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compositionComposition:IBUPROFEN-400MG+PARACETAMOL-325MG
prescription
Prescription Medicine
info
Combipain Tablet 15'S

Combipain Tablet is used to relieve symptoms of muscle pain, arthritis pain, dysmenorrhea (painful periods or menstrual cramps), and dental pain and reduces fever. It contains Ibuprofen and Paracetamol, which work by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. It may cause side effects such as tightness of the chest, breathing difficulties, fever, skin rashes, increased heart rate and or in case of any signs of hypersensitivity. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IBUPROFEN-400MG+PARACETAMOL-325MG

Manufacturer/Marketer :

Scott Edil Pharmacia Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Combipain Tablet

Combipain Tablet is a prescription medicine used to relieve mild to moderate pain and reduce fever. It combines ibuprofen and paracetamol, two medicines that work through different mechanisms to provide effective pain relief and temperature control. It is commonly used for headaches, toothaches, muscle pain, back pain, joint discomfort, menstrual cramps, and fever associated with infections or other illnesses.

Take Combipain Tablet exactly as prescribed by your doctor. Depending on your condition, it may be taken when needed for symptom relief or on a regular schedule for short-term management of pain. Taking the medicine with food or milk may help reduce stomach irritation. Adequate rest, proper hydration, and maintaining a healthy lifestyle can also support recovery.

Some people may experience mild side effects such as nausea, stomach discomfort, heartburn, or dizziness. These effects are usually temporary and may improve as your body adjusts to the medicine. However, seek medical attention if you develop severe stomach pain, vomiting blood, black stools, difficulty breathing, severe skin reactions, or signs of liver problems.

Before taking Combipain Tablet , inform your doctor if you have a history of stomach ulcers, gastrointestinal bleeding, kidney disease, liver disease, heart disease, high blood pressure, or asthma. This medicine may not be suitable for people with severe liver impairment, active stomach bleeding, or known allergies to ibuprofen, paracetamol, or other nonsteroidal anti-inflammatory drugs (NSAIDs).

Avoid excessive alcohol consumption while taking this medicine, as alcohol may increase the risk of stomach bleeding and liver-related side effects. Tell your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are older than 65 years, so they can determine whether this medicine is appropriate for you.
 

Uses of Combipain Tablet

Combipain Tablet is used to relieve pain and reduce fever. The detailed uses of Combipain Tablet are as follows:

  • Mild to Moderate Pain: Helps relieve headaches, toothaches, muscle pain, sprains, strains, and other common painful conditions.
  • Fever Reduction: Helps lower elevated body temperature associated with infections and other illnesses.
  • Joint and Back Pain: Helps reduce discomfort and inflammation associated with musculoskeletal conditions.
  • Menstrual Pain: Helps relieve abdominal cramps and discomfort associated with menstruation.
  • Post-Procedural or Dental Pain: May be prescribed for short-term pain relief following certain medical or dental procedures.
     

Key Benefits

Combipain Tablet provides effective relief from pain and fever by combining two complementary medicines in a single treatment. This combination may offer greater symptom relief than either ingredient alone for some individuals.

  • Enhanced Pain Relief: Works through multiple pathways to help reduce pain and improve comfort.
  • Reliable Fever Control: Helps lower fever and relieve associated symptoms such as chills and body aches.
  • Improved Physical Function: By reducing pain and discomfort, the medicine may help you perform daily activities more comfortably.
  • Convenient Combination Therapy: Combines two commonly used pain-relieving medicines into a single tablet, simplifying treatment.
     
Side effects of Combipain Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Drink fluids: Water, clear broth, or electrolyte-rich beverages.
  • Follow a balanced diet, which would be rich in fruits, vegetables, whole grains, lean proteins, and healthy fats.
  • Mindfulness: Manage stress with meditation, deep breathing or yoga.
  • Stay away from smoke, dust and other irritants.
  • Get adequate rest to facilitate recovery.
  • Wash hands and avoid close contact, do not share personal items.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.

