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  3. Cobaleo AM-P Tablet 10's

Cobaleo AM-P Tablet 10's, Pack of 10
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Cobaleo AM-P Tablet is used for the management of neuropathic pain. It contains Pregabalin and Amitriptyline, which works by increasing the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Thus, helps in relieving nerve pain. It may cause common side effects such as weight gain, dry mouth, blurred vision, dizziness, tiredness, nausea, vomiting, diarrhoea, and constipation. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

AMITRIPTYLINE-10MG + PREGABALIN-75MG

Manufacturer/Marketer :

Win Life Science Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Cobaleo AM-P Tablet

Cobaleo AM-P Tablet is a combination medicine indicated for the management of neuropathic pain. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain due to nerve damage or a malfunctioning nervous system. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation.

Cobaleo AM-P Tablet is a combination of two drugs: Pregabalin (anti-convulsant), and Amitriptyline (antidepressant). Pregabalin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Amitriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Together, Cobaleo AM-P Tablet helps to treat neuropathic pain. 

You are advised to take Cobaleo AM-P Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as weight gain, dry mouth, blurred vision, dizziness, tiredness, nausea, vomiting, diarrhoea, and constipation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Cobaleo AM-P Tablet may cause drowsiness and dizziness, so drive only if you are alert. Cobaleo AM-P Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Cobaleo AM-P Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of Cobaleo AM-P Tablet

Treatment of Neuropathic pain

Directions for Use

• Take Cobaleo AM-P Tablet with or without food or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Cobaleo AM-P Tablet is a combination of two drugs: Pregabalin (anti-convulsant), and Amitriptyline (antidepressant). Pregabalin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Amitriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Together, Cobaleo AM-P Tablet helps to treat neuropathic pain. 

How Cobaleo AM-P Tablet Works

Cobaleo AM-P Tablet is a combination of two drugs: Pregabalin (anti-convulsant), and Amitriptyline (antidepressant). Pregabalin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Amitriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Together, Cobaleo AM-P Tablet helps to treat neuropathic pain.

Storage

Keep Cobaleo AM-P Tablet out of reach and sight of children.
Side effects of Cobaleo AM-P Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Include fruits, vegetables, and whole grains in your diet.
  • Exercise regularly.
  • Quit smoking as it may increase the risk of neuropathy.
  • Getting massage therapy and acupuncture might help with pain.
  • Avoid massaging the bruise, as this might worsen the damage to the injured tissue.
  • Resting the affected area helps prevent more injury and aids healing.
  • Place a cloth-wrapped ice pack or cold compress on the affected area for 10 to 15 minutes.
  • If the bruise is extensive, severe, or accompanied by other symptoms like warmth, redness, or swelling, get medical help.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Limit your intake of carbonated drinks, alcohol and caffeine as these substances can irritate your bladder.
  • Do Kegel exercises to strengthen pelvic floor muscles and improve bladder control.
  • Use absorbent pads or underwear to manage accidental urination.
  • If incontinence continues or worsens, see a doctor to check for underlying issues.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.

What if I have taken an overdose of Cobaleo AM-P Tablet

Do not take more than the prescribed dose of Cobaleo AM-P Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Cobaleo AM-P Tablet if you are allergic to any of its contents; if you have taken MAO inhibitors in the last 14days. Inform your doctor before taking Cobaleo AM-P Tablet if you have/had heart problems, bipolar syndrome, severe liver disease or porphyria. Consult your doctor if you are pregnant or breastfeeding. Cobaleo AM-P Tablet may cause drowsiness and dizziness, so drive only if you are alert. Cobaleo AM-P Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Cobaleo AM-P Tablet as it could lead to increased drowsiness and sleepiness.

Drug-Drug Interactions

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AmitriptylinePotassium chloride
Critical
AmitriptylineHalofantrine
Critical

Drug-Drug Interactions

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AmitriptylinePotassium chloride
Critical
How does the drug interact with Cobaleo AM-P Tablet:
The combination of Cobaleo AM-P Tablet and Potassium chloride may cause stomach and upper intestinal discomfort. (Only applicable to an oral preparation)

How to manage the interaction:
Although co-administration of Cobaleo AM-P Tablet and Potassium chloride is not recommended as it can possibly lead to an interaction, they can be taken if prescribed by a doctor. If you experience severe stomach pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (in particular with blood), decreased hunger, and black stools while taking these medications, consult a doctor immediately. Do not discontinue any medications without talking to a doctor.
AmitriptylineHalofantrine
Critical
How does the drug interact with Cobaleo AM-P Tablet:
Combining Cobaleo AM-P Tablet and Halofantrine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Cobaleo AM-P Tablet with Halofantrine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineLinezolid
Critical
How does the drug interact with Cobaleo AM-P Tablet:
Taking Linezolid with Cobaleo AM-P Tablet can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Linezolid and Cobaleo AM-P Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Cobaleo AM-P Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineMesoridazine
Critical
How does the drug interact with Cobaleo AM-P Tablet:
Coadministration of Cobaleo AM-P Tablet and Mesoridazine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Cobaleo AM-P Tablet with Mesoridazine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineDronedarone
Critical
How does the drug interact with Cobaleo AM-P Tablet:
Combining Cobaleo AM-P Tablet and Dronedarone may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Cobaleo AM-P Tablet with Dronedarone may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineCisapride
Critical
How does the drug interact with Cobaleo AM-P Tablet:
Coadministration of Cobaleo AM-P Tablet and Cisapride may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Cobaleo AM-P Tablet with Cisapride may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineSelegiline
Critical
How does the drug interact with Cobaleo AM-P Tablet:
Co-administration of Cobaleo AM-P Tablet together with Selegiline can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a mood stabilizer).

