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compositionComposition:AZELASTINE-140MCG+FLUTICASONE PROPIONATE-27.5MCG
prescription
Prescription Medicine
info
Combinase FT Nasal Spray 9.8 gm
Combinase FT Nasal Spray 9.8 gm
Combinase FT Nasal Spray 9.8 gm
Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AZELASTINE-140MCG+FLUTICASONE PROPIONATE-27.5MCG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

Nasal

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Combinase FT Nasal Spray

Combinase FT Nasal Spray is a prescription nasal spray used to treat symptoms of allergic rhinitis, such as nasal congestion, sneezing, and an itchy or runny nose. It is designed to relieve both seasonal allergies, like those caused by pollen, and year-round allergies caused by indoor triggers. By targeting inflammation and allergic responses directly in the nasal passages, it helps restore comfortable breathing.

To get the best results, you should use Combinase FT Nasal Spray consistently every day as directed by your doctor, rather than only when your symptoms flare up. Since it is a nasal spray, it can be used regardless of your meal times. Making simple lifestyle adjustments, such as keeping windows closed during high pollen seasons and using allergen-proof bedding covers, can further support your treatment.

While using Combinase FT Nasal Spray , you may notice mild side effects like a temporary bitter taste, nasal dryness, or minor nosebleeds. These are usually harmless, but you should consult your doctor immediately if you experience severe nasal pain, constant bleeding, or changes in your vision.

Before starting this medicine, tell your doctor if you have a history of glaucoma, cataracts, tuberculosis, untreated infections, or recent nasal surgery, injury, or sores. Do not take this if you are allergic to any of the ingredients in this nasal spray.

Using Combinase FT Nasal Spray alongside alcohol, sedatives, or sleep medications may increase drowsiness and should be avoided. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to ensure this medication is safe for your specific situation.

This medication works best when used consistently every day. The fluticasone component is not intended for immediate relief and builds its effect over time, so regular use is essential even when symptoms improve. The azelastine component provides quicker symptom relief, making the combination effective for both immediate and ongoing control of allergies. 

Uses of Combinase FT Nasal Spray

Combinase FT Nasal Spray is commonly used to manage both seasonal and perennial allergic nasal conditions, helping to relieve inflammation and allergy-related symptoms:

  • Seasonal Allergic Rhinitis: Combinase FT Nasal Spray helps reduce swelling, sneezing, and a runny nose caused by outdoor allergens like pollen, grass, and weeds.
  • Perennial Allergic Rhinitis: It manages year-round indoor allergy symptoms triggered by dust mites, mold, and pet dander.
  • Nasal Congestion: It relieves severe stuffiness and blockage in the nasal passages, making it easier to breathe through your nose.
     

Key Benefits

Combinase FT Nasal Spray provides dual-action relief by combining a fast-acting antihistamine with a long-acting anti-inflammatory steroid for better control of allergic rhinitis symptoms.

  • Fast Relief of Allergy Symptoms: Azelastine, the antihistamine component, can begin reducing sneezing, runny nose, and nasal itching within 30–60 minutes of use by quickly blocking histamine effects.
  • Long-Lasting Anti-Inflammatory Control: Fluticasone propionate works more gradually by reducing inflammation inside the nasal passages. With consistent daily use, it typically provides noticeable improvement over several days and continues to build stronger control over time.
  • Better Overall Symptom Management: By combining rapid symptom relief with ongoing inflammation control, this spray helps manage both sudden discomfort and long-term nasal blockage more effectively than single-action treatments.
  • Improved Breathing and Daily Functioning: Regular use helps reduce nasal congestion, improve airflow, and support better sleep and daytime comfort.
     
