Cisplatin
About Cisplatin
Cisplatin is an injectable prescription medicine used to treat advanced cancers of the bladder, ovaries, and testicles. It is a chemotherapy treatment that helps stop cancer cells from growing and multiplying in the body. Doctors typically prescribe it when these types of cancer have spread or have not responded well to other therapies.
This medicine is given as an injection directly into a vein, usually in treatment cycles that take place every three to four weeks. Because it is injected directly into your bloodstream, you do not need to worry about food affecting how well it is absorbed. However, staying highly hydrated before, during, and after your treatment is one of the most important steps you can take to help protect your body during therapy.
While this medicine is highly effective, it can cause common side effects like severe nausea, vomiting, and a temporary loss of appetite. It is important to watch for more serious symptoms, such as ringing in your ears or a sudden decrease in how much you urinate. If you notice any of these serious signs, you must contact your doctor right away.
Before you begin treatment, you should talk to your doctor if you have a history of kidney disease, hearing difficulties, or low blood cell counts. Do not take this medicine if you have severe kidney problems, pre-existing hearing loss, or severely weakened bone marrow activity.
This medication can interact with certain strong antibiotics and water pills, which can increase the risk of kidney and hearing damage. It is also important to talk to your doctor if you drink alcohol or smoke, as these habits can worsen nausea and dehydration. Pregnant or breastfeeding individuals must not receive this medicine, and elderly patients may require closer monitoring by their healthcare team.
Uses of Cisplatin
Medicinal Benefits
Cisplatin helps treat certain types of cancer by slowing or stopping the growth of rapidly dividing cancer cells. With regular use as prescribed, it helps control disease progression, reduce tumour-related symptoms, and support better treatment outcomes.
- Helps Control Cancer Growth: By interfering with the division of rapidly growing cancer cells, this medicine helps shrink tumours and slow the progression of the disease.
- Relieves Cancer-Related Symptoms: As tumour growth is controlled, this medicine may help reduce pain, pressure, and discomfort caused by advanced cancers, improving daily comfort.
- Supports Long-Term Disease Management: By helping prevent the spread of cancer to other parts of the body, this medicine supports ongoing cancer control, improves quality of life, and contributes to better overall treatment outcomes.
Directions for Use
- Follow your doctor’s instructions on the dosage and timing of this medication.
- Cisplatin will be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.
- Do not self-administer.
Storage
Side Effects of Cisplatin
Common Side Effects (Usually mild):
- Severe nausea and vomiting
- Temporary hair thinning or loss
- Loss of appetite or a metallic taste in the mouth
- Feeling unusually tired or weak
Serious Side Effects (Consult a doctor right away):
- Signs of kidney damage, such as urinating much less than usual, blood in your urine, or swelling in your legs and ankles
- Hearing changes, such as ringing in your ears, ear pain, or difficulty hearing high-pitched sounds
- Signs of infection, including a high fever, chills, severe sore throat, or body aches
- Unusual bruising, nosebleeds, or tiny purple spots on your skin
- Nerve issues, like numbness, tingling, or a 'pins and needles' feeling in your hands and feet
- Allergic reactions, such as a skin rash, hives, swelling of the face or throat, or trouble breathing
Medicines Containing this Salt
View AllDrug Warnings
- Check the solution before your infusion; it should be clear, colourless, and free of any visible floating particles.
- Tell your nurse immediately if you feel any burning, stinging, coldness, or pain around the injection site while the medicine is being injected.
- Keep all your scheduled appointments for blood tests and hearing checks, as your doctor needs these to monitor your kidneys, blood counts, and hearing.
- Use reliable birth control during your treatment and for several months afterwards, as this medicine can cause severe harm to an unborn baby.
- Do not get any live vaccines while receiving this medicine without talking to your doctor first.
Drug Interactions
- Strong antibiotics (like gentamicin): May increase the risk of severe kidney damage and hearing loss.
Water pills (like furosemide): Can increase the risk of hearing damage when used at the same time as this medication.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is not known if alcohol affects Cisplatin. Please consult your doctor.
Pregnancy
unsafeCisplatin belongs to pregnancy category D. Cisplatin may cause foetal harm. Therefore, it should not be used during pregnancy.
Breast Feeding
unsafeCisplatin has been reported to be found in human milk. Breastfeeding is not recommended during treatment and for four weeks after the treatment with Cisplatin.
