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  3. CLADRIM 10MG INJECTION

CLADRIM 10MG INJECTION, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

CLADRIM 10MG INJECTION is used to treat hairy cell leukaemia (cancer of a specific type of white blood cell). It contains Cladribine, a class of medications known as purine analogues. It works by stopping or slowing the growth of cancer cells. Common side effects of this medication include insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection.

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Composition :

CLADRIBINE-10MG

Manufacturer/Marketer :

Dabur India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About CLADRIM 10MG INJECTION

CLADRIM 10MG INJECTION belongs to a group of anticancer medicines called purine analogue used in the treatment of hairy cell leukaemia. Leukaemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. 

CLADRIM 10MG INJECTION contains Cladribine, which belongs to the class of purine antimetabolites. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

CLADRIM 10MG INJECTION may cause certain side effects such as insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection. Most of these side effects of CLADRIM 10MG INJECTION do not require medical attention and gradually resolve over time. A trained healthcare professional will administer CLADRIM 10MG INJECTION. Hence, do not self-administer.

If you are allergic to CLADRIM 10MG INJECTION, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with CLADRIM 10MG INJECTION. CLADRIM 10MG INJECTION is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, hemolytic anaemia, or severe bone marrow suppression before starting the treatment, as it may worsen your condition. Inform your doctor if you have received any vaccination before starting the treatment.

Uses of CLADRIM 10MG INJECTION

CLADRIM 10MG INJECTION is used in the treatment of Hairy cell Leukemia. The detailed use of CLADRIM 10MG INJECTION is as follows:

  • Hairy Cell Leukemia: CLADRIM 10MG INJECTION is used to reduce abnormal white blood cells and restore normal bone marrow function.

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Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • CLADRIM 10MG INJECTION is administered by the doctor or nurse in a clinical setting.
  • Do not self-administer.

Medicinal Benefits

CLADRIM 10MG INJECTION contains Cladribine, which is used in the treatment of multiple sclerosis. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, CLADRIM 10MG INJECTION stops the multiplication of abnormal cells and causes the death of cancer cells.

How CLADRIM 10MG INJECTION Works

CLADRIM 10MG INJECTION contains Cladribine, which belongs to the class of purine antimetabolites. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

Storage

• Store in a cool and dry place away from sunlight.• Keep CLADRIM 10MG INJECTION out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Cladrim 10mg Injection
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Receive vaccinations to guard against bacterial infections.
  • Maintain good hygiene by washing hands often and covering your mouth/nose when coughing or sneezing.
  • Make sure to store, cook, and handle food properly, to prevent food-borne infections.
  • Regularly clean surfaces that are touched often with disinfectants.
  • Protect yourself from insect bites by using repellents and wearing appropriate clothing, especially in high-risk areas.
  • Use latex or polyurethane condoms during sex to minimize the risk of infections.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.

What if I have taken an overdose of CLADRIM 10MG INJECTION

As CLADRIM 10MG INJECTION is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of CLADRIM 10MG INJECTION may cause black and tarry or bloody stools, bloody vomit or vomited material that looks like coffee grounds, decreased urination, fever, sore throat, chills, or other signs of infection, loss of ability to move the arms or legs, pain, burning, numbness, or tingling in the hands or feet, swelling of the face, arms, hands, feet, ankles, or lower legs, unusual tiredness or weakness, unusual bleeding or bruising and weakness in the arms or legs.

Drug Warnings

If you are allergic to CLADRIM 10MG INJECTION, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with CLADRIM 10MG INJECTION. CLADRIM 10MG INJECTION is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, haemolytic anaemia, severe bone marrow suppression, thrombocytopenia (low number of platelets), or neutropenia (low white blood cells) before starting the treatment, as it may worsen your condition. If you are about to receive any vaccinations, inform your doctor beforehand, as it may cause infection.

Drug-Drug Interactions

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CladribineIbrutinib
Severe
CladribineObinutuzumab
Severe

Drug-Drug Interactions

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CladribineIbrutinib
Severe
How does the drug interact with Cladrim 10mg Injection:
Co-administration of Cladrim 10mg Injection with Ibrutinib can increase the chances of serious infections.

How to manage the interaction:
Although there is a possible interaction between Ibrutinib and Cladrim 10mg Injection, you can take these medicines together if prescribed by a doctor. However, if you have any of these signs & symptoms of infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CladribineObinutuzumab
Severe
How does the drug interact with Cladrim 10mg Injection:
Combining Cladrim 10mg Injection with Obinutuzumab can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladrim 10mg Injection and Obinutuzumab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineHydrocortisone
Severe
How does the drug interact with Cladrim 10mg Injection:
The combined use of Cladrim 10mg Injection and Hydrocortisone can increase the risk of infections.

