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Composition:IBUPROFEN-400MG+PARACETAMOL-325MG

Prescription Medicine

Combiflam Tablet is used to relieve symptoms of muscle pain, arthritis pain, dysmenorrhea (painful periods or menstrual cramps), and dental pain and reduces fever. It contains Ibuprofen and Paracetamol, which work by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. It may cause side effects such as tightness of the chest, breathing difficulties, fever, skin rashes, increased heart rate and or in case of any signs of hypersensitivity. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding.

Written By Lakshmithulasi Yarragunta ,

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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More about the Product

Composition :

IBUPROFEN-400MG+PARACETAMOL-325MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

Quick Overview

Understanding Combiflam Tablet 20's

Usage & Safety

About Combiflam Tablet

Combiflam Tablet is a prescription medicine used to relieve mild to moderate pain and reduce fever. It combines ibuprofen and paracetamol, two medicines that work through different mechanisms to provide effective pain relief and temperature control. It is commonly used for headaches, toothaches, muscle pain, back pain, joint discomfort, menstrual cramps, and fever associated with infections or other illnesses.

Take Combiflam Tablet exactly as prescribed by your doctor. Depending on your condition, it may be taken when needed for symptom relief or on a regular schedule for short-term management of pain. Taking the medicine with food or milk may help reduce stomach irritation. Adequate rest, proper hydration, and maintaining a healthy lifestyle can also support recovery.

Some people may experience mild side effects such as nausea, stomach discomfort, heartburn, or dizziness. These effects are usually temporary and may improve as your body adjusts to the medicine. However, seek medical attention if you develop severe stomach pain, vomiting blood, black stools, difficulty breathing, severe skin reactions, or signs of liver problems.

Before taking Combiflam Tablet , inform your doctor if you have a history of stomach ulcers, gastrointestinal bleeding, kidney disease, liver disease, heart disease, high blood pressure, or asthma. This medicine may not be suitable for people with severe liver impairment, active stomach bleeding, or known allergies to ibuprofen, paracetamol, or other nonsteroidal anti-inflammatory drugs (NSAIDs).

Avoid excessive alcohol consumption while taking this medicine, as alcohol may increase the risk of stomach bleeding and liver-related side effects. Tell your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are older than 65 years, so they can determine whether this medicine is appropriate for you.

Uses of Combiflam Tablet

Combiflam Tablet is used to relieve pain and reduce fever. The detailed uses of Combiflam Tablet are as follows:

Mild to Moderate Pain: Helps relieve headaches, toothaches, muscle pain, sprains, strains, and other common painful conditions.
Fever Reduction: Helps lower elevated body temperature associated with infections and other illnesses.
Joint and Back Pain: Helps reduce discomfort and inflammation associated with musculoskeletal conditions.
Menstrual Pain: Helps relieve abdominal cramps and discomfort associated with menstruation.
Post-Procedural or Dental Pain: May be prescribed for short-term pain relief following certain medical or dental procedures.

Key Benefits

Combiflam Tablet provides effective relief from pain and fever by combining two complementary medicines in a single treatment. This combination may offer greater symptom relief than either ingredient alone for some individuals.

Enhanced Pain Relief: Works through multiple pathways to help reduce pain and improve comfort.
Reliable Fever Control: Helps lower fever and relieve associated symptoms such as chills and body aches.
Improved Physical Function: By reducing pain and discomfort, the medicine may help you perform daily activities more comfortably.
Convenient Combination Therapy: Combines two commonly used pain-relieving medicines into a single tablet, simplifying treatment.

Side effects of Combiflam Tablet

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Feeling Sick

Drink fluids: Water, clear broth, or electrolyte-rich beverages.
Follow a balanced diet, which would be rich in fruits, vegetables, whole grains, lean proteins, and healthy fats.
Mindfulness: Manage stress with meditation, deep breathing or yoga.
Stay away from smoke, dust and other irritants.
Get adequate rest to facilitate recovery.
Wash hands and avoid close contact, do not share personal items.

Loose/ Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Abnormal liver function test

High levels of liver enzymes need immediate medical attention.
Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
Regularly do strengthening exercises to control your cholesterol levels.
Avoid drinking alcohol as it can affect your liver.
Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
Practice yoga and meditation to improve liver functioning and overall health.

Directions for Use

To get the full benefit of Combiflam Tablet and minimise side effects, follow these simple guidelines:

Take the tablet orally with a full glass of water.
Swallow the tablet whole unless your doctor advises otherwise.
Take the medicine with food or milk if stomach irritation occurs.
Do not exceed the prescribed dose or recommended duration of treatment.
Avoid taking other medicines containing paracetamol or ibuprofen unless advised by your doctor.
Always follow your doctor's exact instructions regarding dosage and duration of treatment.