How to manage the interaction:
Although using Selegiline and Cobaleo AM-P Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Cobaleo AM-P Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylinePhenelzine
Critical
How does the drug interact with Cobaleo AM-P Tablet:
Using Cobaleo AM-P Tablet together with Phenelzine can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Phenelzine and Cobaleo AM-P Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Cobaleo AM-P Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineSafinamide
Critical
How does the drug interact with Cobaleo AM-P Tablet:
Using Cobaleo AM-P Tablet together with Safinamide can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Safinamide and Cobaleo AM-P Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Cobaleo AM-P Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineGrepafloxacin
Critical
How does the drug interact with Cobaleo AM-P Tablet:
Combining Cobaleo AM-P Tablet and Grepafloxacin may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Cobaleo AM-P Tablet with Grepafloxacin may result in an interaction, it can be used if a doctor recommends it. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor. Note: Grepafloxacin is no longer available in the market. Grepafloxacin should not be combined with any other medications.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.

  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.

  • Exercising regularly helps in improving overall health and combating pain.

  • Rest well, and get plenty of sleep.

  • Try taking a warm bath, as it can be soothing.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.

  • Acupuncture can be helpful by stimulating pressure points.

  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Cobaleo AM-P Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Cobaleo AM-P Tablet as it may increase drowsiness and sleepiness.

bannner image

Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Consult your doctor before taking Cobaleo AM-P Tablet ; your doctor will decide whether Cobaleo AM-P Tablet can be taken by breastfeeding mothers or not.

bannner image

Driving

Unsafe

Cobaleo AM-P Tablet may cause drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

Cobaleo AM-P Tablet should not be given to children as the safety and efficacy have not been established.

Have a query?

FAQs

Cobaleo AM-P Tablet is used for the management of neuropathic pain. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain due to nerve damage or a malfunctioning nervous system.Â

Cobaleo AM-P Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.

Dry mouth could be a side-effect of Cobaleo AM-P Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

To treat your condition effectually, continue taking Cobaleo AM-P Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Cobaleo AM-P Tablet ; your doctor will reduce the dose gradually.

Cobaleo AM-P Tablet is used to treat neuropathic pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in legs and feet.

Cobaleo AM-P Tablet may cause sexual disturbances such as decreased sex drive and problems with erection. Consult your doctor if you have any concerns regarding this.

Cobaleo AM-P Tablet contains Pregabalin and Amitriptyline. Pregabalin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Amitriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Together, Cobaleo AM-P Tablet helps to treat neuropathic pain.

Cobaleo AM-P Tablet is a combination of two drugs: Pregabalin (anti-convulsant), and Amitriptyline (antidepressant). Helps in the management of neuropathic pain.

To manage weight gain associated with the use of Cobaleo AM-P Tablet , focus on healthy habits such as consuming nutrient-dense foods, limiting your intake, and frequent exercising. Additionally, stay hydrated and get sufficient sleep. Also, seek advice from your doctor regarding weight management.

Cobaleo AM-P Tablet may cause sleepiness or drowsiness as it is a common side effect in some individuals. To ensure your safety, rest for a while after taking Cobaleo AM-P Tablet and avoid driving. In most cases, sleepiness or drowsiness vanishes as your body adjusts to the medication. If the sleepiness or drowsiness worsens or persists, consult your doctor for guidance.

The use of Cobaleo AM-P Tablet may rarely cause turn urine colour to blue or green. If you notice any unusual changes, inform your doctor.

In rare cases, some side effects of Cobaleo AM-P Tablet may become serious in some individuals including severe blurred vision, dizziness, stomach issues like nausea and vomiting, and unusual weight gain. If you experience any of these, seek medical help.

Usually, Cobaleo AM-P Tablet starts working within a few weeks, but it may vary from person to person depending on individual condition, response, and dosage. Always follow your doctor's instructions.

If you forget a dose of Cobaleo AM-P Tablet , take it immediately when you remember. But, if your next dose is nearer, skip the missed dose and continue with your regular schedule. Never double dose to make up for a missed dose, as this may increase side effects.

If you take too much Cobaleo AM-P Tablet by mistake, please contact your doctor or emergency services immediately. Overdose symptoms may include drowsiness, confusion, and changes in heartbeat.

No, higher than the recommended dose of Cobaleo AM-P Tablet does not provide more effectiveness or additional relief. Instead, it may increase the risk of adverse effects.

When taking Cobaleo AM-P Tablet avoid drinking alcohol, driving if you are feeling dizzy or sleepy, and taking other medications without consulting your doctor. Always follow your doctor's instructions and don't increase the prescribed dose.

See your doctor as per your scheduled follow-up. The frequency of visits varies based on your health needs. If you are having any concerns or unusual symptoms, you can schedule a visit to discuss with your doctor.

Store Cobaleo AM-P Tablet in a cool dry place protected from sunlight and moisture. Keep them out of reach of children and pets. Regularly check the expiry date. To dispose of the medicine place it in a plastic bag, and throw it away in the household trash. Remember, never flush the medicine down the toilet or sink.

The common side effects of the Cobaleo AM-P Tablet , which may occur in some individuals are weight gain, dry mouth, blurred vision, dizziness, tiredness, nausea, vomiting, diarrhoea, and constipation. Most of these side effects will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects frequently.

Country of origin

India

Manufacturer/Marketer address

Gf- 1, Jay Yogeshwar Soc, Navjivan Ajwa Road, Vadodara, Gujarat, 390025, India
Other Info - COB0285

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 18, 2025 | 6:44 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.7057.pdf
  2. https://www.medicines.org.uk/emc/files/pil.5698.pdf
  3. https://www.drugs.com/amitriptyline.html
  4. https://www.drugs.com/mtm/pregabalin.html

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