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Crimat 25 mg Injection is used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care. It contains Atracurium, which stops sending pain signal to the brain, relieves muscle stiffness or muscle spasm. It is also used during general anaesthesia to ease tracheal intubation (a tube into the windpipe) and controlled ventilation.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ATRACURIUM-25MG

Manufacturer/Marketer :

Miracle Formulations India Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Crimat 25 mg Injection

Crimat 25 mg Injection is a prescription medicine used to relax muscles during surgical procedures and when a patient requires breathing support from a ventilator. It temporarily prevents muscle movement, allowing doctors to perform procedures safely and effectively. It is commonly used to make insertion of a breathing tube easier and to keep muscles relaxed during surgery.

Because Crimat 25 mg Injection is given only in hospitals or specialised healthcare settings, it is administered as an injection or continuous infusion by trained medical professionals. Since it is given directly into a vein, food does not affect how it works. Following your healthcare team's recovery instructions can help support a smooth recovery after your procedure.

While receiving Crimat 25 mg Injection , some people may experience temporary side effects such as skin flushing, mild skin rash, hives, or a temporary drop in blood pressure. You will be continuously monitored throughout your procedure, allowing your medical team to quickly identify and manage any unexpected reactions.

Before receiving Crimat 25 mg Injection , tell your doctor if you have neuromuscular conditions such as myasthenia gravis, previous reactions to anesthesia, severe allergies, or any history of unusual responses to muscle-relaxing medicines. Do not receive Crimat 25 mg Injection if you have had a severe allergic reaction to Crimat 25 mg Injection or similar muscle-relaxing medicines from the same family.

Certain medicines, including some antibiotics, anesthetics, lithium, and magnesium-containing products, can affect how Crimat 25 mg Injection works. If you are pregnant, breastfeeding, an older adult, or the parent of a child receiving Crimat 25 mg Injection , discuss any concerns with your doctor before the procedure. Crimat 25 mg Injection is often preferred in patients with kidney or liver impairment because its breakdown does not depend heavily on these organs. It is also commonly used in operating rooms and intensive care units where reliable muscle relaxation is needed.

Uses of Crimat 25 mg Injection

Crimat 25 mg Injection is used in the treatment of Muscle contraction during surgery. The detailed uses of Crimat 25 mg Injection are as follows:

  • Muscle relaxation during surgery: It relaxes skeletal muscles, which helps surgeons perform operations safely and with fewer complications.
  • Support for mechanical ventilation: It relaxes the chest and airway muscles, allowing a breathing machine to work smoothly for patients in intensive care.
  • Tracheal intubation: It relaxes the throat muscles, making it easier and safer for a healthcare provider to insert a breathing tube.

Key Benefits

Crimat 25 mg Injection helps provide controlled muscle relaxation during surgical procedures and intensive care treatment. By relaxing the muscles effectively, it supports safe medical procedures and helps healthcare professionals manage breathing support when needed. Benefits may include:

  • Provides reliable muscle relaxation during surgical procedures.
  • Helps prevent involuntary muscle movements, allowing greater surgical precision.
  • Facilitates endotracheal intubation and airway management during anesthesia.
  • Supports better synchronization with mechanical ventilation in critically ill patients.
  • Helps reduce the effort required for assisted breathing during intensive care treatment.
  • Can be used in patients with impaired kidney or liver function under appropriate medical supervision.
Side effects of Crimat 25 mg Injection 2.5 ml
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.
  • Injection site reaction can include numbness or redness.
  • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
  • Apply cold compress for pain relief.
  • Practice good hygiene and keep the injection site away from heat and pressure.
  • Avoid scratching the affected area.
  • Wear loose clothing to reduce irritation.
  • Keep the affected area moisturized with a gentle moisturiser.
  • To alleviate the reaction, remove the irritant by immediately stopping contact and washing the area with mild soap and cool water.
  • Apply a cool, wet compress to reduce inflammation and itching.
  • Consult a doctor if your skin reaction is severe, widespread, or accompanied by swelling, blistering, or breathing difficulties.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Directions for Use

  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Crimat 25 mg Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Crimat 25 mg Injection Works

Crimat 25 mg Injection contains Atracurium, which helps relax the muscles by temporarily blocking the signals between nerves and muscles. This makes it easier for healthcare professionals to perform procedures such as surgery or assist with breathing support when needed. It works for a short period and the muscle function gradually returns as the medicine is naturally broken down and cleared from the body.
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Alcohol

Unsafe

Avoid consumption of alcohol after taking Crimat 25 mg Injection as it may increase the risk of side effects.

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Pregnancy

Consult your doctor

If you are pregnant, inform your doctor before receiving Crimat 25 mg Injection ; Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

If you are breastfeeding, inform your doctor before receiving Crimat 25 mg Injection ; Your doctor will prescribe only if the benefits outweigh the risks.

