treatment with a single daily dose, improving convenience and treatment adherence.
  • Provides broad-spectrum bacterial coverage: Cesafe 250mg Injection is active against a wide range of bacteria, making it useful for treating various types of infections.
  • Supports recovery and symptom relief: By eliminating the bacteria causing the infection, it helps reduce symptoms such as fever, pain, inflammation, and discomfort.
  • Helps prevent surgical site infections: When used before surgery, it can reduce the likelihood of bacterial infections developing after the procedure.
  • Remains effective against many resistant bacteria: Cesafe 250mg Injection is stable against certain bacterial resistance mechanisms, making it a reliable treatment option for many difficult-to-treat infections.
Side effects of Cesafe 250mg Injection
  • Drink plenty of water to stay hydrated.
  • Avoid foods that can cause black stools, such as liquorice, blueberries, and iron-rich foods.
  • Practice stress-reducing techniques like meditation, deep breathing, or yoga to help minimize stress-related digestive issues.
  • Avoid taking medications that can cause black stools, such as iron supplements or bismuth subsalicylate.
  • Monitor your stool colour, consistency, and frequency to identify any changes or patterns.
  • Seek medical attention if you experience persistent or severe black stools, abdominal pain, or other symptoms.
  • Get tested if your doctor suspects an underlying condition, such as gastrointestinal bleeding or ulcers.
  • Make lifestyle changes, such as getting regular exercise and quitting smoking, to help improve overall digestive health.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Directions for Use

To ensure the best treatment outcomes, Cesafe 250mg Injection should be administered exactly as prescribed by your healthcare provider.

  • Cesafe 250mg Injection is given as an injection, either into a muscle (intramuscularly) or into a vein (intravenously), usually by a trained healthcare professional.
  • The medication may be administered in a hospital, clinic, or home-care setting, depending on your treatment plan.
  • If you have been instructed to administer Cesafe 250mg Injection at home, ensure you receive proper training on preparation, handling, and injection techniques before use.
  • Check the prepared solution before administration. It should generally appear clear and free from visible particles. Do not use the medication if it appears cloudy, discoloured, or contains particles.
  • Administer the medication at the times recommended by your doctor to maintain effective levels in the body.
  • Complete the full course of treatment exactly as prescribed, even if you start feeling better before the treatment is finished.
  • Do not skip doses or stop treatment early unless instructed by your healthcare provider, as this may reduce treatment effectiveness and increase the risk of antibiotic resistance.

How Cesafe 250mg Injection Works

Cesafe 250mg Injection belongs to a group of medicines known as cephalosporin antibiotics. It works by interfering with the formation of the bacterial cell wall. Bacteria require a strong, fully formed cell wall to protect themselves from their environment and to survive. By blocking the chemical processes needed to build these walls, the medication causes the bacterial cells to develop leaks and rupture. This directly kills the bacteria causing the illness, allowing your body's natural immune system to easily clear the remaining infection.
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Alcohol

Caution

Avoid consuming alcohol while taking Cesafe 250mg Injection to prevent unpleasant side-effects.

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Pregnancy

Caution

Please consult your doctor if you are pregnant; your doctor will prescribe Cesafe 250mg Injection only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding; your doctor will prescribe Cesafe 250mg Injection only if the benefits outweigh the risks.

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Driving

Caution

Cesafe 250mg Injection may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have liver impairment/liver disease.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease.

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Children

Safe if prescribed

Cesafe 250mg Injection is safe for children if prescribed by a doctor. Cesafe 250mg Injection is not recommended for a premature baby, or a newborn baby who has jaundice (yellowing of the skin or eyes).

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Heart

Consult your doctor

Please consult your doctor before receiving Cesafe 250mg Injection if you have pre-existing heart problems. Your doctor will administer Cesafe 250mg Injection if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Cesafe 250mg Injection to geriatric patients. Your doctor will prescribe Cesafe 250mg Injection if the benefits outweigh the risks.

What if I have taken an overdose of Cesafe 250mg Injection

Because this medication is typically prepared and administered under professional medical supervision, an overdose is highly unlikely. However, if you suspect an overdose or experience severe symptoms like muscle twitches or seizures, seek immediate emergency medical attention.

Diet & Lifestyle Advise

  • Stay Well-Hydrated: Drink plenty of water throughout the day to help your kidneys process and safely eliminate the medication from your body.
  • Support Gut Health: Eat probiotic-rich foods (such as yoghurt or kefir) or take a probiotic supplement a few hours after your injection to help maintain healthy gut bacteria and minimise stomach upset.
  • Get Adequate Rest: Prioritise rest and avoid strenuous physical activities to give your immune system the energy it needs to fight off the infection.
  • Avoid Alcohol: Avoid drinking alcohol during your treatment, as it can strain your digestive system and liver while your body is recovering.
health query

Have a query?

