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compositionComposition:ISAVUCONAZOLE-100MG
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Prescription Medicine
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CRESEMBA 100MG CAPSULES is used to treat fungal infections such as invasive aspergillosis and mucormycosis. It contains Isavuconazole which works by killing or inhibiting the growth of the fungus. In some cases, this medicine may cause side effects such as headache, decreased appetite, drowsiness, nausea, vomiting, stomach pain, diarrhoea or chest pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ISAVUCONAZOLE-100MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About CRESEMBA 100MG CAPSULES

CRESEMBA 100MG CAPSULES is an oral prescription medication used to treat serious, invasive fungal infections in adults. It is primarily prescribed to combat deep tissue infections, such as those affecting the lungs or other internal organs, caused by specific types of molds. This medication helps clear these complex infections by stopping the growth of the fungi responsible for them.

For the treatment to be successful, you must take CRESEMBA 100MG CAPSULES regularly and exactly as prescribed by your doctor. You can take this medicine with or without food, making it easy to incorporate into your daily routine. While undergoing treatment, getting plenty of rest, staying well-hydrated, and avoiding environments with high mold exposure can support your body's recovery process.

While taking CRESEMBA 100MG CAPSULES, some people may experience mild side effects like nausea, vomiting, or headache. However, you should contact your healthcare provider immediately if you notice signs of liver damage, such as yellowing of your skin or eyes, dark urine, or severe upper stomach pain. Your doctor may perform regular blood tests to monitor your liver health during your treatment.

Before starting CRESEMBA 100MG CAPSULES, inform your doctor if you have a history of liver disease, heart rhythm issues, or severe allergies. Do not take this if you have a genetic heart condition known as familial short QT syndrome, as this medicine can affect your heart's electrical activity. It is crucial to share your complete medical history to ensure this treatment is safe for you.

This medication can interact with several other drugs, including certain heart medicines, antibiotics, or herbal supplements, which may alter how they or CRESEMBA 100MG CAPSULES work in your body. Avoid drinking alcohol while on this medication, as it can place extra strain on your liver. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist before starting treatment.

You may notice the name isavuconazonium sulfate on your medicine pack or hospital records. This is the inactive form (prodrug) of the medicine that is converted into active CRESEMBA 100MG CAPSULES inside your body. Both names refer to the same treatment. 
 

Uses of CRESEMBA 100MG CAPSULES

Your doctor may prescribe this medicine to treat several conditions, including:

  • Invasive aspergillosis: This is a severe fungal infection that typically affects the lungs of individuals with weakened immune systems. CRESEMBA 100MG CAPSULES helps target and eliminate the Aspergillus fungus to stop the infection from spreading to other parts of the body.
  • Invasive mucormycosis: This is a rare but highly serious fungal infection caused by mucormycete molds, often affecting the sinuses, brain, or lungs. CRESEMBA 100MG CAPSULES works to clear this aggressive infection and support the healing of affected tissues.

This medicine is most commonly prescribed for people with weakened immune systems, such as those who have received an organ or stem cell transplant, are being treated for certain blood cancers, or have other conditions that reduce the body's ability to fight infections. If this applies to you, follow your doctor's advice carefully, attend all follow-up appointments, and avoid exposure to environments where mold is common whenever possible. 
 

Key Benefits

CRESEMBA 100MG CAPSULES provides the following benefits when used as prescribed:

  • Treat Severe Fungal Infection: CRESEMBA 100MG CAPSULES provides crucial support for patients fighting severe fungal infections, helping them on the path to recovery. By stopping the spread of dangerous fungi, this medication allows your body's immune system to heal and reduces the risk of life-threatening complications.
  • High Oral Absorption: CRESEMBA 100MG CAPSULES is well absorbed when taken by mouth, allowing many patients who start treatment with intravenous (IV) medicine in the hospital to switch to oral capsules once their condition is stable. This makes long-term treatment more convenient. Any switch between IV and oral treatment should always be decided by your doctor. 
     
Side effects of Cresemba 100 mg Capsule
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • CRESEMBA 100MG CAPSULES can be taken with or without food.
  • It is recommended to take CRESEMBA 100MG CAPSULES 3 times a day on the first two days, then once daily afterward, or as advised by your doctor.
  • Swallow CRESEMBA 100MG CAPSULES as a whole with a glass of water.
  • Do not crush, chew, or open it.