Directions for Use

To get the full benefit of Combipain Tablet and minimise side effects, follow these simple guidelines:

  • Take the tablet orally with a full glass of water.
  • Swallow the tablet whole unless your doctor advises otherwise.
  • Take the medicine with food or milk if stomach irritation occurs.
  • Do not exceed the prescribed dose or recommended duration of treatment.
  • Avoid taking other medicines containing paracetamol or ibuprofen unless advised by your doctor.
  • Always follow your doctor's exact instructions regarding dosage and duration of treatment.
     

How Combipain Tablet Works

Combipain Tablet contains ibuprofen and paracetamol. Together, these medicines help relieve pain and reduce fever through complementary mechanisms. Reduces Pain Signals: Paracetamol acts primarily within the central nervous system to help reduce pain perception and lower fever. Reduces Inflammation: Ibuprofen blocks cyclooxygenase (COX) enzymes, reducing the production of prostaglandins that contribute to pain, swelling, and inflammation. Controls Fever: Both ingredients contribute to lowering elevated body temperature by acting on the body's temperature-regulating mechanisms. By combining these actions, Combipain Tablet helps provide effective relief from pain and fever.
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Alcohol

Unsafe

Taking Combipain Tablet with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit intake of alcoholic beverages with Combipain Tablet .

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Pregnancy

Unsafe

Use of Combipain Tablet during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby.

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Breast Feeding

Consult your doctor

Take Combipain Tablet only if prescribed by your doctor.

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Driving

Unsafe

After taking Combipain Tablet you may notice dizziness, sleepiness, drowsiness or fatigue.

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Liver

Caution

Combipain Tablet to be taken with caution, especially if you have a history of liver disease. Dose may have to be adjusted by your doctor.

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Kidney

Caution

Combipain Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

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Children

Caution

Combipain Tablet is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.

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Heart

Unsafe

Combipain Tablet should be avoided in cardiac patients as it can lead to serious cardiavascular risks

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Geriatrics

Caution

Combipain Tablet should be used under caution in geriatric patients as it can lead to serious side effects.

What if I have taken an overdose of Combipain Tablet

Do not take more than the prescribed dose of Combipain Tablet as it may cause severe side effects. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid Excessive Alcohol Consumption: Alcohol may increase the risk of stomach bleeding and liver-related complications.
  • Stay Well Hydrated: Drinking adequate fluids supports kidney function, especially during fever or illness.
  • Get Adequate Rest: Rest allows your body to recover more effectively from illness or injury.
  • Use Supportive Measures: Warm or cold compresses may help relieve muscle aches, joint discomfort, or minor injuries.
  • Maintain a Healthy Lifestyle: Regular exercise, balanced nutrition, and proper sleep habits may help reduce the frequency of certain pain conditions.
     

Have a query?

How Soon It Starts Working

The time required for Combipain Tablet to start to work: The time required for Combipain Tablet to show its action is unknown. 

The time for which the effects of Combipain Tablet last: The duration of action for Combipain Tablet is unknown.

What if you forget to take Combipain Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

• Store Combipain Tablet at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F).. •Keep the tablets in their original packaging to protect them from moisture and light.

Drug Warnings

  • Check Other Medicines Carefully: Many cold, flu, and pain medicines may contain paracetamol or NSAIDs. Avoid accidental duplication of ingredients.
  • Do Not Exceed Recommended Doses: Taking more than the prescribed amount may increase the risk of serious liver, kidney, or stomach complications.
  • Watch for Signs of Bleeding: Seek medical advice if you notice unusual bruising, prolonged bleeding, black stools, or blood in vomit.
  • Monitor Liver Health: Inform your doctor if you have liver disease or consume alcohol regularly.
  • Use for the Shortest Necessary Duration: Prolonged use should only occur under medical supervision.
     

