Do not take Ciplox-500 Tablet 10's if you are allergic or have had a severe reaction to ciprofloxacin or any other quinolone or fluoroquinolone antibiotic such as delafloxacin gemifloxacin, levofloxacin, moxifloxacin and ofloxacin. Taking Ciplox-500 Tablet 10's may increase the chances of developing tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle). Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, kidney disease, a joint or tendon disorder such as rheumatoid arthritis (auto immune disorder of joints causing pain, swelling, and loss of function), seizures (fits), epilepsy or if you participate in regular physical activity. Taking Ciplox-500 Tablet 10's may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Dairy products should be avoided along with Ciplox-500 Tablet 10's. And also, exposure to sunlight should be avoided while taking Ciplox-500 Tablet 10's as it may cause increased phototoxicity or photosensitivity. Patients with epilepsy, and irregular heartbeat (especially a condition known as QT prolongation) should tell their doctor before taking Ciplox-500 Tablet 10's.

Drug-drug interactions: This medicine may have an interaction with blood thinners (such as warfarin), antidepressants and antipsychotics (like clozapine, olanzapine), caffeine-containing medications, insulin or other anti-diabetic medications (like chlorpropamide, glimepiride, glipizide, glyburide, tolazamide, and tolbutamide), medications for regulating irregular heartbeat (like amiodarone, disopyramide, procainamide, quinidine), pain killers (like ibuprofen and naproxen).

Drug-Food Interactions:  Ciplox-500 Tablet 10's interacts with dairy products (like milk or yoghurt) or calcium-fortified juices alone.

Drug-Disease Interactions: Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, kidney disease, a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its joints, causing pain, swelling, and loss of function), seizures, epilepsy or if you participate in regular physical activity before starting Ciplox-500 Tablet 10's.

• Do not drink or eat a lot of caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. Ciplox-500 Tablet 10's may increase nervousness, sleeplessness and anxiety caused by caffeine.
• Probiotics should be taken after taking the full course of Ciplox-500 Tablet 10's to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha and kimchi can help restore the intestine's good bacteria. 
• Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet. Make sure you drink plenty of water or other fluids daily while taking Ciplox-500 Tablet 10's.
• Avoid intake of alcoholic beverages with Ciplox-500 Tablet 10's as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Ciplox-500 Tablet 10's in fighting off infections.