How CRESEMBA 100MG CAPSULES Works

This medication belongs to a class of drugs known as triazole antifungals. It works by targeting the outer protective layer, or cell membrane, of the fungus. Specifically, it blocks a vital enzyme that the fungus needs to produce a compound called ergosterol. Without ergosterol, the fungal cell membrane becomes weak, develops holes, and eventually breaks down. This prevents the fungi from growing, multiplying, and spreading throughout your body, allowing your immune system to successfully clear the remaining infection.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking CRESEMBA 100MG CAPSULES as it may increase the risk of liver damage.

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Pregnancy

Caution

CRESEMBA 100MG CAPSULES is given to a pregnant woman if the doctor thinks benefits outweigh risks. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking CRESEMBA 100MG CAPSULES. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Drive only if you are alert after taking CRESEMBA 100MG CAPSULES as it may cause drowsiness, confusion or tiredness.

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Liver

Caution

CRESEMBA 100MG CAPSULES should be given with caution, especially if you have a history of Liver diseases/conditions.

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Kidney

Caution

CRESEMBA 100MG CAPSULES should be given with caution, especially if you have a history of Kidney diseases/conditions.

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Children

Unsafe

CRESEMBA 100MG CAPSULES is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Caution

Please inform your doctor if you have a history of heart disease before using CRESEMBA 100MG CAPSULES. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

CRESEMBA 100MG CAPSULES should be given to elderly patients only if prescribed by a doctor. Please consult your doctor before using CRESEMBA 100MG CAPSULES.

What if I have taken an overdose of CRESEMBA 100MG CAPSULES

If you suspect an overdose or have taken more than your prescribed amount, seek emergency medical attention.

Diet & Lifestyle Advise

  • Eat Balanced Diet: Keep your immune system supported by eating a balanced diet rich in vitamins and minerals, as recommended by your healthcare provider.
  • Avoid Mold Exposure: Avoid environments with a high risk of mold spores, such as damp basements, construction sites, or heavily wooded areas, especially if you have a weakened immune system.
  • Stay Hydrated: Stay well-hydrated by drinking plenty of water throughout the day to help your kidneys and liver process the medication efficiently.
  • Avoid Alcohol: Avoid drinking alcohol during your treatment, as both alcohol and this medication are processed by the liver, and combining them can increase the risk of liver strain.

 

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How Soon It Starts Working

The time required for CRESEMBA 100MG CAPSULES to start to work: CRESEMBA 100MG CAPSULES starts to show its action within 1 to 2 hours of administration. The time for which the effects of CRESEMBA 100MG CAPSULES last: CRESEMBA 100MG CAPSULES effect lasts for 24 hours.

What if you forget to take CRESEMBA 100MG CAPSULES

If you miss a dose of CRESEMBA 100MG CAPSULES, take it as soon as you remember. However, if your next scheduled dose is less than a few hours away, skip the missed dose and return to your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store the capsules at room temperature, specifically between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Complete the Full Course: Always complete the entire course of treatment prescribed by your doctor, even if you start feeling better after a few days.
  • Inspect Packaging Before Use: Regularly inspect your medication packaging to ensure the blister seals are completely intact before taking a capsule.
  • Monitor Liver Function: Have regular blood tests as recommended by your doctor to monitor your liver function while taking this medication.
  • Inform all Healthcare Providers: Inform every healthcare provider you visit that you are currently taking CRESEMBA 100MG CAPSULES, as it can interact with many other drugs.
  • Use Effective Contraception: Use effective birth control during treatment and for a specified time after your final dose, as this medication may harm an unborn baby.
  • Attend Follow-up Appointments: Your doctor may recommend additional blood tests or other monitoring during treatment to check how well the medicine is working and ensure it remains safe for you. In some complex cases, special blood tests may be performed to measure medicine levels in your body. 
     

Drug-Drug Interactions

verifiedApollotooltip

Some medicines may affect how CRESEMBA 100MG CAPSULES works or increase the risk of side effects:

  • CYP Enzyme Interaction: Taking CRESEMBA 100MG CAPSULES with strong liver enzyme inhibitors or inducers (such as rifampin, ketoconazole, or carbamazepine) can significantly alter the levels of the medicine in your body.
  • Increase Other Drug Levels: It may also increase the levels of other drugs, such as certain blood thinners, immunosuppressants, or cholesterol-lowering medicines, raising the risk of their side effects.