Driving
cautionCisplatin may cause dizziness and tiredness. Avoid driving if you experience any side effects that might lessen your ability to do so.
Liver
consult your doctorIf you have a history of liver disease, inform your doctor before receiving Cisplatin.
Kidney
cautionCisplatin should not be used if you have severe kidney disease or pre-existing renal impairment. If you have a history of kidney disease, inform your doctor before receiving Cisplatin.
Children
cautionCisplatin is not recommended for children as safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Drink plenty of fluids: Drink at least 8 to 12 cups of water or clear broths daily, especially in the days surrounding your treatment, to help flush your kidneys and protect them from damage.
- Eat small, frequent meals: To manage nausea, try eating five or six small meals throughout the day instead of three large ones. Stick to dry, bland foods like toast, crackers, or rice.
- Avoid infections: Wash your hands frequently, avoid crowds, and stay away from people who are sick, as this medicine can temporarily lower your white blood cell count.
- Practice gentle mouth care: Use a soft-bristled toothbrush and rinse your mouth with water or a mild baking soda solution to help prevent painful mouth sores.
- Protect your ears: Avoid very loud environments and wear ear protection when necessary, as your ears may be more sensitive to damage during therapy.
Special Advise
- Regular liver/kidney function tests and blood tests are advised as Cisplatin may cause problems with blood, kidneys, and liver.
- Women must use reliable contraception during treatment and for seven months after receiving the last dose.
- Men with female partners of childbearing potential are advised to use effective contraception during treatment and for four months after the last dose.
Patients Concern
Disease/Condition Glossary
Testicular cancer: It is the cancer in the male organs that make testicles/sperm and male hormones. A feeling of heaviness in the scrotum and a lump in either testicle are the symptoms of testicular cancer.
Ovarian cancer: Ovarian cancer is a cancer that begins in the female reproductive organs where the ovaries/eggs are formed. It often has no symptoms in the early stages. Later stages are associated with symptoms such as weight loss and loss of appetite.
Bladder cancer: It is a cancer that begins in the bladder. It typically affects older adults. The most common symptom is blood in the urine.
Head and neck cancer: It is a group of cancers of the mouth, nose, sinuses, or throat. A significant risk factor is smoking. Symptoms include a sore/lump that does not heal, trouble swallowing, persistent sore throat, and voice change.
Lung cancer: It is a disease that begins in the lungs and mostly occurs in people who smoke. Symptoms of lung cancer are cough, wheezing, chest pain, and weight loss.
Cervical cancer: It is the malignant tumour of the cervix (lowermost part of the uterus). Symptoms include bleeding between periods and after sexual intercourse, foul-smelling white discharge, low back pain, or lower abdominal pain.
FAQs
You should consult your doctor before receiving any vaccines while being treated with Cisplatin. Live vaccines are generally avoided because this medicine may weaken your immune system and increase the risk of infection. Your doctor will advise which vaccines are safe and when they should be given.
Yes. Cisplatin can cause hearing problems, including ringing in the ears (tinnitus) and hearing loss, which may sometimes be permanent. Inform your doctor if you already have hearing problems before starting treatment. Your doctor may perform hearing tests before and during treatment and adjust therapy if necessary. Contact your doctor immediately if you notice changes in your hearing.
Yes. Hair thinning or hair loss is a common side effect of Cisplatin. It is usually temporary, and hair generally grows back after treatment ends. Be gentle when brushing and washing your hair, and speak with your healthcare team if you have concerns or would like advice on managing hair loss.
This medicine is given as a slow drip into a vein (an intravenous infusion) by a healthcare professional in a hospital or clinic. Talk to your doctor if you have questions about the infusion process.
Staying deeply hydrated helps flush the medicine through your kidneys, which is critical for protecting them from damage. Talk to your doctor about exactly how much water you should drink.
Tell your nurse or doctor immediately if you feel pain, burning, coldness, or swelling around the needle. Talk to your doctor or nurse right away if this occurs.
No, this medicine can harm an unborn baby and must not be used during pregnancy. Talk to your doctor about effective birth control options during your treatment.
It is typically given in treatment cycles, often once every 3 to 4 weeks, to allow your body time to rest and recover between sessions. Talk to your doctor about your specific treatment schedule.