How Soon It Starts Working

The time required for Cesafe 250mg Injection to start to work: Cesafe 250mg Injection ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Cesafe 250mg Injection last: The effect of Cesafe 250mg Injection lasts for 48 hours.

What if you forget to take Cesafe 250mg Injection

If you miss a dose, contact your doctor or home-care provider immediately for instructions on when to receive your next injection. Do not double the dose to make up for a missed one.

Storage

• Store unmixed (dry powder) Cesafe 250mg Injection vials at room temperature, typically between 20°C and 25°C (68°F and 77°F). • Keep the vials in their original packaging to protect them from light and moisture.

Drug Warnings

  • Inspect the Solution Before Use: Always check the liquid solution before injecting. Do not use it if it appears cloudy, contains floating particles, or has changed to a dark colour.
  • Avoid Mixing With Calcium-Containing Fluids: Never mix Cesafe 250mg Injection with any fluids containing calcium in the same intravenous line, as this can cause dangerous solid particles to form.
  • Rotate Injection Sites: If you are receiving intramuscular injections, rotate your injection sites regularly to help prevent muscle soreness and tissue hardening.
  • Monitor for Injection Site Reactions: Watch the injection site closely and contact your doctor if you notice worsening redness, warmth, throbbing pain, swelling, or pus.
  • Inform Healthcare Providers: Tell all of your healthcare providers, including your dentist, that you are being treated with Cesafe 250mg Injection before undergoing any medical tests, procedures, or surgeries.

Drug-Drug Interactions

verifiedApollotooltip

Cesafe 250mg Injection may interact with certain medications, requiring additional monitoring or precautions during treatment.

  • Calcium-containing intravenous solutions: Cesafe 250mg Injection should not be mixed or administered simultaneously with calcium-containing intravenous products through the same infusion line, particularly in newborns, as this can result in the formation of precipitates that may cause serious complications.
  • Blood thinners (such as warfarin): Using Cesafe 250mg Injection together with anticoagulants may increase the risk of bleeding and may require monitoring of blood clotting parameters.
  • Aminoglycosides and certain other antibiotics: Concurrent use may increase the risk of kidney-related side effects, particularly in patients with existing kidney impairment.
CeftriaxoneCalcium chloride
Critical
CeftriaxoneCalcium gluconate
Critical

Drug-Drug Interactions

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CeftriaxoneCalcium chloride
Critical
How does the drug interact with Cesafe 250mg Injection:
Co-administration of Calcium chloride with Cesafe 250mg Injection can increase the risk of side effects.

How to manage the interaction:
Taking Cesafe 250mg Injection with Calcium chloride is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
CeftriaxoneCalcium gluconate
Critical
How does the drug interact with Cesafe 250mg Injection:
Co-administration of Calcium gluconate with Cesafe 250mg Injection can increase the risk of adverse effects.

How to manage the interaction:
Taking Cesafe 250mg Injection with Calcium gluconate is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CeftriaxoneCholera, live attenuated
Severe
How does the drug interact with Cesafe 250mg Injection:
Taking the cholera vaccine after or along with Cesafe 250mg Injection may reduce the activity of the vaccine.