 

IsavuconazoleItraconazole
Critical
IsavuconazolePrimidone
Critical

Drug-Drug Interactions

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IsavuconazoleItraconazole
Critical
How does the drug interact with Cresemba 100 mg Capsule:
The blood levels and effects of Cresemba 100 mg Capsule may be significantly enhanced by taking Itraconazole along with it.

How to manage the interaction:
Co-administration of Cresemba 100 mg Capsule and Itraconazole can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IsavuconazolePrimidone
Critical
How does the drug interact with Cresemba 100 mg Capsule:
Taking Cresemba 100 mg Capsule with primidone may decrease the blood levels of Cresemba 100 mg Capsule and reduce its effectiveness.

How to manage the interaction:
Taking Cresemba 100 mg Capsule with primidone is not recommended, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsavuconazoleCisapride
Critical
How does the drug interact with Cresemba 100 mg Capsule:
When Cresemba 100 mg Capsule is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Cresemba 100 mg Capsule with Cisapride is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
IsavuconazoleFosamprenavir
Critical
How does the drug interact with Cresemba 100 mg Capsule:
When Fosamprenavir is taken with Cresemba 100 mg Capsule, it can increase the risk of side effects like liver damage.

How to manage the interaction:
Taking Cresemba 100 mg Capsule with Fosamprenavir is not recommended, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea while on therapy with these drugs, consult the doctor.
IsavuconazoleCeritinib
Critical
How does the drug interact with Cresemba 100 mg Capsule:
Taking ceritinib with Cresemba 100 mg Capsule may significantly increase the blood levels of Cresemba 100 mg Capsule.

How to manage the interaction:
Taking Cresemba 100 mg Capsule with Ceritinib is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loose stools, yellow discoloration of skin and eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IsavuconazoleCarbamazepine
Critical
How does the drug interact with Cresemba 100 mg Capsule:
When Carbamazepine and Cresemba 100 mg Capsule are taken together, carbamazepine will reduce the effectiveness of the Cresemba 100 mg Capsule.

How to manage the interaction:
Taking Cresemba 100 mg Capsule with Carbamazepine is not recommended, it can be taken if prescribed by the doctor. Do not discontinue any medications without doctor's advice.
IsavuconazoleKetoconazole
Critical
How does the drug interact with Cresemba 100 mg Capsule:
Co-administration of Ketoconazole and Cresemba 100 mg Capsule can significantly increase the blood levels of Cresemba 100 mg Capsule, which may increase the risk of side effects.

How to manage the interaction:
Taking Cresemba 100 mg Capsule with Ketoconazole is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, stomach pain, headache while on therapy with these drugs, consult the doctor. Do not discontinue any medication without consulting a doctor.
IsavuconazoleSaquinavir
Critical
How does the drug interact with Cresemba 100 mg Capsule:
When Cresemba 100 mg Capsule is taken with Saquinavir, it can increase the risk of liver damage.

How to manage the interaction:
Taking Cresemba 100 mg Capsule with Saquinavir is not recommended, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, vomiting, diarrhea while on therapy with these drugs, consult the doctor.
IsavuconazoleClarithromycin
Critical
How does the drug interact with Cresemba 100 mg Capsule:
When Cresemba 100 mg Capsule is taken with Clarithromycin, it can increase the risk of side effects.

How to manage the interaction:
Co-administration of Clarithromycin and Cresemba 100 mg Capsule can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IsavuconazolePosaconazole
Critical
How does the drug interact with Cresemba 100 mg Capsule:
When Cresemba 100 mg Capsule is taken with Posaconazole, it can increase the levels of Cresemba 100 mg Capsule in the blood.

How to manage the interaction:
Although there is an interaction between Cresemba 100 mg Capsule and posaconazole, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with CRESEMBA 100MG CAPSULES when used as directed.

