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  3. Combitide 50 Inhaler 1's

Combitide 50 Inhaler 1's, Pack of 1
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

COMBITIDE 50MG INHALER is used to treat and prevent respiratory disorders, such as asthma attacks and chronic obstructive pulmonary disease (COPD). It contains Salmeterol and Fluticasone, which relax the muscles in the airways and increase airflow to the lungs. It makes breathing easier by widening the airways. Also, it acts by blocking the production of prostaglandins (chemical messengers) that cause inflammation (swelling) of the airways. It may cause common side effects such as nausea, vomiting, respiratory tract infection, headache, sore throat, cough, bone, muscle or joint pain, increased heart rate, chills, black or tarry stools, and noisy breathing. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

FLUTICASONE-50MCG + SALMETEROL-25MCG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

INHALATION

Return Policy :

Not Returnable

Expires on or after :

About COMBITIDE 50MG INHALER

COMBITIDE 50MG INHALER is a respiratory medication used to treat and prevent respiratory disorders like asthma and chronic obstructive pulmonary disease (COPD). Asthma is a breathing disorder characterised by airway narrowing, swelling, and excessive mucus production, resulting in difficulty breathing. COPD is a group of lung diseases that includes emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of the bronchial tubes).

COMBITIDE 50MG INHALER is a combination of two medicines: Salmeterol and Fluticasone. Salmeterol is a long-acting bronchodilator that relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone belongs to the class of corticosteroids. It acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways.

Your doctor will advise on how often you take COMBITIDE 50MG INHALER based on your medical condition. The common side effects of COMBITIDE 50MG INHALER include nausea, vomiting, respiratory tract infection, headache, sore throat, cough, bone, muscle or joint pain, increased heart rate, chills, black or tarry stools, and noisy breathing. Most of these side effects of COMBITIDE 50MG INHALER do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine on your own. Brief your medical history to the doctor if you have heart, liver, kidney diseases, hypokalaemia (low potassium levels in the blood), hyperadrenocorticism (high levels of cortisol), eye disorders like cataract and glaucoma, seizure (fits), osteoporosis (weak and brittle bones), and diabetes before taking COMBITIDE 50MG INHALER. Therapy with nasal or inhaled corticosteroids like Fluticasone should be cautiously administered in patients with a fungal, bacterial, parasitic, or viral infection and tuberculosis, since there is a chance of developing a secondary infection. Please check with your doctor if you are pregnant, currently breastfeeding, or taking any other prescribed or non-prescribed medicines.

Uses of COMBITIDE 50MG INHALER

COMBITIDE 50MG INHALER is used to treat and prevent breathing problems associated with asthma and chronic obstructive pulmonary disease (COPD). The detailed uses of COMBITIDE 50MG INHALER are as follows:
• Treatment of asthma: Used to relieve and prevent difficulty breathing, wheezing, shortness of breath, coughing, and chest tightness in people with asthma.
• Management of chronic obstructive pulmonary disease (COPD): COMBITIDE 50MG INHALER controls and minimises symptoms such as wheezing, dyspnea, coughing, and chest tightness in patients with COPD, including chronic bronchitis and emphysema.
• Control of COPD flare-ups: Reduces the frequency and severity of COPD exacerbations while improving overall lung function.
• Anti-inflammatory effect: Fluticasone reduces airway irritation, which makes breathing easier.
• Long-acting bronchodilation: Salmeterol relaxes the airway muscles, helping breathing become easier over time.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Please read the instruction leaflet and use it as suggested by your doctor.
  • Rinse your mouth with water and spit it out after using COMBITIDE 50MG INHALER to avoid fungal infections in the mouth and throat.

