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compositionComposition:INCLISIRAN-284MG
prescription
Prescription Medicine
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Best Price

₹90733 with coupons*

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Crenzlo Injection 1.5 ml is used as part of a comprehensive treatment plan, which includes a balanced diet and other medications, to help control cholesterol levels. It lowers LDL cholesterol (LDL-C) in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who need further reduction of LDL-C. Some individuals may experience side effects such as headache, dizziness, cough, injection site reactions, and diarrhoea. Let the doctor know if you are pregnant, breastfeeding, taking other medicines or have pre-existing medical conditions.

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Written By ,
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

INCLISIRAN-284MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Crenzlo Injection 1.5 ml

Crenzlo Injection 1.5 ml is used to lower low-density lipoprotein cholesterol (LDL-C), commonly known as bad cholesterol, in patients with hyperlipidemia. Hyperlipidemia is a condition marked by elevated levels of lipids (fats), such as cholesterol and triglycerides, in the blood, which can increase the risk of heart disease, stroke, and other health complications.

Crenzlo Injection 1.5 ml contains Inclisiran, a PCSK9 inhibitor monoclonal antibody. It works by blocking PCSK9, a protein that regulates receptors on liver cells responsible for clearing LDL-C from the bloodstream. Inhibiting PCSK9 increases the number of LDL receptors, which lowers LDL-C levels and reduces the risk of atherosclerotic cardiovascular diseases.

A healthcare professional will administer Crenzlo Injection 1.5 ml. In some cases, this medicine may cause side effects like headache, dizziness, cough, bronchitis, diarrhoea, back pain, pain in a joint, or injection site reactions. The majority of these side effects may not require medical treatment and will subside with time. However, if the side effects persist or worsen, consult a doctor.

Crenzlo Injection 1.5 ml should not be administered if you are allergic to it. Before receiving the injection, inform your doctor about any allergies, medications, or conditions that may affect your treatment, such as a history of heart, liver, or kidney disorder. Pregnant and breastfeeding women should consult their doctor before receiving Crenzlo Injection 1.5 ml. Crenzlo Injection 1.5 ml is not recommended for children below 18 years, as its safety and efficacy have not been established.

Uses of Crenzlo Injection 1.5 ml

Treatment of familial heterozygous hypercholesterolemia (HeFH):Crenzlo Injection 1.5 ml is used to treat heterozygous familial hypercholesterolemia (HeFH) in people who require extra LDL cholesterol reduction. It can be administered alone or in combination with other medications (e.g. statins).
  • Treatment of atherosclerotic cardiovascular disease (ASCVD):Crenzlo Injection 1.5 ml lowers the levels of low-density lipoprotein (LDL) cholesterol in individuals with clinical ASCVD. This helps reduce the risk of other cardiovascular issues by preventing cholesterol from blocking blood flow in the arteries.

    • Key Benefits

    Crenzlo Injection 1.5 ml effectively reduces LDL cholesterol (LDL-C) in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD). Lowering LDL cholesterol helps prevent cholesterol buildup on the arterial walls, thereby reducing the risk of blockages that can restrict blood flow to the heart, brain, and other vital organs. It has minimal interactions with most other cholesterol-lowering medications, making it suitable for use in combination with other treatments.

    Side effects of Crenzlo Injection 1.5 ml
    • Injection site reaction can include numbness or redness.
    • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
    • Apply cold compress for pain relief.
    • Practice good hygiene and keep the injection site away from heat and pressure.
    Here are the steps to manage Joint Pain caused by medication usage:
    • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
    • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
    • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
    • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
    • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
    • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
    Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
    • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
    • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
    • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
    • Regularly track your symptoms and report any changes or concerns to your healthcare provider.

    Directions for Use

    • Follow your doctor's instructions on the dosage and timing of this medication.
    • Crenzlo Injection 1.5 ml is administered by the doctor or nurse in a healthcare setting.
    • Do not self-administer.

    How Crenzlo Injection 1.5 ml Works

    Crenzlo Injection 1.5 ml contains Inclisiran, a PCSK9 inhibitor monoclonal antibody. It works by blocking PCSK9, a protein that regulates receptors on liver cells responsible for clearing LDL-C from the bloodstream. Inhibiting PCSK9 increases the number of LDL-C receptors, which lowers LDL-C levels and reduces the risk of atherosclerotic cardiovascular diseases.
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    Alcohol

    Caution

    It is unknown if alcohol interacts with Crenzlo Injection 1.5 ml. Please consult a doctor if you have any concerns.

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    Pregnancy

    Caution

    Please consult a doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.

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    Breast Feeding

    Caution

    There is limited data on the use of Crenzlo Injection 1.5 ml during breastfeeding. Consult your healthcare provider to assess risks and benefits.

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    Driving

    Caution

    Crenzlo Injection 1.5 ml is unlikely to impair your ability to drive or operate machinery. However, sometimes, Crenzlo Injection 1.5 ml makes you feel tired and dizzy; if it happens to you, do not drive or operate machinery.

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    Liver

    Caution

    Inform your doctor if you have liver impairment. Your doctor will weigh the benefits and any potential risks before prescribing Crenzlo Injection 1.5 ml.

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    Kidney

    Caution

    Inform your doctor if you have kidney impairment. Your doctor will weigh the benefits and any potential risks before prescribing Crenzlo Injection 1.5 ml.

