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compositionComposition:ETORICOXIB-60MG+SERRATIOPEPTIDASE-10MG
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Prescription Medicine
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Cox-SP Tablet is used to relieve pain. It contains Etoricoxib and Serratiopeptidase which work by inhibiting chemical messengers that cause pain and lowering inflammation. In some cases, this medicine may cause side effects such as stomach pain, diarrhoea, flatulence, indigestion, feet swelling, swelling of hands and flu-like symptoms. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ETORICOXIB-60MG+SERRATIOPEPTIDASE-10MG

Manufacturer/Marketer :

Elite Pharmaceuticals, Inc

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cox-SP Tablet

Cox-SP Tablet is a prescription medication used to relieve moderate-to-severe pain, swelling, and tissue inflammation. It is commonly prescribed to treat painful conditions affecting the bones, joints, and muscles, such as arthritis, dental pain, and post-surgical recovery. By targeting both pain and swelling, this medicine helps restore comfort and supports physical rehabilitation. Serratiopeptidase is used as a supportive component for swelling, although evidence for its clinical anti-inflammatory benefits is still evolving.

For the best results, this medication should be taken consistently at the same time each day as directed by your physician. You can take the tablet with or without food, though taking it with a light meal may help if you experience stomach discomfort. Incorporating joint-friendly habits, such as maintaining a healthy weight and performing gentle, low-impact stretching exercises, can further support your recovery.

While taking Cox-SP Tablet , some people may experience mild, temporary side effects such as an upset stomach, mild dizziness, or nausea. Etoricoxib may increase the risk of serious cardiovascular events, including heart attack or stroke, particularly in people with existing risk factors or with prolonged use. Contact your doctor immediately if you develop serious symptoms, including severe abdominal pain, chest pain, difficulty breathing, sudden weakness, or slurred speech.

Do not take this medicine if you have an active stomach ulcer, severe heart failure, or a history of allergic reactions to aspirin or other anti-inflammatory medications. Before starting treatment, inform your doctor if you have high blood pressure, kidney or liver disease, or a history of heart conditions so they can evaluate whether this medication is safe for you.

This medicine can interact with other substances, so tell your doctor about all medicines you are taking, especially blood thinners, which can increase the risk of bleeding. Avoid drinking alcohol or smoking while on this medication, as both may increase the risk of stomach irritation and ulcers. Additionally, if you are pregnant, breastfeeding, or elderly, consult your healthcare provider to ensure this treatment is appropriate for your specific needs.

Uses of Cox-SP Tablet

Cox-SP Tablet is used to manage pain, inflammation, and swelling associated with joint conditions, musculoskeletal injuries, and recovery after certain procedures. Its uses include:

  • Osteoarthritis: Helps relieve pain, stiffness, and localised swelling in the affected joints, improving daily movement.
  • Rheumatoid Arthritis: Reduces chronic joint inflammation, pain, and tenderness caused by this autoimmune condition.
  • Ankylosing Spondylitis: Eases inflammation and pain in the spine, helping to restore physical flexibility.
  • Post-operative Pain and Swelling: Accelerates healing by controlling surgical wound pain and reducing tissue swelling after operations or dental surgeries.
  • Acute Musculoskeletal Pain: Alleviates sudden, intense pain and swelling resulting from muscle strains, sprains, or sports injuries.

Key Benefits

Cox-SP Tablet combines an anti-inflammatory pain reliever with an enzyme that helps reduce swelling. It provides relief from pain and inflammation associated with musculoskeletal conditions, injuries, and post-operative recovery.

  • Relieves Pain and Inflammation: Helps reduce pain, tenderness, and inflammation associated with joint, muscle, and other musculoskeletal conditions.
  • Reduces Swelling: Helps decrease localised swelling and tissue oedema, improving comfort around the affected area.
  • Improves Mobility: By reducing pain, stiffness, and swelling, it helps you move more comfortably and perform daily activities with greater ease.
  • Supports Recovery: Better control of pain and swelling may make rehabilitation and physiotherapy exercises more comfortable during recovery.
  • Provides Dual-Action Relief: Combines complementary actions to manage both pain and swelling in a single treatment.
Side effects of Cox-SP Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Cox-SP Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow Cox-SP Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Cox-SP Tablet Works