Medicinal Benefits

COMBITIDE 50MG INHALER is used to treat and prevent respiratory disorders, such as asthma attacks and chronic obstructive pulmonary disease (COPD). COMBITIDE 50MG INHALER improves pulmonary function and effectively treats and prevents the worsening of emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes). COMBITIDE 50MG INHALER is a combination of Salmeterol (bronchodilator) and Fluticasone (corticosteroid). Salmeterol relaxes the muscles in the airways, increasing airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone acts by blocking the production of prostaglandins (chemical messengers) that cause inflammation (swelling) of the airways. Fluticasone has potent vasoconstrictive (narrowing of the blood vessels) and anti-inflammatory activity.

How COMBITIDE 50MG INHALER Works

COMBITIDE 50MG INHALER is a combination of two medicines: Salmeterol (bronchodilator) and Fluticasone. Salmeterol is a long-acting bronchodilator that relaxes the muscles in the airways and increases airflow to the lungs. It makes breathing easier by widening the airways. Fluticasone belongs to the class of corticosteroids. It acts by blocking prostaglandins' production (chemical messengers) that cause inflammation (swelling) of the airways.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of COMBITIDE 50MG INHALER

Do not use COMBITIDE 50MG INHALER in more doses or more often than prescribed, as it may cause an overdose. The symptoms of overdose include chest pain, dry mouth, confusion, decreased urine output, loss of appetite, high blood pressure, nervousness or mood changes. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not stop taking this medicine on your own unless advised by your doctor. Before taking COMBITIDE 50MG INHALER, let your doctor know if you have a history of heart, liver, kidney diseases, hyperadrenocorticism (high levels of cortisol), eye disorders like cataracts and glaucoma, seizure (fits), osteoporosis (weak and brittle bones), and diabetes. COMBITIDE 50MG INHALER may cause hypokalemia (low potassium levels in the blood); therefore, it should be used with caution in patients with hypokalaemia to prevent any cardiovascular effects. Special precautions should be taken in patients with a fungal, bacterial, parasitic, or viral infection and tuberculosis, since nasal or inhaled corticosteroids like Fluticasone can cause secondary infections. COMBITIDE 50MG INHALER can cause a rise in blood glucose levels. Hence, monitor your blood glucose levels regularly if you are diabetic. Please let your doctor know if you plan to become pregnant or are already pregnant and a lactating mother. Do not drive or operate machinery if you experience drowsiness and increased/uneven heart rate while using COMBITIDE 50MG INHALER. Avoid drinking alcohol while taking this medicine, as it can worsen your side effects.

Drug-Drug Interactions

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FluticasoneMifepristone
Critical
SalmeterolCobicistat
Severe

Drug-Drug Interactions

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FluticasoneMifepristone
Critical
How does the drug interact with Combitide 50 Inhaler:
Co-administration of Combitide 50 Inhaler with Mifepristone may make Combitide 50 Inhaler less effective as a therapy.

How to manage the interaction:
Taking Combitide 50 Inhaler with Mifepristone is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
SalmeterolCobicistat
Severe
How does the drug interact with Combitide 50 Inhaler:
Cobicistat may significantly increase the blood levels of Combitide 50 Inhaler. High blood levels of Combitide 50 Inhaler can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Co-administration of Combitide 50 Inhaler with Cobicistat can result in an interaction, but it can be taken if your doctor has advised it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
SalmeterolDelavirdine
Severe
How does the drug interact with Combitide 50 Inhaler:
The combined use of Delavirdine and Combitide 50 Inhaler can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Combitide 50 Inhaler with Delavirdine can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
SalmeterolTelithromycin
Severe
How does the drug interact with Combitide 50 Inhaler:
Telithromycin may significantly increase the blood levels of Combitide 50 Inhaler. High blood levels of Combitide 50 Inhaler can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is a possible interaction between Combitide 50 Inhaler and Telithromycin, you can take these medicines together if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
SalmeterolRitonavir
Severe
How does the drug interact with Combitide 50 Inhaler:
Taking Combitide 50 Inhaler with ritonavir can significantly increase the blood levels of Combitide 50 Inhaler.