Drug-Drug Interactions

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Drug-Drug Interactions
Inform your doctor if you are taking any of the following medicines, as they may interact with Combipain Tablet :

  • Blood Thinners: Medicines such as warfarin may increase the risk of bleeding.
  • Other NSAIDs: Medicines such as naproxen, diclofenac, or aspirin may increase the risk of stomach ulcers, bleeding, and kidney problems.
  • Blood Pressure Medicines: Certain medicines used to treat high blood pressure may become less effective, and kidney function may require monitoring.
  • Corticosteroids: Medicines such as prednisone may increase the risk of gastrointestinal bleeding.
  • Other Paracetamol-Containing Medicines: Concurrent use may increase the risk of overdose and liver toxicity.


Drug-Food Interactions

  • Alcohol: Excessive alcohol consumption may increase the risk of liver damage and gastrointestinal bleeding.


Drug-Disease Interactions


Inform your doctor if you have a history of the following conditions before taking Combipain Tablet , as it may worsen your condition or require additional monitoring:

  • Liver Disease: May increase the risk of liver toxicity.
  • Kidney Disease: May increase the risk of kidney-related complications.
  • Active Stomach Ulcers or Gastrointestinal Bleeding: Ibuprofen may worsen these conditions.
  • Heart Failure or Cardiovascular Disease: NSAIDs may increase fluid retention and cardiovascular risks in some individuals.
  • Asthma: Some people with asthma may experience worsening symptoms after taking NSAIDs.
     
Ibuprofen + ParacetamolKetorolac
Critical
Ibuprofen + ParacetamolMeloxicam
Critical

Drug-Drug Interactions

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Ibuprofen + ParacetamolKetorolac
Critical
How does the drug interact with Combipain Tablet:
Taking ketorolac with ibuprofen can increase the risk of side effects in inflammation, bleeding, and ulceration.

How to manage the interaction:
Although there is an interaction between ketorolac and ibuprofen, it can be taken if advised by a doctor. However, if you experience dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
Ibuprofen + ParacetamolMeloxicam
Critical
How does the drug interact with Combipain Tablet:
Coadministration of meloxicam and ibuprofen can increase the risk of side effects such as inflammation, bleeding, and ulceration.

How to manage the interaction:
Although there is an interaction between meloxicam and ibuprofen, it can be taken if advised by a doctor. However, if you experience dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Ibuprofen + ParacetamolDasatinib
Severe
How does the drug interact with Combipain Tablet:
Coadministration of dasatinib and ibuprofen can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between dasatinib and ibuprofen, it can be taken if advised by your doctor. However, if you experience dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
Ibuprofen + ParacetamolVorapaxar
Severe
How does the drug interact with Combipain Tablet:
Coadministration of vorapaxar and ibuprofen can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between vorapaxar and ibuprofen, it can be taken if advised by a doctor. However, if you experience dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Ibuprofen + ParacetamolApixaban
Severe
How does the drug interact with Combipain Tablet:
Coadministration of Combipain Tablet and apixaban can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Combipain Tablet and apixaban, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
Ibuprofen + ParacetamolIbrutinib
Severe
How does the drug interact with Combipain Tablet:
Coadministration of ibrutinib and ibuprofen can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between ibrutinib and ibuprofen, it can be taken if advised by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ibuprofen + ParacetamolFenoprofen
Severe
How does the drug interact with Combipain Tablet:
Coadministration of fenoprofen and ibuprofen can increase the risk of inflammation, bleeding, and stomach ulcers.

How to manage the interaction:
Although there is an interaction between fenoprofen and ibuprofen, it can be taken if advised by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
Ibuprofen + ParacetamolTinzaparin
Severe
How does the drug interact with Combipain Tablet:
Coadministration of tinzaparin and ibuprofen can increase the risk of bleeding complications.

How to manage the interaction:
Although there is an interaction between tinzaparin and ibuprofen, it can be taken if advised by a doctor. However, if you experience unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Ibuprofen + ParacetamolCelecoxib
Severe
How does the drug interact with Combipain Tablet:
Coadministration of celecoxib and ibuprofen can increase the risk of bleeding and ulcers.

