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compositionComposition:MEFENAMIC ACID-250MG+TRANEXAMIC ACID-500MG
prescription
Prescription Medicine
info
Cosklot MF Tablet 10's

Cosklot MF Tablet is used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Additionally, it is used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headaches. It contains two medicines, namely Tranexamic acid and Mefenamic acid. It may cause common side effects such as nausea, vomiting, diarrhoea, indigestion, heartburn, and headache.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

MEFENAMIC ACID-250MG+TRANEXAMIC ACID-500MG

Manufacturer/Marketer :

Oaknet Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cosklot MF Tablet

Cosklot MF Tablet is used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Menstrual cramps, also known as dysmenorrhea, are characterized by cramps and pain during menstruation. Menorrhagia is a condition with abnormally heavy or prolonged bleeding during menstruation/periods.

Cosklot MF Tablet is a combination of Tranexamic acid and Mefenamic acid. Tranexamic acid helps the body's natural blood clotting process by preventing fibrin breakdown, which stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.

In some cases, you may experience certain common side effects such as nausea, vomiting, diarrhoea, indigestion, heartburn, and headache. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

You are advised to take Cosklot MF Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. Cosklot MF Tablet can be taken with or without food. Do not crush, chew, or break it.

Avoid taking Cosklot MF Tablet if you are allergic to it. Consult your doctor if you are pregnant or breastfeeding. Cosklot MF Tablet may cause dizziness, so drive with caution. Cosklot MF Tablet should not be given to children as safety and efficacy have not been established.

Uses of Cosklot MF Tablet

Cosklot MF Tablet is used in the treatment of dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). The detailed uses of Cosklot MF Tablet are as follows:

  • Management of Menstrual Disorders: Cosklot MF Tablet is used to help regulate menstrual cycles in women experiencing irregular periods or hormonal imbalances.
  • Relief from Menopausal Symptoms: Cosklot MF Tablet can alleviate symptoms associated with menopause, such as hot flashes and mood swings.
  • PMS Symptom Relief: Cosklot MF Tablet is effective in minimizing premenstrual syndrome (PMS) symptoms, including cramps, anxiety, and other mood-related issues associated with the menstrual cycle.

Key Benefits

  • Cosklot MF Tablet is used to treat abdominal pain, dysmenorrhea (period pain), and menorrhagia (heavy menstrual bleeding).
  • Additionally, Cosklot MF Tablet is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache.
  • Cosklot MF Tablet is a combination of two drugs, namely: Tranexamic acid and Mefenamic acid.
  • Tranexamic acid is an anti-fibrinolytic agent that helps the body's natural blood clot process by preventing fibrin's breakdown, this stops fibrinolysis, a process that stops blood clot formation.
  • Mefenamic acid is an NSAID that works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins.
  • By blocking the COX enzyme's effect, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.
Side effects of Cosklot MF Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Stay hydrated to promote healthy digestion and general well-being.
  • Nonsteroidal anti-inflammatory medications (NSAIDs) have the potential to make worse ulcers by irritating the stomach lining.
  • Avoiding or consuming alcohol is advised because it can irritate the stomach lining and slow down the healing process.
  • limit intake of hot foods, caffeine, and acidic foods such as citrus and tomatoes, as they can worsen the ulcer.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Directions for Use

  • Cosklot MF Tablet can be taken with or without food.
  • Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow Cosklot MF Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Cosklot MF Tablet Works

Cosklot MF Tablet is a combination of two drugs: Tranexamic acid (anti-fibrinolytic) and Mefenamic acid (NSAID). Tranexamic acid helps the body's natural blood clotting process by preventing fibrin breakdown, which stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Cosklot MF Tablet as it may cause increased drowsiness. It can also increase the risk of stomach bleeding.

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Pregnancy

Consult your doctor

Please consult your doctor if you are pregnant or if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Cosklot MF Tablet if you are breastfeeding, your doctor will decide if Cosklot MF Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Cosklot MF Tablet may cause drowsiness and dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Consult your doctor

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Cosklot MF Tablet should not be given to children as the safety and effectiveness were not established.

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Heart

Unsafe

This medicine is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

Cosklot MF Tablet can be given in elderly patients with caution and only if prescribed by the doctor.

What if I have taken an overdose of Cosklot MF Tablet

Do not take more than the prescribed dose of Cosklot MF Tablet as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Follow a healthy diet. Include vegetables, fruits, and whole grains in your meals.
  • Stay hydrated; drink plenty of water.
  • Cut down on sugars, salts, spicy food, coffee, and alcohol.
  • A heating pad can help ease the pain by placing it on the belly or lower back.
  • Exercise can help ease the pain of menstrual cramps.
  • Avoid stress by performing meditation or yoga.
  • Massage your lower back or abdomen to relieve the pain.
  • Take proper rest.

Have a query?