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Driving

Unsafe

Crimat 25 mg Injection causes sleepiness and drowsiness. So, avoid driving or operating heavy machinery after taking this medicine.

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Liver

Caution

Crimat 25 mg Injection should be used with caution in patients with liver diseases. Your doctor may adjust the dose of Crimat 25 mg Injection before prescribing.

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Kidney

Caution

Crimat 25 mg Injection should be used with caution in patients with kidney diseases. Your doctor may adjust the dose of Crimat 25 mg Injection before prescribing.

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Children

Consult your doctor

Crimat 25 mg Injection use is not recommended in neonates (children under the age of one month). Your doctor will decide the dose of Crimat 25 mg Injection based on age and condition of your child.

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Heart

Consult your doctor

Limited information is available; please consult your doctor.

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Geriatrics

Consult your doctor

Limited information available for use of Crimat 25 mg Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Crimat 25 mg Injection

Since medical professionals inject this medication under strict monitoring, an overdose is highly unlikely. If an overdose occurs, your healthcare team is trained to immediately manage it by providing breathing support and using medicines to reverse the muscle relaxation.

Diet & Lifestyle Advise

  • Follow fasting instructions carefully: Do not eat or drink anything as directed by your surgical team before the procedure, as fasting helps reduce the risk of serious breathing complications during anesthesia.
  • Get adequate rest after the procedure: Rest quietly following your surgery to allow your muscles time to recover and regain their full strength.
  • Avoid walking without assistance: Do not get out of bed, stand, or walk on your own until your healthcare team confirms that the effects of the medicine have completely worn off.
  • Stay well hydrated when permitted: Once your doctor allows you to drink fluids, consume plenty of water to support recovery and help your body process fluids effectively.
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Have a query?

How Soon It Starts Working

The time required for Crimat 25 mg Injection to start to work: The time required for Crimat 25 mg Injection to start to work is 2 to 3 minutes after administration. 

The time for which the effects of Crimat 25 mg Injection last: The effect of Crimat 25 mg Injection lasts for 20 to 35 minutes.

What if you forget to take Crimat 25 mg Injection

Because Crimat 25 mg Injection is given only by healthcare professionals in a controlled medical setting, it is not possible for you to miss a dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Crimat 25 mg Injection out of the sight and reach of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Inspect the solution before use: The solution should appear clear and colorless to pale yellow. Do not use it if it appears cloudy, discolored, or contains visible particles.
  • Inform your medical team about allergies: Tell your healthcare providers about any allergies, especially previous reactions to anesthesia, muscle relaxants, or other medicines.
  • Expect close monitoring during treatment: Your heart rate, blood pressure, oxygen levels, and breathing will be continuously monitored while Crimat 25 mg Injection is being administered.
  • Discuss any muscle or nerve disorders: Inform your doctor if you have myasthenia gravis or any other condition affecting the muscles or nervous system, as these conditions may alter your response to the medicine.
  • Inform your doctor about electrolyte abnormalities: Tell your healthcare provider if you have abnormal blood levels of minerals such as potassium or calcium, as these may affect how the medicine works.
  • Avoid activities requiring coordination after anesthesia: Do not drive, operate machinery, or perform tasks requiring full alertness and coordination for at least 24 hours after anesthesia, or for as long as advised by your doctor.

Drug-Drug Interactions

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  • Inhalation anesthetics (e.g., isoflurane, halothane): Taking these medicines alongside Crimat 25 mg Injection may increase and prolong its muscle-relaxing effects.
  • Certain antibiotics (e.g., aminoglycosides, polymyxins, tetracyclines): These medicines may enhance the effects of Crimat 25 mg Injection and prolong muscle relaxation.
  • Lithium or magnesium-containing medicines: Combining these with Crimat 25 mg Injection may increase its muscle-relaxing effects and raise the risk of excessive muscle weakness.
    Other muscle-relaxing medicines: Taking these alongside Crimat 25 mg Injection may increase the risk of prolonged or excessive muscle weakness.

Drug-Drug Interactions

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How does the drug interact with Crimat 25 mg Injection 2.5 ml:
Co-administration of Streptomycin with Crimat 25 mg Injection 2.5 ml may increase the risk or severity of side effects.

How to manage the interaction:
Co-administration of Streptomycin with Crimat 25 mg Injection 2.5 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Crimat 25 mg Injection 2.5 ml:
Using Crimat 25 mg Injection 2.5 ml with Tobramycin can increase the risk of respiratory depression (breathing disorder).

How to manage the interaction:
Although there is a interaction between Tobramycin and Crimat 25 mg Injection 2.5 ml, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
How does the drug interact with Crimat 25 mg Injection 2.5 ml:
Co-administration of Amikacin with Crimat 25 mg Injection 2.5 ml can increase the risk of developing breathing difficulties.