How to manage the interaction:
Although taking Cesafe 250mg Injection and Cholera, live attenuated together can evidently cause an interaction, it can be taken if your doctor has suggested it. To ensure adequate vaccine response, you should not receive cholera vaccine, live until at least 14 days after you complete your antibiotic therapy. In case you experience any unusual side effects, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Cesafe 250mg Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Cesafe 250mg Injection is used to treat bacterial infections of the brain, lungs, middle ear, abdomen, urinary tract, kidneys, bones, joints, skin, soft tissues, blood, heart, chest, lime disease (caused by tick bites), and gonorrhoea (sexually transmitted disease).
Cesafe 250mg Injection works by preventing the formation of bacterial cell covering, which is necessary for their survival. Thereby, kills the bacteria and helps in treating and preventing the spread of infections.
Cesafe 250mg Injection may cause dizziness, so drive only if you are alert and omit driving and operating machinery if you experience dizziness.
Cesafe 250mg Injection may affect the results of urine tests for sugar and blood test known as coomb’s test (antiglobulin test). Inform the person performing the tests that you are taking Cesafe 250mg Injection.
Do not take antacids along with Cesafe 250mg Injection; maintain a gap of 2-3 hours between both. However, consult your doctor before taking other medicines while on treatment with Cesafe 250mg Injection.
Yes, Cesafe 250mg Injection is generally considered safe when taken in the recommended dose and duration as directed by your doctor. However, sometimes it may cause side effects or allergic reactions in some individuals. Please let your doctor know if any of the side effects bother you.
Cesafe 250mg Injection usually starts working within a few hours after administration. However, Cesafe 250mg Injection may take a few days to show its full effect, depending on the infection being treated. If your symptoms do not improve or get worse, please consult your doctor.
Cesafe 250mg Injection should not be used by individuals who are allergic to its components or other cephalosporin antibiotics. It is also not recommended for use in newborns, especially those with jaundice (yellowing of the skin or eyes).
If you do not feel better after using Cesafe 250mg Injection, it could mean that the infection isn't responding to the antibiotic, or you might have a different type of infection that needs a different treatment. Please consult your doctor for further evaluation and to discuss possible changes to your treatment plan.
Yes, Cesafe 250mg Injection is effective against a wide range of bacterial infections, including respiratory, urinary tract, skin, and bloodstream infections.
Cesafe 250mg Injection will be administered either intravenously (IV) or intramuscularly (IM), depending on the condition being treated, by your healthcare provider. Please do not self-administer.
No, you should complete the full course of treatment with Cesafe 250mg Injection as prescribed by your doctor, even if you feel better. Please consult your doctor before stopping the medication early, as your infection may not be completely treated and the bacteria may become resistant to the antibiotics.
If you are allergic to Cefuroxime, there is a possible risk of an allergic reaction to Cesafe 250mg Injection, since both are in the same group of antibiotics (cephalosporins). Please consult your healthcare provider before taking Cesafe 250mg Injection or any other cephalosporin antibiotics to ensure safety.
Before starting Cesafe 250mg Injection, you should inform your doctor if you have recently received calcium-containing products, have had diarrhoea after taking antibiotics, or have a history of colitis (inflammation of the large intestine), malnutrition (inability to consume or digest essential nutrients), problems with vitamin K levels, or kidney or liver disease.
No, Cesafe 250mg Injection should only be administered by a healthcare professional, as it requires proper injection technique and monitoring for potential side effects. Please do not administer Cesafe 250mg Injection at home.
No, Cesafe 250mg Injection belongs to the cephalosporin class of antibiotics. However, because they are chemically related to penicillins, you must tell your doctor if you have ever had a severe allergic reaction to penicillin. Talk to your doctor or pharmacist.
Intramuscular injections can cause temporary stinging or aching because of the volume of the medicine entering the muscle. Healthcare providers often mix the powder with a local numbing medicine (like lidocaine) to make the injection much more comfortable. Talk to your doctor or pharmacist.
Yes, for certain infections like uncomplicated gonorrhoea, a single intramuscular injection of Cesafe 250mg Injection is often highly effective and sufficient to cure the infection. For other severe infections, a multi-day course is required. Talk to your doctor or pharmacist.
This medicine is long-acting, which is why it is usually given only once a day. It can take several days after your last dose for the active medication to be completely cleared from your body. Talk to your doctor or pharmacist.
No, Cesafe 250mg Injection is an antibiotic that only kills bacteria. It will not work against viral infections like the common cold, flu, or COVID-19. Talk to your doctor or pharmacist.
Contact your healthcare provider immediately to reschedule your dose. Keeping steady levels of the medication in your body is critical to successfully curing the bacterial infection. Talk to your doctor or pharmacist.
Yes, diarrhoea is a possible side effect of Cesafe 250mg Injection. Drink plenty of fluids and eat simple, non-spicy foods. If the diarrhoea becomes severe, watery, or bloody, do not take anti-diarrhoeal medicines without medical advice and contact your doctor immediately, as this may indicate a serious bowel infection.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 0550585S063Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Ceftriaxone Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. National Center for Biotechnology Information (NCBI). Ceftriaxone Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Ceftriaxone Ceftriaxone. 2013. [Accessed on 07 Feb. 2019]Check here
  5. Ceftriaxone Ceftriaxone. [Accessed on 19 Mar. 2025]Check here
  6. Rocephin 1g Powder for Solution for Injection or Infusion [Internet]. Accessdata.fda.gov. 2021 [Accessed on 18 November 2025]Check here
  7. CEFBACT Injection [Internet]. CiplaMed. 2021 [Accessed on 18 November 2025]Check here

Country of origin

India

Manufacturer/Marketer address

MAHIMA PLACE M G ROADPATNA PS PIRBAHORE PATNA PATNA PS PIRBAHORE PATNA BR 800004 IN
Other Info - CE47149
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