How Combiflam Tablet Works

Combiflam Tablet contains ibuprofen and paracetamol. Together, these medicines help relieve pain and reduce fever through complementary mechanisms. Reduces Pain Signals: Paracetamol acts primarily within the central nervous system to help reduce pain perception and lower fever. Reduces Inflammation: Ibuprofen blocks cyclooxygenase (COX) enzymes, reducing the production of prostaglandins that contribute to pain, swelling, and inflammation. Controls Fever: Both ingredients contribute to lowering elevated body temperature by acting on the body's temperature-regulating mechanisms. By combining these actions, Combiflam Tablet helps provide effective relief from pain and fever.

Alcohol

Unsafe

Taking Combiflam Tablet with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit intake of alcoholic beverages with Combiflam Tablet .

Pregnancy

Unsafe

Use of Combiflam Tablet during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby.

Breast Feeding

Consult your doctor

Take Combiflam Tablet only if prescribed by your doctor.

Driving

Unsafe

After taking Combiflam Tablet you may notice dizziness, sleepiness, drowsiness or fatigue.

Liver

Caution

Combiflam Tablet to be taken with caution, especially if you have a history of liver disease. Dose may have to be adjusted by your doctor.

Kidney

Caution

Combiflam Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

Children

Caution

Combiflam Tablet is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.

Heart

Unsafe

Combiflam Tablet should be avoided in cardiac patients as it can lead to serious cardiavascular risks

Geriatrics

Caution

Combiflam Tablet should be used under caution in geriatric patients as it can lead to serious side effects.

What if I have taken an overdose of Combiflam Tablet

Do not take more than the prescribed dose of Combiflam Tablet as it may cause severe side effects. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

Avoid Excessive Alcohol Consumption: Alcohol may increase the risk of stomach bleeding and liver-related complications.
Stay Well Hydrated: Drinking adequate fluids supports kidney function, especially during fever or illness.
Get Adequate Rest: Rest allows your body to recover more effectively from illness or injury.
Use Supportive Measures: Warm or cold compresses may help relieve muscle aches, joint discomfort, or minor injuries.
Maintain a Healthy Lifestyle: Regular exercise, balanced nutrition, and proper sleep habits may help reduce the frequency of certain pain conditions.

Health Queries

I am experiencing severe pain after a tooth extraction that is not relieved by standard painkillers; what effective pain relief medication can I take?

Veda Maddala

M Pharmacy

It is common to experience discomfort after a tooth extraction, but severe pain that doesn't respond to over-the-counter medicine warrants a call to your dentist. You may be experiencing a common, highly treatable condition called dry socket, where the protective clot dislodges. For stronger relief, alternating generic ibuprofen with paracetamol can sometimes be highly effective, provided you have no contraindications. Please avoid using straws, spitting, or smoking, as these can worsen the pain. I strongly recommend contacting your dentist or oral surgeon promptly. They can examine the site, apply a soothing dressing, or prescribe targeted prescription-strength medication to safely manage your pain.

I have swelling in my right testicle that feels like it is filled with fluid. What medication should I take to treat this?

Chandrakanta Jena

Pharm D

A fluid-filled swelling in the testicle is very common and often due to harmless conditions like a hydrocele (fluid collection) or a cyst. There is no single medication that treats all causes of testicular swelling. If an infection is the cause, a doctor will prescribe specific antibiotics. If it is a simple, painless hydrocele, medication is usually not needed at all. For any mild discomfort, you can temporarily take over-the-counter pain relievers like ibuprofen or acetaminophen. Please visit a doctor or urologist for a simple physical exam and ultrasound. This is the safest, most accurate way to get the correct treatment.

I have been experiencing pain and a wound in my molar tooth for the past 2 to 3 days. What medicine should I take to treat this?

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

I understand you are experiencing discomfort. For temporary relief from the pain, you can take over-the-counter pain relievers like ibuprofen or paracetamol, following the package instructions. To help soothe and clean the wound, gently rinse your mouth with warm salt water a few times a day. Please avoid placing any pain relief tablets directly against the gums, as this can cause irritation. While these steps will help manage your symptoms temporarily, it is very important to see a dentist. Molar pain with an open wound needs a proper physical examination to treat the underlying cause, such as an infection or decay, and ensure it heals safely.

I have cavities in my teeth that cause severe pain all night; what medication or painkiller should I take for relief?

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

To help manage severe toothache pain tonight, you can take over-the-counter pain relievers like ibuprofen (an anti-inflammatory) or acetaminophen. Please follow the package instructions carefully and do not exceed the recommended dose. Avoid placing any painkiller directly against your gums, as this can cause chemical burns. Holding a cool compress to your cheek and sleeping with your head elevated can also help reduce throbbing. Please remember that these medications only provide temporary relief and will not cure the cavity. It is very important to see a dentist as soon as possible to properly treat the tooth and stop the pain permanently.

