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compositionComposition:PROGESTERONE-8%W/W
prescription
Prescription Medicine
info
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Corpistone 8% Prefilled Applicator Gel 1.125 gm is a female hormone used in the treatment of female infertility. This medicine helps boost the production of hormones involved in the ovulation process. Common side effects include flushing (reddening of the skin, especially the face), headache, Insomnia, tiredness, dizziness, breast pain or tenderness, heavy periods, etc. It is also used to restore the menstrual cycle in women who have missed their periods. This medicine is only intended for use in women. Hence should not be used in male population, pregnant/breastfeeding women, and children.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

PROGESTERONE-8%W/W

Manufacturer/Marketer :

Nuvanta Life Sciences Pvt Ltd

Consume Type :

Vaginal

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Corpistone 8% Prefilled Applicator Gel 1.125 gm

Corpistone 8% Prefilled Applicator Gel 1.125 gm is a vaginal medication used to support early pregnancy, especially during fertility treatments, and to help prevent preterm birth in women with high-risk pregnancies. It is also used to treat irregular menstrual cycles or to protect the lining of the womb in women undergoing hormone replacement therapy. By delivering the key hormone directly where it is needed, it helps prepare and maintain a stable environment in the uterus.

To achieve the best results, you must use this medicine consistently at the same time every day as directed by your healthcare provider. Because it is inserted vaginally, its absorption is not affected by food, meaning you can insert it with or without meals. Making certain lifestyle adjustments, such as eating a balanced diet, staying hydrated, and reducing stress, can also help support your overall treatment plan.

While using Corpistone 8% Prefilled Applicator Gel 1.125 gm, you may experience mild, temporary side effects such as light vaginal discharge, bloating, or breast tenderness. These symptoms are common as your body adjusts to the hormone, but you should consult your doctor immediately if you experience severe symptoms like sudden chest pain, difficulty breathing, or severe headaches.

Before starting this medication, tell your doctor about any health conditions you have, especially if you have ever had liver issues or blood clots. Do not use this medicine if you have unexplained vaginal bleeding, severe liver damage, or a history of active blood clots.

Inform your doctor about all other medicines you are using, as some treatments may interact with Corpistone 8% Prefilled Applicator Gel 1.125 gm. While this medication is frequently prescribed during early pregnancy to support gestation, you should consult your healthcare provider if you are breastfeeding, and always discuss your treatment plan if you are an older adult, to ensure it is safe for your specific situation.

Corpistone 8% Prefilled Applicator Gel 1.125 gm is available in different vaginal dosage forms, including gels, tablets/inserts, capsules, and suppositories. Depending on your condition, your doctor may prescribe a brand such as Crinone®, Utrogestan®, or Endogest® or another suitable equivalent.

Uses of Corpistone 8% Prefilled Applicator Gel 1.125 gm

Your doctor may prescribe Corpistone 8% Prefilled Applicator Gel 1.125 gm to help manage the following conditions: 

