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  3. Combimist-L Respules 5 x 2.5 ml

Combimist-L Respules 5 x 2.5 ml, Pack of 5 RespulesS
Combimist-L Respules 5 x 2.5 ml, Pack of 5 RespulesS
Combimist-L Respules 5 x 2.5 ml, Pack of 5 RespulesS
Combimist-L Respules 5 x 2.5 ml, Pack of 5 RespulesS
Combimist-L Respules 5 x 2.5 ml, Pack of 5 RespulesS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Santoshini Reddy G , M Pharmacy

Combimist-L Respules 5 x 2.5 ml is used to treat or prevent symptoms of chronic obstructive pulmonary disease (COPD), like shortness of breath, coughing or wheezing (whistling sound while breathing). It contains Levosalbutamol and Ipratropium bromide, which work by relaxing muscles and widening the airways of the lungs. Some people may experience headache, sore throat, dry mouth, runny or stuffy nose, cough with mucus, and vomiting. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

IPRATROPIUM BROMIDE-500MCG + LEVOSALBUTAMOL-1.25MCG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

INHALATION

Return Policy :

Not Returnable

Expires on or after :

About Combimist-L Respules 5 x 2.5 ml

Combimist-L Respules 5 x 2.5 ml is used to treat or prevent symptoms of chronic obstructive pulmonary disease (COPD), like shortness of breath, coughing or wheezing (whistling sound while breathing).

Combimist-L Respules 5 x 2.5 ml is a combination of two bronchodilators: Levosalbutamol and Ipratropium bromide, which work by relaxing muscles and widening the airways of the lungs. Thereby, it makes breathing easier.

Some people may experience headache, sore throat, dry mouth, runny or stuffy nose, nausea and vomiting. Most of these side effects of Combimist-L Respules 5 x 2.5 ml do not require medical attention and typically resolve on their own over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Combimist-L Respules 5 x 2.5 ml or any other medicines, are pregnant or breastfeeding, please consult a doctor. Keep your doctor informed about your health condition and medications to prevent any potential interactions. 

Uses of Combimist-L Respules 5 x 2.5 ml

Combimist-L Respules 5 x 2.5 ml is used to treat chronic obstructive pulmonary disease (COPD). The detailed uses of Combimist-L Respules 5 x 2.5 ml are as follows:

  • Chronic Obstructive Pulmonary Disease (COPD): Combimist-L Respules 5 x 2.5 ml is used to treat COPD symptoms by improving lung function and relieving chronic cough and breathing difficulties.
  • Prevention of Exercise-Induced Bronchospasm: Combimist-L Respules 5 x 2.5 ml helps to prevent exercise-induced bronchospasm, enabling easier breathing during physical activity.
  • Reduce Mucus Clearance: Combimist-L Respules 5 x 2.5 ml helps to thin mucus, making it easier to clear from airways, which improves breathing and respiratory function.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Check the label for directions and use as advised by the doctor. Twist off the top of the respule and squeeze the solution into the nebuliser. This solution is formulated into a fine mist for inhalation. Inhale the medicine through the nebuliser's mouthpiece.
  • The respule should be opened only before actual use, and any solution remaining after use should be discarded.
  • To prevent any fungal infections in your mouth and throat, gargle with warm water after each inhalation.

Medicinal Benefits

  • Combimist-L Respules 5 x 2.5 ml is a combination of two bronchodilators: Levosalbutamol and Ipratropium bromide, used to treat chronic obstructive pulmonary disease (COPD).
  • It relaxes the airway muscles and widens the air passages in the lungs. This action improves airflow to the lungs and makes breathing easier.
  • Combimist-L Respules 5 x 2.5 ml provides quick and sustained relief from respiratory symptoms like shortness of breath, wheezing, and coughing.
  • The dual action of both components makes it more effective than either medicine alone in managing moderate to severe COPD symptoms.

How Combimist-L Respules 5 x 2.5 ml Works

Combimist-L Respules 5 x 2.5 ml is a combination of two bronchodilators: Levosalbutamol and Ipratropium bromide. It works by relaxing muscles and widening the airways of the lungs. Thereby, Combimist-L Respules 5 x 2.5 ml makes breathing easier.

Storage

• Store in a cool and dry place away from sunlight.• Keep Combimist-L Respules 5 x 2.5 ml out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Combimist-L Respules 5 x 2.5 ml
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Drink warm fluids such as warm water with honey, broth or herbal tea to soothe sore throat.
  • Gargle with warm salt water to decrease inflammation.
  • Suck on hard candies or lozenges to increase the production of saliva and soothe your throat.
  • Avoid smoking, spicy foods, and extremely hot fluids.
  • Rest your voice and get enough sleep.
  • Drink plenty of fluids like water to thin mucus.
  • Use a humidifier to moisten the air.
  • Lie down in specific positions to help drain mucus from different areas of the lungs.
  • Inhale steam from a bowl of hot water, it can help loosen mucus.
  • Gargling with a saltwater solution can soothe a sore throat and help clear mucus.
  • Gentle exercise can help mobilize mucus and clear airways.
  • Limit exposure to smoke, dust, and other airborne irritants that can worsen mucus production.
  • Consult your doctor if the issue persists or is accompanied by other concerning symptoms.

