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compositionComposition:CILOSTAZOL-50MG
prescription
Prescription Medicine
info
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Cilokem 50mg Tablet is used to treat intermittent claudication (pain, tingling, and numbness in the legs). It contains Cilostazol, which works by expanding the veins and reducing the stickiness of the platelets. Therefore, enhancing the blood flow to the lower limbs. This medicine may sometimes cause side effects such as headache, dizziness, diarrhoea, abnormal stool, bleeding, loss of appetite, and rashes. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CILOSTAZOL-50MG

Manufacturer/Marketer :

Mediva Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cilokem 50mg Tablet

Cilokem 50mg Tablet is an oral prescription medication used to improve the symptoms of a circulation problem in the legs called intermittent claudication. This condition causes painful cramping in your calf or thigh muscles when you walk or exercise. By helping blood flow more easily, this medicine allows you to walk longer distances before the pain starts.

To get the best results, you need to take this medicine consistently every day, typically twice daily. If you are also taking certain medicines that strongly slow the breakdown of Cilokem 50mg Tablet (such as some antifungals or antibiotics), your doctor may reduce the dose to lower the risk of side effects. It is highly recommended to take it on an empty stomach, either 30 minutes before or 2 hours after your morning and evening meals. Making healthy adjustments, such as quitting smoking and eating a heart-healthy diet, can also significantly improve your walking distance.

Some people taking Cilokem 50mg Tablet may experience mild side effects like headaches, a runny nose, or diarrhoea. However, if you experience serious symptoms such as a fast or irregular heartbeat, severe chest pain, or unusual bruising, you should contact your doctor immediately.

Talk to your doctor before starting this medicine if you have any history of heart issues. Do not take this medicine if you have heart failure of any severity, are allergic to Cilokem 50mg Tablet or any of its ingredients, or have active bleeding issues such as a bleeding stomach ulcer. It is also generally not recommended for people with severe liver impairment, and those with severe kidney disease may require careful monitoring.

Cilokem 50mg Tablet can interact with other blood thinners, certain stomach acid medicines, and even grapefruit juice, which can raise its levels in your body. It is important to discuss its safety with your healthcare provider if you are pregnant, planning to become pregnant, breastfeeding, or if you are an older adult.

Uses of Cilokem 50mg Tablet

Cilokem 50mg Tablet used in the treatment of Intermittent claudication (pain, tingling, and numbness in the legs). The detailed uses of Cilokem 50mg Tablet are as follows:

  • Intermittent claudication: Cilokem 50mg Tablet helps improve blood flow in the legs, reducing the muscle pain, cramping, numbness, and weakness that occur during physical activity.
  • Improving walking distance: By keeping blood vessels open and preventing blood cells from sticking together, Cilokem 50mg Tablet allows patients with circulation issues to walk farther before needing to stop and rest.

Key Benefits

Cilokem 50mg Tablet brings real-world relief to patients dealing with painful circulation problems. By addressing the root cause of poor blood flow, this medication provides several clinical benefits:

  • Helps reduce the painful muscle cramps in your calves, thighs, or buttocks during physical activity.
  • Allows you to walk longer distances comfortably, making daily tasks like grocery shopping or walking the dog much easier.
  • Supports better overall circulation in your lower limbs, helping you regain physical independence and mobility.
Side effects of Cilokem 50mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Your doctor may adjust the dose of your medication, discontinue, or switch to alternative medicines to manage your symptoms.
  • Drink plenty of water and caffeine-free drinks.
  • Eat more fibre by consuming fruits, vegetables, and whole grains.
  • Avoid processed, spicy, or fatty foods.
  • Try not to skip meals, delay eating, or eat too quickly.
  • Regular exercise can help improve digestion and promote better stool movement.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
  • Take this medicine on an empty stomach. This means you should take it at least 30 minutes before breakfast and dinner, or at least 2 hours after you have eaten.
  • Set a daily routine by taking your doses at the same times every day to maintain a steady level of the medication in your body.
  • Always follow your doctor's exact instructions regarding how many tablets to take and when to take them.

How Cilokem 50mg Tablet Works

Cilokem 50mg Tablet contains Cilostazol, which works in two main ways to improve blood flow in your limbs. First, it helps to widen blood vessels in your legs. This allows oxygen-rich blood to flow more freely to your tired leg muscles, reducing the painful cramping that happens when you walk or exercise. Second, it stops certain blood cells called platelets from sticking together and forming clots. By keeping your blood flowing smoothly and keeping the pathways open, Cilokem 50mg Tablet directly addresses the underlying circulation issues that cause leg pain.
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Alcohol

Caution

It is best to limit or avoid alcohol while taking this medicine.

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Pregnancy

Consult your doctor

Cilokem 50mg Tablet should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Breast Feeding

Consult your doctor

Cilokem 50mg Tablet should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Driving

Unsafe

Cilokem 50mg Tablet may cause dizziness. So, it is not recommended to drive or operate heavy machinery when you take Cilokem 50mg Tablet .

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Liver

Safe if prescribed

Cilokem 50mg Tablet is safely given to the liver patients as there have been no published reports of hepatotoxicity. No dosage adjustment is necessary for patients with liver disease.