Side effects of Combinase FT Nasal Spray 9.8 gm
  • Nasal ulcers can be painful and must be shown to a doctor
  • Limit exposure to cigarette smoke, dust, strong odours, and other environmental pollutants.
  • Regularly use saline nasal spray to cleanse and moisturize nasal passages.
  • Practice good hand hygiene to prevent spreading germs and avoid touching your nose unnecessarily.
  • To loosen mucus, inhale steam from a hot shower or steaming machine.
  • Practice yoga or meditation to manage stress, which can exacerbate nasal discomfort.
  • Intake of balanced diet rich in fruits and vegetables can support immune function.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

Always use this nasal spray exactly as your doctor has instructed. Follow these step-by-step guidelines for correct use:

  • Gently blow your nose to clear your nostrils before each use.
  • Shake the bottle well and remove the protective dust cap.
  • Tilt your head slightly downward, looking down toward your toes.
  • Hold the spray bottle upright and gently insert the tip into one nostril, closing the other nostril with your finger.
  • Point the spray nozzle toward the outer side of your nose (toward your ear), away from the middle wall of your nose.
  • Press the pump firmly to release the spray while breathing in gently through your nose. Do not sniff hard.
  • Breathe out through your mouth, then repeat the process in your other nostril if prescribed.
  • Wipe the nozzle with a clean tissue and replace the cap.
     

How Combinase FT Nasal Spray Works

Combinase FT Nasal Spray contains two active ingredients that work together directly in the nasal passages to relieve allergy symptoms such as sneezing, runny nose, nasal congestion, and itching. Azelastine is an antihistamine that works by blocking histamine, a natural chemical released by the body during allergic reactions. By preventing histamine from binding to its receptors, it provides quick relief from symptoms such as sneezing, nasal itching, watery eyes, and runny nose. Fluticasone propionate is a corticosteroid that works by reducing inflammation inside the nasal passages. It decreases the release of inflammatory substances that cause swelling, irritation, and nasal congestion, helping to open up blocked airways and improve breathing. Together, azelastine provides rapid symptom relief while fluticasone propionate controls underlying inflammation, resulting in more complete and longer-lasting relief from allergic rhinitis symptoms.
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Alcohol

Unsafe

Avoid consumption of alcohol with Combinase FT Nasal Spray as it may increase adverse effects. Please consult a doctor before consuming alcohol with Combinase FT Nasal Spray .

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Pregnancy

Caution

The safety of Combinase FT Nasal Spray in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks benefits outweigh risks.

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Breast Feeding

Caution

It is unknown whether Combinase FT Nasal Spray is excreted in human milk. It is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

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Driving

Caution

Combinase FT Nasal Spray may cause drowsiness in some people. Therefore, drive only if you are alert after taking Combinase FT Nasal Spray .

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Liver

Safe if prescribed

If you have any concerns regarding the use of Combinase FT Nasal Spray in patients with Liver problems, please consult a doctor.

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Kidney

Safe if prescribed

If you have any concerns regarding the use of Combinase FT Nasal Spray in patients with Kidney problems, please consult a doctor.

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Children

Caution

Combinase FT Nasal Spray is not recommended for children below 6 years as the safety and effectiveness were not established.

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Heart

Consult your doctor

Inform your doctor if you have any existing heart disease. Your doctor will prescribe this medicine only if the potential benefits outweigh the risks.

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Geriatrics

Caution

Combinase FT Nasal Spray should be used in elderly patients only when prescribed by a doctor. If you have any concerns about using Combinase FT Nasal Spray in older adults, please consult your doctor.

What if I have taken an overdose of Combinase FT Nasal Spray

Do not use Combinase FT Nasal Spray in more doses or more often than prescribed. If you have any unusual signs or symptoms, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Keep Indoor Air Clean: Keep your home windows closed and use air conditioning during high pollen seasons to reduce exposure to outdoor allergens.
  • Maintain Bedding Hygiene: Wash your bedding weekly in hot water to eliminate dust mites, and use allergen-proof covers on pillows and mattresses.
  • Use Saline Nasal Rinse: Consider using a sterile saline nasal rinse before applying Combinase FT Nasal Spray to help clear out mucus and allergens from your nasal passages, allowing the medicine to work more effectively.
  • Vacuum Regularly: Vacuum carpets and rugs regularly with a vacuum cleaner equipped with a HEPA filter to capture pet dander and dust.
  • Avoid Irritants: Avoid exposing yourself to tobacco smoke, strong chemical fumes, and heavy perfumes, as these can severely irritate your nasal lining and worsen allergy symptoms.
     

Have a query?