I am a 45-year-old woman suffering from severe pain in both legs at night that prevents me from sleeping. I currently use painkillers like Combiflam, but what medicine would you suggest for better relief?

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Since Combiflam is not providing relief, your nighttime leg pain may not be simple muscle soreness. Bilateral leg pain at night can be caused by conditions like Restless Legs Syndrome (RLS), nerve pain (neuropathy), poor circulation, or vitamin deficiencies (such as B12, D, or iron). I strongly advise against self-medicating with stronger painkillers. Please consult a physician for a proper evaluation, including blood tests. Depending on the diagnosis, they may prescribe targeted medications like gabapentin for nerve pain or dopamine agonists for RLS. For temporary relief, try gentle stretching before bed, a warm bath, and staying well-hydrated.

Have a query?

How Soon It Starts Working

The time required for Combiflam Tablet to start to work: The time required for Combiflam Tablet to show its action is unknown.

The time for which the effects of Combiflam Tablet last: The duration of action for Combiflam Tablet is unknown.

What if you forget to take Combiflam Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

• Store Combiflam Tablet at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).. •Keep the tablets in their original packaging to protect them from moisture and light.

Drug Warnings

Check Other Medicines Carefully: Many cold, flu, and pain medicines may contain paracetamol or NSAIDs. Avoid accidental duplication of ingredients.
Do Not Exceed Recommended Doses: Taking more than the prescribed amount may increase the risk of serious liver, kidney, or stomach complications.
Watch for Signs of Bleeding: Seek medical advice if you notice unusual bruising, prolonged bleeding, black stools, or blood in vomit.
Monitor Liver Health: Inform your doctor if you have liver disease or consume alcohol regularly.
Use for the Shortest Necessary Duration: Prolonged use should only occur under medical supervision.

Drug-Drug Interactions

Drug-Drug Interactions
Inform your doctor if you are taking any of the following medicines, as they may interact with Combiflam Tablet :

Blood Thinners: Medicines such as warfarin may increase the risk of bleeding.
Other NSAIDs: Medicines such as naproxen, diclofenac, or aspirin may increase the risk of stomach ulcers, bleeding, and kidney problems.
Blood Pressure Medicines: Certain medicines used to treat high blood pressure may become less effective, and kidney function may require monitoring.
Corticosteroids: Medicines such as prednisone may increase the risk of gastrointestinal bleeding.
Other Paracetamol-Containing Medicines: Concurrent use may increase the risk of overdose and liver toxicity.

Drug-Food Interactions

Alcohol: Excessive alcohol consumption may increase the risk of liver damage and gastrointestinal bleeding.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Combiflam Tablet , as it may worsen your condition or require additional monitoring:

Liver Disease: May increase the risk of liver toxicity.
Kidney Disease: May increase the risk of kidney-related complications.
Active Stomach Ulcers or Gastrointestinal Bleeding: Ibuprofen may worsen these conditions.
Heart Failure or Cardiovascular Disease: NSAIDs may increase fluid retention and cardiovascular risks in some individuals.
Asthma: Some people with asthma may experience worsening symptoms after taking NSAIDs.

Ibuprofen + ParacetamolMeloxicam

Critical

Ibuprofen + ParacetamolKetorolac

Critical

Drug-Drug Interactions

Ibuprofen + ParacetamolMeloxicam

Critical

How does the drug interact with Combiflam Tablet:
Coadministration of meloxicam and ibuprofen can increase the risk of side effects such as inflammation, bleeding, and ulceration.

How to manage the interaction:
Although there is an interaction between meloxicam and ibuprofen, it can be taken if advised by a doctor. However, if you experience dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Ibuprofen + ParacetamolKetorolac

Critical

How does the drug interact with Combiflam Tablet:
Taking ketorolac with ibuprofen can increase the risk of side effects in inflammation, bleeding, and ulceration.

How to manage the interaction:
Although there is an interaction between ketorolac and ibuprofen, it can be taken if advised by a doctor. However, if you experience dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

Ibuprofen + ParacetamolRivaroxaban

Severe

How does the drug interact with Combiflam Tablet:
Co-administration of rivaroxaban and ibuprofen can increase the risk of bleeding problems.

How to manage the interaction:
Although there is an interaction between rivaroxaban and ibuprofen, it can be taken if advised by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Ibuprofen + ParacetamolOxaprozin

Severe

How does the drug interact with Combiflam Tablet:
The combined use of Oxaprozin and Ibuprofen can increase the risk of side effects such as inflammation, bleeding, ulceration.