ISAVUCONAZOLE-100MGGrapefruit and Grapefruit Juice

Drug-Food Interactions

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ISAVUCONAZOLE-100MGGrapefruit and Grapefruit Juice
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grapefruit and grapefruit juice during Cresemba 100 mg Capsule treatment may cause an interaction. Avoid grapefruit products during treatment with Cresemba 100 mg Capsule

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Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

CRESEMBA 100MG CAPSULES is used to treat fungal infections such as invasive aspergillosis and mucormycosis.
CRESEMBA 100MG CAPSULES contains Isavuconazole that works by inhibiting the synthesis of fungal cell membranes which are essential for their survival. Thereby, CRESEMBA 100MG CAPSULES kills or inhibits the growth of the fungus.
Mucormycosis is not contagious. Mucormycosis is a severe fungal infection of the skin or respiratory system that occurs in people with weakened immune system.
CRESEMBA 100MG CAPSULES may cause headache as a common side effect. However, if the condition persists or worsen, please consult a doctor.
You are not recommended to take CRESEMBA 100MG CAPSULES with ketoconazole as it may increase the levels of CRESEMBA 100MG CAPSULES in blood and increase the risk of side effects such as diarrhoea, vomiting, nausea or liver problems. However, please consult your doctor before taking CRESEMBA 100MG CAPSULES with other medicines.
CRESEMBA 100MG CAPSULES belongs to the class of medicines called antifungals used to treat fungal infections such as invasive aspergillosis and mucormycosis.
Inform your doctor about your medical history, current medications, allergies, and if you're pregnant or breastfeeding before starting treatment with CRESEMBA 100MG CAPSULES.
CRESEMBA 100MG CAPSULES should not be used in people who are allergic to any of its components and children below 18 years as the safety and effectiveness were not established.
CRESEMBA 100MG CAPSULES is safe when used as prescribed by your doctor. However, it may cause side effects like headache, decreased appetite, drowsiness, nausea, vomiting, stomach pain, and chest pain while using it.
The common side effects of CRESEMBA 100MG CAPSULES may include headache, decreased appetite, drowsiness, nausea, vomiting, stomach pain, diarrhoea or chest pain. Most of these side effects of CRESEMBA 100MG CAPSULES do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.
Yes, you can take CRESEMBA 100MG CAPSULES either with or without food. However, it is important to take it consistently and exactly as directed by your healthcare provider. Talk to your doctor or pharmacist if you experience stomach upset.
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular routine. Do not double the dose. Talk to your doctor or pharmacist if you are unsure.
In some cases, CRESEMBA 100MG CAPSULES can cause liver strain or damage. Your doctor will likely monitor your liver enzymes with blood tests before and during treatment. Seek immediate medical attention if you notice yellow skin or eyes, dark urine, or severe stomach pain. Talk to your doctor for more information.
You should avoid drinking alcohol while taking this medication. Both alcohol and CRESEMBA 100MG CAPSULES are processed by your liver, and combining them can increase the risk of liver damage. Talk to your doctor or pharmacist for personalized advice.
This medication is generally not recommended during pregnancy as it may cause harm to an unborn baby. It is also unknown if it passes into breast milk. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor or pharmacist before starting this treatment.
Store the capsules at room temperature between 20°C and 25°C (68°F to 77°F) in their original blister packaging to protect them from moisture. Keep them away from heat, freezing conditions, and out of reach of children. Talk to your pharmacist about proper disposal of unused capsules.
No, you must complete the entire course of treatment prescribed by your doctor, even if you start feeling better. Stopping early can allow the fungal infection to return or worsen. Talk to your doctor before making any changes to your medication schedule.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.5071 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Isavuconazonium sulfate [EMC Label]. 2021. [Accessed on 03 Jul. 2021]Check here
  3. Clinical research advances of isavuconazole in the treatment of invasive fungal diseases. National Center for Biotechnology Information. National Library of Medicine. PMC. PubMed Central. December 2022. [Accessed on 22nd August 2024]Check here
  4. NHS Manchester University. Isavuconazole. National Aspergillosis Centre. [Accessed on 22nd August 2024]Check here
  5. Isavuconazonium sulfate [Prescription Information]. 2021. [Accessed on 03 Jul. 2021]Check here
  6. CRESEMBA® (isavuconazonium sulfate). [Accessed on 03 Jul. 2021]Check here
  7. Isavuconazonium sulfate [Dosing and Administration Guide]. 2022. [Accessed on 05 Jul. 2023]Check here

Country of origin

INDIA

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ?G? Block , Bandra Kurla Complex, Bandra East , Mumbai ? 400051.
Other Info - CRE0249
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