How Soon It Starts Working

The time required for Combinase FT Nasal Spray to start to work: Combinase FT Nasal Spray ideally shows its action within 5 minutes after administration. The time for which the effects of Combinase FT Nasal Spray last: The effect of Combinase FT Nasal Spray lasts for 12 hours.

What if you forget to take Combinase FT Nasal Spray

If you miss a dose of Combinase FT Nasal Spray , use the spray as soon as you remember. However, if it is time for the next dose, skip the missed dose and follow your regular dosing schedule. Do not spray Combinase FT Nasal Spray more frequently to make up for your missed dose.

Storage

• Store Combinase FT Nasal Spray upright at room temperature, between 20°C and 25°C (68°F to 77°F). • Do not refrigerate or freeze the bottle.

Drug Warnings

  • Correct Spray Direction: Always point the spray tip toward the outer wall of your nostril (toward your ear) rather than the middle wall of your nose to prevent irritation, pain, or bleeding of the nasal septum.
  • Do Not Share Spray: Do not share your nasal spray bottle with anyone else, as this can easily spread germs and cause nasal infections.
  • Drowsiness Warning: If you experience drowsiness after using this spray, avoid driving, riding a bicycle, or operating heavy machinery until you know how the medication affects you.
  • Clean Nozzle Regularly: Clean the spray nozzle weekly by gently pulling it off the bottle, washing it in warm tap water, drying it completely, and putting it back on. Never use a pin or sharp object to clear a clog, as this can damage the spray mechanism.
  • Avoid Eye or Mouth Contact: Avoid spraying this medication directly into your eyes or mouth. If accidental contact occurs, rinse your eyes thoroughly with water.

Drug-Drug Interactions

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Drug-Drug Interactions

The following medicines may interact with Combinase FT Nasal Spray and increase the risk of side effects or reduce treatment safety:

  • CNS Depressants (Alcohol, Sleeping Pills, Muscle Relaxants): May increase the risk of drowsiness when used alongside alcohol, sleeping pills, muscle relaxants, or other medicines that cause sleepiness.
  • Strong CYP3A4 Inhibitors (e.g., Ketoconazole, Ritonavir): Certain medicines used to treat fungal infections (such as ketoconazole) or HIV (such as ritonavir) may increase the amount of the steroid component in your body, which can raise the risk of systemic side effects.

Drug-Food Interactions

Certain food and drink habits may affect how Combinase FT Nasal Spray works or increase side effects:

  • Alcohol: Avoid consuming alcohol while using Combinase FT Nasal Spray , as it can worsen drowsiness and decrease your alertness.

Drug-Disease Interactions

The following medical conditions may affect the safety or effectiveness of Combinase FT Nasal Spray :

  • Glaucoma or Cataracts: May worsen eye pressure or vision problems if you have a history of glaucoma or cataracts.
  • Nasal Surgery or Injury: May delay healing or increase the risk of infection if you have recent nasal ulcers, nasal surgery, or a nasal injury.
  • Active or Untreated Infections: If you have an untreated nasal, sinus, bacterial, viral, fungal, or parasitic infection (including tuberculosis), inform your doctor before using this medicine. While nasal corticosteroids are generally low-risk when used at recommended doses, your doctor may need to assess whether treatment should be started or delayed depending on your condition.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Habit Forming

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Therapeutic Class

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FAQs

Combinase FT Nasal Spray is used to treat allergic symptoms like sneezing, runny nose, congestion, stuffy nose, or watery eyes.

Combinase FT Nasal Spray contains Fluticasone propionate and Azelastine. Fluticasone propionate is a corticosteroid that works by acting inside cells of the nasal lining and stops the release of certain chemicals in the body that cause inflammatory reactions. Thereby, provides relief from sneezing, runny or blocked nose and sinus discomfort. Azelastine is an antihistamine (anti-allergic drug) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness.

You are recommended to avoid taking grapefruit juice with Combinase FT Nasal Spray as they may lead to adrenal insufficiency and Cushing’s syndrome.

No, you are not recommended to consume alcohol with Combinase FT Nasal Spray as it may cause increased drowsiness, dizziness, impairment of judgement and thinking. However, please consult a doctor before consuming alcohol with Combinase FT Nasal Spray .