  • Supporting early pregnancy in fertility treatments: Corpistone 8% Prefilled Applicator Gel 1.125 gm helps prepare and maintain the lining of the womb, making it easier for a fertilised egg to attach and grow during assisted reproduction procedures.
  • Preventing preterm birth: In women with a short cervix or a history of early deliveries, this vaginal treatment helps relax the uterine muscles to reduce the risk of giving birth too early.
  • Treating absent menstrual periods: It helps restore a regular monthly cycle in women who have stopped menstruating due to a lack of natural hormones.
  • Hormone Replacement Therapy: When used alongside estrogen, it protects the lining of the womb from overgrowing, lowering the risk of complications in postmenopausal women.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Targeted Local Support: Corpistone 8% Prefilled Applicator Gel 1.125 gm provides targeted support directly where your body needs it most.
  • High Uterine Delivery: Because the medicine is inserted vaginally, it delivers high concentrations of Corpistone 8% Prefilled Applicator Gel 1.125 gm to the uterus (often called the first uterine pass effect).
  • Effective Local Treatment: Although a small amount is also absorbed into the bloodstream, this route helps provide effective local treatment while keeping overall hormone levels relatively lower than with some oral forms, which may help reduce widespread side effects.
  • Supports Early Pregnancy: For women undergoing fertility treatments, this medicine provides the necessary support to secure and nourish an early pregnancy.
  • Helps Prevent Preterm Birth: For those at risk of early labour, it helps prolong the pregnancy, giving the baby vital time to develop.
  • Restores Hormonal Balance: It also helps restore a healthy hormonal balance, bringing comfort and predictability back to irregular menstrual cycles and helping manage postmenopausal health safely.
Side effects of Corpistone 8% Prefilled Applicator Gel 1.125 gm
  • Regular activity including cardio and weightlifting can help in weight loss and breast tissue reduction.
  • Limit alcohol intake to lower your chances of gynecomastia and hormonal changes.
  • Eat a balanced diet and avoid foods high in estrogen-like compounds.
  • Follow your doctor's instructions take medication consistently to reduce breast enlargement and do not stop taking medication on your own.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Mood swings can be managed but cannot be controlled. Therefore, spending time in nature can help you feel light and improve your mood.
  • Practice meditation, deep breathing and do regular exercise that can positively affect your mood. Also helps in processing the situation before responding to it.
  • Food has direct impact on mood. Therefore, eat foods that are less processed and reduce sugar intake.
  • Consult your doctor if the mood swings are uncontrollable or unmanageable.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Use hot or cold packs on your breasts to help alleviate discomfort.
  • Choose a supportive, well-fitting bra, preferably one that has been professionally fitted.
  • Practice relaxation techniques to manage stress and anxiety that may accompany severe breast pain.
  • Limit or avoid caffeine consumption.
  • Eat a low-fat diet and focus on foods rich in complex carbohydrates.
  • Rubbing evening primrose oil on your breasts may help balance fatty acids in the cells and reduce pain.
  • Keep track of when your breast pain occurs and any other symptoms to determine if the pain is regular or not.
  • Vitamin E supplements may help reduce pain for women who experience pain linked to their menstrual cycle.
  • Over-the-counter pain relievers like acetaminophen or ibuprofen can provide relief, but be sure to consult your doctor for the correct dosage, as prolonged use may cause side effects.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Check the label for directions before using Corpistone 8% Prefilled Applicator Gel 1.125 gm.
  • Gently insert the applicator into the vagina while lying down or standing with one leg raised. Push the plunger to release the medication.
  • Wash your hands thoroughly with soap and water.
  • Ensure the vaginal area is clean and dry.
  • Remove the applicator carefully and remain lying down for a few minutes to allow the medication to absorb.

How Corpistone 8% Prefilled Applicator Gel 1.125 gm Works

The active hormone in Corpistone 8% Prefilled Applicator Gel 1.125 gm is identical to the progesterone naturally produced by the ovaries. This hormone is essential for preparing the uterus for pregnancy and maintaining it. The medicine works by binding to specific receptors in the uterus, signalling the uterine lining to thicken and become rich in blood vessels and nutrients, which prepares the womb to receive and support a fertilised egg. When inserted vaginally, the medicine avoids passing through the digestive system first and delivers Corpistone 8% Prefilled Applicator Gel 1.125 gm directly to the vaginal tissues, allowing high concentrations to reach the uterus while some of the medicine is also absorbed into the bloodstream. This localised action helps relax the muscles of the uterus, preventing premature contractions, and ensures that the uterine lining remains stable and supportive throughout your treatment.
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Alcohol

Caution

It is not known if alcohol affects Corpistone 8% Prefilled Applicator Gel 1.125 gm. However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Caution

Contact the doctor before using Corpistone 8% Prefilled Applicator Gel 1.125 gm. Your doctor will decide whether Corpistone 8% Prefilled Applicator Gel 1.125 gm should be used by the pregnant woman or not depending on her condition.