How to manage the interaction:
There may be a possibility of interaction between Combitide 50 Inhaler and Ritonavir, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not stop using any medications without talking to a doctor.
SalmeterolMetipranolol
Severe
How does the drug interact with Combitide 50 Inhaler:
The combined use of Metipranolol and Combitide 50 Inhaler can increase the effect of both Metipranolol and Combitide 50 Inhaler. It may increase the risk of severe asthma attacks or breathing problems.

How to manage the interaction:
Although there is a possible interaction between Combitide 50 Inhaler and Metipranolol, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
SalmeterolIndinavir
Severe
How does the drug interact with Combitide 50 Inhaler:
Indinavir may significantly increase the blood levels of Combitide 50 Inhaler. High blood levels of Combitide 50 Inhaler can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Combitide 50 Inhaler with Indinavir together can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
SalmeterolLevobunolol
Severe
How does the drug interact with Combitide 50 Inhaler:
Using levobunolol ophthalmic together with Combitide 50 Inhaler may reduce the benefits of both medications. It may increase the risk of severe asthmatic attacks or breathing problems.

How to manage the interaction:
There may be a possibility of interaction between Combitide 50 Inhaler and Levobunolol, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
SalmeterolDarunavir
Severe
How does the drug interact with Combitide 50 Inhaler:
Darunavir may significantly increase the blood levels of Combitide 50 Inhaler. High blood levels of Combitide 50 Inhaler can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Darunavir and Combitide 50 Inhaler together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
SalmeterolFosamprenavir
Severe
How does the drug interact with Combitide 50 Inhaler:
The combined use of Fosamprenavir and Combitide 50 Inhaler can increase the risk of irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Combitide 50 Inhaler and Fosamprenavir, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals. Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take COMBITIDE 50MG INHALER.
  • Know your triggers, such as allergens, such as pollen, dust, and food items, that make your asthma severe.
  • Quit smoking and avoid passive smoking. Smoking also reduces the effectiveness of the medicine.
  • Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.
  • Learning breathing exercises will help you move more air in and out of your lungs.

Habit Forming

No

Therapeutic Class

RESPIRATORY STIMULANTS

COMBITIDE 50MG INHALER Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Avoid drinking alcohol while taking this medicine as it can worsen your side effects.

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Pregnancy

Caution

Please consult your doctor if you are planning to conceive or are already pregnant before starting COMBITIDE 50MG INHALER.

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Breast Feeding

Caution

There is limited data on how COMBITIDE 50MG INHALER affects breastfeeding. Please consult your doctor before starting COMBITIDE 50MG INHALER.

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Driving

Caution

Do not drive or operate machinery if you experience drowsiness and an increased or uneven heart rate while using COMBITIDE 50MG INHALER. This may affect your ability to drive. Seek medical attention if the symptoms persist longer.

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Liver

Caution

COMBITIDE 50MG INHALER should be used with caution in patients with liver diseases. Let your doctor know if you have any history of liver disease or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing COMBITIDE 50MG INHALER.

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Kidney

Caution

COMBITIDE 50MG INHALER should be used with caution in patients with kidney diseases. Inform your doctor if you have a history of kidney disease. Your doctor will weigh the benefits and potential risks before prescribing COMBITIDE 50MG INHALER.

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Children

Caution

COMBITIDE 50MG INHALER is not recommended for use for children less than four years of age. The dose may have to be adjusted by your doctor depending upon the condition of the child's disease and age.

Have a query?

FAQs

COMBITIDE 50MG INHALER is used to treat and prevent respiratory disorders like asthma and chronic obstructive pulmonary disease (COPD).

COMBITIDE 50MG INHALER consists of Salmeterol (bronchodilator) and Fluticasone (Fluticasone). Salmeterol relaxes the muscles in the airways, increasing airflow to the lungs. Fluticasone acts by blocking the production of prostaglandins (chemical messengers) that cause inflammation (swelling) of the airways.