Combinase FT Nasal Spray is not recommended for children below 6 years as the safety and effectiveness were not established. However, please consult a doctor before using Combinase FT Nasal Spray in children.

Yes, Combinase FT Nasal Spray may cause drowsiness or sleepiness in some people because it contains azelastine, an antihistamine. The risk may be increased if you consume alcohol while using Combinase FT Nasal Spray . Avoid driving, operating machinery, or performing tasks requiring alertness if you feel drowsy. Consult your doctor if this side effect becomes troublesome.

You are not recommended to take more than the prescribed dose of Combinase FT Nasal Spray or for a prolonged time as it may cause adverse effects such as changes in body fat (especially in the back, waist, neck and face), easy bruising, skin thinning, increased facial hair or acne, loss of interest in sex, impotence or menstrual problems. However, if you experience any of these symptoms while taking Combinase FT Nasal Spray , please consult a doctor immediately.

No, Combinase FT Nasal Spray is not used to treat asthma attacks. Combinase FT Nasal Spray is used to prevent allergic symptoms that can cause asthma. Therefore, it is recommended to carry a rescue inhaler always to treat asthma attacks.

No, you are not recommended to stop taking Combinase FT Nasal Spray without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Combinase FT Nasal Spray for as long as your doctor has prescribed it, and if you experience any difficulty while taking Combinase FT Nasal Spray , please consult your doctor.

You should avoid taking Combinase FT Nasal Spray and consult a doctor before using Combinase FT Nasal Spray if you have had any recent nose problems (like nose bleed, nose injury, nose ulcers, or nose surgery), infections like tuberculosis (TB), eye problems like herpes eye infection, glaucoma, or cataracts.

Shake the bottle gently for 5 seconds by tilting it upwards and downwards and then remove the protective cap. Blow your nose to clear your nostrils. Keep your head straight and hold the bottle upright insert the tip of the bottle into a nostril while closing the other nostril with your finger and rapidly press down once and sniff gently at the same time. Repeat the same process for another nostril. Breathe out through your mouth. Follow the dosage and frequency as prescribed by your doctor.

Store Combinase FT Nasal Spray at room temperature in a cool and dry place. Away from excess heat and moisture. Keep out of reach of children. Do not refrigerate.

The common side effects of Combinase FT Nasal Spray are headache, taste changes, or nose bleeds. If any of these side effects persist or worsen, please consult your doctor.

Many people begin to feel relief from their allergy symptoms within 30 minutes of using the spray, though it can take several days of regular use to experience the full benefits. It is important to understand that the two ingredients work at different speeds. Azelastine provides faster relief within about 30–60 minutes, while fluticasone propionate builds its anti-inflammatory effect gradually over several days of regular use. For best results, the spray should be used consistently rather than only during symptom flare-ups.

No, Combinase FT Nasal Spray is specifically designed to treat allergic rhinitis (allergies) and will not cure a viral infection like the common cold. Talk to your doctor or pharmacist for cold remedy recommendations.

Mild stinging or burning can happen when you first spray the medicine. To minimise this, make sure you are pointing the nozzle away from the middle wall of your nose toward your outer ear. If the stinging is severe or leads to bleeding, stop using it and talk to your doctor.

You should only use Combinase FT Nasal Spray during pregnancy if your doctor determines that the benefits outweigh the risks. Always talk to your doctor before starting any new medication while pregnant or breastfeeding.

Gently pull off the plastic spray nozzle, rinse it under warm running water, let it air dry completely, and then slide it back onto the bottle. Never use a pin or sharp object to clear a clog, as this can damage the spray pump. Talk to your pharmacist if you have trouble cleaning it.

You can generally use saline nasal sprays alongside Combinase FT Nasal Spray , but you should use the saline spray first and wait a few minutes before using Combinase FT Nasal Spray . Avoid using other steroid or antihistamine nasal sprays at the same time unless advised by your healthcare provider. Talk to your doctor about all the medications you use.

Your doctor will advise you on how long to use Combinase FT Nasal Spray . Many patients use it safely throughout the allergy season, but long-term use requires periodic nasal checks by a doctor to ensure your nasal passages remain healthy. Talk to your doctor for personalised guidance.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - COM0494

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