Cox-SP Tablet contains etoricoxib and serratiopeptidase, which work in different ways to target pain and swelling at the source. The first active component, etoricoxib, belongs to a class of medicines known as selective COX-2 inhibitors. It works by specifically blocking the cyclooxygenase-2 (COX-2) enzyme. This enzyme is responsible for producing chemicals called prostaglandins, which trigger pain and inflammation at the site of an injury. By stopping these chemicals from forming, it effectively quietens pain signals and reduces localised inflammation. The second active component, serratiopeptidase, is a proteolytic enzyme that is proposed to help break down certain proteins involved in inflammatory fluid and tissue swelling. This may support the body's natural clearance of excess fluid from affected tissues and help reduce swelling. However, its exact clinical benefits in inflammatory conditions are still being studied, so its role is considered supportive. Together, these actions help reduce pain and inflammation, decrease swelling, and support tissue recovery.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Cox-SP Tablet to avoid unpleasant side-effects.

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Pregnancy

Unsafe

Cox-SP Tablet shows toxic effects on the fetus when given to pregnant women. Cox-SP Tablet may impair female fertility and is not recommended in pregnant women or those planning for pregnancy. Consult your doctor for further advice.

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Breast Feeding

Unsafe

Cox-SP Tablet passes into the breast milk, so it is not recommended for nursing mothers. Consult your doctor for further advice.

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Driving

Unsafe

Cox-SP Tablet may affect driving as it causes dizziness. So do not drive a motor vehicle or operate heavy machinery after taking Cox-SP Tablet .

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Liver

Caution

Cox-SP Tablet may alter liver function. So, dose adjustments are necessary for patients with liver diseases.

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Kidney

Caution

Cox-SP Tablet should be used with caution in patients with kidney diseases. Dosage adjustments are necessary for patients with severe renal impairment.

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Children

Unsafe

Cox-SP Tablet is not recommended for children under 16 years of age, unless prescribed by a child specialist.

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Heart

Unsafe

Cox-SP Tablet is not recommended in cardiac patients due to its adverse effects. However, if prescribed, extreme caution should be exercised.

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Geriatrics

Consult your doctor

Limited information available for use of Cox-SP Tablet in elderly patients. Please consult your doctor.

What if I have taken an overdose of Cox-SP Tablet

If you suspect an accidental overdose, seek immediate medical attention or visit the nearest emergency room. Take the medicine pack with you so the healthcare professionals know exactly what you have taken.

Diet & Lifestyle Advise

  • Stay Well-Hydrated: Drink adequate water throughout the day to support overall health and normal body functions.
  • Choose a Balanced Diet: Include fruits, vegetables, whole grains, nuts, and sources of omega-3 fatty acids, such as fatty fish, as part of a nutritious diet that supports overall joint and tissue health.
  • Stay Gently Active: Engage in low-impact activities such as walking, swimming, or stationary cycling, as advised by your doctor or physiotherapist, to maintain flexibility without placing excessive strain on painful joints or muscles.
  • Avoid Alcohol and Tobacco: Alcohol may increase the risk of stomach irritation and other side effects, while smoking can negatively affect healing and overall cardiovascular health.
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Have a query?

How Soon It Starts Working

The time required for Cox-SP Tablet to start to work: Cox-SP Tablet starts to show its action within 1 to 2 hour of administration. The time for which the effects of Cox-SP Tablet last: The duration of action for Cox-SP Tablet is clinically unknown.

What if you forget to take Cox-SP Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is only a few hours away, skip the missed dose and resume your regular schedule. Do not take a double dose to compensate for a missed one.

Storage

•Store Cox-SP Tablet at room temperature, ideally between 15°C and 30°C (59°F to 86°F), in a cool, dry place. •Keep the tablets in their original blister packaging to protect them from direct light, moisture, and extreme heat.