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    Children

    Caution

    Crenzlo Injection 1.5 ml is not recommended for children below 18 years, as its safety and efficacy have not been established.

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    Heart

    Caution

    Inform your doctor if you have heart disease before using Crenzlo Injection 1.5 ml. Your doctor will prescribe only if the benefits outweigh the risks.

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    Geriatrics

    Consult your doctor

    Crenzlo Injection 1.5 ml can be used in the elderly when prescribed by a doctor. If you have any concerns about using Crenzlo Injection 1.5 ml, please consult a doctor.

    What if I have taken an overdose of Crenzlo Injection 1.5 ml

    Crenzlo Injection 1.5 ml is administered in a controlled medical setting by a healthcare professional, and the likelihood of an overdose is much less. However, if you suspect an overdose or experience any adverse effects, seek medical attention immediately.

    Diet & Lifestyle Advise

    • To improve heart health, include omega-3-rich foods like salmon, mackerel, and sardines in your diet.
    • Limit dietary cholesterol from eggs, shellfish, and fatty meats.
    • Limit alcohol to moderate levels to avoid increasing cholesterol.
    • Relaxation techniques such as meditation and yoga might help you manage your stress.
    • Minimize processed and refined carbohydrates like white bread and sugary snacks.
    • Exercise for at least 30 minutes most days to raise HDL and lower LDL cholesterol.
    • Maintain a healthy weight to help lower LDL levels.
    • Quit smoking to improve HDL cholesterol and overall heart health.
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    How Soon It Starts Working

    The time required for Crenzlo Injection 1.5 ml to start to work: The time required for Crenzlo Injection 1.5 ml to show its action is unknown. The time for which the effects of Crenzlo Injection 1.5 ml last: The duration of action for Crenzlo Injection 1.5 ml is unknown.

    What if you forget to take Crenzlo Injection 1.5 ml

    If a scheduled dose of Crenzlo Injection 1.5 ml is missed by less than 3 months, Crenzlo Injection 1.5 ml should be administered as soon as possible, and the patient should continue with the original dosing schedule. If a scheduled dose of Crenzlo Injection 1.5 ml is missed by more than 3 months, a new dosing schedule should be initiated. Crenzlo Injection 1.5 ml should be given immediately, then again after 3 months, and subsequently every 6 months.

    Storage

    • Store in a cool and dry place away from sunlight. • Keep Crenzlo Injection 1.5 ml out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

    Drug Warnings

    Inform your doctor if you are allergic to any of the components in Crenzlo Injection 1.5 ml. If you are pregnant or breastfeeding, consult your doctor before receiving Crenzlo Injection 1.5 ml. Let your doctor know if you have a history of heart disease, kidney or liver disease, allergic reactions, breathing problems, arthritis, psoriasis, eczema, urinary tract infections or if you have had any recent vaccinations. Crenzlo Injection 1.5 ml is not recommended for children below 18 years, as its safety and efficacy have not been established.

    Drug-Drug Interactions

    verifiedApollotooltip

    Drug-Drug Interactions: No interactions found/established.

    Drug-Food Interactions: No interactions found/established.

    Drug-Disease Interactions: No interactions found/established.

    No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

    Drug-Drug Interactions

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    Drug-Food Interactions

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    No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

    Drug-Food Interactions

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    All Substitutes & Brand Comparisons

    Habit Forming

    No

    Therapeutic Class

    [ANTILIPEMICS]

    FAQs

    Crenzlo Injection 1.5 ml is used to reduce low-density lipoprotein cholesterol (LDL-C) in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who need further reduction of LDL-C.
    Crenzlo Injection 1.5 ml contains Inclisiran, a PCSK9 inhibitor monoclonal antibody. It works by lowering the amount of LDL cholesterol in the blood, decreasing the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
    Crenzlo Injection 1.5 ml is usually given as an initial dose, followed by a second dose after 3 months, and then administered every 6 months thereafter.
    If a dose is missed by less than 3 months, the doctor will administer Crenzlo Injection 1.5 ml and continue the original dosing schedule. If more than 3 months are missed, a new schedule will be started with an initial dose, another dose at 3 months, and then every 6 months.
    No dose adjustment is required for elderly patients, but caution is advised when administering Crenzlo Injection 1.5 ml to individuals with severe renal disease, as they may be at a higher risk for complications. Close monitoring is important during treatment.
    Some people may experience reactions at the injection site, such as pain, redness, or swelling, but these typically resolve on their own. Seek medical advice if the reactions persist.
    PCSK9 is a protein that regulates the number of LDL receptors on cells. These receptors help control cholesterol levels by binding to LDL particles, which carry cholesterol in the blood. Most of these receptors are in the liver, where they remove excess cholesterol from the body.
    Pregnant or breastfeeding women should consult their healthcare provider before using Crenzlo Injection 1.5 ml, as its safety during pregnancy and breastfeeding is not fully established.
    The side effects of Crenzlo Injection 1.5 ml may include headache, dizziness, cough, bronchitis, diarrhoea, back pain, or pain in a joint. Seek medical care if the side effects persist or worsen.
    Crenzlo Injection 1.5 ml may increase the risk of urinary tract infections. Consult the doctor if you experience symptoms of urinary tract infection like frequent urination, pain/burning sensation during urination, pelvic/rectal pain, discoloured urine or smelly urine.

    Disclaimer

    While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

    Country of origin

    India

    Manufacturer/Marketer address

    Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
    Other Info - CRE0424
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