COMBITIDE 50MG INHALER should be cautiously administered under the doctor's guidance in seizures since bronchodilators like Salmeterol can cause central nervous system stimulation that can lead to other adverse conditions. Please consult your doctor before using COMBITIDE 50MG INHALER if you have seizures.

COMBITIDE 50MG INHALER contains bronchodilator (Fluticasone), which can cause a rise in blood glucose levels. Hence, therapy with COMBITIDE 50MG INHALER is cautiously administered in patients with diabetes. Please monitor your blood glucose levels regularly and inform your doctor so that the dose can be adjusted accordingly.

Bronchodilator (Salmeterol) in COMBITIDE 50MG INHALER may decrease the potassium levels in your body; therefore, it should be used with caution. Please consult your doctor before taking COMBITIDE 50MG INHALER since low potassium levels can lead to other cardiovascular problems in patients with hypokalaemia.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.

COMBITIDE 50MG INHALER is a combination medication used to treat and prevent respiratory disorders, such as asthma and chronic obstructive pulmonary disease (COPD). It contains two active ingredients: Salmeterol and Fluticasone Propionate.

COMBITIDE 50MG INHALER is a controller medication. It manages and prevents symptoms of asthma and chronic obstructive pulmonary disease (COPD) by keeping the airways open and reducing inflammation. It should be used regularly to be effective, and not to relieve sudden asthma attacks immediately.

COMBITIDE 50MG INHALER contains a Fluticasone Propionate, which belongs to the family of medicines known as corticosteroids or steroids (cortisone-like medicines), which helps reduce inflammation in the airways.

Yes, COMBITIDE 50MG INHALER may increase heart rate due to the Salmeterol component, which is a long-acting beta2-adrenergic receptor agonist (LABA). This can lead to palpitations, tremors, and increased heart rate in some individuals. Try deep breathing exercises, relaxation techniques, staying hydrated, and avoiding caffeine and nicotine to manage an increased heart rate. If the increased heart rate persists or worsens, consult your healthcare provider for guidance.

COMBITIDE 50MG INHALER may cause some common side effects, including nausea, vomiting, respiratory tract infection, headache, sore throat, cough, bone, muscle, or joint pain, increased heart rate, chills, black or tarry stools, and noisy breathing. Most of these side effects of COMBITIDE 50MG INHALER do not require medical attention and typically resolve on their own over time. However, if the side effects persist, contact your doctor.

COMBITIDE 50MG INHALER is not addictive. It is a very effective and useful medication for people suffering from breathing difficulties due to asthma and COPD.

Taking COMBITIDE 50MG INHALER more frequently than prescribed will not make it more effective and can increase the risk of side effects. It is essential to use this medication exactly as directed by your doctor to manage your asthma or COPD effectively.

When using COMBITIDE 50MG INHALER, following certain precautions is essential to ensure safe and effective use. Follow your doctor's instructions, and do not use it for sudden asthma attacks. Instead, use a rescue inhaler as your doctor advises. Additionally, rinse your mouth with water after inhaling to prevent fungal infections. Avoid asthma triggers, such as dust, pollen, or smoke, and store the inhaler correctly, out of the reach of children, pets, and extreme temperatures. Inform your doctor about other medications, supplements, or vitamins you're taking, and regularly monitor for side effects, such as increased heart rate, tremors, or mood changes.

COMBITIDE 50MG INHALER should be stored below 30°C and kept away from moisture. Keep out of the reach of children. Always follow the storage instructions provided on the packaging or by your healthcare provider.

Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - COM0045

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jun 30, 2025 | 11:46 AM IST

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Reference

  1. https://www.drugs.com/dosage/fluticasone-salmeterol.html
  2. https://www.mayoclinic.org/drugs-supplements/fluticasone-and-salmeterol-inhalation-route/description/drg-20063110
  3. https://medlineplus.gov/druginfo/meds/a699063.html
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