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Kidney

Caution

Cilokem 50mg Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Cilokem 50mg Tablet is not recommended for children. The safety and effectiveness of Cilokem 50mg Tablet have not been established in children.

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Heart

Caution

Cilokem 50mg Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Cilokem 50mg Tablet .

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Geriatrics

Safe if prescribed

Cilokem 50mg Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Cilokem 50mg Tablet

If you take too much of this medicine, you may experience severe headaches, rapid heartbeat, or dizziness. Seek emergency medical attention or contact your local poison control centre immediately.

Diet & Lifestyle Advise

  • Avoid grapefruit and grapefruit juice: Grapefruit can block the enzymes that break down Cilokem 50mg Tablet in your body, leading to unsafe levels of the medication in your bloodstream.
  • Quit smoking: Smoking constricts your blood vessels and accelerates plaque buildup, which directly conflicts with the benefits of this medicine.
  • Engage in a structured walking program: Regularly walking up to the point of mild pain, resting, and walking again can help build your vascular stamina over time. Talk to your doctor to design a safe exercise plan.
  • Eat a heart-healthy diet: Focus on low-fat, low-sodium foods to help manage cholesterol and blood pressure, supporting overall vascular health.
health query

Have a query?

How Soon It Starts Working

  • The time required for Cilokem 50mg Tablet to start to work: The time required for Cilokem 50mg Tablet to show its action is unknown.
  • The time for which the effects of Cilokem 50mg Tablet last: The effect of Cilokem 50mg Tablet lasts for 12 hours.

What if you forget to take Cilokem 50mg Tablet

If you miss a dose, skip the missed dose and take your next scheduled dose at your usual time. Do not take two doses at once to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep this medicine out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Avoid high-fat meals around your dose: Do not eat a high-fat meal just before or after taking this medicine. It can increase the amount of medicine your body absorbs and raise the risk of side effects.
  • Monitor your heart rate: Check your pulse regularly if advised by your doctor. Tell your doctor if your resting heart rate is consistently higher than usual.
  • Stand up slowly: Get up slowly from a sitting or lying position. This can help reduce dizziness and lower the risk of falling.
  • Inform healthcare providers: Tell your dentist or surgeon that you are taking this medicine before any medical or dental procedure. It can affect how your blood clots.
  • Check before taking pain relievers: Do not take aspirin or other over-the-counter pain medicines without asking your doctor first. Some of these medicines can increase your risk of bleeding.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (e.g., warfarin, clopidogrel, aspirin): Combining these medicines with Cilokem 50mg Tablet can significantly increase your risk of internal or external bleeding.
  • Stomach acid reducers (e.g., omeprazole): These medicines can increase the amount of Cilokem 50mg Tablet absorbed into your system, raising the risk of side effects like headaches and dizziness.
  • Certain antibiotics and antifungals (e.g., erythromycin, ketoconazole): These medicines may block the breakdown of Cilokem 50mg Tablet , leading to higher, unsafe levels of the drug in your body.
CilostazolCisapride
Critical
CilostazolMesoridazine
Critical

Drug-Drug Interactions

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CilostazolCisapride
Critical
How does the drug interact with Cilokem 50mg Tablet:
When Cilokem 50mg Tablet is taken with Cisapride, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Cisapride and Cilokem 50mg Tablet is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolMesoridazine
Critical
How does the drug interact with Cilokem 50mg Tablet:
When Mesoridazine is taken with Cisapride, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Mesoridazine with Cilokem 50mg Tablet, is not recommended but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolSparfloxacin
Critical
How does the drug interact with Cilokem 50mg Tablet:
When Cilokem 50mg Tablet is taken with Sparfloxacin, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Sparfloxacin and Cilokem 50mg Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolPimozide
Critical
How does the drug interact with Cilokem 50mg Tablet:
When Cilokem 50mg Tablet is taken with Pimozide, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Pimozide with Cilokem 50mg Tablet is not generally advised, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolThioridazine
Critical
How does the drug interact with Cilokem 50mg Tablet:
When Cilokem 50mg Tablet is taken with Thioridazine, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Thioridazine with Cilokem 50mg Tablet is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolZiprasidone
Critical
How does the drug interact with Cilokem 50mg Tablet:
When Cilokem 50mg Tablet is taken with Ziprasidone, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Ziprasidone and Cilokem 50mg Tablet is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolMifepristone
Severe
How does the drug interact with Cilokem 50mg Tablet:
Co-administration of Cilokem 50mg Tablet with mifepristone may increase the risk of side effects.

How to manage the interaction:
Taking cilastazol with mifepristone together can possibly result in an interaction, it can be taken if your doctor has advised it. Contact a doctor immediately if you experience symptoms such as dizziness, lightheadedness, headache, fainting, and heart palpitations, nausea, diarrhea, bleeding. Do not discontinue any medications without consulting a doctor.
CilostazolDelavirdine
Severe
How does the drug interact with Cilokem 50mg Tablet:
Co-administration of delavirdine with Cilokem 50mg Tablet may increase the risk of side effects.