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Breast Feeding

Unsafe

The use of Corpistone 8% Prefilled Applicator Gel 1.125 gm during breastfeeding is not recommended.

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Driving

Caution

Corpistone 8% Prefilled Applicator Gel 1.125 gm does not influence the ability to drive and use machines.

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Liver

Unsafe

Do not use Corpistone 8% Prefilled Applicator Gel 1.125 gm if you have/had liver disease or abnormal liver tests.

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Kidney

Consult your doctor

Please consult your doctor if you have aany kidney disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Corpistone 8% Prefilled Applicator Gel 1.125 gm is not recommended for use in children or adolescents.

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Heart

Caution

Corpistone 8% Prefilled Applicator Gel 1.125 gm should be used with caution in patients with heart conditions, as it may increase the risk of side effects. Please inform your doctor before using Corpistone 8% Prefilled Applicator Gel 1.125 gm.

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Geriatrics

Consult your doctor

Limited information is available regarding the use of Corpistone 8% Prefilled Applicator Gel 1.125 gm in elderly patients. If you have any concerns about the usage of Corpistone 8% Prefilled Applicator Gel 1.125 gm in geriatrics, please consult your doctor.

What if I have taken an overdose of Corpistone 8% Prefilled Applicator Gel 1.125 gm

Because Corpistone 8% Prefilled Applicator Gel 1.125 gm is applied locally inside the vagina, a serious overdose is highly unlikely. However, if you or someone else accidentally swallows the medicine, or if you insert far too much, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat fibre-rich foods: Hormonal treatments can sometimes slow down your digestion, which may lead to constipation. Incorporate plenty of whole grains, vegetables, and fruits into your meals to support healthy digestion.
  • Stay well-hydrated: Drink plenty of water throughout the day to support circulation and digestive health, especially during early pregnancy.
  • Wear breathable underwear: It is normal to experience some vaginal discharge or medication leakage. Wear loose, breathable cotton underwear and avoid synthetic fabrics to stay dry and prevent irritation.
  • Avoid douching: Do not use vaginal douches or harsh soaps inside the vaginal area while using this medication, as this can wash away the medicine, cause irritation, or alter your natural vaginal pH.
  • Engage in gentle exercise: If approved by your doctor, light activities like walking can improve circulation and help ease mild bloating or sluggish digestion.
health query

Have a query?

How Soon It Starts Working

The time required for Corpistone 8% Prefilled Applicator Gel 1.125 gm to start to work: The time required for Corpistone 8% Prefilled Applicator Gel 1.125 gm to show its action is unknown. 

The time for which the effects of Corpistone 8% Prefilled Applicator Gel 1.125 gm last: The duration of action for Corpistone 8% Prefilled Applicator Gel 1.125 gm is unknown.

What if you forget to take Corpistone 8% Prefilled Applicator Gel 1.125 gm

If you miss a dose, insert it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and return to your regular schedule. Do not insert a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Do not store it in the bathroom where humidity levels change quickly, and do not freeze vaginal gels or inserts.

Drug Warnings

  • Inspect Before Use: Inspect the product before use. Do not use the vaginal gel, tablet, or insert if the wrapper is torn, punctured, or shows any signs of leaking or damage.
  • Use the Provided Applicator: Always use the specific applicator provided in the packaging. Never share applicators with anyone else, and do not reuse disposable, single-use applicators.
  • Avoid Other Vaginal Products: Avoid using other vaginal medications or products (such as anti-yeast creams, vaginal moisturisers, or spermicides) at the same time as Corpistone 8% Prefilled Applicator Gel 1.125 gm, as they can interfere with how your body absorbs the hormone. If you must use another vaginal product, space them out or talk to your doctor or pharmacist first.
  • Report Unusual Bleeding: If you experience any unexpected vaginal bleeding or spotting while using this medicine, notify your healthcare provider immediately to determine the cause.
  • Wash Hands Before & After Use: Wash your hands thoroughly both before and after inserting the medicine to prevent introducing bacteria into the vaginal area.