How to manage the interaction:
Co-administration of Cladrim 10mg Injection and hydrocortisone can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CladribineValganciclovir
Severe
How does the drug interact with Cladrim 10mg Injection:
The combined use of Cladrim 10mg Injection and valganciclovir can increase the risk of infections.

How to manage the interaction:
Taking Cladrim 10mg Injection with Valganciclovir together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while urinating - contact your doctor right away. Do not discontinue any medications without consulting your doctor.
CladribineAltretamine
Severe
How does the drug interact with Cladrim 10mg Injection:
The combined use of adalimumab with Cladrim 10mg Injection can increase the risk of side effects.

How to manage the interaction:
Co-administration of Cladrim 10mg Injection with Altretamine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without talking to a doctor.
CladribineTemsirolimus
Severe
How does the drug interact with Cladrim 10mg Injection:
Combining Cladrim 10mg Injection with Temsirolimus can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladrim 10mg Injection and Temsirolimus together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineFluorouracil
Severe
How does the drug interact with Cladrim 10mg Injection:
Combining Cladrim 10mg Injection with Fluorouracil can increase the risk of side effects.

How to manage the interaction:
Taking Cladrim 10mg Injection with Fluorouracil together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineTemozolomide
Severe
How does the drug interact with Cladrim 10mg Injection:
Using Cladrim 10mg Injection together with temozolomide may increase the risk of serious infections.

How to manage the interaction:
Although taking temozolomide and Cladrim 10mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
CladribineChlorambucil
Severe
How does the drug interact with Cladrim 10mg Injection:
The combined Cladrim 10mg Injection with Chlorambucil can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladrim 10mg Injection with Chlorambucil together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CladribineFluticasone Propionate
Severe
How does the drug interact with Cladrim 10mg Injection:
Taking Cladrim 10mg Injection with Fluticasone propionate can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a interaction, Cladrim 10mg Injection can be taken with fluticasone propionate if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while receiving the medication, as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Caution

It is not known if alcohol interacts with CLADRIM 10MG INJECTION. Please consult the doctor.

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Pregnancy

Unsafe

CLADRIM 10MG INJECTION is not recommended for use in pregnancy as it may harm the foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving CLADRIM 10MG INJECTION. You should not become pregnant while on treatment with CLADRIM 10MG INJECTION.

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Breast Feeding

Unsafe

CLADRIM 10MG INJECTION is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

CLADRIM 10MG INJECTION will be administered to hospitalized patients. Hence, avoid driving.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

CLADRIM 10MG INJECTION is not recommended for use in children as safety and effectiveness have not been established.

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Heart

Please consult your doctor before receiving CLADRIM 10MG INJECTION if you have pre-existing heart problems. Your doctor will prescribe CLADRIM 10MG INJECTION if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering CLADRIM 10MG INJECTION to geriatric patients. Your doctor will prescribe CLADRIM 10MG INJECTION if the benefits outweigh the risks.

FAQs

CLADRIM 10MG INJECTION is used to treat Hairy cell Leukemia.

CLADRIM 10MG INJECTION contains Cladribine, which works by inhibiting the production of genetic material (DNA) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

It is said that concomitant use of CLADRIM 10MG INJECTION along with live vaccines may cause serious adverse effects. Hence, inform your doctor if you have taken any vaccines recently before receiving CLADRIM 10MG INJECTION.

No, CLADRIM 10MG INJECTION is not a vesicant. CLADRIM 10MG INJECTION belongs to a group of anticancer medications called purine analogues used in the treatment of hairy cell leukaemia (a rare type of blood and bone marrow cancer).

CLADRIM 10MG INJECTION may cause hair loss in some cases. However, it is an uncommon side effect of CLADRIM 10MG INJECTION. Consult the doctor if you notice hair loss during treatment with CLADRIM 10MG INJECTION.

The common side effects of CLADRIM 10MG INJECTION may include insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection. Most of these side effects of CLADRIM 10MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, consult the doctor.

Country of origin

India

Manufacturer/Marketer address

8/3, Asaf Ali Road, New Delhi-110002
Other Info - CLA0132

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:51 AM IST

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Reference

  1. https://www.mayoclinic.org/drugs-supplements/cladribine-intravenous-route/description/drg-20062966
  2. https://reference.medscape.com/drug/mavenclad-cladribine-342213
  3. https://medlineplus.gov/druginfo/meds/a693015.html
  4. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a2592a9b-bca6-4a5a-89c2-855a0634d5fe&type=display
  5. https://www.drugs.com/mtm/cladribine-injection.html
  6. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020229s034lbl.pdf

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