What if I have taken an overdose of Combimist-L Respules 5 x 2.5 ml

Do not use Combimist-L Respules 5 x 2.5 ml in more doses or more often than prescribed, as it may cause unpleasant side effects. If you have any unusual signs or symptoms, please consult a doctor immediately.

Drug Warnings

  • Do not use Combimist-L Respules 5 x 2.5 ml if you are allergic to any of its components.
  • If you are pregnant or breastfeeding, please consult a doctor before starting Combimist-L Respules 5 x 2.5 ml.
  • Combimist-L Respules 5 x 2.5 ml may cause low potassium levels. If you experience irregular heartbeats, leg cramps, extreme thirst, constipation, increased urination, muscle weakness, numbness or tingling, please consult a doctor immediately, as these might be signs of low potassium.
  • If you have high blood pressure, diabetes, epilepsy (fits), enlarged prostate, glaucoma, thyroid or heart problems, bladder obstruction or other urinary problems, inform your doctor before taking Combimist-L Respules 5 x 2.5 ml.
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

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SalbutamolLabetalol
Severe
SalbutamolPindolol
Severe

Drug-Drug Interactions

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SalbutamolLabetalol
Severe
How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Co-administration of Salbutaml with Labetalol, the effectiveness of Combimist-L Respules 5 x 2.5 ml might be reduced.

How to manage the interaction:
Although taking Labetalol and Combimist-L Respules 5 x 2.5 ml together can possibly result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
SalbutamolPindolol
Severe
How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Using pindolol and Combimist-L Respules 5 x 2.5 ml together can increase the risk of narrowing of the airways.

How to manage the interaction:
The combined use of pindolol and Combimist-L Respules 5 x 2.5 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience Coughing, wheezing, shortness of breath, and high-pitched breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
SalbutamolMifepristone
Severe
How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Coadministration of mifepristone and Combimist-L Respules 5 x 2.5 ml can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Combimist-L Respules 5 x 2.5 ml with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
SalbutamolLevobunolol
Severe
How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Using levobunolol and Combimist-L Respules 5 x 2.5 ml together can reduce the benefits of both drugs and can cause narrowing of the airways.

How to manage the interaction:
The combined use of levobunolol and Combimist-L Respules 5 x 2.5 ml can lead to an interaction, it can be taken if advised by your doctor. Don't forget to inform if you have any history of asthma, or severe chronic obstructive pulmonary disease (COPD), consult the doctor immediately. Do not stop using any medications without a doctor's advice.
SalbutamolPapaverine
Severe
How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
The combined use of Papaverine and Combimist-L Respules 5 x 2.5 ml can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Co-administration of Papaverine and Combimist-L Respules 5 x 2.5 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
SalbutamolTimolol
Severe
How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Co-administration of Combimist-L Respules 5 x 2.5 ml with timolol can increase the risk of narrowing of the airways.

How to manage the interaction:
Although taking Combimist-L Respules 5 x 2.5 ml and timolol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience Coughing, wheezing, shortness of breath, and high-pitched breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
SalbutamolCarvedilol
Severe
How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Coadministration of Carvedilol and Combimist-L Respules 5 x 2.5 ml may reduce the effects of both medications.

How to manage the interaction:
Although there is a possible interaction between Carvedilol and Combimist-L Respules 5 x 2.5 ml, they can be taken if your doctor advises. Consult your doctor if you experience shortness of breath, chest pain or any difficulties in breathing. Do not stop using any medications without a doctor's advice.
SalbutamolPenbutolol
Severe
How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Coadministration of Penbutolol and Combimist-L Respules 5 x 2.5 ml can reduce the effects of both medications and can cause narrowing of the airways.

How to manage the interaction:
Taking Penbutolol and Combimist-L Respules 5 x 2.5 ml can lead to an interaction, it can be taken if advised by your doctor. However, if you experience Coughing, wheezing, shortness of breath, and high-pitched breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
SalbutamolPropranolol
Severe
How does the drug interact with Combimist-L Respules 5 x 2.5 ml:
Using propranolol and Combimist-L Respules 5 x 2.5 ml together can reduce the effects or increase the risk of narrowing of the airways.

How to manage the interaction:
The combined use of propranolol and Combimist-L Respules 5 x 2.5 ml can lead to an interaction, but they can be taken if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat foods rich in potassium, such as tomatoes, bananas, asparagus, oranges, potatoes, avocados, dark leafy greens, and beetroots, as potassium is important for lung function and a potassium deficiency may cause breathing problems.
  • Drink plenty of fluids every day to thin mucus, which makes it easier to cough out.
  • Maintain a diet that includes complex carbohydrates such as lentils, beans, barley, oats, quinoa, bran, peas, and potatoes with skin.
  • Limit or avoid the intake of caffeinated drinks such as tea, coffee, soda, and energy drinks.
  • Eat protein-rich foods such as meat, fish (particularly salmon, sardines, and mackerel), eggs, and poultry.
  • Exercise regularly to strengthen your breathing muscles and boost your immune system.
  • Learning breathing exercises will help you move more air in and out of your lungs.
  • Quit smoking as it may irritate the lungs, worsening breathing problems.