How Soon It Starts Working

  • The time required for Cosklot MF Tablet to start to work: The time required for Cosklot MF Tablet to show its action is unknown. 
  • The time for which the effects of Cosklot MF Tablet last: The duration of action for Cosklot MF Tablet is unknown.

What if you forget to take Cosklot MF Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Cosklot MF Tablet if you are allergic to any of its contents or if you have severe heart failure.
  • Inform your doctor if you have/had deep vein thrombosis, pulmonary embolism (blockage of a blood vessel in the lungs), coagulopathy (formation of blood clots), epilepsy, irregular periods, heart, kidney, or liver problems.
  • Consult your doctor if you are pregnant or breastfeeding.
  • Cosklot MF Tablet may cause dizziness and drowsiness, so drive only if you are alert.
  • Cosklot MF Tablet should not be given to children as safety and effectiveness have not been established.
  • Avoid consuming alcohol along with Cosklot MF Tablet as it could lead to increased drowsiness and can increase the risk of stomach bleeding.
  • Do not take any other NSAIDs for pain relief along with Cosklot MF Tablet unless prescribed.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Cosklot MF Tablet may interact with pain killers (ibuprofen, celecoxib), anti-depressants (duloxetine, fluoxetine, sertraline), fibrinolytic medicine, birth control pills, drugs that prevent bleeding (factor IX complex, anti-inhibitor coagulant concentrates), blood thinners (anticoagulants such as warfarin, heparin)

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have deep vein thrombosis, pulmonary embolism (blockage of blood vessels in the lungs), coagulopathy (formation of blood clots), epilepsy, peptic ulcers, asthma, glaucoma, gastrointestinal toxicity, high blood pressure, or heart problems.

Mefenamic acid + Tranexamic acidKetorolac
Critical
Mefenamic acid + Tranexamic acidEthinylestradiol
Critical

Drug-Drug Interactions

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Mefenamic acid + Tranexamic acidKetorolac
Critical
How does the drug interact with Cosklot MF Tablet:
Coadministration of Mefenamic acid with Ketorolac can increase the risk or severity of inflammation, bleeding, and ulceration.

How to manage the interaction:
Taking Mefenamic acid with Ketorolac together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acid + Tranexamic acidEthinylestradiol
Critical
How does the drug interact with Cosklot MF Tablet:
Taking Ethinylestradiol with Cosklot MF Tablet acid may increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between Cosklot MF Tablet and ethinylestradiol, it can be taken if a doctor has prescribed it. However, if you experience chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acid + Tranexamic acidDrospirenone
Critical
How does the drug interact with Cosklot MF Tablet:
Taking drospirenone with Cosklot MF Tablet may increase the risk of blood clots.

How to manage the interaction:
Taking Cosklot MF Tablet with drospirenone is not recommended, as it can lead to an interaction, but can be taken if prescribed by the doctor. However, if you experience chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult your doctor immediately.
Mefenamic acid + Tranexamic acidLevonorgestrel
Critical
How does the drug interact with Cosklot MF Tablet:
Taking levonorgestrel with tranexamic acid may increase the risk of blood clot.

How to manage the interaction:
Taking Tranexamic acid with Levonorgestrel may lead to an interaction, it can be taken together if prescribed by the doctor. However, if you experience chest pain, shortness of breath, coughing up blood, blood in the urine, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acid + Tranexamic acidMedroxyprogesterone
Critical
How does the drug interact with Cosklot MF Tablet:
Taking medroxyprogesterone acetate with tranexamic acid may increase the risk of blood clots.

How to manage the interaction:
Taking Medroxyprogesterone with Tranexamic acid is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to a doctor.
Mefenamic acid + Tranexamic acidEtonogestrel
Critical
How does the drug interact with Cosklot MF Tablet:
Co-administration of tranexamic acid with etonogestrel may cause blood clots.

How to manage the interaction:
Taking Tranexamic acid with Etonogestrel is not recommended, as it can lead to an interaction, it can be taken if prescribed by the doctor. However, If you experience chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult a doctor immediately.
Mefenamic acid + Tranexamic acidMeloxicam
Critical
How does the drug interact with Cosklot MF Tablet:
Co-administration of mefenamic acid with meloxicam can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mefenamic acid with Meloxicam together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking a doctor.
Mefenamic acid + Tranexamic acidNorethisterone
Critical
How does the drug interact with Cosklot MF Tablet:
Taking tranexamic acid together with norethindrone may increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between norethisterone and tranexamic acid, they can be taken together if prescribed by a doctor. However, If you experience chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Mefenamic acid + Tranexamic acidTamoxifen
Severe
How does the drug interact with Cosklot MF Tablet:
Co-administration of tamoxifen with tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between tamoxifen and tranexamic acid, they can be taken together if prescribed by a doctor. However, consult the doctor immediately if you experience shortness of breath, difficulty breathing, coughing up blood, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
Mefenamic acid + Tranexamic acidLomitapide
Severe
How does the drug interact with Cosklot MF Tablet:
Coadministration of Mefenamic acid with Lomitapide can cause liver problems.