How to manage the interaction:
Although there is an interaction between oxaprozin and ibuprofen, it can be taken if advised by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Ibuprofen + ParacetamolWarfarin

Severe

How does the drug interact with Combiflam Tablet:
Coadministration of warfarin and ibuprofen can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between warfarin and ibuprofen, it can be taken if advised by a doctor. However, if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Ibuprofen + ParacetamolEtodolac

Severe

How does the drug interact with Combiflam Tablet:
Coadministration of etodolac and ibuprofen can increase the risk of inflammation, bleeding, and stomach ulcers.

How to manage the interaction:
Although there is an interaction between etodolac and ibuprofen, it can be taken if advised by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

Ibuprofen + ParacetamolTolmetin

Severe

How does the drug interact with Combiflam Tablet:
Coadministration of tolmetin and ibuprofen can increase the risk of inflammation, bleeding, and ulceration.

How to manage the interaction:
Although there is an interaction between tolmetin and ibuprofen, it can be taken if advised by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Ibuprofen + ParacetamolLeflunomide

Severe

How does the drug interact with Combiflam Tablet:
Co-administration of ibuprofen and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between ibuprofen and leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Ibuprofen + ParacetamolHuman immunoglobulin

Severe

How does the drug interact with Combiflam Tablet:
Taking human immunoglobulin with ibuprofen may raise the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between human immunoglobulin with ibuprofen, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, less desire to eat, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, consult a doctor. Do not discontinue any medications without consulting a doctor.

Ibuprofen + ParacetamolMethotrexate

Severe

How does the drug interact with Combiflam Tablet:
Coadministration of methotrexate with ibuprofen can increase the effect and side effects of methotrexate.

How to manage the interaction:
Although there is an interaction between methotrexate and ibuprofen, they can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, diarrhea, rash, less desire to eat, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, dizziness or fainting, unusual bruising or bleeding, consult a doctor immediately. Do not stop using medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Author Details

Reviewed By

Dr Aneela Siddabathuni
MPharma., PhD

Last Updated

Jun 17, 2026 | 6:54 AM IST

We provide you with authentic, trustworthy and relevant information.

See our editorial policy

Reference

Country of origin

India

Manufacturer/Marketer address

CT Survey No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072.

Other Info - COM0004

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Welcome User

Combiflam Tablet 20's

Delivery Information

More about the Product

Composition :

Manufacturer/Marketer :

Consume Type :

Expires on or after :

Return Policy :

About Combiflam Tablet

Uses of Combiflam Tablet

Key Benefits

Stomach Pain

Feeling Sick

Loose/ Watery Stools

Abnormal liver function test

Directions for Use

How Combiflam Tablet Works

Alcohol

Pregnancy

Breast Feeding

Driving

Liver

Kidney

Children

Heart

Geriatrics

What if I have taken an overdose of Combiflam Tablet

Diet & Lifestyle Advise

Health Queries

I am experiencing severe pain after a tooth extraction that is not relieved by standard painkillers; what effective pain relief medication can I take?

I have swelling in my right testicle that feels like it is filled with fluid. What medication should I take to treat this?

I have been experiencing pain and a wound in my molar tooth for the past 2 to 3 days. What medicine should I take to treat this?

I have cavities in my teeth that cause severe pain all night; what medication or painkiller should I take for relief?

I am a 45-year-old woman suffering from severe pain in both legs at night that prevents me from sleeping. I currently use painkillers like Combiflam, but what medicine would you suggest for better relief?

How Soon It Starts Working

What if you forget to take Combiflam Tablet

Storage

Drug Warnings

Drug-Drug Interactions

Drug-Drug Interactions

Drug-Food Interactions

Drug-Food Interactions

All Substitutes & Brand Comparisons

Norflam 400mg/325mg Tablet

Osofen Plus 400mg/325mg Tablet

RENOFEN TABLET

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FAQs

What is the use of Combiflam Tablet ?

How does Combiflam Tablet work?

Can I take Combiflam Tablet along with my depression medication?

Can I stop taking Combiflam Tablet if I feel better?

Are there any specific contraindications associated with the use of Combiflam Tablet ?

Can Combiflam Tablet cause dizziness?

Can I take Combiflam Tablet for stomach pain?

Can I take Combiflam Tablet with other pain relievers, cough, or cold medicines?

Can I take Combiflam Tablet as a long term medication?

Can I take Combiflam Tablet on an empty stomach?

Can I drink alcohol while taking Combiflam Tablet ?

Is Combiflam Tablet safe during pregnancy?

How quickly does Combiflam Tablet start working?

What should I do if my pain does not improve?

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