How to manage the interaction:
Although there is a interaction between ibuprofen and celecoxib, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ibuprofen + ParacetamolValdecoxib
Severe
How does the drug interact with Combipain Tablet:
Co-administration of ibuprofen and valdecoxib may increase the risk of inflammation, bleeding, and ulceration.

How to manage the interaction:
Although there is an interaction between ibuprofen and valdecoxib, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANALGESIC AND ANTIPYRETIC AGENT]

FAQs

Combipain Tablet is used to relieve symptoms of muscle pain, arthritis pain, dysmenorrhea (painful periods or menstrual cramps), and dental pain and reduces fever.
Combipain Tablet is comprised of two medications, Ibuprofen and Paracetamol. Combipain Tablet has analgesic and anti-inflammatory properties that help relieve mild to moderate pain. Combipain Tablet functions by inhibiting the production of specific chemical messengers that induce fever, discomfort, and inflammation (redness and swelling).
No, it is not advisable to take Combipain Tablet with depression medication. Please inform your doctor if you are taking depression medicine before starting Combipain Tablet .
Yes, Combipain Tablet is a short term medication and if you feel better you can stop taking Combipain Tablet , but only after consulting your doctor.
Combipain Tablet is known to be contra-indicated in patients with allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. Its use should also be avoided in patients with history of stomach ulcer and kidney/liver disease.
Yes, Combipain Tablet may cause dizziness, light-headedness, and occasionally drowsiness in some people. If these symptoms occur, avoid driving, operating machinery, or performing tasks that require alertness until you feel better. Consult your doctor if symptoms persist or worsen.
No, Combipain Tablet is not indicated for stomach pain. Also, If you have stomach pain post ingestion it may be a sign of stomach ulcer, or gastric bleeding. Do not take Combipain Tablet in this condition. It is better to inform your doctor in case of stomach pain post ingestion of this medication.
Consult your doctor before taking other pain relievers, cough medicines, or cold remedies while using Combipain Tablet . Some products may contain ibuprofen, paracetamol, or similar ingredients, which can increase the risk of accidental overdose and side effects.
No, Combipain Tablet is generally intended for short-term use unless specifically recommended by your doctor. Long-term or daily use may increase the risk of stomach ulcers, gastrointestinal bleeding, kidney problems, liver problems, and cardiovascular complications. Consult your doctor for appropriate long-term pain management options.
Yes, Combipain Tablet can be taken on an empty stomach, but taking it with food, milk, or after meals may help reduce the risk of stomach irritation, indigestion, and stomach upset. Consult your doctor if you experience persistent stomach discomfort.
It is best to avoid or limit alcohol consumption while taking this medicine. Alcohol may increase the risk of stomach bleeding and liver-related side effects. Talk to your doctor or pharmacist if you have concerns.
This medicine may not be suitable during pregnancy, particularly during the later stages. Your healthcare provider will determine the safest treatment option based on your individual circumstances. Talk to your doctor or pharmacist before using this medicine during pregnancy.
If your symptoms persist or worsen despite taking the medicine as directed, contact your healthcare provider for further evaluation. Do not increase your dose without medical advice. Talk to your doctor or pharmacist.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.7020 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Electronic Medicines Compendium (EMC). Pil.1958 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  3. CiplaMed Clinical Compendium. Ibugesic Plus Oral Suspension Product Specification Guide. Mumbai, India: Cipla; 2024. [Accessed on 02 Jun. 2026] Check here
  4. ScienceDirect ScienceDirect. [Accessed on 23 Apr. 2019] Check here
  5. Acetaminophen and ibuprofen [Prescribing Information]. 2023. [Accessed on 14 Aug. 2024] Check here
  6. Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database Syst Rev. 2013;2013(6):CD010210. Published 2013 Jun 24. [Accessed on 4 Mar 2025]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Plot NO. 28/6, Industrial Area,Phase 2, Chandigarh (India)
Other Info - COM0618

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