How to manage the interaction:
Although there is an interaction between mefenamic acid and lomitapide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience ever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Cosklot MF Tablet is used to treat dysmenorrhea (period pain) and menorrhagia (heavy menstrual bleeding). Besides this, it is also used to treat severe blood loss, swelling in various body parts, fever, inflammation, and migraine headache.
Cosklot MF Tablet contains Tranexamic acid and Mefenamic acid. Tranexamic acid helps the body's natural blood clot process by preventing the breakdown of fibrin, this stops fibrinolysis, a process that stops blood clot formation. Mefenamic acid works by blocking the effect of chemical messengers that cause pain.
Diarrhea might be a side-effect of Cosklot MF Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhea. Consult your doctor if you experience severe diarrhea or if you find blood in stools.
Cosklot MF Tablet should not be taken for longer durations unless prescribed by the doctor. Cosklot MF Tablet is usually prescribed for a few days at the time of heavy bleeding and cramps.
Cosklot MF Tablet is used to treat dysmenorrhea (period pain), pain due to heavy bleeding during periods, and menstrual cramps. Take Cosklot MF Tablet only as prescribed and do not overdose.
Consult your doctor before taking contraceptive pills along with Cosklot MF Tablet . When taken together, there is an increased risk of deep vein thrombosis (blood clot in the deep vein, usually in the legs).
Cosklot MF Tablet contains mefenamic acid, an NSAID which might increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke. Therefore, avoid taking Cosklot MF Tablet if you have heart-related problems unless prescribed by the doctor.
Cosklot MF Tablet typically starts to show its effects within 1-2 hours of taking it, and it helps to reduce heavy menstrual bleeding by improving blood clotting but does not stop bleeding. However, the exact duration for bleeding to stop can vary from one person to other.
Yes, Cosklot MF Tablet can cause acidity. If you experience heartburn and indigestion, it's advisable to take Cosklot MF Tablet with food to minimize discomfort. If the symptoms persist, please consult your doctor.
Yes, Cosklot MF Tablet is safe if you take as per the dose and duration prescribed by your doctor. However, it's important to be aware of potential side effects and contraindications. Always consult your doctor before starting any new medication to ensure it is safe for you, especially if you have pre-existing conditions or are taking other medications.
Always follow your doctor's instructions regarding dosage and duration. Usually it is prescribed for a short duration. Do not exceed the prescribed duration. As overuse can lead to side effects and other health issues.
Cosklot MF Tablet is a combination of two drugs, tranexamic acid (anti-fibrinolytic) and mefenamic acid (NSAID).
Yes, do not take Cosklot MF Tablet if you are allergic to any of its contents or if you have severe heart failure. Inform your doctor if you have/had deep vein thrombosis, pulmonary embolism (block a blood vessel in the lungs), coagulopathy (formation of blood clots), epilepsy, irregular periods, heart, kidney, or liver problems. Consult your doctor if you are pregnant or breastfeeding. Do not take any other NSAIDs for pain relief along with Cosklot MF Tablet unless prescribed.
Store Cosklot MF Tablet at a temperature not exceeding 25°C. Protect it from light and moisture. Keep out of reach of children.
Yes, you can take Cosklot MF Tablet with food. It is often recommended to take it after a meal to avoid stomach upset or other gastrointestinal side effects.
Please consult your doctor if you are pregnant. Your doctor will prescribes Cosklot MF Tablet only if the benefits outweigh the risks.
The common side effects of Cosklot MF Tablet are nausea, vomiting, diarrhea, indigestion, heartburn, and headache. If any of these side effects persist or worsen, please consult your doctor.
You are recommended to consult your doctor before taking other medicines with Cosklot MF Tablet to avoid possible interactions.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Health Service (NHS). Tranexamic Acid - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  2. U.S. Food and Drug Administration (FDA). 015034S040Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  3. Drugs.com Clinical Review Team. Mefenamic Acid Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  4. Mefenamic acid. 2005. [Accessed on 10 Apr. 2019] Check here
  5. Rivopharm UK Ltd. Electronic medicines Compendium (EMC)Tranexamic Acid 500 mg film-coated tablets. [Revised on June 2018] [Accessed on 24th May 2022] Check here
  6. CDSCO [Internet]. Cdscoonline.gov.in. 2021 [Accessed on 22 November 2021] Check here
  7. Clinical Reference Document. [Accessed on 02 Jun. 2026]Check here

Country of origin

INDIA

Manufacturer/Marketer address

DEMPO TOWERS 5TH FLOOREDC PATTO PLAZA PANJIM GOA GA 403001 IN
Other Info - COS0020

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