Habit Forming

No

Therapeutic Class

BRONCHODILATOR
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Alcohol

Consult your doctor

The interaction of Combimist-L Respules 5 x 2.5 ml with alcohol is unknown. Please consult a doctor before consuming alcohol with Combimist-L Respules 5 x 2.5 ml.

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Pregnancy

Consult your doctor

The safety of Combimist-L Respules 5 x 2.5 ml in pregnant women is unknown. Please consult your doctor if you are pregnant. It is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Combimist-L Respules 5 x 2.5 ml is excreted in human milk. Please consult your doctor if you are breastfeeding. It is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Caution

Combimist-L Respules 5 x 2.5 ml may cause blurred vision or dizziness in some people. Therefore, avoid driving if you notice any changes in vision or feel dizzy after taking Combimist-L Respules 5 x 2.5 ml.

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Liver

Caution

Combimist-L Respules 5 x 2.5 ml should be used with caution in patients with liver impairment. If you have any concerns regarding the use of Combimist-L Respules 5 x 2.5 ml in patients with liver problems, please consult a doctor.

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Kidney

Caution

Dose adjustment may be needed. If you have any concerns regarding the use of Combimist-L Respules 5 x 2.5 ml in patients with kidney problems, please consult a doctor.

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Children

Consult your doctor

The safety of Combimist-L Respules 5 x 2.5 ml in children below 12 years is unknown. Please consult a doctor before giving Combimist-L Respules 5 x 2.5 ml to children.

Have a query?

FAQs

Combimist-L Respules 5 x 2.5 ml is used to treat or prevent symptoms of chronic obstructive pulmonary disease (COPD), like shortness of breath, coughing or wheezing (whistling sound while breathing).

Combimist-L Respules 5 x 2.5 ml is a combination of two bronchodilators: Levosalbutamol and Ipratropium bromide. It works by relaxing muscles and widening the airways of the lungs. Thereby, Combimist-L Respules 5 x 2.5 ml makes breathing easier.

Combimist-L Respules 5 x 2.5 ml should be used with caution in diabetic patients if prescribed by a doctor. However, regular monitoring of blood sugar levels is recommended while taking Combimist-L Respules 5 x 2.5 ml as it may increase blood sugar levels.

Combimist-L Respules 5 x 2.5 ml should be used with caution in hyperthyroid (overactive thyroid) patients as it may worsen the condition. Inform your doctor if you have hyperthyroidism before taking Combimist-L Respules 5 x 2.5 ml so that the dose may be adjusted appropriately. However, regular monitoring of thyroid hormone levels is recommended while taking Combimist-L Respules 5 x 2.5 ml.

Yes, Combimist-L Respules 5 x 2.5 ml may cause dry mouth as a temporary side effect in some people. It is not necessary for everyone taking Combimist-L Respules 5 x 2.5 ml to experience this side effect. However, to avoid such side effects, drink plenty of water, regularly rinse your mouth, practice good oral hygiene and suck on sugarless candy. However, if the condition persists or worsens, please consult a doctor.

No, Combimist-L Respules 5 x 2.5 ml does not relieve sudden symptoms such as shortness of breath. Therefore, it is advised to carry a rescue inhaler always to treat sudden symptoms.

Combimist-L Respules 5 x 2.5 ml may cause side effects such as headache, sore throat, dry mouth, and respiratory issues like cough, sneezing, and difficulty breathing. Other possible side effects include dizziness, nervousness, tiredness, irregular heartbeats, and vomiting. In most cases, these side effects are temporary and resolve on their own. However, if they persist or worsen, it's essential to consult your doctor for proper guidance.

No, you are not recommended to stop using Combimist-L Respules 5 x 2.5 ml without consulting your doctor, as it may worsen the condition or cause recurring symptoms. Therefore, take Combimist-L Respules 5 x 2.5 ml for as long as your doctor has prescribed it, and if you experience any difficulty while taking Combimist-L Respules 5 x 2.5 ml, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads, Ahmedabad – 380015, Gujarat, India.
Other Info - COM0437

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Author Details

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 29, 2025 | 11:40 AM IST

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Reference

  1. https://www.ciplamed.com/product-index/duolin-respules
  2. https://www.humanbiolife.com/lv-prime-it-0-63-500mcg-respules
  3. https://www.criticinecare.com/product/levosulbutamol-1-25mg-ipratropium-500mcg
  4. https://www.nutrarespiro.com/product/levosalbutamol-ipratropium-bromide-respiratory-solution

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