Drug Warnings

  • Monitor Your Blood Pressure: Check your blood pressure regularly, particularly if you have hypertension, as etoricoxib may increase blood pressure in some people.
  • Inform Healthcare Providers Before Procedures: Tell your surgeon, anaesthetist, or dentist that you are taking Cox-SP Tablet before any planned surgery or dental procedure.
  • Avoid Other NSAIDs: Do not take other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen, or high-dose aspirin, unless specifically advised by your doctor.
  • Use Caution During Activities: Avoid driving or operating machinery if you experience dizziness, drowsiness, or blurred vision after taking this medicine.
  • Use the Lowest Effective Dose: Take Cox-SP Tablet at the lowest effective dose for the shortest duration recommended by your doctor to reduce the risk of side effects.
  • Watch for Heart or Stroke Warning Signs: Etoricoxib may increase the risk of serious cardiovascular events, including heart attack or stroke. Seek emergency medical help if you develop chest pain, sudden shortness of breath, weakness on one side of the body, slurred speech, or sudden vision changes.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Cox-SP Tablet and require caution, closer monitoring, or advice from your doctor:

  • Blood Thinners (e.g., warfarin, aspirin): May significantly increase the risk of stomach bleeding and bruising.
  • Blood Pressure Medications (e.g., ACE inhibitors, diuretics): This medicine may reduce their effectiveness and increase the risk of kidney strain.
  • Lithium: May increase the levels of lithium in your blood, raising the risk of toxicity.
  • Methotrexate: Taking these together can increase the level of methotrexate in your body, which may lead to serious side effects.
  • Cyclosporine or Tacrolimus: Concurrent use may increase the risk of kidney problems, so closer monitoring may be required.
  • Rifampicin: May reduce the level and effectiveness of etoricoxib by increasing how quickly the body processes it.
  • Oral Contraceptives or Hormone Replacement Therapy: Etoricoxib may increase exposure to oestrogen-containing medicines, which could increase the risk of related side effects in some people.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

Certain foods or meal patterns may affect how quickly Cox-SP Tablet begins to work. Important considerations include:

  • High-Fat Meals: Taking this medicine with extremely heavy or high-fat meals may slightly delay the rate at which the medication begins to work.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANALGESICS]

FAQs

Cox-SP Tablet is used to provide pain relief in conditions like spondylitis, osteoarthritis, rheumatoid arthritis, and migraine. It helps treat post-traumatic pain, lower back pain, and cervical pain.
Cox-SP Tablet is a combination of two medicines that include etoricoxib and serratiopeptidase. Cox-SP Tablet contains ‘etoricoxib’ which works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, which is responsible for pain, swelling and inflammation. On the other hand, Cox-SP Tablet contains serratiopeptidase which reduces swelling and inflammation through the breakdown of proteins.
Cox-SP Tablet may increase blood pressure, especially in high doses. It should not be given to patients with uncontrolled blood pressure, heart problems or recent heart surgeries.
Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation and pain of the joints. Here, the body's immune system attacks its own tissue, including joints.
Ankylosing spondylitis is arthritis of the spine that can lead to pain and inflammation in the spine, which may lead to the fusion of the vertebrae causing stiffness and pain.
The most common side effects of Cox-SP Tablet are stomach pain, diarrhea, flatulence, indigestion, feet swelling, swelling of hands and flu-like symptoms. Most of these side effects of Cox-SP Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
No, do not stop taking Cox-SP Tablet if you feel well, take Cox-SP Tablet for as long as your doctor has advised it for you, to avoid any unwanted side effects.
Yes, you can take Cox-SP Tablet with or without food. However, if you are prone to indigestion or acid reflux, taking it with a meal or a glass of milk can help prevent stomach upset. Talk to your doctor if stomach discomfort persists.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol increases the risk of serious stomach irritation, bleeding, and ulcers when combined with anti-inflammatory drugs. Talk to your doctor if you have concerns.
Cox-SP Tablet is generally avoided throughout pregnancy unless a doctor specifically decides that treatment is necessary. It is particularly unsuitable during the third trimester because it may affect the baby's circulation and complicate labour. If you are pregnant, think you may be pregnant, or are planning a pregnancy, inform your doctor before taking this medicine.
Some patients may experience mild dizziness or sleepiness as a side effect. If you experience these symptoms, avoid driving, cycling, or operating machinery until you know how the medicine affects you. Talk to your doctor for further guidance.
While paracetamol works differently, you should always check with your healthcare provider before combining any pain medications to avoid accidental overuse or potential interactions. Talk to your doctor first.
Severe stomach pain, black or tarry stools, or vomiting blood may indicate gastrointestinal bleeding and require urgent medical attention. If these symptoms occur, do not take another dose until you have received immediate medical advice. Mild indigestion or stomach discomfort does not necessarily require stopping the medicine, but it should be reported if it persists or worsens.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

1210/11/12, G I D C Phase-Iii, Vatva, Ahmedabad, Gujarat 382445
Other Info - COX0054

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