Drug-Drug Interactions

verifiedApollotooltip
  • Other vaginal products: Using other vaginal creams, gels, or suppositories (such as antifungal treatments like clotrimazole or miconazole) at the same time may reduce the effectiveness and absorption of Corpistone 8% Prefilled Applicator Gel 1.125 gm.
  • Medicines that affect liver enzymes: Some medicines, including rifampicin, certain anti-seizure medicines (such as carbamazepine or phenytoin), and antifungal medicines such as ketoconazole, may change how Corpistone 8% Prefilled Applicator Gel 1.125 gm is processed in the body. Tell your doctor about all prescription medicines, over-the-counter medicines, and herbal supplements you are taking.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Corpistone 8% Prefilled Applicator Gel 1.125 gm when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Corpistone 8% Prefilled Applicator Gel 1.125 gm belongs to the class of medicines known as hormones used to treat female infertility and to aid pregnancy. It is also used to restore the menstrual cycle in women who have missed their periods.
Corpistone 8% Prefilled Applicator Gel 1.125 gm causes secretory changes in the uterine endometrium, relaxes the uterus, prevents follicle maturation, and helps to maintain pregnancy.
Do not use Corpistone 8% Prefilled Applicator Gel 1.125 gm if you are allergic to any of its components or if you have/had porphyria, breast or genital cancer, abnormal vaginal bleeding due to miscarriage or missed abortion, blood clots or stroke, liver disease or abnormal liver tests.
Abnormal uterine bleeding, irregular or missed periods (amenorrhea), abdominal pain during pregnancy and frequent miscarriages are the signs of low progesterone. Additionally, low progesterone levels lead to high estrogen levels, and women can have decreased sex drive, weight gain or gallbladder problems.
Corpistone 8% Prefilled Applicator Gel 1.125 gm may cause vaginal spotting, vaginal irritation, or application site reactions. Consult your doctor if the condition persists or worsens.
Yes, in many cases, your doctor will advise you to continue using this medicine even if your period begins. Stopping the medicine suddenly can disrupt your hormonal balance and affect your treatment. Always follow your doctor's instructions, and talk to your doctor if you have questions.
Having intercourse is generally safe, but it is best to wait a few hours after inserting the medicine to ensure it has been fully absorbed. Additionally, some vaginal residues may coat the vaginal walls and transfer to your partner. If you are using this medicine to support a high-risk pregnancy or fertility treatment, talk to your doctor to see if intercourse is recommended.
No, you should avoid using tampons while using this vaginal medication. Tampons can absorb the medicine, preventing your body from receiving the correct dose. Instead, use a sanitary pad or panty liner to manage any discharge or leakage. Talk to your doctor for more information.
Vaginal Corpistone 8% Prefilled Applicator Gel 1.125 gm is less likely to cause severe drowsiness than oral Corpistone 8% Prefilled Applicator Gel 1.125 gm pills because it is absorbed locally, with lower levels entering your general bloodstream. However, some mild tiredness or sleepiness can still occur. If you feel unusually drowsy, avoid driving or operating machinery and talk to your doctor.
If the applicator causes irritation, ensure you are inserting it gently and at the correct angle. You can also moisten the tip of the applicator with a little water to make insertion smoother. Do not use petroleum jelly or other oil-based lubricants unless directed. If the irritation persists, talk to your doctor.
Corpistone 8% Prefilled Applicator Gel 1.125 gm may be prescribed to support early pregnancy in certain situations, such as during fertility treatment or for some women who have had previous miscarriages or are at higher risk. However, it does not guarantee that a miscarriage can be prevented, and it is not appropriate for every pregnancy. If you have bleeding, pain, or any concerns during pregnancy, contact your doctor promptly for advice.

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Country of origin

India

Manufacturer/Marketer address

Block B/SF-05, Radhe Shopping Mall, Khokhra Cir, Maninagar East, Ahmedabad, Gujarat 380008
Other Info - COR0969
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