How to manage the interaction:
Taking Crimat 25 mg Injection 2.5 ml with Amikacin together can result in an interaction, but it can be taken if your doctor has advised it. Consult your doctor if you experience shortness of breath, palpitations, chest discomfort, or dizziness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Crimat 25 mg Injection 2.5 ml:
Coadministration of Botulinum toxin with Crimat 25 mg Injection 2.5 ml may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Botulinum toxin and Crimat 25 mg Injection 2.5 ml, it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience excessive muscle weakness or trouble breathing, swallowing, or speaking. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Crimat 25 mg Injection 2.5 ml:
Co-administration of Crimat 25 mg Injection 2.5 ml with doxycycline may increase the risk of breathing problems.

How to manage the interaction:
Although there is an interaction between Crimat 25 mg Injection 2.5 ml and Doxycycline, bit it can be taken together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Crimat 25 mg Injection 2.5 ml:
Co-administration of Polymyxin B with Crimat 25 mg Injection 2.5 ml may cause serious breathing problems

How to manage the interaction:
There may be a possibility of interaction between Polymyxin b and Crimat 25 mg Injection 2.5 ml, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Crimat 25 mg Injection 2.5 ml:
Combining Crimat 25 mg Injection 2.5 ml with Fentanyl can increase the risk of irregular heart rhythm and low blood pressure.

How to manage the interaction:
There may be a possibility of interaction between Crimat 25 mg Injection 2.5 ml and Fentanyl, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Crimat 25 mg Injection 2.5 ml:
Coadministration of Crimat 25 mg Injection 2.5 ml with Colistin can increase the risk of Crimat 25 mg Injection 2.5 ml side effects.

How to manage the interaction:
Although there is a possible interaction between Colistin and Crimat 25 mg Injection 2.5 ml, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, slurred speech, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Crimat 25 mg Injection 2.5 ml:
Co-administration of Clindamycin with Crimat 25 mg Injection 2.5 ml can increase the risk of muscle weakness.

How to manage the interaction:
Taking Clindamycin with Crimat 25 mg Injection 2.5 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. "Clindamycin can affect the muscles and nerves in your body. When used with other medications that also affect the muscles and nerves, it can cause a serious problem called neuromuscular blockade. If you have trouble breathing or can't breathe at all, please call your doctor right away." Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No interactions found

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[MUSCLE RELAXANTS/SKELETAL MUSCLE RELAXANTS]

FAQs

Crimat 25 mg Injection is used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring during surgery in intensive care.
Crimat 25 mg Injection contains 'Atracurium' that relaxes the muscles by blocking the impulses from the nerves. It is used for skeletal muscle relaxation during surgery.
Crimat 25 mg Injection causes sleepiness and drowsiness. So, drive only if you are alert and omit driving or operating machinery if you feel sleepy or drowsy.
Crimat 25 mg Injection is safe and effective when administered to patients with severe heart disease. However, rapid administration of large doses may occasionally produce transient hypotension in patients with heart problems. Please consult your doctor. Your doctor will prescribe only if the benefits outweigh the risks.
Do not use Crimat 25 mg Injection have had myasthenia gravis or Eaton-Lambert syndrome, severe electrolyte disorder, asthma-like symptoms (a history of allergy, asthma or bronchospasm), burns, and lack of adequate circulatory filling (hypovolaemia), pregnant or breastfeeding mother. Avoid driving or performing hazardous tasks until you know how Crimat 25 mg Injection will affect you, and your reactions could be impaired.
Crimat 25 mg Injection is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer or the fridge.
Crimat 25 mg Injection is given by IV injection administered by a healthcare professional under carefully controlled conditions. Do not self-administer Crimat 25 mg Injection .
The common side effects of the Crimat 25 mg Injection are tachycardia (rapid heartbeat), temporary hypotension (low blood pressure), wheezing, bronchospasm (asthma-like symptoms), skin flushing, and urticaria (nettle rash). However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
Crimat 25 mg Injection usually begins working within 2 to 3 minutes after intravenous administration. Your anesthesiologist will monitor its effects throughout the procedure.
No. Crimat 25 mg Injection only relaxes muscles and does not provide pain relief or cause sleep. It is used together with anesthetics and pain-relieving medicines during procedures.
Crimat 25 mg Injection is often preferred for people with kidney or liver impairment because it is broken down mainly through Hofmann elimination and ester hydrolysis rather than relying heavily on these organs.
Crimat 25 mg Injection may be used during pregnancy when medically necessary, such as during surgical procedures. Your doctor will carefully weigh the benefits and potential risks before use.
Doctors may allow the Crimat 25 mg Injection to wear off naturally or use anticholinesterase medicines such as neostigmine to help restore normal muscle strength more quickly.

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Country of origin

INDIA

Manufacturer/Marketer address

213, Shivai Dongre Industrial Premises, Andheri - Kurla Road, Andheri(E), Mumbai - 400 072, Maharashtra, India.
Other Info - CRI0060
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