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Composition :

INCLISIRAN-284MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Crenzlo Injection 1.5 ml

Crenzlo Injection 1.5 ml is used to lower low-density lipoprotein cholesterol (LDL-C), commonly known as bad cholesterol, in patients with hyperlipidemia. Hyperlipidemia is a condition marked by elevated levels of lipids (fats), such as cholesterol and triglycerides, in the blood, which can increase the risk of heart disease, stroke, and other health complications.

Crenzlo Injection 1.5 ml contains Inclisiran, a PCSK9 inhibitor monoclonal antibody. It works by blocking PCSK9, a protein that regulates receptors on liver cells responsible for clearing LDL-C from the bloodstream. Inhibiting PCSK9 increases the number of LDL receptors, which lowers LDL-C levels and reduces the risk of atherosclerotic cardiovascular diseases.

A healthcare professional will administer Crenzlo Injection 1.5 ml. In some cases, this medicine may cause side effects like headache, dizziness, cough, bronchitis, diarrhoea, back pain, pain in a joint, or injection site reactions. The majority of these side effects may not require medical treatment and will subside with time. However, if the side effects persist or worsen, consult a doctor.

Crenzlo Injection 1.5 ml should not be administered if you are allergic to it. Before receiving the injection, inform your doctor about any allergies, medications, or conditions that may affect your treatment, such as a history of heart, liver, or kidney disorder. Pregnant and breastfeeding women should consult their doctor before receiving Crenzlo Injection 1.5 ml. Crenzlo Injection 1.5 ml is not recommended for children below 18 years, as its safety and efficacy have not been established.

Uses of Crenzlo Injection 1.5 ml

Treatment of familial heterozygous hypercholesterolemia (HeFH): Crenzlo Injection 1.5 ml is used to treat heterozygous familial hypercholesterolemia (HeFH) in people who require extra LDL cholesterol reduction. It can be administered alone or in combination with other medications (e.g. statins).<br/>Treatment of atherosclerotic cardiovascular disease (ASCVD): Crenzlo Injection 1.5 ml lowers the levels of low-density lipoprotein (LDL) cholesterol in individuals with clinical ASCVD. This helps reduce the risk of other cardiovascular issues by preventing cholesterol from blocking blood flow in the arteries.

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Crenzlo Injection 1.5 ml is administered by the doctor or nurse in a healthcare setting.• Do not self-administer.

Medicinal Benefits

Crenzlo Injection 1.5 ml effectively reduces LDL cholesterol (LDL-C) in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD). Lowering LDL cholesterol helps prevent cholesterol buildup on the arterial walls, thereby reducing the risk of blockages that can restrict blood flow to the heart, brain, and other vital organs. It has minimal interactions with most other cholesterol-lowering medications, making it suitable for use in combination with other treatments.

How Crenzlo Injection 1.5 ml Works

Crenzlo Injection 1.5 ml contains Inclisiran, a PCSK9 inhibitor monoclonal antibody. It works by blocking PCSK9, a protein that regulates receptors on liver cells responsible for clearing LDL-C from the bloodstream. Inhibiting PCSK9 increases the number of LDL-C receptors, which lowers LDL-C levels and reduces the risk of atherosclerotic cardiovascular diseases.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Crenzlo Injection 1.5 ml

Crenzlo Injection 1.5 ml is administered in a controlled medical setting by a healthcare professional, and the likelihood of an overdose is much less. However, if you suspect an overdose or experience any adverse effects, seek medical attention immediately.

Drug Warnings

Inform your doctor if you are allergic to any of the components in Crenzlo Injection 1.5 ml. If you are pregnant or breastfeeding, consult your doctor before receiving Crenzlo Injection 1.5 ml. Let your doctor know if you have a history of heart disease, kidney or liver disease, allergic reactions, breathing problems, arthritis, psoriasis, eczema, urinary tract infections or if you have had any recent vaccinations. Crenzlo Injection 1.5 ml is not recommended for children below 18 years, as its safety and efficacy have not been established.

Diet & Lifestyle Advise

  • To improve heart health, include omega-3-rich foods like salmon, mackerel, and sardines in your diet.
  • Limit dietary cholesterol from eggs, shellfish, and fatty meats.
  • Limit alcohol to moderate levels to avoid increasing cholesterol.
  • Relaxation techniques such as meditation and yoga might help you manage your stress.
  • Minimize processed and refined carbohydrates like white bread and sugary snacks.
  • Exercise for at least 30 minutes most days to raise HDL and lower LDL cholesterol.
  • Maintain a healthy weight to help lower LDL levels.
  • Quit smoking to improve HDL cholesterol and overall heart health.

Habit Forming

No

Therapeutic Class

ANTILIPEMICS
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Alcohol

Caution

It is unknown if alcohol interacts with Crenzlo Injection 1.5 ml. Please consult a doctor if you have any concerns.

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Pregnancy

Caution

Please consult a doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

There is limited data on the use of Crenzlo Injection 1.5 ml during breastfeeding. Consult your healthcare provider to assess risks and benefits.

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Driving

Caution

Crenzlo Injection 1.5 ml is unlikely to impair your ability to drive or operate machinery. However, sometimes, Crenzlo Injection 1.5 ml makes you feel tired and dizzy; if it happens to you, do not drive or operate machinery.

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Liver

Caution

Inform your doctor if you have liver impairment. Your doctor will weigh the benefits and any potential risks before prescribing Crenzlo Injection 1.5 ml.

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Kidney

Caution

Inform your doctor if you have kidney impairment. Your doctor will weigh the benefits and any potential risks before prescribing Crenzlo Injection 1.5 ml.

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Children

Caution

Crenzlo Injection 1.5 ml is not recommended for children below 18 years, as its safety and efficacy have not been established.

Have a query?

FAQs

Crenzlo Injection 1.5 ml is used to reduce low-density lipoprotein cholesterol (LDL-C) in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who need further reduction of LDL-C.

Crenzlo Injection 1.5 ml contains Inclisiran, a PCSK9 inhibitor monoclonal antibody. It works by lowering the amount of LDL cholesterol in the blood, decreasing the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Crenzlo Injection 1.5 ml is usually given as an initial dose, followed by a second dose after 3 months, and then administered every 6 months thereafter.

If a dose is missed by less than 3 months, the doctor will administer Crenzlo Injection 1.5 ml and continue the original dosing schedule. If more than 3 months are missed, a new schedule will be started with an initial dose, another dose at 3 months, and then every 6 months.

No dose adjustment is required for elderly patients, but caution is advised when administering Crenzlo Injection 1.5 ml to individuals with severe renal disease, as they may be at a higher risk for complications. Close monitoring is important during treatment.

Some people may experience reactions at the injection site, such as pain, redness, or swelling, but these typically resolve on their own. Seek medical advice if the reactions persist.

PCSK9 is a protein that regulates the number of LDL receptors on cells. These receptors help control cholesterol levels by binding to LDL particles, which carry cholesterol in the blood. Most of these receptors are in the liver, where they remove excess cholesterol from the body.

Pregnant or breastfeeding women should consult their healthcare provider before using Crenzlo Injection 1.5 ml, as its safety during pregnancy and breastfeeding is not fully established.

The side effects of Crenzlo Injection 1.5 ml may include headache, dizziness, cough, bronchitis, diarrhoea, back pain, or pain in a joint. Seek medical care if the side effects persist or worsen.

Crenzlo Injection 1.5 ml may increase the risk of urinary tract infections. Consult the doctor if you experience symptoms of urinary tract infection like frequent urination, pain/burning sensation during urination, pelvic/rectal pain, discoloured urine or smelly urine.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - CRE0424

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