How to manage the interaction:
Taking delavirdine with Cilokem 50mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, nausea, diarrhea, bleeding. Do not discontinue any medications without consulting a doctor.
CilostazolKetoconazole
Severe
How does the drug interact with Cilokem 50mg Tablet:
Co-administration of ketoconazole with Cilokem 50mg Tablet may increase the risk of side effects.

How to manage the interaction:
Although taking Ketoconazole and Cilokem 50mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you notice nausea, diarrhea, fainting, bleeding, abnormal heartbeat, or palpitations and dizziness, consult a doctor. Do not discontinue any medications without consulting a doctor.
CilostazolPapaverine
Severe
How does the drug interact with Cilokem 50mg Tablet:
Co-administration of papaverine with Cilokem 50mg Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking papaverine with Cilokem 50mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: This fruit interferes with how your liver processes the medication, which can cause levels to rise to unsafe amounts.
  • High-fat meals: Taking this medicine with fat-heavy food increases its absorption, which can make side effects like headaches or rapid heartbeat more severe.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

Cilokem 50mg Tablet consists of the anti-platelet drug (blood thinner) primarily used to treat intermittent claudication (pain, tingling, and numbness in the legs).
Cilokem 50mg Tablet belongs to a class of medications called a blood thinner or an antiplatelet medication. Cilokem 50mg Tablet plays a vital role in preventing the formation of harmful blood clots (plaque) in your veins. Cilokem 50mg Tablet works by expands the veins and reduces the stickiness of the platelets. Therefore, enhancing the blood flow to the lower limbs.
Yes, Cilokem 50mg Tablet increases the risk of bleeding. Always be careful while doing activities that may lead to bleeding or an injury. Immediately inform your doctor if you observe any abnormal damaging or bleeding.
Cilokem 50mg Tablet decreases your risk of developing blood clots in the veins of your leg, heart, lungs, and brain. You may not feel any change after taking Cilokem 50mg Tablet . However, keep taking this Cilokem 50mg Tablet as recommended by your doctor as you will still be receiving its full advantages.
Since Cilokem 50mg Tablet widens veins, it generally reduces blood pressure. Hence, if you are taking medicines that lower blood pressure, you should be cautious. Taking Cilokem 50mg Tablet with other blood pressure-lowering medicines may reduce your blood pressure to very low amounts. Monitor your blood pressure frequently and talk to your doctor if a dose adjustment is needed. Cilokem 50mg Tablet has also been reported to raise blood pressure, and the reason for this is unknown.
Yes, Cilokem 50mg Tablet causes blood thinning. It works by preventing platelets (a type of blood cell) from sticking together and forming clots.
Please consult your doctor if Cilokem 50mg Tablet needs to be stopped before undergoing surgery. The doctor might ask you to stop taking Cilokem 50mg Tablet a few days before surgery to avoid the increased risk of bleeding during the procedure.
Cilokem 50mg Tablet is usually taken as a long-term treatment if it improves your symptoms. Your doctor will typically reassess your progress after about 3 months. If you have not experienced a meaningful improvement in your walking distance or leg pain, your doctor may recommend stopping the medicine and exploring other treatment options. Continue taking it only as directed by your healthcare provider.
No, you should take Cilokem 50mg Tablet on an empty stomach, either 30 minutes before breakfast and dinner, or 2 hours after. Taking it with food, especially high-fat meals, increases side effects. Talk to your doctor or pharmacist if you have trouble scheduling your doses.
Cilokem 50mg Tablet belongs to a class of medicines that can make heart failure worse and increase the risk of serious complications or death in people with heart failure. Do not take this medicine if you have heart failure. Talk to your doctor to find a safer alternative.
It is best to limit or avoid alcohol while taking this medicine, as alcohol can widen your blood vessels further, increasing your risk of dizziness, headaches, and low blood pressure. Talk to your doctor for personalised advice.
No, Cilokem 50mg Tablet does not cure the disease, but it manages the symptoms by widening blood vessels and preventing clotting. It helps you walk further with less pain as long as you continue taking it. Talk to your doctor about comprehensive lifestyle plans.
Headaches are a very common side effect, especially when starting the medicine, and they often improve over time. However, if the headache is severe, persistent, or accompanied by vision changes, contact your doctor. Do not take aspirin or other pain relievers without consulting your pharmacist first.
It is generally not recommended to take this medicine during pregnancy or while breastfeeding unless your doctor decides it is absolutely necessary. Talk to your doctor about the risks and benefits.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Cilostazol Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.2590 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Cilostazol Cilostazol. [Accessed on 15 Mar. 2019]Check here
  4. Balinski AM, Preuss CV Cilostazol. [Updated 2023 Mar 27]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023Check here
  5. Cilostazol [Prescrining Information]. 2022. [Accessed on 16 Jun. 2023]Check here
  6. Cilostazol 50 mg tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 20 May 2022]Check here
  7. Cilostazol 50 mg tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 20 May 2022]Check here

Country of origin

India

Manufacturer/Marketer address

50, OKHLA INDUSTRIAL ESTATE PHASE-III NEW DELHI DL 110020 IN
Other Info - CIL0029
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